Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 1
missense 674
nonsense 158
start codon destroyed 5
start gained 1
synonymous 0
splice acceptor site 25
splice donor site 30
critical splice acceptor site 15
critical splice donor site 81
splice site 0
large deletion 4
large insertion 0
rearrangement 0
small deletion 2
small insertion 2
exon 0
frame shift 6
intragenic 0
intron 6
utr 3 prime 1
utr 5 prime 0
Total: 1011
Incidental Mutation Types
Mutation TypeNumber*
makesense 1383
missense 328138
nonsense 17397
start codon destroyed 715
start gained 805
synonymous 523
splice acceptor site 12974
splice donor site 13015
critical splice acceptor site 1244
critical splice donor site 5336
splice site 8415
large deletion 0
large insertion 0
rearrangement 0
small deletion 753
small insertion 357
exon 34
frame shift 1312
intragenic 6
intron 1172
utr 3 prime 95
utr 5 prime 100
Total: 393774
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 22
A ⇒ G 174
A ⇒ T 157
C ⇒ A 40
C ⇒ G 5
C ⇒ T 77
G ⇒ A 86
G ⇒ C 2
G ⇒ T 57
T ⇒ A 161
T ⇒ C 188
T ⇒ G 28
Total: 997
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9744
A ⇒ G 83012
A ⇒ T 52484
C ⇒ A 17816
C ⇒ G 1794
C ⇒ T 33066
G ⇒ A 32655
G ⇒ C 1723
G ⇒ T 17376
T ⇒ A 53290
T ⇒ C 83589
T ⇒ G 9836
Total: 396385
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 1
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 3
Arginine Cysteine 6
Arginine Glutamine 7
Arginine Glycine 6
Arginine Histidine 6
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 2
Arginine Stop codon 24
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 6
Asparagine Lysine 7
Asparagine Serine 5
Asparagine Threonine 0
Asparagine Tyrosine 3
Aspartic acid Alanine 3
Aspartic acid Asparagine 1
Aspartic acid Glutamic Acid 6
Aspartic acid Glycine 22
Aspartic acid Histidine 0
Aspartic acid Tyrosine 3
Aspartic acid Valine 10
Cysteine Arginine 13
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 10
Cysteine Tryptophan 3
Cysteine Tyrosine 6
Cysteine Stop codon 19
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 2
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 14
Glutamic Acid Lysine 2
Glutamic Acid Valine 2
Glutamic Acid Stop codon 8
Glutamine Arginine 1
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 28
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 2
Glycine Glutamic Acid 0
Glycine Serine 3
Glycine Tryptophan 1
Glycine Valine 3
Glycine Stop codon 1
Histidine Arginine 13
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 3
Histidine Leucine 8
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 1
Isoleucine Asparagine 24
Isoleucine Leucine 4
Isoleucine Lysine 4
Isoleucine Methionine 0
Isoleucine Phenylalanine 11
Isoleucine Serine 0
Isoleucine Threonine 18
Isoleucine Valine 8
Leucine Arginine 4
Leucine Glutamine 13
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 34
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 10
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 2
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 18
Methionine Arginine 1
Methionine Isoleucine 1
Methionine Leucine 2
Methionine Lysine 16
Methionine Threonine 5
Methionine Valine 7
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 8
Phenylalanine Leucine 7
Phenylalanine Serine 7
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 1
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 3
Serine Alanine 0
Serine Arginine 3
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 1
Serine Isoleucine 1
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 33
Serine Threonine 5
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 14
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 7
Threonine Lysine 5
Threonine Methionine 4
Threonine Proline 2
Threonine Serine 7
Tryptophan Arginine 12
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 7
Tyrosine Asparagine 1
Tyrosine Aspartic acid 4
Tyrosine Cysteine 26
Tyrosine Histidine 10
Tyrosine Phenylalanine 5
Tyrosine Serine 0
Tyrosine Stop codon 36
Valine Alanine 37
Valine Aspartic acid 9
Valine Glutamic Acid 18
Valine Glycine 3
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 8
Valine Phenylalanine 3
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
829 changes of 126 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 469
Alanine Glutamic Acid 1056
Alanine Glycine 146
Alanine Proline 215
Alanine Serine 1735
Alanine Threonine 2825
Alanine Valine 2755
Arginine Cysteine 2410
Arginine Glutamine 2343
Arginine Glycine 2542
Arginine Histidine 2886
Arginine Isoleucine 77
Arginine Leucine 2175
Arginine Lysine 401
Arginine Methionine 99
Arginine Proline 172
Arginine Serine 1851
Arginine Threonine 33
Arginine Tryptophan 1744
Arginine Stop codon 2403
Asparagine Aspartic acid 2288
Asparagine Histidine 167
Asparagine Isoleucine 1983
Asparagine Lysine 5063
Asparagine Serine 6208
Asparagine Threonine 446
Asparagine Tyrosine 1065
Aspartic acid Alanine 1136
Aspartic acid Asparagine 1639
Aspartic acid Glutamic Acid 6619
Aspartic acid Glycine 14025
Aspartic acid Histidine 97
Aspartic acid Tyrosine 675
Aspartic acid Valine 4121
Cysteine Arginine 1988
Cysteine Glycine 398
Cysteine Phenylalanine 1215
Cysteine Serine 3110
Cysteine Tryptophan 224
Cysteine Tyrosine 1836
Cysteine Stop codon 2282
Glutamic Acid Alanine 515
Glutamic Acid Aspartic acid 1574
Glutamic Acid Glutamine 128
Glutamic Acid Glycine 9874
Glutamic Acid Lysine 2278
Glutamic Acid Valine 1432
Glutamic Acid Stop codon 1127
Glutamine Arginine 1460
Glutamine Glutamic Acid 85
Glutamine Histidine 529
Glutamine Leucine 2520
Glutamine Lysine 1854
Glutamine Proline 430
Glutamine Stop codon 2773
Glycine Alanine 148
Glycine Arginine 1191
Glycine Aspartic acid 1853
Glycine Cysteine 608
Glycine Glutamic Acid 651
Glycine Serine 979
Glycine Tryptophan 408
Glycine Valine 745
Glycine Stop codon 362
Histidine Arginine 3360
Histidine Asparagine 900
Histidine Aspartic acid 71
Histidine Glutamine 3146
Histidine Leucine 3326
Histidine Proline 357
Histidine Tyrosine 1206
Isoleucine Arginine 182
Isoleucine Asparagine 5168
Isoleucine Leucine 2053
Isoleucine Lysine 1306
Isoleucine Methionine 1317
Isoleucine Phenylalanine 5807
Isoleucine Serine 760
Isoleucine Threonine 7552
Isoleucine Valine 6593
Leucine Arginine 1166
Leucine Glutamine 3279
Leucine Histidine 913
Leucine Isoleucine 606
Leucine Methionine 416
Leucine Phenylalanine 2039
Leucine Proline 7062
Leucine Serine 912
Leucine Tryptophan 80
Leucine Valine 401
Leucine Stop codon 1423
Lysine Arginine 2329
Lysine Asparagine 1691
Lysine Glutamic Acid 3674
Lysine Glutamine 252
Lysine Isoleucine 207
Lysine Methionine 427
Lysine Threonine 353
Lysine Stop codon 1705
Methionine Arginine 604
Methionine Isoleucine 1572
Methionine Leucine 3107
Methionine Lysine 5186
Methionine Threonine 2161
Methionine Valine 2372
Phenylalanine Cysteine 233
Phenylalanine Isoleucine 1927
Phenylalanine Leucine 5753
Phenylalanine Serine 3278
Phenylalanine Tyrosine 826
Phenylalanine Valine 550
Proline Alanine 167
Proline Arginine 158
Proline Glutamine 1004
Proline Histidine 181
Proline Leucine 2029
Proline Serine 2806
Proline Threonine 696
Serine Alanine 1276
Serine Arginine 2535
Serine Asparagine 1185
Serine Cysteine 900
Serine Glycine 2805
Serine Isoleucine 386
Serine Leucine 1166
Serine Phenylalanine 750
Serine Proline 13096
Serine Threonine 4172
Serine Tryptophan 15
Serine Tyrosine 237
Serine Stop codon 644
Threonine Alanine 14665
Threonine Arginine 83
Threonine Asparagine 664
Threonine Isoleucine 5439
Threonine Lysine 2001
Threonine Methionine 2265
Threonine Proline 857
Threonine Serine 4448
Tryptophan Arginine 2349
Tryptophan Cysteine 128
Tryptophan Glycine 153
Tryptophan Leucine 416
Tryptophan Serine 24
Tryptophan Stop codon 852
Tyrosine Asparagine 2044
Tyrosine Aspartic acid 295
Tyrosine Cysteine 7040
Tyrosine Histidine 5347
Tyrosine Phenylalanine 2467
Tyrosine Serine 317
Tyrosine Stop codon 3859
Valine Alanine 17536
Valine Aspartic acid 2680
Valine Glutamic Acid 4330
Valine Glycine 1523
Valine Isoleucine 4778
Valine Leucine 1846
Valine Methionine 3243
Valine Phenylalanine 1258
Stop codon Arginine 362
Stop codon Cysteine 60
Stop codon Glutamic Acid 25
Stop codon Glutamine 362
Stop codon Glycine 33
Stop codon Leucine 101
Stop codon Lysine 90
Stop codon Serine 11
Stop codon Tryptophan 318
Stop codon Tyrosine 30
348561 changes of 170 types
We have now tabulated 349390 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.