Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 1
missense 716
nonsense 166
start codon destroyed 7
start gained 1
synonymous 0
splice acceptor site 25
splice donor site 30
critical splice acceptor site 16
critical splice donor site 90
splice site 5
large deletion 4
large insertion 0
rearrangement 0
small deletion 2
small insertion 2
exon 0
frame shift 6
intragenic 0
intron 8
utr 3 prime 1
utr 5 prime 0
Total: 1080
Incidental Mutation Types
Mutation TypeNumber*
makesense 1402
missense 333725
nonsense 17663
start codon destroyed 733
start gained 850
synonymous 549
splice acceptor site 12974
splice donor site 13015
critical splice acceptor site 1305
critical splice donor site 5629
splice site 8576
large deletion 0
large insertion 0
rearrangement 0
small deletion 759
small insertion 371
exon 38
frame shift 1348
intragenic 6
intron 1264
utr 3 prime 104
utr 5 prime 101
Total: 400412
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 25
A ⇒ G 192
A ⇒ T 163
C ⇒ A 44
C ⇒ G 5
C ⇒ T 83
G ⇒ A 91
G ⇒ C 2
G ⇒ T 59
T ⇒ A 176
T ⇒ C 197
T ⇒ G 30
Total: 1067
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9927
A ⇒ G 84243
A ⇒ T 53330
C ⇒ A 18101
C ⇒ G 1832
C ⇒ T 33587
G ⇒ A 33174
G ⇒ C 1753
G ⇒ T 17694
T ⇒ A 54136
T ⇒ C 84904
T ⇒ G 9994
Total: 402675
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 3
Arginine Cysteine 6
Arginine Glutamine 8
Arginine Glycine 7
Arginine Histidine 6
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 2
Arginine Stop codon 25
Asparagine Aspartic acid 4
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 8
Asparagine Serine 7
Asparagine Threonine 0
Asparagine Tyrosine 3
Aspartic acid Alanine 3
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 6
Aspartic acid Glycine 25
Aspartic acid Histidine 0
Aspartic acid Tyrosine 3
Aspartic acid Valine 10
Cysteine Arginine 13
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 10
Cysteine Tryptophan 3
Cysteine Tyrosine 6
Cysteine Stop codon 19
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 16
Glutamic Acid Lysine 2
Glutamic Acid Valine 2
Glutamic Acid Stop codon 10
Glutamine Arginine 1
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 5
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 31
Glycine Alanine 0
Glycine Arginine 5
Glycine Aspartic acid 7
Glycine Cysteine 2
Glycine Glutamic Acid 0
Glycine Serine 3
Glycine Tryptophan 1
Glycine Valine 3
Glycine Stop codon 1
Histidine Arginine 13
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 4
Histidine Leucine 9
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 1
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 4
Isoleucine Methionine 0
Isoleucine Phenylalanine 12
Isoleucine Serine 0
Isoleucine Threonine 19
Isoleucine Valine 7
Leucine Arginine 5
Leucine Glutamine 13
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 36
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 10
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 2
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 19
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 17
Methionine Threonine 5
Methionine Valine 8
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 8
Phenylalanine Leucine 8
Phenylalanine Serine 9
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 1
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 3
Serine Alanine 0
Serine Arginine 3
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 2
Serine Isoleucine 1
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 33
Serine Threonine 7
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 15
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 8
Threonine Lysine 5
Threonine Methionine 5
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 12
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 6
Tyrosine Asparagine 2
Tyrosine Aspartic acid 4
Tyrosine Cysteine 28
Tyrosine Histidine 12
Tyrosine Phenylalanine 5
Tyrosine Serine 0
Tyrosine Stop codon 38
Valine Alanine 38
Valine Aspartic acid 12
Valine Glutamic Acid 18
Valine Glycine 4
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 9
Valine Phenylalanine 3
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
882 changes of 126 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 478
Alanine Glutamic Acid 1080
Alanine Glycine 147
Alanine Proline 216
Alanine Serine 1763
Alanine Threonine 2872
Alanine Valine 2802
Arginine Cysteine 2451
Arginine Glutamine 2379
Arginine Glycine 2574
Arginine Histidine 2931
Arginine Isoleucine 77
Arginine Leucine 2202
Arginine Lysine 413
Arginine Methionine 100
Arginine Proline 177
Arginine Serine 1887
Arginine Threonine 33
Arginine Tryptophan 1763
Arginine Stop codon 2433
Asparagine Aspartic acid 2317
Asparagine Histidine 170
Asparagine Isoleucine 2019
Asparagine Lysine 5145
Asparagine Serine 6295
Asparagine Threonine 453
Asparagine Tyrosine 1085
Aspartic acid Alanine 1157
Aspartic acid Asparagine 1673
Aspartic acid Glutamic Acid 6734
Aspartic acid Glycine 14276
Aspartic acid Histidine 100
Aspartic acid Tyrosine 681
Aspartic acid Valine 4202
Cysteine Arginine 2020
Cysteine Glycine 404
Cysteine Phenylalanine 1231
Cysteine Serine 3169
Cysteine Tryptophan 226
Cysteine Tyrosine 1865
Cysteine Stop codon 2317
Glutamic Acid Alanine 523
Glutamic Acid Aspartic acid 1590
Glutamic Acid Glutamine 131
Glutamic Acid Glycine 10046
Glutamic Acid Lysine 2314
Glutamic Acid Valine 1461
Glutamic Acid Stop codon 1144
Glutamine Arginine 1486
Glutamine Glutamic Acid 86
Glutamine Histidine 536
Glutamine Leucine 2561
Glutamine Lysine 1880
Glutamine Proline 440
Glutamine Stop codon 2804
Glycine Alanine 149
Glycine Arginine 1217
Glycine Aspartic acid 1883
Glycine Cysteine 618
Glycine Glutamic Acid 657
Glycine Serine 995
Glycine Tryptophan 416
Glycine Valine 760
Glycine Stop codon 366
Histidine Arginine 3421
Histidine Asparagine 913
Histidine Aspartic acid 71
Histidine Glutamine 3205
Histidine Leucine 3376
Histidine Proline 365
Histidine Tyrosine 1231
Isoleucine Arginine 186
Isoleucine Asparagine 5246
Isoleucine Leucine 2093
Isoleucine Lysine 1326
Isoleucine Methionine 1340
Isoleucine Phenylalanine 5914
Isoleucine Serine 777
Isoleucine Threonine 7682
Isoleucine Valine 6689
Leucine Arginine 1182
Leucine Glutamine 3326
Leucine Histidine 924
Leucine Isoleucine 617
Leucine Methionine 430
Leucine Phenylalanine 2071
Leucine Proline 7175
Leucine Serine 934
Leucine Tryptophan 81
Leucine Valine 408
Leucine Stop codon 1454
Lysine Arginine 2360
Lysine Asparagine 1718
Lysine Glutamic Acid 3743
Lysine Glutamine 258
Lysine Isoleucine 209
Lysine Methionine 435
Lysine Threonine 364
Lysine Stop codon 1733
Methionine Arginine 608
Methionine Isoleucine 1593
Methionine Leucine 3157
Methionine Lysine 5281
Methionine Threonine 2197
Methionine Valine 2412
Phenylalanine Cysteine 238
Phenylalanine Isoleucine 1959
Phenylalanine Leucine 5877
Phenylalanine Serine 3331
Phenylalanine Tyrosine 834
Phenylalanine Valine 562
Proline Alanine 167
Proline Arginine 160
Proline Glutamine 1023
Proline Histidine 182
Proline Leucine 2078
Proline Serine 2855
Proline Threonine 713
Serine Alanine 1307
Serine Arginine 2585
Serine Asparagine 1202
Serine Cysteine 911
Serine Glycine 2840
Serine Isoleucine 393
Serine Leucine 1184
Serine Phenylalanine 768
Serine Proline 13314
Serine Threonine 4237
Serine Tryptophan 15
Serine Tyrosine 241
Serine Stop codon 656
Threonine Alanine 14888
Threonine Arginine 84
Threonine Asparagine 678
Threonine Isoleucine 5520
Threonine Lysine 2040
Threonine Methionine 2300
Threonine Proline 873
Threonine Serine 4534
Tryptophan Arginine 2397
Tryptophan Cysteine 130
Tryptophan Glycine 157
Tryptophan Leucine 423
Tryptophan Serine 25
Tryptophan Stop codon 872
Tyrosine Asparagine 2086
Tyrosine Aspartic acid 302
Tyrosine Cysteine 7150
Tyrosine Histidine 5454
Tyrosine Phenylalanine 2510
Tyrosine Serine 326
Tyrosine Stop codon 3912
Valine Alanine 17816
Valine Aspartic acid 2723
Valine Glutamic Acid 4409
Valine Glycine 1551
Valine Isoleucine 4847
Valine Leucine 1879
Valine Methionine 3303
Valine Phenylalanine 1278
Stop codon Arginine 363
Stop codon Cysteine 62
Stop codon Glutamic Acid 25
Stop codon Glutamine 369
Stop codon Glycine 33
Stop codon Leucine 101
Stop codon Lysine 90
Stop codon Serine 11
Stop codon Tryptophan 324
Stop codon Tyrosine 30
354392 changes of 170 types
We have now tabulated 355274 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.