Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 1
missense 756
nonsense 189
start codon destroyed 8
start gained 1
synonymous 0
splice acceptor site 28
splice donor site 34
critical splice acceptor site 16
critical splice donor site 101
splice site 5
large deletion 4
large insertion 0
rearrangement 0
small deletion 2
small insertion 2
exon 0
frame shift 6
intragenic 0
intron 11
utr 3 prime 1
utr 5 prime 0
Total: 1165
Incidental Mutation Types
Mutation TypeNumber*
makesense 1413
missense 335350
nonsense 17782
start codon destroyed 746
start gained 938
synonymous 558
splice acceptor site 11248
splice donor site 11231
critical splice acceptor site 1211
critical splice donor site 5023
splice site 1303
large deletion 0
large insertion 0
rearrangement 0
small deletion 777
small insertion 385
exon 627
frame shift 1367
intragenic 6
intron 1277
utr 3 prime 603
utr 5 prime 459
Total: 392304
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 27
A ⇒ G 201
A ⇒ T 182
C ⇒ A 50
C ⇒ G 5
C ⇒ T 91
G ⇒ A 92
G ⇒ C 2
G ⇒ T 66
T ⇒ A 188
T ⇒ C 210
T ⇒ G 31
Total: 1145
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10071
A ⇒ G 85428
A ⇒ T 54100
C ⇒ A 18366
C ⇒ G 1867
C ⇒ T 34023
G ⇒ A 33629
G ⇒ C 1789
G ⇒ T 17928
T ⇒ A 54920
T ⇒ C 86051
T ⇒ G 10118
Total: 408290
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 3
Arginine Cysteine 8
Arginine Glutamine 8
Arginine Glycine 8
Arginine Histidine 7
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 5
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 26
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 9
Asparagine Serine 7
Asparagine Threonine 0
Asparagine Tyrosine 3
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 7
Aspartic acid Glycine 28
Aspartic acid Histidine 0
Aspartic acid Tyrosine 3
Aspartic acid Valine 9
Cysteine Arginine 15
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 9
Cysteine Tryptophan 3
Cysteine Tyrosine 7
Cysteine Stop codon 23
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 17
Glutamic Acid Lysine 3
Glutamic Acid Valine 2
Glutamic Acid Stop codon 14
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 5
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 32
Glycine Alanine 0
Glycine Arginine 5
Glycine Aspartic acid 7
Glycine Cysteine 3
Glycine Glutamic Acid 0
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 3
Glycine Stop codon 2
Histidine Arginine 14
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 9
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 1
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 4
Isoleucine Methionine 1
Isoleucine Phenylalanine 13
Isoleucine Serine 0
Isoleucine Threonine 19
Isoleucine Valine 5
Leucine Arginine 5
Leucine Glutamine 13
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 36
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 11
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 4
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 25
Methionine Arginine 3
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 19
Methionine Threonine 5
Methionine Valine 8
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 8
Phenylalanine Leucine 9
Phenylalanine Serine 10
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 1
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 3
Serine Alanine 1
Serine Arginine 4
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 3
Serine Isoleucine 1
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 37
Serine Threonine 7
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 5
Threonine Alanine 16
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 8
Threonine Lysine 5
Threonine Methionine 4
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 11
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 6
Tyrosine Asparagine 3
Tyrosine Aspartic acid 4
Tyrosine Cysteine 28
Tyrosine Histidine 12
Tyrosine Phenylalanine 6
Tyrosine Serine 0
Tyrosine Stop codon 43
Valine Alanine 38
Valine Aspartic acid 14
Valine Glutamic Acid 19
Valine Glycine 4
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 10
Valine Phenylalanine 3
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
944 changes of 128 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 481
Alanine Glutamic Acid 1091
Alanine Glycine 150
Alanine Proline 217
Alanine Serine 1788
Alanine Threonine 2919
Alanine Valine 2844
Arginine Cysteine 2478
Arginine Glutamine 2398
Arginine Glycine 2621
Arginine Histidine 2965
Arginine Isoleucine 75
Arginine Leucine 2222
Arginine Lysine 420
Arginine Methionine 102
Arginine Proline 178
Arginine Serine 1916
Arginine Threonine 34
Arginine Tryptophan 1773
Arginine Stop codon 2472
Asparagine Aspartic acid 2341
Asparagine Histidine 172
Asparagine Isoleucine 2037
Asparagine Lysine 5192
Asparagine Serine 6360
Asparagine Threonine 459
Asparagine Tyrosine 1095
Aspartic acid Alanine 1181
Aspartic acid Asparagine 1678
Aspartic acid Glutamic Acid 6795
Aspartic acid Glycine 14425
Aspartic acid Histidine 108
Aspartic acid Tyrosine 691
Aspartic acid Valine 4264
Cysteine Arginine 2038
Cysteine Glycine 405
Cysteine Phenylalanine 1242
Cysteine Serine 3220
Cysteine Tryptophan 227
Cysteine Tyrosine 1874
Cysteine Stop codon 2354
Glutamic Acid Alanine 526
Glutamic Acid Aspartic acid 1602
Glutamic Acid Glutamine 133
Glutamic Acid Glycine 10152
Glutamic Acid Lysine 2337
Glutamic Acid Valine 1467
Glutamic Acid Stop codon 1149
Glutamine Arginine 1494
Glutamine Glutamic Acid 89
Glutamine Histidine 543
Glutamine Leucine 2582
Glutamine Lysine 1901
Glutamine Proline 440
Glutamine Stop codon 2843
Glycine Alanine 154
Glycine Arginine 1239
Glycine Aspartic acid 1894
Glycine Cysteine 627
Glycine Glutamic Acid 662
Glycine Serine 1003
Glycine Tryptophan 420
Glycine Valine 770
Glycine Stop codon 367
Histidine Arginine 3470
Histidine Asparagine 924
Histidine Aspartic acid 71
Histidine Glutamine 3247
Histidine Leucine 3422
Histidine Proline 368
Histidine Tyrosine 1248
Isoleucine Arginine 189
Isoleucine Asparagine 5309
Isoleucine Leucine 2122
Isoleucine Lysine 1343
Isoleucine Methionine 1351
Isoleucine Phenylalanine 5969
Isoleucine Serine 783
Isoleucine Threonine 7761
Isoleucine Valine 6772
Leucine Arginine 1195
Leucine Glutamine 3359
Leucine Histidine 938
Leucine Isoleucine 621
Leucine Methionine 445
Leucine Phenylalanine 2100
Leucine Proline 7272
Leucine Serine 940
Leucine Tryptophan 83
Leucine Valine 413
Leucine Stop codon 1464
Lysine Arginine 2380
Lysine Asparagine 1730
Lysine Glutamic Acid 3781
Lysine Glutamine 261
Lysine Isoleucine 213
Lysine Methionine 440
Lysine Threonine 363
Lysine Stop codon 1749
Methionine Arginine 610
Methionine Isoleucine 1609
Methionine Leucine 3191
Methionine Lysine 5333
Methionine Threonine 2219
Methionine Valine 2436
Phenylalanine Cysteine 239
Phenylalanine Isoleucine 1982
Phenylalanine Leucine 5932
Phenylalanine Serine 3356
Phenylalanine Tyrosine 840
Phenylalanine Valine 567
Proline Alanine 169
Proline Arginine 161
Proline Glutamine 1040
Proline Histidine 179
Proline Leucine 2101
Proline Serine 2828
Proline Threonine 721
Serine Alanine 1323
Serine Arginine 2619
Serine Asparagine 1209
Serine Cysteine 923
Serine Glycine 2877
Serine Isoleucine 397
Serine Leucine 1192
Serine Phenylalanine 775
Serine Proline 13473
Serine Threonine 4284
Serine Tryptophan 15
Serine Tyrosine 243
Serine Stop codon 666
Threonine Alanine 15079
Threonine Arginine 86
Threonine Asparagine 684
Threonine Isoleucine 5557
Threonine Lysine 2052
Threonine Methionine 2337
Threonine Proline 887
Threonine Serine 4601
Tryptophan Arginine 2425
Tryptophan Cysteine 132
Tryptophan Glycine 159
Tryptophan Leucine 424
Tryptophan Serine 25
Tryptophan Stop codon 884
Tyrosine Asparagine 2119
Tyrosine Aspartic acid 310
Tyrosine Cysteine 7255
Tyrosine Histidine 5534
Tyrosine Phenylalanine 2539
Tyrosine Serine 330
Tyrosine Stop codon 3968
Valine Alanine 18017
Valine Aspartic acid 2746
Valine Glutamic Acid 4450
Valine Glycine 1564
Valine Isoleucine 4903
Valine Leucine 1900
Valine Methionine 3351
Valine Phenylalanine 1284
Stop codon Arginine 369
Stop codon Cysteine 62
Stop codon Glutamic Acid 25
Stop codon Glutamine 374
Stop codon Glycine 34
Stop codon Leucine 102
Stop codon Lysine 93
Stop codon Serine 11
Stop codon Tryptophan 332
Stop codon Tyrosine 30
358335 changes of 170 types
We have now tabulated 359279 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.