Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 2
missense 789
nonsense 200
start codon destroyed 10
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 30
critical splice acceptor site 21
critical splice donor site 100
splice site 20
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 8
intragenic 0
intron 14
utr 3 prime 1
utr 5 prime 1
Total: 1217
Incidental Mutation Types
Mutation TypeNumber*
makesense 783
missense 333139
nonsense 16434
start codon destroyed 881
start gained 1170
synonymous 454
splice acceptor site 467
splice donor site 491
critical splice acceptor site 1695
critical splice donor site 7150
splice site 13707
large deletion 0
large insertion 0
rearrangement 0
small deletion 857
small insertion 1102
exon 2187
frame shift 1265
intragenic 0
intron 3119
utr 3 prime 971
utr 5 prime 782
Total: 386654
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 26
A ⇒ G 215
A ⇒ T 181
C ⇒ A 58
C ⇒ G 5
C ⇒ T 101
G ⇒ A 96
G ⇒ C 3
G ⇒ T 64
T ⇒ A 212
T ⇒ C 212
T ⇒ G 28
Total: 1201
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9923
A ⇒ G 82710
A ⇒ T 53620
C ⇒ A 17990
C ⇒ G 1798
C ⇒ T 32536
G ⇒ A 32142
G ⇒ C 1734
G ⇒ T 17659
T ⇒ A 54318
T ⇒ C 83355
T ⇒ G 9913
Total: 397698
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 1
Alanine Valine 4
Arginine Cysteine 8
Arginine Glutamine 9
Arginine Glycine 7
Arginine Histidine 7
Arginine Isoleucine 0
Arginine Leucine 5
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 21
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 13
Asparagine Serine 9
Asparagine Threonine 0
Asparagine Tyrosine 5
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 11
Aspartic acid Glycine 32
Aspartic acid Histidine 1
Aspartic acid Tyrosine 3
Aspartic acid Valine 11
Cysteine Arginine 16
Cysteine Glycine 2
Cysteine Phenylalanine 8
Cysteine Serine 9
Cysteine Tryptophan 2
Cysteine Tyrosine 6
Cysteine Stop codon 27
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 21
Glutamic Acid Lysine 2
Glutamic Acid Valine 1
Glutamic Acid Stop codon 15
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 3
Glutamine Proline 1
Glutamine Stop codon 35
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 2
Glycine Glutamic Acid 2
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 5
Glycine Stop codon 2
Histidine Arginine 11
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 10
Histidine Proline 2
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 6
Isoleucine Methionine 1
Isoleucine Phenylalanine 10
Isoleucine Serine 0
Isoleucine Threonine 19
Isoleucine Valine 6
Leucine Arginine 5
Leucine Glutamine 10
Leucine Histidine 1
Leucine Isoleucine 2
Leucine Methionine 0
Leucine Phenylalanine 2
Leucine Proline 31
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 15
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 5
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 26
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 21
Methionine Threonine 7
Methionine Valine 9
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 9
Phenylalanine Leucine 12
Phenylalanine Serine 13
Phenylalanine Tyrosine 1
Phenylalanine Valine 2
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 3
Proline Serine 1
Proline Threonine 4
Serine Alanine 1
Serine Arginine 4
Serine Asparagine 2
Serine Cysteine 2
Serine Glycine 3
Serine Isoleucine 0
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 31
Serine Threonine 9
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 4
Threonine Alanine 15
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 10
Threonine Lysine 6
Threonine Methionine 6
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 13
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 4
Tyrosine Asparagine 3
Tyrosine Aspartic acid 1
Tyrosine Cysteine 34
Tyrosine Histidine 16
Tyrosine Phenylalanine 6
Tyrosine Serine 0
Tyrosine Stop codon 48
Valine Alanine 39
Valine Aspartic acid 14
Valine Glutamic Acid 20
Valine Glycine 4
Valine Isoleucine 7
Valine Leucine 0
Valine Methionine 11
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
991 changes of 129 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 527
Alanine Glutamic Acid 1080
Alanine Glycine 145
Alanine Proline 203
Alanine Serine 1774
Alanine Threonine 2925
Alanine Valine 2789
Arginine Cysteine 2383
Arginine Glutamine 2330
Arginine Glycine 2354
Arginine Histidine 2848
Arginine Isoleucine 75
Arginine Leucine 2233
Arginine Lysine 374
Arginine Methionine 98
Arginine Proline 172
Arginine Serine 1847
Arginine Threonine 28
Arginine Tryptophan 1732
Arginine Stop codon 2186
Asparagine Aspartic acid 2352
Asparagine Histidine 178
Asparagine Isoleucine 2056
Asparagine Lysine 5342
Asparagine Serine 6365
Asparagine Threonine 478
Asparagine Tyrosine 1111
Aspartic acid Alanine 1201
Aspartic acid Asparagine 1681
Aspartic acid Glutamic Acid 7093
Aspartic acid Glycine 14754
Aspartic acid Histidine 120
Aspartic acid Tyrosine 714
Aspartic acid Valine 4393
Cysteine Arginine 1832
Cysteine Glycine 384
Cysteine Phenylalanine 1193
Cysteine Serine 3022
Cysteine Tryptophan 220
Cysteine Tyrosine 1707
Cysteine Stop codon 2041
Glutamic Acid Alanine 531
Glutamic Acid Aspartic acid 1680
Glutamic Acid Glutamine 134
Glutamic Acid Glycine 10321
Glutamic Acid Lysine 2340
Glutamic Acid Valine 1511
Glutamic Acid Stop codon 1119
Glutamine Arginine 1501
Glutamine Glutamic Acid 93
Glutamine Histidine 526
Glutamine Leucine 2599
Glutamine Lysine 1900
Glutamine Proline 422
Glutamine Stop codon 2597
Glycine Alanine 151
Glycine Arginine 1232
Glycine Aspartic acid 1867
Glycine Cysteine 597
Glycine Glutamic Acid 636
Glycine Serine 1036
Glycine Tryptophan 411
Glycine Valine 781
Glycine Stop codon 322
Histidine Arginine 3290
Histidine Asparagine 936
Histidine Aspartic acid 55
Histidine Glutamine 3180
Histidine Leucine 3204
Histidine Proline 344
Histidine Tyrosine 1155
Isoleucine Arginine 196
Isoleucine Asparagine 5584
Isoleucine Leucine 2131
Isoleucine Lysine 1326
Isoleucine Methionine 1309
Isoleucine Phenylalanine 6050
Isoleucine Serine 809
Isoleucine Threonine 7735
Isoleucine Valine 6774
Leucine Arginine 1170
Leucine Glutamine 3342
Leucine Histidine 943
Leucine Isoleucine 599
Leucine Methionine 433
Leucine Phenylalanine 2045
Leucine Proline 7058
Leucine Serine 880
Leucine Tryptophan 81
Leucine Valine 402
Leucine Stop codon 1349
Lysine Arginine 2384
Lysine Asparagine 1750
Lysine Glutamic Acid 3794
Lysine Glutamine 265
Lysine Isoleucine 213
Lysine Methionine 481
Lysine Threonine 380
Lysine Stop codon 1710
Methionine Arginine 620
Methionine Isoleucine 1619
Methionine Leucine 3224
Methionine Lysine 5413
Methionine Threonine 2195
Methionine Valine 2449
Phenylalanine Cysteine 232
Phenylalanine Isoleucine 1966
Phenylalanine Leucine 5921
Phenylalanine Serine 3293
Phenylalanine Tyrosine 870
Phenylalanine Valine 563
Proline Alanine 151
Proline Arginine 153
Proline Glutamine 973
Proline Histidine 175
Proline Leucine 2030
Proline Serine 2670
Proline Threonine 689
Serine Alanine 1309
Serine Arginine 2617
Serine Asparagine 1136
Serine Cysteine 913
Serine Glycine 2725
Serine Isoleucine 396
Serine Leucine 1109
Serine Phenylalanine 735
Serine Proline 12954
Serine Threonine 4148
Serine Tryptophan 15
Serine Tyrosine 249
Serine Stop codon 577
Threonine Alanine 14555
Threonine Arginine 91
Threonine Asparagine 686
Threonine Isoleucine 5411
Threonine Lysine 2081
Threonine Methionine 2333
Threonine Proline 870
Threonine Serine 4542
Tryptophan Arginine 2174
Tryptophan Cysteine 127
Tryptophan Glycine 142
Tryptophan Leucine 372
Tryptophan Serine 24
Tryptophan Stop codon 734
Tyrosine Asparagine 2184
Tyrosine Aspartic acid 318
Tyrosine Cysteine 7363
Tyrosine Histidine 5617
Tyrosine Phenylalanine 2541
Tyrosine Serine 325
Tyrosine Stop codon 3840
Valine Alanine 17730
Valine Aspartic acid 2749
Valine Glutamic Acid 4582
Valine Glycine 1581
Valine Isoleucine 4869
Valine Leucine 1919
Valine Methionine 3420
Valine Phenylalanine 1287
Stop codon Arginine 161
Stop codon Cysteine 47
Stop codon Glutamic Acid 17
Stop codon Glutamine 180
Stop codon Glycine 27
Stop codon Leucine 43
Stop codon Lysine 53
Stop codon Serine 4
Stop codon Tryptophan 221
Stop codon Tyrosine 15
353328 changes of 170 types
We have now tabulated 354319 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.