Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 2
missense 844
nonsense 212
start codon destroyed 10
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 30
critical splice acceptor site 24
critical splice donor site 103
splice site 25
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 8
intragenic 0
intron 17
utr 3 prime 1
utr 5 prime 1
Total: 1298
Incidental Mutation Types
Mutation TypeNumber*
makesense 806
missense 340619
nonsense 16807
start codon destroyed 907
start gained 1239
synonymous 269
splice acceptor site 467
splice donor site 500
critical splice acceptor site 1745
critical splice donor site 7355
splice site 13843
large deletion 0
large insertion 0
rearrangement 0
small deletion 877
small insertion 1119
exon 2180
frame shift 1309
intragenic 1
intron 3209
utr 3 prime 978
utr 5 prime 789
Total: 395019
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 26
A ⇒ G 232
A ⇒ T 190
C ⇒ A 63
C ⇒ G 5
C ⇒ T 106
G ⇒ A 102
G ⇒ C 3
G ⇒ T 69
T ⇒ A 223
T ⇒ C 232
T ⇒ G 31
Total: 1282
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10122
A ⇒ G 84411
A ⇒ T 54734
C ⇒ A 18329
C ⇒ G 1855
C ⇒ T 33219
G ⇒ A 32803
G ⇒ C 1780
G ⇒ T 18021
T ⇒ A 55486
T ⇒ C 85097
T ⇒ G 10123
Total: 405980
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 2
Alanine Threonine 1
Alanine Valine 4
Arginine Cysteine 8
Arginine Glutamine 9
Arginine Glycine 7
Arginine Histidine 8
Arginine Isoleucine 0
Arginine Leucine 5
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 22
Asparagine Aspartic acid 6
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 14
Asparagine Serine 9
Asparagine Threonine 0
Asparagine Tyrosine 5
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 12
Aspartic acid Glycine 35
Aspartic acid Histidine 1
Aspartic acid Tyrosine 2
Aspartic acid Valine 11
Cysteine Arginine 17
Cysteine Glycine 2
Cysteine Phenylalanine 8
Cysteine Serine 9
Cysteine Tryptophan 2
Cysteine Tyrosine 7
Cysteine Stop codon 28
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 22
Glutamic Acid Lysine 2
Glutamic Acid Valine 3
Glutamic Acid Stop codon 15
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 5
Glutamine Proline 1
Glutamine Stop codon 39
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 2
Glycine Glutamic Acid 2
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 5
Glycine Stop codon 2
Histidine Arginine 13
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 10
Histidine Proline 2
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 6
Isoleucine Methionine 1
Isoleucine Phenylalanine 12
Isoleucine Serine 0
Isoleucine Threonine 19
Isoleucine Valine 6
Leucine Arginine 6
Leucine Glutamine 10
Leucine Histidine 1
Leucine Isoleucine 2
Leucine Methionine 0
Leucine Phenylalanine 2
Leucine Proline 35
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 17
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 5
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 2
Lysine Threonine 1
Lysine Stop codon 27
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 23
Methionine Threonine 7
Methionine Valine 11
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 9
Phenylalanine Leucine 12
Phenylalanine Serine 15
Phenylalanine Tyrosine 1
Phenylalanine Valine 2
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 3
Proline Serine 1
Proline Threonine 4
Serine Alanine 1
Serine Arginine 5
Serine Asparagine 2
Serine Cysteine 3
Serine Glycine 3
Serine Isoleucine 0
Serine Leucine 2
Serine Phenylalanine 1
Serine Proline 38
Serine Threonine 9
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 19
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 12
Threonine Lysine 7
Threonine Methionine 7
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 14
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 4
Tyrosine Asparagine 3
Tyrosine Aspartic acid 1
Tyrosine Cysteine 35
Tyrosine Histidine 20
Tyrosine Phenylalanine 6
Tyrosine Serine 1
Tyrosine Stop codon 49
Valine Alanine 39
Valine Aspartic acid 14
Valine Glutamic Acid 20
Valine Glycine 4
Valine Isoleucine 7
Valine Leucine 1
Valine Methionine 12
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
1058 changes of 131 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 545
Alanine Glutamic Acid 1100
Alanine Glycine 154
Alanine Proline 209
Alanine Serine 1824
Alanine Threonine 2994
Alanine Valine 2860
Arginine Cysteine 2430
Arginine Glutamine 2385
Arginine Glycine 2409
Arginine Histidine 2902
Arginine Isoleucine 79
Arginine Leucine 2285
Arginine Lysine 381
Arginine Methionine 98
Arginine Proline 179
Arginine Serine 1889
Arginine Threonine 28
Arginine Tryptophan 1763
Arginine Stop codon 2235
Asparagine Aspartic acid 2404
Asparagine Histidine 185
Asparagine Isoleucine 2101
Asparagine Lysine 5462
Asparagine Serine 6518
Asparagine Threonine 489
Asparagine Tyrosine 1150
Aspartic acid Alanine 1229
Aspartic acid Asparagine 1730
Aspartic acid Glutamic Acid 7252
Aspartic acid Glycine 15090
Aspartic acid Histidine 121
Aspartic acid Tyrosine 727
Aspartic acid Valine 4483
Cysteine Arginine 1863
Cysteine Glycine 392
Cysteine Phenylalanine 1212
Cysteine Serine 3085
Cysteine Tryptophan 222
Cysteine Tyrosine 1756
Cysteine Stop codon 2080
Glutamic Acid Alanine 539
Glutamic Acid Aspartic acid 1723
Glutamic Acid Glutamine 137
Glutamic Acid Glycine 10533
Glutamic Acid Lysine 2393
Glutamic Acid Valine 1550
Glutamic Acid Stop codon 1146
Glutamine Arginine 1522
Glutamine Glutamic Acid 98
Glutamine Histidine 540
Glutamine Leucine 2654
Glutamine Lysine 1950
Glutamine Proline 430
Glutamine Stop codon 2651
Glycine Alanine 154
Glycine Arginine 1269
Glycine Aspartic acid 1905
Glycine Cysteine 607
Glycine Glutamic Acid 648
Glycine Serine 1070
Glycine Tryptophan 415
Glycine Valine 805
Glycine Stop codon 334
Histidine Arginine 3359
Histidine Asparagine 963
Histidine Aspartic acid 57
Histidine Glutamine 3247
Histidine Leucine 3271
Histidine Proline 353
Histidine Tyrosine 1195
Isoleucine Arginine 199
Isoleucine Asparagine 5710
Isoleucine Leucine 2174
Isoleucine Lysine 1364
Isoleucine Methionine 1341
Isoleucine Phenylalanine 6195
Isoleucine Serine 822
Isoleucine Threonine 7921
Isoleucine Valine 6942
Leucine Arginine 1199
Leucine Glutamine 3408
Leucine Histidine 962
Leucine Isoleucine 610
Leucine Methionine 442
Leucine Phenylalanine 2088
Leucine Proline 7214
Leucine Serine 897
Leucine Tryptophan 86
Leucine Valine 409
Leucine Stop codon 1382
Lysine Arginine 2435
Lysine Asparagine 1798
Lysine Glutamic Acid 3872
Lysine Glutamine 273
Lysine Isoleucine 214
Lysine Methionine 491
Lysine Threonine 391
Lysine Stop codon 1749
Methionine Arginine 641
Methionine Isoleucine 1643
Methionine Leucine 3279
Methionine Lysine 5535
Methionine Threonine 2242
Methionine Valine 2510
Phenylalanine Cysteine 234
Phenylalanine Isoleucine 2014
Phenylalanine Leucine 6053
Phenylalanine Serine 3370
Phenylalanine Tyrosine 890
Phenylalanine Valine 575
Proline Alanine 154
Proline Arginine 153
Proline Glutamine 985
Proline Histidine 178
Proline Leucine 2073
Proline Serine 2736
Proline Threonine 709
Serine Alanine 1335
Serine Arginine 2660
Serine Asparagine 1161
Serine Cysteine 933
Serine Glycine 2786
Serine Isoleucine 402
Serine Leucine 1128
Serine Phenylalanine 751
Serine Proline 13254
Serine Threonine 4249
Serine Tryptophan 15
Serine Tyrosine 251
Serine Stop codon 586
Threonine Alanine 14893
Threonine Arginine 93
Threonine Asparagine 693
Threonine Isoleucine 5539
Threonine Lysine 2112
Threonine Methionine 2383
Threonine Proline 888
Threonine Serine 4658
Tryptophan Arginine 2225
Tryptophan Cysteine 129
Tryptophan Glycine 147
Tryptophan Leucine 382
Tryptophan Serine 27
Tryptophan Stop codon 752
Tyrosine Asparagine 2230
Tyrosine Aspartic acid 325
Tyrosine Cysteine 7541
Tyrosine Histidine 5737
Tyrosine Phenylalanine 2598
Tyrosine Serine 330
Tyrosine Stop codon 3928
Valine Alanine 18095
Valine Aspartic acid 2814
Valine Glutamic Acid 4675
Valine Glycine 1604
Valine Isoleucine 4973
Valine Leucine 1952
Valine Methionine 3501
Valine Phenylalanine 1319
Stop codon Arginine 168
Stop codon Cysteine 47
Stop codon Glutamic Acid 18
Stop codon Glutamine 187
Stop codon Glycine 29
Stop codon Leucine 44
Stop codon Lysine 54
Stop codon Serine 4
Stop codon Tryptophan 224
Stop codon Tyrosine 16
361225 changes of 170 types
We have now tabulated 362283 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.