Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 1
missense 749
nonsense 181
start codon destroyed 8
start gained 1
synonymous 0
splice acceptor site 28
splice donor site 33
critical splice acceptor site 16
critical splice donor site 98
splice site 5
large deletion 4
large insertion 0
rearrangement 0
small deletion 2
small insertion 2
exon 0
frame shift 6
intragenic 0
intron 10
utr 3 prime 1
utr 5 prime 0
Total: 1145
Incidental Mutation Types
Mutation TypeNumber*
makesense 1414
missense 335823
nonsense 17773
start codon destroyed 737
start gained 870
synonymous 547
splice acceptor site 12974
splice donor site 13015
critical splice acceptor site 1349
critical splice donor site 5783
splice site 8678
large deletion 0
large insertion 0
rearrangement 0
small deletion 765
small insertion 377
exon 40
frame shift 1349
intragenic 6
intron 1258
utr 3 prime 106
utr 5 prime 107
Total: 402971
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 26
A ⇒ G 201
A ⇒ T 178
C ⇒ A 47
C ⇒ G 5
C ⇒ T 88
G ⇒ A 93
G ⇒ C 2
G ⇒ T 66
T ⇒ A 185
T ⇒ C 206
T ⇒ G 31
Total: 1128
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9976
A ⇒ G 84747
A ⇒ T 53638
C ⇒ A 18213
C ⇒ G 1847
C ⇒ T 33781
G ⇒ A 33350
G ⇒ C 1771
G ⇒ T 17795
T ⇒ A 54471
T ⇒ C 85363
T ⇒ G 10032
Total: 404984
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 3
Arginine Cysteine 8
Arginine Glutamine 8
Arginine Glycine 7
Arginine Histidine 6
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 2
Arginine Stop codon 26
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 9
Asparagine Serine 7
Asparagine Threonine 0
Asparagine Tyrosine 3
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 6
Aspartic acid Glycine 28
Aspartic acid Histidine 0
Aspartic acid Tyrosine 3
Aspartic acid Valine 9
Cysteine Arginine 15
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 9
Cysteine Tryptophan 3
Cysteine Tyrosine 7
Cysteine Stop codon 23
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 17
Glutamic Acid Lysine 3
Glutamic Acid Valine 2
Glutamic Acid Stop codon 12
Glutamine Arginine 1
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 5
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 31
Glycine Alanine 0
Glycine Arginine 5
Glycine Aspartic acid 7
Glycine Cysteine 3
Glycine Glutamic Acid 0
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 3
Glycine Stop codon 2
Histidine Arginine 14
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 9
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 1
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 4
Isoleucine Methionine 1
Isoleucine Phenylalanine 13
Isoleucine Serine 0
Isoleucine Threonine 19
Isoleucine Valine 5
Leucine Arginine 5
Leucine Glutamine 13
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 36
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 11
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 3
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 23
Methionine Arginine 3
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 19
Methionine Threonine 5
Methionine Valine 8
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 8
Phenylalanine Leucine 9
Phenylalanine Serine 10
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 1
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 3
Serine Alanine 0
Serine Arginine 4
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 3
Serine Isoleucine 1
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 36
Serine Threonine 7
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 5
Threonine Alanine 15
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 8
Threonine Lysine 5
Threonine Methionine 5
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 11
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 6
Tyrosine Asparagine 3
Tyrosine Aspartic acid 4
Tyrosine Cysteine 29
Tyrosine Histidine 12
Tyrosine Phenylalanine 6
Tyrosine Serine 0
Tyrosine Stop codon 41
Valine Alanine 39
Valine Aspartic acid 14
Valine Glutamic Acid 18
Valine Glycine 4
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 10
Valine Phenylalanine 3
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
929 changes of 127 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 482
Alanine Glutamic Acid 1084
Alanine Glycine 149
Alanine Proline 216
Alanine Serine 1776
Alanine Threonine 2893
Alanine Valine 2820
Arginine Cysteine 2467
Arginine Glutamine 2394
Arginine Glycine 2594
Arginine Histidine 2949
Arginine Isoleucine 78
Arginine Leucine 2210
Arginine Lysine 418
Arginine Methionine 100
Arginine Proline 177
Arginine Serine 1903
Arginine Threonine 33
Arginine Tryptophan 1767
Arginine Stop codon 2456
Asparagine Aspartic acid 2329
Asparagine Histidine 171
Asparagine Isoleucine 2033
Asparagine Lysine 5173
Asparagine Serine 6335
Asparagine Threonine 453
Asparagine Tyrosine 1092
Aspartic acid Alanine 1168
Aspartic acid Asparagine 1683
Aspartic acid Glutamic Acid 6767
Aspartic acid Glycine 14362
Aspartic acid Histidine 104
Aspartic acid Tyrosine 684
Aspartic acid Valine 4233
Cysteine Arginine 2028
Cysteine Glycine 407
Cysteine Phenylalanine 1236
Cysteine Serine 3190
Cysteine Tryptophan 226
Cysteine Tyrosine 1868
Cysteine Stop codon 2326
Glutamic Acid Alanine 524
Glutamic Acid Aspartic acid 1596
Glutamic Acid Glutamine 133
Glutamic Acid Glycine 10103
Glutamic Acid Lysine 2327
Glutamic Acid Valine 1468
Glutamic Acid Stop codon 1147
Glutamine Arginine 1495
Glutamine Glutamic Acid 88
Glutamine Histidine 538
Glutamine Leucine 2576
Glutamine Lysine 1895
Glutamine Proline 441
Glutamine Stop codon 2822
Glycine Alanine 151
Glycine Arginine 1228
Glycine Aspartic acid 1895
Glycine Cysteine 624
Glycine Glutamic Acid 661
Glycine Serine 999
Glycine Tryptophan 417
Glycine Valine 766
Glycine Stop codon 366
Histidine Arginine 3433
Histidine Asparagine 918
Histidine Aspartic acid 71
Histidine Glutamine 3227
Histidine Leucine 3396
Histidine Proline 368
Histidine Tyrosine 1241
Isoleucine Arginine 186
Isoleucine Asparagine 5289
Isoleucine Leucine 2104
Isoleucine Lysine 1336
Isoleucine Methionine 1344
Isoleucine Phenylalanine 5949
Isoleucine Serine 781
Isoleucine Threonine 7730
Isoleucine Valine 6730
Leucine Arginine 1187
Leucine Glutamine 3350
Leucine Histidine 930
Leucine Isoleucine 622
Leucine Methionine 437
Leucine Phenylalanine 2085
Leucine Proline 7224
Leucine Serine 938
Leucine Tryptophan 81
Leucine Valine 409
Leucine Stop codon 1457
Lysine Arginine 2368
Lysine Asparagine 1726
Lysine Glutamic Acid 3760
Lysine Glutamine 258
Lysine Isoleucine 212
Lysine Methionine 439
Lysine Threonine 363
Lysine Stop codon 1748
Methionine Arginine 609
Methionine Isoleucine 1601
Methionine Leucine 3180
Methionine Lysine 5309
Methionine Threonine 2215
Methionine Valine 2428
Phenylalanine Cysteine 238
Phenylalanine Isoleucine 1969
Phenylalanine Leucine 5923
Phenylalanine Serine 3346
Phenylalanine Tyrosine 841
Phenylalanine Valine 565
Proline Alanine 167
Proline Arginine 160
Proline Glutamine 1030
Proline Histidine 182
Proline Leucine 2092
Proline Serine 2874
Proline Threonine 716
Serine Alanine 1318
Serine Arginine 2603
Serine Asparagine 1206
Serine Cysteine 916
Serine Glycine 2858
Serine Isoleucine 394
Serine Leucine 1188
Serine Phenylalanine 771
Serine Proline 13406
Serine Threonine 4258
Serine Tryptophan 15
Serine Tyrosine 244
Serine Stop codon 657
Threonine Alanine 14991
Threonine Arginine 85
Threonine Asparagine 686
Threonine Isoleucine 5542
Threonine Lysine 2051
Threonine Methionine 2323
Threonine Proline 878
Threonine Serine 4568
Tryptophan Arginine 2414
Tryptophan Cysteine 131
Tryptophan Glycine 158
Tryptophan Leucine 426
Tryptophan Serine 25
Tryptophan Stop codon 874
Tyrosine Asparagine 2100
Tyrosine Aspartic acid 302
Tyrosine Cysteine 7198
Tyrosine Histidine 5501
Tyrosine Phenylalanine 2526
Tyrosine Serine 328
Tyrosine Stop codon 3940
Valine Alanine 17913
Valine Aspartic acid 2737
Valine Glutamic Acid 4437
Valine Glycine 1561
Valine Isoleucine 4874
Valine Leucine 1889
Valine Methionine 3333
Valine Phenylalanine 1284
Stop codon Arginine 367
Stop codon Cysteine 62
Stop codon Glutamic Acid 25
Stop codon Glutamine 371
Stop codon Glycine 33
Stop codon Leucine 102
Stop codon Lysine 90
Stop codon Serine 11
Stop codon Tryptophan 326
Stop codon Tyrosine 30
356562 changes of 170 types
We have now tabulated 357491 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.