Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 1
missense 666
nonsense 161
start codon destroyed 8
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 31
critical splice acceptor site 15
critical splice donor site 87
splice site 5
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 6
intragenic 0
intron 11
utr 3 prime 1
utr 5 prime 0
Total: 1013
Incidental Mutation Types
Mutation TypeNumber*
makesense 768
missense 328951
nonsense 16222
start codon destroyed 852
start gained 1078
synonymous 3030
splice acceptor site 467
splice donor site 491
critical splice acceptor site 1664
critical splice donor site 6955
splice site 13550
large deletion 0
large insertion 0
rearrangement 0
small deletion 720
small insertion 353
exon 2047
frame shift 1140
intragenic 0
intron 2701
utr 3 prime 910
utr 5 prime 736
Total: 382635
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 23
A ⇒ G 180
A ⇒ T 151
C ⇒ A 47
C ⇒ G 5
C ⇒ T 82
G ⇒ A 83
G ⇒ C 2
G ⇒ T 52
T ⇒ A 170
T ⇒ C 181
T ⇒ G 26
Total: 1002
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 9776
A ⇒ G 82090
A ⇒ T 52859
C ⇒ A 17877
C ⇒ G 1817
C ⇒ T 32593
G ⇒ A 32292
G ⇒ C 1772
G ⇒ T 17443
T ⇒ A 53638
T ⇒ C 82761
T ⇒ G 9811
Total: 394729
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 2
Arginine Cysteine 8
Arginine Glutamine 8
Arginine Glycine 7
Arginine Histidine 7
Arginine Isoleucine 0
Arginine Leucine 5
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 19
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 8
Asparagine Serine 7
Asparagine Threonine 0
Asparagine Tyrosine 2
Aspartic acid Alanine 4
Aspartic acid Asparagine 1
Aspartic acid Glutamic Acid 6
Aspartic acid Glycine 24
Aspartic acid Histidine 0
Aspartic acid Tyrosine 3
Aspartic acid Valine 8
Cysteine Arginine 11
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 7
Cysteine Tryptophan 2
Cysteine Tyrosine 6
Cysteine Stop codon 20
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 17
Glutamic Acid Lysine 2
Glutamic Acid Valine 1
Glutamic Acid Stop codon 12
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 29
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 6
Glycine Cysteine 2
Glycine Glutamic Acid 0
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 3
Glycine Stop codon 2
Histidine Arginine 10
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 9
Histidine Proline 2
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 24
Isoleucine Leucine 4
Isoleucine Lysine 4
Isoleucine Methionine 1
Isoleucine Phenylalanine 7
Isoleucine Serine 0
Isoleucine Threonine 17
Isoleucine Valine 5
Leucine Arginine 5
Leucine Glutamine 10
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 27
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 10
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 4
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 24
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 19
Methionine Threonine 4
Methionine Valine 8
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 7
Phenylalanine Leucine 9
Phenylalanine Serine 10
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 2
Proline Serine 2
Proline Threonine 3
Serine Alanine 1
Serine Arginine 4
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 3
Serine Isoleucine 0
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 26
Serine Threonine 7
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 2
Threonine Alanine 14
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 7
Threonine Lysine 4
Threonine Methionine 4
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 8
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 4
Tyrosine Asparagine 3
Tyrosine Aspartic acid 1
Tyrosine Cysteine 25
Tyrosine Histidine 13
Tyrosine Phenylalanine 5
Tyrosine Serine 0
Tyrosine Stop codon 37
Valine Alanine 36
Valine Aspartic acid 12
Valine Glutamic Acid 19
Valine Glycine 4
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 10
Valine Phenylalanine 3
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
827 changes of 125 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 499
Alanine Glutamic Acid 1069
Alanine Glycine 147
Alanine Proline 203
Alanine Serine 1746
Alanine Threonine 2888
Alanine Valine 2746
Arginine Cysteine 2372
Arginine Glutamine 2351
Arginine Glycine 2339
Arginine Histidine 2829
Arginine Isoleucine 73
Arginine Leucine 2214
Arginine Lysine 384
Arginine Methionine 99
Arginine Proline 177
Arginine Serine 1840
Arginine Threonine 32
Arginine Tryptophan 1736
Arginine Stop codon 2157
Asparagine Aspartic acid 2296
Asparagine Histidine 174
Asparagine Isoleucine 2032
Asparagine Lysine 5259
Asparagine Serine 6282
Asparagine Threonine 469
Asparagine Tyrosine 1095
Aspartic acid Alanine 1188
Aspartic acid Asparagine 1687
Aspartic acid Glutamic Acid 7013
Aspartic acid Glycine 14553
Aspartic acid Histidine 126
Aspartic acid Tyrosine 702
Aspartic acid Valine 4296
Cysteine Arginine 1824
Cysteine Glycine 383
Cysteine Phenylalanine 1166
Cysteine Serine 2994
Cysteine Tryptophan 217
Cysteine Tyrosine 1698
Cysteine Stop codon 2023
Glutamic Acid Alanine 521
Glutamic Acid Aspartic acid 1667
Glutamic Acid Glutamine 135
Glutamic Acid Glycine 10157
Glutamic Acid Lysine 2350
Glutamic Acid Valine 1474
Glutamic Acid Stop codon 1109
Glutamine Arginine 1462
Glutamine Glutamic Acid 89
Glutamine Histidine 531
Glutamine Leucine 2562
Glutamine Lysine 1860
Glutamine Proline 413
Glutamine Stop codon 2578
Glycine Alanine 148
Glycine Arginine 1207
Glycine Aspartic acid 1834
Glycine Cysteine 596
Glycine Glutamic Acid 624
Glycine Serine 1019
Glycine Tryptophan 405
Glycine Valine 762
Glycine Stop codon 317
Histidine Arginine 3254
Histidine Asparagine 923
Histidine Aspartic acid 53
Histidine Glutamine 3140
Histidine Leucine 3139
Histidine Proline 342
Histidine Tyrosine 1160
Isoleucine Arginine 188
Isoleucine Asparagine 5480
Isoleucine Leucine 2110
Isoleucine Lysine 1314
Isoleucine Methionine 1308
Isoleucine Phenylalanine 5976
Isoleucine Serine 804
Isoleucine Threonine 7613
Isoleucine Valine 6693
Leucine Arginine 1150
Leucine Glutamine 3258
Leucine Histidine 935
Leucine Isoleucine 598
Leucine Methionine 434
Leucine Phenylalanine 2023
Leucine Proline 6958
Leucine Serine 867
Leucine Tryptophan 81
Leucine Valine 400
Leucine Stop codon 1332
Lysine Arginine 2354
Lysine Asparagine 1721
Lysine Glutamic Acid 3769
Lysine Glutamine 264
Lysine Isoleucine 213
Lysine Methionine 470
Lysine Threonine 377
Lysine Stop codon 1678
Methionine Arginine 604
Methionine Isoleucine 1607
Methionine Leucine 3174
Methionine Lysine 5353
Methionine Threonine 2139
Methionine Valine 2413
Phenylalanine Cysteine 236
Phenylalanine Isoleucine 1927
Phenylalanine Leucine 5831
Phenylalanine Serine 3266
Phenylalanine Tyrosine 852
Phenylalanine Valine 554
Proline Alanine 148
Proline Arginine 163
Proline Glutamine 962
Proline Histidine 169
Proline Leucine 2040
Proline Serine 2671
Proline Threonine 682
Serine Alanine 1295
Serine Arginine 2588
Serine Asparagine 1138
Serine Cysteine 896
Serine Glycine 2671
Serine Isoleucine 377
Serine Leucine 1111
Serine Phenylalanine 741
Serine Proline 12762
Serine Threonine 4101
Serine Tryptophan 15
Serine Tyrosine 251
Serine Stop codon 576
Threonine Alanine 14402
Threonine Arginine 97
Threonine Asparagine 682
Threonine Isoleucine 5349
Threonine Lysine 2065
Threonine Methionine 2292
Threonine Proline 852
Threonine Serine 4465
Tryptophan Arginine 2150
Tryptophan Cysteine 125
Tryptophan Glycine 148
Tryptophan Leucine 370
Tryptophan Serine 22
Tryptophan Stop codon 736
Tyrosine Asparagine 2157
Tyrosine Aspartic acid 311
Tyrosine Cysteine 7253
Tyrosine Histidine 5531
Tyrosine Phenylalanine 2501
Tyrosine Serine 322
Tyrosine Stop codon 3791
Valine Alanine 17512
Valine Aspartic acid 2714
Valine Glutamic Acid 4489
Valine Glycine 1553
Valine Isoleucine 4826
Valine Leucine 1906
Valine Methionine 3396
Valine Phenylalanine 1260
Stop codon Arginine 155
Stop codon Cysteine 43
Stop codon Glutamic Acid 17
Stop codon Glutamine 178
Stop codon Glycine 27
Stop codon Leucine 43
Stop codon Lysine 53
Stop codon Serine 4
Stop codon Tryptophan 222
Stop codon Tyrosine 14
348923 changes of 170 types
We have now tabulated 349750 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.