Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 3
missense 892
nonsense 236
start codon destroyed 10
start gained 1
synonymous 0
splice acceptor site 16
splice donor site 29
critical splice acceptor site 27
critical splice donor site 114
splice site 33
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 9
intragenic 0
intron 20
utr 3 prime 1
utr 5 prime 1
Total: 1396
Incidental Mutation Types
Mutation TypeNumber*
makesense 799
missense 346189
nonsense 17041
start codon destroyed 996
start gained 1267
synonymous 277
splice acceptor site 453
splice donor site 484
critical splice acceptor site 1917
critical splice donor site 8305
splice site 14494
large deletion 0
large insertion 0
rearrangement 0
small deletion 887
small insertion 1152
exon 2169
frame shift 1343
intragenic 3
intron 3503
utr 3 prime 971
utr 5 prime 783
unclassified 15840
Total: 418873
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 31
A ⇒ G 246
A ⇒ T 209
C ⇒ A 70
C ⇒ G 5
C ⇒ T 118
G ⇒ A 108
G ⇒ C 3
G ⇒ T 75
T ⇒ A 233
T ⇒ C 247
T ⇒ G 34
Total: 1379
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10323
A ⇒ G 86279
A ⇒ T 55923
C ⇒ A 18755
C ⇒ G 1901
C ⇒ T 33955
G ⇒ A 33527
G ⇒ C 1826
G ⇒ T 18427
T ⇒ A 56710
T ⇒ C 86998
T ⇒ G 10363
Total: 414987
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 3
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 2
Alanine Threonine 1
Alanine Valine 5
Arginine Cysteine 9
Arginine Glutamine 8
Arginine Glycine 7
Arginine Histidine 8
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 4
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 26
Asparagine Aspartic acid 7
Asparagine Histidine 0
Asparagine Isoleucine 5
Asparagine Lysine 16
Asparagine Serine 10
Asparagine Threonine 0
Asparagine Tyrosine 5
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 14
Aspartic acid Glycine 35
Aspartic acid Histidine 1
Aspartic acid Tyrosine 2
Aspartic acid Valine 12
Cysteine Arginine 17
Cysteine Glycine 3
Cysteine Phenylalanine 9
Cysteine Serine 9
Cysteine Tryptophan 2
Cysteine Tyrosine 8
Cysteine Stop codon 32
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 22
Glutamic Acid Lysine 2
Glutamic Acid Valine 3
Glutamic Acid Stop codon 17
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 4
Glutamine Lysine 5
Glutamine Proline 1
Glutamine Stop codon 44
Glycine Alanine 0
Glycine Arginine 4
Glycine Aspartic acid 7
Glycine Cysteine 3
Glycine Glutamic Acid 2
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 5
Glycine Stop codon 2
Histidine Arginine 13
Histidine Asparagine 4
Histidine Aspartic acid 0
Histidine Glutamine 6
Histidine Leucine 10
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 0
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 7
Isoleucine Methionine 1
Isoleucine Phenylalanine 12
Isoleucine Serine 0
Isoleucine Threonine 20
Isoleucine Valine 6
Leucine Arginine 7
Leucine Glutamine 12
Leucine Histidine 1
Leucine Isoleucine 2
Leucine Methionine 1
Leucine Phenylalanine 2
Leucine Proline 37
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 17
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 6
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 2
Lysine Threonine 1
Lysine Stop codon 29
Methionine Arginine 2
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 26
Methionine Threonine 7
Methionine Valine 11
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 9
Phenylalanine Leucine 12
Phenylalanine Serine 17
Phenylalanine Tyrosine 1
Phenylalanine Valine 2
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 0
Proline Histidine 0
Proline Leucine 3
Proline Serine 1
Proline Threonine 3
Serine Alanine 1
Serine Arginine 5
Serine Asparagine 2
Serine Cysteine 3
Serine Glycine 4
Serine Isoleucine 0
Serine Leucine 2
Serine Phenylalanine 1
Serine Proline 44
Serine Threonine 9
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 21
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 12
Threonine Lysine 7
Threonine Methionine 8
Threonine Proline 2
Threonine Serine 8
Tryptophan Arginine 14
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 6
Tyrosine Asparagine 3
Tyrosine Aspartic acid 2
Tyrosine Cysteine 36
Tyrosine Histidine 20
Tyrosine Phenylalanine 5
Tyrosine Serine 1
Tyrosine Stop codon 54
Valine Alanine 40
Valine Aspartic acid 16
Valine Glutamic Acid 21
Valine Glycine 5
Valine Isoleucine 8
Valine Leucine 2
Valine Methionine 13
Valine Phenylalanine 2
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
1132 changes of 134 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 569
Alanine Glutamic Acid 1129
Alanine Glycine 158
Alanine Proline 215
Alanine Serine 1868
Alanine Threonine 3055
Alanine Valine 2927
Arginine Cysteine 2484
Arginine Glutamine 2449
Arginine Glycine 2463
Arginine Histidine 2967
Arginine Isoleucine 81
Arginine Leucine 2361
Arginine Lysine 386
Arginine Methionine 102
Arginine Proline 187
Arginine Serine 1919
Arginine Threonine 29
Arginine Tryptophan 1804
Arginine Stop codon 2287
Asparagine Aspartic acid 2472
Asparagine Histidine 188
Asparagine Isoleucine 2152
Asparagine Lysine 5595
Asparagine Serine 6703
Asparagine Threonine 499
Asparagine Tyrosine 1196
Aspartic acid Alanine 1264
Aspartic acid Asparagine 1765
Aspartic acid Glutamic Acid 7410
Aspartic acid Glycine 15450
Aspartic acid Histidine 124
Aspartic acid Tyrosine 745
Aspartic acid Valine 4564
Cysteine Arginine 1906
Cysteine Glycine 396
Cysteine Phenylalanine 1236
Cysteine Serine 3150
Cysteine Tryptophan 228
Cysteine Tyrosine 1798
Cysteine Stop codon 2126
Glutamic Acid Alanine 558
Glutamic Acid Aspartic acid 1759
Glutamic Acid Glutamine 138
Glutamic Acid Glycine 10776
Glutamic Acid Lysine 2456
Glutamic Acid Valine 1576
Glutamic Acid Stop codon 1171
Glutamine Arginine 1553
Glutamine Glutamic Acid 98
Glutamine Histidine 559
Glutamine Leucine 2717
Glutamine Lysine 1990
Glutamine Proline 437
Glutamine Stop codon 2715
Glycine Alanine 157
Glycine Arginine 1320
Glycine Aspartic acid 1963
Glycine Cysteine 625
Glycine Glutamic Acid 663
Glycine Serine 1099
Glycine Tryptophan 428
Glycine Valine 821
Glycine Stop codon 338
Histidine Arginine 3437
Histidine Asparagine 984
Histidine Aspartic acid 59
Histidine Glutamine 3340
Histidine Leucine 3343
Histidine Proline 366
Histidine Tyrosine 1220
Isoleucine Arginine 203
Isoleucine Asparagine 5849
Isoleucine Leucine 2228
Isoleucine Lysine 1396
Isoleucine Methionine 1366
Isoleucine Phenylalanine 6323
Isoleucine Serine 840
Isoleucine Threonine 8115
Isoleucine Valine 7083
Leucine Arginine 1224
Leucine Glutamine 3479
Leucine Histidine 988
Leucine Isoleucine 620
Leucine Methionine 451
Leucine Phenylalanine 2145
Leucine Proline 7394
Leucine Serine 916
Leucine Tryptophan 87
Leucine Valine 417
Leucine Stop codon 1411
Lysine Arginine 2492
Lysine Asparagine 1837
Lysine Glutamic Acid 3950
Lysine Glutamine 283
Lysine Isoleucine 222
Lysine Methionine 499
Lysine Threonine 395
Lysine Stop codon 1795
Methionine Arginine 658
Methionine Isoleucine 1683
Methionine Leucine 3362
Methionine Lysine 5682
Methionine Threonine 2286
Methionine Valine 2558
Phenylalanine Cysteine 241
Phenylalanine Isoleucine 2059
Phenylalanine Leucine 6179
Phenylalanine Serine 3443
Phenylalanine Tyrosine 897
Phenylalanine Valine 590
Proline Alanine 158
Proline Arginine 157
Proline Glutamine 1002
Proline Histidine 181
Proline Leucine 2109
Proline Serine 2799
Proline Threonine 720
Serine Alanine 1380
Serine Arginine 2721
Serine Asparagine 1191
Serine Cysteine 950
Serine Glycine 2853
Serine Isoleucine 410
Serine Leucine 1145
Serine Phenylalanine 761
Serine Proline 13546
Serine Threonine 4338
Serine Tryptophan 16
Serine Tyrosine 259
Serine Stop codon 598
Threonine Alanine 15238
Threonine Arginine 95
Threonine Asparagine 710
Threonine Isoleucine 5648
Threonine Lysine 2161
Threonine Methionine 2435
Threonine Proline 903
Threonine Serine 4767
Tryptophan Arginine 2263
Tryptophan Cysteine 133
Tryptophan Glycine 153
Tryptophan Leucine 390
Tryptophan Serine 27
Tryptophan Stop codon 759
Tyrosine Asparagine 2282
Tyrosine Aspartic acid 331
Tyrosine Cysteine 7733
Tyrosine Histidine 5876
Tyrosine Phenylalanine 2650
Tyrosine Serine 331
Tyrosine Stop codon 4011
Valine Alanine 18546
Valine Aspartic acid 2862
Valine Glutamic Acid 4778
Valine Glycine 1638
Valine Isoleucine 5087
Valine Leucine 1998
Valine Methionine 3581
Valine Phenylalanine 1350
Stop codon Arginine 171
Stop codon Cysteine 48
Stop codon Glutamic Acid 18
Stop codon Glutamine 191
Stop codon Glycine 29
Stop codon Leucine 44
Stop codon Lysine 54
Stop codon Serine 4
Stop codon Tryptophan 227
Stop codon Tyrosine 17
369552 changes of 170 types
We have now tabulated 370684 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.