Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 1
missense 756
nonsense 184
start codon destroyed 8
start gained 1
synonymous 0
splice acceptor site 28
splice donor site 33
critical splice acceptor site 16
critical splice donor site 99
splice site 5
large deletion 4
large insertion 0
rearrangement 0
small deletion 2
small insertion 2
exon 0
frame shift 6
intragenic 0
intron 11
utr 3 prime 1
utr 5 prime 0
Total: 1157
Incidental Mutation Types
Mutation TypeNumber*
makesense 1420
missense 339035
nonsense 17942
start codon destroyed 746
start gained 898
synonymous 548
splice acceptor site 12974
splice donor site 13015
critical splice acceptor site 1373
critical splice donor site 5873
splice site 8686
large deletion 0
large insertion 0
rearrangement 0
small deletion 777
small insertion 385
exon 40
frame shift 1367
intragenic 6
intron 1260
utr 3 prime 106
utr 5 prime 107
Total: 406558
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 27
A ⇒ G 202
A ⇒ T 181
C ⇒ A 48
C ⇒ G 5
C ⇒ T 88
G ⇒ A 93
G ⇒ C 2
G ⇒ T 66
T ⇒ A 187
T ⇒ C 208
T ⇒ G 31
Total: 1138
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10081
A ⇒ G 85476
A ⇒ T 54127
C ⇒ A 18375
C ⇒ G 1864
C ⇒ T 34040
G ⇒ A 33643
G ⇒ C 1789
G ⇒ T 17945
T ⇒ A 54954
T ⇒ C 86104
T ⇒ G 10126
Total: 408524
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 2
Alanine Glutamic Acid 2
Alanine Glycine 0
Alanine Proline 0
Alanine Serine 1
Alanine Threonine 0
Alanine Valine 3
Arginine Cysteine 8
Arginine Glutamine 8
Arginine Glycine 7
Arginine Histidine 6
Arginine Isoleucine 0
Arginine Leucine 7
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 1
Arginine Serine 5
Arginine Threonine 0
Arginine Tryptophan 3
Arginine Stop codon 26
Asparagine Aspartic acid 5
Asparagine Histidine 0
Asparagine Isoleucine 7
Asparagine Lysine 9
Asparagine Serine 7
Asparagine Threonine 0
Asparagine Tyrosine 3
Aspartic acid Alanine 4
Aspartic acid Asparagine 2
Aspartic acid Glutamic Acid 7
Aspartic acid Glycine 28
Aspartic acid Histidine 0
Aspartic acid Tyrosine 3
Aspartic acid Valine 9
Cysteine Arginine 15
Cysteine Glycine 2
Cysteine Phenylalanine 7
Cysteine Serine 9
Cysteine Tryptophan 3
Cysteine Tyrosine 7
Cysteine Stop codon 23
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 0
Glutamic Acid Glycine 17
Glutamic Acid Lysine 3
Glutamic Acid Valine 2
Glutamic Acid Stop codon 12
Glutamine Arginine 2
Glutamine Glutamic Acid 0
Glutamine Histidine 0
Glutamine Leucine 5
Glutamine Lysine 2
Glutamine Proline 1
Glutamine Stop codon 31
Glycine Alanine 0
Glycine Arginine 5
Glycine Aspartic acid 7
Glycine Cysteine 3
Glycine Glutamic Acid 0
Glycine Serine 3
Glycine Tryptophan 2
Glycine Valine 3
Glycine Stop codon 2
Histidine Arginine 14
Histidine Asparagine 3
Histidine Aspartic acid 0
Histidine Glutamine 5
Histidine Leucine 9
Histidine Proline 3
Histidine Tyrosine 0
Isoleucine Arginine 1
Isoleucine Asparagine 25
Isoleucine Leucine 4
Isoleucine Lysine 4
Isoleucine Methionine 1
Isoleucine Phenylalanine 13
Isoleucine Serine 0
Isoleucine Threonine 19
Isoleucine Valine 5
Leucine Arginine 5
Leucine Glutamine 13
Leucine Histidine 0
Leucine Isoleucine 3
Leucine Methionine 0
Leucine Phenylalanine 1
Leucine Proline 36
Leucine Serine 4
Leucine Tryptophan 0
Leucine Valine 1
Leucine Stop codon 11
Lysine Arginine 1
Lysine Asparagine 0
Lysine Glutamic Acid 4
Lysine Glutamine 0
Lysine Isoleucine 0
Lysine Methionine 1
Lysine Threonine 1
Lysine Stop codon 23
Methionine Arginine 3
Methionine Isoleucine 1
Methionine Leucine 3
Methionine Lysine 19
Methionine Threonine 5
Methionine Valine 8
Phenylalanine Cysteine 0
Phenylalanine Isoleucine 8
Phenylalanine Leucine 9
Phenylalanine Serine 10
Phenylalanine Tyrosine 1
Phenylalanine Valine 1
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 1
Proline Histidine 0
Proline Leucine 3
Proline Serine 2
Proline Threonine 3
Serine Alanine 1
Serine Arginine 4
Serine Asparagine 1
Serine Cysteine 1
Serine Glycine 3
Serine Isoleucine 1
Serine Leucine 3
Serine Phenylalanine 1
Serine Proline 37
Serine Threonine 7
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 5
Threonine Alanine 16
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 8
Threonine Lysine 5
Threonine Methionine 5
Threonine Proline 3
Threonine Serine 7
Tryptophan Arginine 11
Tryptophan Cysteine 1
Tryptophan Glycine 0
Tryptophan Leucine 1
Tryptophan Serine 0
Tryptophan Stop codon 6
Tyrosine Asparagine 3
Tyrosine Aspartic acid 4
Tyrosine Cysteine 28
Tyrosine Histidine 12
Tyrosine Phenylalanine 6
Tyrosine Serine 0
Tyrosine Stop codon 43
Valine Alanine 38
Valine Aspartic acid 14
Valine Glutamic Acid 19
Valine Glycine 4
Valine Isoleucine 5
Valine Leucine 0
Valine Methionine 10
Valine Phenylalanine 3
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 0
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 0
Stop codon Tyrosine 0
938 changes of 128 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 483
Alanine Glutamic Acid 1094
Alanine Glycine 150
Alanine Proline 217
Alanine Serine 1796
Alanine Threonine 2923
Alanine Valine 2852
Arginine Cysteine 2490
Arginine Glutamine 2410
Arginine Glycine 2620
Arginine Histidine 2978
Arginine Isoleucine 78
Arginine Leucine 2226
Arginine Lysine 421
Arginine Methionine 102
Arginine Proline 178
Arginine Serine 1920
Arginine Threonine 34
Arginine Tryptophan 1785
Arginine Stop codon 2477
Asparagine Aspartic acid 2348
Asparagine Histidine 171
Asparagine Isoleucine 2048
Asparagine Lysine 5228
Asparagine Serine 6384
Asparagine Threonine 460
Asparagine Tyrosine 1102
Aspartic acid Alanine 1186
Aspartic acid Asparagine 1692
Aspartic acid Glutamic Acid 6844
Aspartic acid Glycine 14508
Aspartic acid Histidine 106
Aspartic acid Tyrosine 693
Aspartic acid Valine 4285
Cysteine Arginine 2041
Cysteine Glycine 410
Cysteine Phenylalanine 1245
Cysteine Serine 3225
Cysteine Tryptophan 229
Cysteine Tyrosine 1885
Cysteine Stop codon 2349
Glutamic Acid Alanine 532
Glutamic Acid Aspartic acid 1608
Glutamic Acid Glutamine 133
Glutamic Acid Glycine 10204
Glutamic Acid Lysine 2346
Glutamic Acid Valine 1480
Glutamic Acid Stop codon 1153
Glutamine Arginine 1502
Glutamine Glutamic Acid 89
Glutamine Histidine 549
Glutamine Leucine 2597
Glutamine Lysine 1913
Glutamine Proline 443
Glutamine Stop codon 2857
Glycine Alanine 154
Glycine Arginine 1238
Glycine Aspartic acid 1908
Glycine Cysteine 630
Glycine Glutamic Acid 665
Glycine Serine 1008
Glycine Tryptophan 420
Glycine Valine 774
Glycine Stop codon 368
Histidine Arginine 3474
Histidine Asparagine 930
Histidine Aspartic acid 71
Histidine Glutamine 3258
Histidine Leucine 3438
Histidine Proline 370
Histidine Tyrosine 1253
Isoleucine Arginine 190
Isoleucine Asparagine 5333
Isoleucine Leucine 2128
Isoleucine Lysine 1350
Isoleucine Methionine 1354
Isoleucine Phenylalanine 6007
Isoleucine Serine 787
Isoleucine Threonine 7805
Isoleucine Valine 6806
Leucine Arginine 1199
Leucine Glutamine 3377
Leucine Histidine 941
Leucine Isoleucine 628
Leucine Methionine 446
Leucine Phenylalanine 2106
Leucine Proline 7306
Leucine Serine 944
Leucine Tryptophan 83
Leucine Valine 415
Leucine Stop codon 1472
Lysine Arginine 2392
Lysine Asparagine 1740
Lysine Glutamic Acid 3805
Lysine Glutamine 263
Lysine Isoleucine 213
Lysine Methionine 441
Lysine Threonine 365
Lysine Stop codon 1759
Methionine Arginine 614
Methionine Isoleucine 1612
Methionine Leucine 3210
Methionine Lysine 5368
Methionine Threonine 2232
Methionine Valine 2448
Phenylalanine Cysteine 241
Phenylalanine Isoleucine 1989
Phenylalanine Leucine 5959
Phenylalanine Serine 3374
Phenylalanine Tyrosine 847
Phenylalanine Valine 569
Proline Alanine 169
Proline Arginine 161
Proline Glutamine 1041
Proline Histidine 184
Proline Leucine 2110
Proline Serine 2901
Proline Threonine 724
Serine Alanine 1327
Serine Arginine 2626
Serine Asparagine 1217
Serine Cysteine 929
Serine Glycine 2884
Serine Isoleucine 397
Serine Leucine 1194
Serine Phenylalanine 777
Serine Proline 13524
Serine Threonine 4300
Serine Tryptophan 15
Serine Tyrosine 245
Serine Stop codon 668
Threonine Alanine 15137
Threonine Arginine 86
Threonine Asparagine 690
Threonine Isoleucine 5591
Threonine Lysine 2064
Threonine Methionine 2342
Threonine Proline 891
Threonine Serine 4611
Tryptophan Arginine 2431
Tryptophan Cysteine 132
Tryptophan Glycine 159
Tryptophan Leucine 428
Tryptophan Serine 25
Tryptophan Stop codon 879
Tyrosine Asparagine 2124
Tyrosine Aspartic acid 310
Tyrosine Cysteine 7280
Tyrosine Histidine 5547
Tyrosine Phenylalanine 2563
Tyrosine Serine 332
Tyrosine Stop codon 3978
Valine Alanine 18090
Valine Aspartic acid 2761
Valine Glutamic Acid 4474
Valine Glycine 1577
Valine Isoleucine 4920
Valine Leucine 1906
Valine Methionine 3356
Valine Phenylalanine 1299
Stop codon Arginine 369
Stop codon Cysteine 62
Stop codon Glutamic Acid 25
Stop codon Glutamine 374
Stop codon Glycine 34
Stop codon Leucine 102
Stop codon Lysine 90
Stop codon Serine 11
Stop codon Tryptophan 326
Stop codon Tyrosine 30
359955 changes of 170 types
We have now tabulated 360893 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.