• Beutler Lab
  APN
• Strains @ MMRRC
• Display Strains By
  • Institution
  • Phenotype
  • Author
  • Chromosome
  • Inheritance
  • Multifield Search
• Search Mutagenetix
  
  
• Staff Login
• Download

Incidental Mutations

80 incidental mutations are currently displayed, and affect 79 genes.

8 are Possibly Damaging.

26 are Probably Damaging.

32 are Probably Benign.

13 are Probably Null.

5 create premature stop codons.

1 are critical splice junction mutations.

---

Mutations in Coding Regions/Splice Sites Identified by Next-Gen Sequencing

[records 1 to 80 of 80] 10 25 50 100 500 1000 per page Full List
	ID	Source UTSW APN	Gene	E-score	Stock #	Gen G0 G0' G1 G2 G3 G3R F1 F2 F3 C0 C1 C2 C3 D1 HES IPS A3	Quality -	Vld Y N ?	Strain	Chr 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X Y	Position	Mutation A R N D C E Q G H I L K M F P S T W Y V * A R N D C E Q G H I L K M F P S T W Y V *	Ref A C G T -	Var A C G T -	Type makesense missense nonsense start codon destroyed start gained synonymous splice acceptor site splice donor site critical splice acceptor site critical splice donor site splice site large deletion large insertion rearrangement small deletion small insertion exon frame shift intragenic intron utr 3 prime utr 5 prime unclassified	Exon Dist	Zygosity Homo Het Hemi Null	Predicted Effect unknown probably benign probably null possibly damaging probably damaging noncoding transcript silent not run no transcript	PPH Score -	Meta Score	MGI Phenotype available none listed	Posted
1	385145		4921504E06Rik	0.053	R4995	G1	225	Y		2	19494184	Q333*	G	A	nonsense		Het	probably null		0.976		05/10/2016
2	385193		4930505A04Rik	0.000	R4995	G1	225	Y		11	30426349	V173M	C	T	missense		Het	probably damaging	0.971	0.647		05/10/2016
3	385211		Acvrl1	1.000	R4995	G1	225	Y		15	101135860	R141H	G	A	missense		Het	probably benign	0.003	0.090	phenotype	05/10/2016
4	385196		Adprm	0.000	R4995	G1	225	Y		11	67041610	F158L	A	G	missense		Het	possibly damaging	0.955	0.189		05/10/2016
5	385203		Aldoart2	0.886	R4995	G1	225	Y		12	55566253	T321M	C	T	missense		Het	probably benign	0.000	0.090		05/10/2016
6	385178		Ap3m2	0.000	R4995	G1	225	Y		8	22803776	V86A	A	G	missense		Het	probably benign	0.190	0.130	phenotype	05/10/2016
7	446649		Arhgef19	0.228	R4995	G1	141	Y		4	141247515		T	A	unclassified	1103 bp	Het	probably null		0.976	phenotype	12/08/2016
8	385217		Armc4	0.260	R4995	G1	225	Y		18	7223663	T460M	G	A	missense		Het	probably damaging	1.000	0.647	phenotype	05/10/2016
9	385170		Bcl2l12	0.000	R4995	G1	225	Y		7	44994191		T	G	splice site		Het	probably null		0.923	phenotype	05/10/2016
10	385200		Bptf	1.000	R4995	G1	225	Y		11	107054565	Q2501R	T	C	missense		Het	probably damaging	0.982	0.162	phenotype	05/10/2016
11	385141		C230029F24Rik	0.143	R4995	G1	225	Y		1	49338136		A	T	exon		Het	noncoding transcript		0.087		05/10/2016
12	385207		C7	0.000	R4995	G1	225	Y		15	5049592	G78D	C	T	missense		Het	probably damaging	1.000	0.647	phenotype	05/10/2016
13	385177		Caly	0.118	R4995	G1	225	Y		7	140070625	T135A	T	C	missense		Het	probably benign	0.006	0.212	phenotype	05/10/2016
14	385182		Cbl	0.716	R4995	G1	225	Y		9	44153811	M740T	A	G	missense		Het	possibly damaging	0.622	0.164	phenotype	05/10/2016
15	385202		Cbx4	1.000	R4995	G1	91	Y		11	119081211	V446A	A	G	missense		Het	probably benign	0.012	0.090	phenotype	05/10/2016
16	385208		Celsr1	0.776	R4995	G1	195	Y		15	85937911	R1735L	C	A	missense		Het	probably damaging	0.987	0.922	phenotype	05/10/2016
17	385153		Cep250	0.000	R4995	G1	225	Y		2	155988316	D135G	A	G	missense		Het	probably damaging	1.000	0.647	phenotype	05/10/2016
18	385155		Cgn	1.000	R4995	G1	225	Y		3	94779936	T19A	T	C	missense		Het	probably damaging	0.999	0.107	phenotype	05/10/2016
19	385163		Chic2	0.192	R4995	G1	116	Y		5	75044204	V32D	A	T	missense		Het	probably damaging	0.961	0.811	phenotype	05/10/2016
20	385156		Cntln	0.176	R4995	G1	225	Y		4	85049883	K780E	A	G	missense		Het	probably benign	0.001	0.090		05/10/2016
21	385157		Col8a2	0.521	R4995	G1	139	Y		4	126310788	D197V	A	T	missense		Het	probably damaging	0.979	0.079	phenotype	05/10/2016
22	385160		Crot	0.140	R4995	G1	225	Y		5	8974000	V372E	A	T	missense		Het	probably damaging	0.996	0.614	phenotype	05/10/2016
23	385187		Cyb561d2	0.000	R4995	G1	225	Y		9	107541548	V26M	C	T	missense		Het	probably damaging	0.997	0.324		05/10/2016
24	385199		Ddx5	1.000	R4995	G1	225	Y		11	106785236	T237I	G	A	missense		Het	probably damaging	0.995	0.128	phenotype	05/10/2016
25	385183		Dmxl2	1.000	R4995	G1	188	Y		9	54501441		G	T	utr 5 prime		Het	probably benign			phenotype	05/10/2016
26	385220		Dock8	0.086	R4995	G1	225	Y		19	25158383	S1188R	T	A	missense		Het	probably benign	0.023	0.109	phenotype	05/10/2016
27	385192		Ehbp1	0.713	R4995	G1	225	Y		11	22101073	H493L	T	A	missense		Het	probably damaging	1.000	0.961	phenotype	05/10/2016
28	385140		Eif5b	1.000	R4995	G1	225	Y		1	38051711	*1217K	T	A	makesense		Het	probably null		0.965	phenotype	05/10/2016
29	385144		Eprs	1.000	R4995	G1	225	Y		1	185410139		A	G	intron		Het	probably benign			phenotype	05/10/2016
30	385154		Etfdh	1.000	R4995	G1	225	Y		3	79605788	D376G	T	C	missense		Het	probably benign	0.027	0.070	phenotype	05/10/2016
31	385210		Fam186a	0.074	R4995	G1	225	Y		15	99945099	Q1088R	T	C	missense		Het	probably benign	0.271	0.106		05/10/2016
32	385188		Fbxw16	0.052	R4995	G1	225	Y		9	109441250	T141N	G	T	missense		Het	probably damaging	1.000	0.647		05/10/2016
33	385197		Fgf11	0.436	R4995	G1	203	Y		11	69798759	H138Y	G	A	missense		Het	probably damaging	0.995	0.106	phenotype	05/10/2016
34	385161		Gm1673	0.159	R4995	G1	223	Y		5	33984926	R79H	G	A	missense		Het	probably damaging	0.990	0.102		05/10/2016
35	385162		Htra3	0.000	R4995	G1	126	Y		5	35671074	E154G	T	C	missense		Het	probably damaging	0.985	0.228		05/10/2016
36	385181		Hydin	0.629	R4995	G1	225	Y		8	110569642	V3601D	T	A	missense		Het	probably damaging	0.971	0.376	phenotype	05/10/2016
37	385198		Jup	1.000	R4995	G1	225	Y		11	100379541	S380*	G	T	nonsense		Het	probably null		0.976	phenotype	05/10/2016
38	385168		Klrg1	0.000	R4995	G1	225	Y		6	122278275	D66V	T	A	missense		Het	probably benign	0.002	0.090	phenotype	05/10/2016
39	385195		Llgl1	1.000	R4995	G1	205	Y		11	60709724	A633V	C	T	missense		Het	probably benign	0.003	0.114	phenotype	05/10/2016
40	385213		Lmln	0.113	R4995	G1	225	Y		16	33074097	Y203*	T	A	nonsense		Het	probably null		0.976	phenotype	05/10/2016
41	385214		Lrrc58	0.261	R4995	G1	225	Y		16	37877056	C165G	T	G	missense		Het	probably benign	0.019	0.086		05/10/2016
42	385190		Lss	1.000	R4995	G1	211	Y		10	76547537	V557A	T	C	missense		Het	probably benign	0.101	0.090	phenotype	05/10/2016
43	385205		Mast4	0.400	R4995	G1	225	Y		13	102905754		T	C	intron		Het	probably benign			phenotype	05/10/2016
44	385166		Med13l	0.960	R4995	G1	225	Y		5	118730949	P754Q	C	A	missense		Het	possibly damaging	0.897	0.059	phenotype	05/10/2016
45	385151		Mga	0.917	R4995	G1	225	Y		2	119932582	R1240*	C	T	nonsense		Het	probably null		0.975	phenotype	05/10/2016
46	385201		Mgat5b	0.102	R4995	G1	118	Y		11	116974199		T	A	critical splice donor site	2 bp	Het	probably null		0.862	phenotype	05/10/2016
47	385159		Mtor	1.000	R4995	G1	180	Y		4	148525752	D1572G	A	G	missense		Het	probably damaging	0.998	0.319	phenotype	05/10/2016
48	385212		Muc4	0.117	R4995	G1	225	N		16	32754214	S1363T	T	A	missense		Het	probably benign	0.015		phenotype	05/10/2016
49	512169		Muc4	0.117	R4995	G1	215	N		16	32754041	S1306T	T	A	missense		Het	probably benign	0.015		phenotype	04/10/2018
50	385165		Myo18b	1.000	R4995	G1	225	Y		5	112760392	V2005A	A	G	missense		Het	probably damaging	0.992	0.071	phenotype	05/10/2016
51	385185		Myo1e	0.000	R4995	G1	225	Y		9	70353272	D571N	G	A	missense		Het	probably benign	0.013	0.128	phenotype	05/10/2016
52	512168		Mypn	0.179	R4995	G1	206	N		10	63119968		T	C	intron	61 bp	Het	probably null			phenotype	04/10/2018
53	385216		Ndufb10	0.912	R4995	G1	225	Y		17	24722757		T	C	unclassified	831 bp	Het	probably null		0.236		05/10/2016
54	385148		Nelfb	1.000	R4995	G1	180	Y		2	25206196	D300E	G	T	missense		Het	probably benign	0.012	0.072	phenotype	05/10/2016
55	385194		Olfr1389	0.258	R4995	G1	225	Y		11	49430655	Y60N	T	A	missense		Het	probably damaging	1.000	0.597	phenotype	05/10/2016
56	385206		Olfr1507	0.058	R4995	G1	225	Y		14	52490531	C61*	A	T	nonsense		Het	probably null		0.938	phenotype	05/10/2016
57	385174		Olfr625-ps1	0.068	R4995	G1	225	Y		7	103683367	D206E	T	A	missense		Het	probably damaging	1.000	0.647		05/10/2016
58	385175		Olfr668	0.256	R4995	G1	225	Y		7	104925735	T10S	T	A	missense		Het	probably benign	0.007	0.090	phenotype	05/10/2016
59	385218		Pcdha11	0.167	R4995	G1	173	N		18	37011027	T57M	C	T	missense		Het	probably benign	0.242		phenotype	05/10/2016
60	385142		Pkp1	0.341	R4995	G1	225	Y		1	135880855	I458N	A	T	missense		Het	possibly damaging	0.913	0.179	phenotype	05/10/2016
61	385171		Prr12	0.265	R4995	G1	119	Y		7	45051229		T	A	unclassified		Het	probably benign		0.139	phenotype	05/10/2016
62	385143		Prrc2c	0.255	R4995	G1	225	Y		1	162705310		A	T	unclassified		Het	probably benign		0.062		05/10/2016
63	385147		Psd4	0.000	R4995	G1	225	Y		2	24397247	F397S	T	C	missense		Het	probably benign	0.000	0.090		05/10/2016
64	385219		Pygm	0.000	R4995	G1	225	Y		19	6398139	I737T	T	C	missense		Het	probably damaging	1.000	0.954	phenotype	05/10/2016
65	385180		Rfx1	1.000	R4995	G1	225	Y		8	84080114		T	A	splice site		Het	probably null		0.976	phenotype	05/10/2016
66	385204		Rsl1	0.063	R4995	G1	225	Y		13	67182249	T254A	A	G	missense		Het	possibly damaging	0.597	0.128		05/10/2016
67	385189		Sh3rf3	0.288	R4995	G1	225	Y		10	59086824	Q574R	A	G	missense		Het	probably benign	0.064	0.066		05/10/2016
68	446650		Spire1	0.223	R4995	G1	225	Y		18	67552779		T	C	unclassified		Het	probably null		0.912	phenotype	12/08/2016
69	385150		St6galnac4	0.000	R4995	G1	206	Y		2	32594063	G91D	G	A	missense		Het	probably damaging	1.000	0.935	phenotype	05/10/2016
70	385173		Sytl2	0.224	R4995	G1	225	Y		7	90382257		T	C	intron		Het	probably benign		0.090	phenotype	05/10/2016
71	385146		Tbpl2	0.381	R4995	G1	225	Y		2	24093860	K188N	T	A	missense		Het	possibly damaging	0.944	0.179	phenotype	05/10/2016
72	385179		Tenm3	0.437	R4995	G1	225	Y		8	48229137	M2486K	A	T	missense		Het	possibly damaging	0.865	0.151	phenotype	05/10/2016
73	385167		Tgoln1	0.095	R4995	G1	225	Y		6	72616140	V119G	A	C	missense		Het	possibly damaging	0.915	0.179		05/10/2016
74	385191		Tpgs1	0.202	R4995	G1	225	Y		10	79669491	N28Y	A	T	missense		Het	probably benign	0.069	0.090	phenotype	05/10/2016
75	385186		U2surp	0.958	R4995	G1	225	Y		9	95462794		A	C	utr 3 prime		Het	probably benign		0.060		05/10/2016
76	385215		Vmn2r103	0.073	R4995	G1	225	Y		17	19773511	H50R	A	G	missense		Het	probably benign	0.135	0.090		05/10/2016
77	385169		Vmn2r19	0.062	R4995	G1	225	Y		6	123329910	N459S	A	G	missense		Het	probably benign	0.003	0.090		05/10/2016
78	385172		Vmn2r72	0.092	R4995	G1	225	Y		7	85738485	S624G	T	C	missense		Het	probably damaging	0.999	0.647		05/10/2016
79	385184		Vps13c	0.000	R4995	G1	225	Y		9	67919321	T1415A	A	G	missense		Het	probably benign	0.001	0.090	phenotype	05/10/2016
80	385158		Vwa5b1	0.000	R4995	G1	225	Y		4	138608843	P147S	G	A	missense		Het	probably damaging	1.000	0.311		05/10/2016
[records 1 to 80 of 80]