• Beutler Lab
  APN
• Strains @ MMRRC
• Display Strains By
  • Institution
  • Phenotype
  • Author
  • Chromosome
  • Inheritance
  • Multifield Search
• Search Mutagenetix
  
  
• Staff Login
• Download

Incidental Mutations

67 incidental mutations are currently displayed, and affect 67 genes.

11 are Possibly Damaging.

28 are Probably Damaging.

16 are Probably Benign.

11 are Probably Null.

4 create premature stop codons.

4 are critical splice junction mutations.

---

Mutations in Coding Regions/Splice Sites Identified by Next-Gen Sequencing

[records 1 to 67 of 67] 10 25 50 100 500 1000 per page Full List
	ID	Source UTSW APN	Gene	E-score	Stock #	Gen G0 G0' G1 G2 G3 G3R F1 F2 F3 C0 C1 C2 C3 D1 HES IPS A3	Quality -	Vld Y N ?	Strain	Chr 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X Y	Position	Mutation A R N D C E Q G H I L K M F P S T W Y V * A R N D C E Q G H I L K M F P S T W Y V *	Ref A C G T -	Var A C G T -	Type makesense missense nonsense start codon destroyed start gained synonymous splice acceptor site splice donor site critical splice acceptor site critical splice donor site splice site large deletion large insertion rearrangement small deletion small insertion exon frame shift intragenic intron utr 3 prime utr 5 prime unclassified	Exon Dist	Zygosity Homo Het Hemi Null	Predicted Effect unknown probably benign probably null possibly damaging probably damaging noncoding transcript silent not run no transcript	PPH Score -	Meta Score	MGI Phenotype available none listed	Posted
1	489804		2810474O19Rik	0.000	R6160	G1	225.01	Y		6	149331507		G	A	critical splice donor site	1 bp	Het	probably null				10/10/2017
2	489807		4930433I11Rik	0.077	R6160	G1	225.01	Y		7	40993526	S297R	T	A	missense		Het	possibly damaging	0.909	0.179		10/10/2017
3	489801		5530400C23Rik	0.262	R6160	G1	225.01	Y		6	133294326	E111G	A	G	missense		Het	possibly damaging	0.847			10/10/2017
4	489830		8030423J24Rik	0.080	R6160	G1	225.01	Y		13	70883910	S34T	T	A	missense		Het	unknown				10/10/2017
5	489824		Ace3	0.173	R6160	G1	225.01	Y		11	105994732	W20R	T	A	missense		Het	possibly damaging	0.508		phenotype	10/10/2017
6	489841		Adgrf1	0.000	R6160	G1	225.01	Y		17	43310687	E605G	A	G	missense		Het	probably damaging	0.999		phenotype	10/10/2017
7	489819		Arhgap44	0.000	R6160	G1	162.01	N		11	65162549		G	A	unclassified		Het	probably benign				10/10/2017
8	489813		Atm	0.853	R6160	G1	225.01	Y		9	53490959	H1404Q	A	C	missense		Het	probably benign	0.043		phenotype	10/10/2017
9	489828		AW209491	0.225	R6160	G1	225.01	Y		13	14636721	E53G	A	G	missense		Het	probably damaging	0.987			10/10/2017
10	489810		Cdt1	0.963	R6160	G1	225.01	Y		8	122571368	T366I	C	T	missense		Het	probably benign	0.357	0.090	phenotype	10/10/2017
11	489834		Cerk	0.093	R6160	G1	225.01	Y		15	86142773	C179S	A	T	missense		Het	probably benign	0.432		phenotype	10/10/2017
12	489833		Cldn10	0.100	R6160	G1	225.01	Y		14	118861843	V123A	T	C	missense		Het	possibly damaging	0.611		phenotype	10/10/2017
13	489798		Clip1	0.000	R6160	G1	225.01	Y		5	123613541	K726E	T	C	missense		Het	possibly damaging	0.659		phenotype	10/10/2017
14	489796		Dcaf12	0.315	R6160	G1	225.01	Y		4	41294043	Y365N	A	T	missense		Het	probably damaging	0.999	0.941	phenotype	10/10/2017
15	489835		Dennd6b	0.156	R6160	G1	225.01	Y		15	89188821	L171P	A	G	missense		Het	probably damaging	0.969			10/10/2017
16	489827		Dip2c	0.448	R6160	G1	225.01	Y		13	9533254	V91I	G	A	missense		Het	probably benign	0.007		phenotype	10/10/2017
17	489814		Dlec1	0.000	R6160	G1	225.01	Y		9	119143319	I1431V	A	G	missense		Het	probably benign	0.019		phenotype	10/10/2017
18	489811		Egln1	1.000	R6160	G1	216.01	Y		8	124948492	D188G	T	C	missense		Het	probably damaging	0.993		phenotype	10/10/2017
19	489842		Enpp5	0.000	R6160	G1	225.01	Y		17	44081368	N229K	T	A	missense		Het	possibly damaging	0.767		phenotype	10/10/2017
20	489787		Fmo1	0.086	R6160	G1	225.01	Y		1	162836298	I221L	T	G	missense		Het	probably benign	0.002		phenotype	10/10/2017
21	489792		Fsip2	0.172	R6160	G1	225.01	Y		2	82987945	W4674*	G	A	nonsense		Het	probably null		0.976	phenotype	10/10/2017
22	489817		Gm12185	0.097	R6160	G1	225.01	Y		11	48908428	Q413*	G	A	nonsense		Het	probably null		0.976		10/10/2017
23	489846		Gm5096	0.230	R6160	G1	225.01	N		18	87757121	C256Y	G	A	missense		Het	probably damaging	0.998			10/10/2017
24	489800		Gm7298	0.185	R6160	G1	225.01	Y		6	121764927	H436L	A	T	missense		Het	probably benign	0.278			10/10/2017
25	489802		Gucy2c	0.000	R6160	G1	170.01	Y		6	136740686	Q430*	G	A	nonsense		Het	probably null			phenotype	10/10/2017
26	489837		Hgd	0.000	R6160	G1	225.01	Y		16	37613298	H134R	A	G	missense		Het	probably damaging	1.000		phenotype	10/10/2017
27	489791		Hoxd8	0.000	R6160	G1	225.01	Y		2	74705999	E151G	A	G	missense		Het	probably damaging	0.999	0.117	phenotype	10/10/2017
28	489788		Il15ra	0.055	R6160	G1	225.01	Y		2	11720016	D99G	A	G	missense		Het	probably damaging	0.985	0.289	phenotype	10/10/2017
29	501891		Ints4	0.959	R6160	G1	225.01	Y		7	97509583		T	A	splice site		Het	probably null			phenotype	12/04/2017
30	489812		Itgb1	1.000	R6160	G1	225.01	Y		8	128720283	F426L	T	A	missense		Het	possibly damaging	0.954	0.973	phenotype	10/10/2017
31	489799		Itpr1	0.785	R6160	G1	225.01	Y		6	108518755	I2534L	A	C	missense		Het	probably benign	0.057	0.390	phenotype	10/10/2017
32	489797		Kcnq4	0.369	R6160	G1	225.01	Y		4	120716559	H235L	T	A	missense		Het	probably damaging	0.999		phenotype	10/10/2017
33	489789		Kcnt1	0.224	R6160	G1	225.01	Y		2	25892383	I178N	T	A	missense		Het	probably damaging	0.964		phenotype	10/10/2017
34	489826		Kidins220	1.000	R6160	G1	225.01	Y		12	24997311	D252G	A	G	missense		Het	probably damaging	1.000		phenotype	10/10/2017
35	489823		Krt23	0.067	R6160	G1	225.01	Y		11	99485718	I204T	A	G	missense		Het	probably damaging	0.994		phenotype	10/10/2017
36	489847		Lipo4	0.083	R6160	G1	225.01	Y		19	33503293	L225P	A	G	missense		Het	probably damaging	0.988			10/10/2017
37	529371		Lrp3	0.133	R6160	G1	58.01	Y		7	35204123	D245G	T	C	missense		Het	possibly damaging	0.786			07/31/2018
38	489795		Mmp16	0.000	R6160	G1	225.01	Y		4	18051857	D282G	A	G	missense		Het	probably damaging	1.000		phenotype	10/10/2017
39	489820		Myo1c	0.540	R6160	G1	198.01	Y		11	75650742	H18L	A	T	missense		Het	probably benign	0.004		phenotype	10/10/2017
40	489840		Myo1f	0.186	R6160	G1	225.01	Y		17	33604344	P981Q	C	A	missense		Het	probably benign	0.000	0.090	phenotype	10/10/2017
41	489821		Nle1	1.000	R6160	G1	205.01	Y		11	82908157	F33I	A	T	missense		Het	probably benign	0.011		phenotype	10/10/2017
42	489806		Nlrp4e	0.000	R6160	G1	225.01	N		7	23321306	M406R	T	G	missense		Het	probably damaging	0.989			10/10/2017
43	489818		Obscn	0.824	R6160	G1	160.01	Y		11	59051785	V4857E	A	T	missense		Het	probably damaging	0.997		phenotype	10/10/2017
44	489809		Palb2	1.000	R6160	G1	225.01	Y		7	122128420		A	T	unclassified		Het	probably null			phenotype	10/10/2017
45	489822		Phospho1	0.078	R6160	G1	94.01	Y		11	95830624	E22V	A	T	missense		Het	probably damaging	1.000		phenotype	10/10/2017
46	489829		Pom121l2	0.063	R6160	G1	225.01	Y		13	21983668	S703L	C	T	missense		Het	possibly damaging	0.522			10/10/2017
47	529370		Prex2	0.215	R6160	G1	76.01	Y		1	10993851	L20P	T	C	missense		Het	probably damaging	1.000		phenotype	07/31/2018
48	489790		Psmb7	0.956	R6160	G1	225.01	Y		2	38643381	T45A	T	C	missense		Het	probably damaging	1.000		phenotype	10/10/2017
49	489816		R3hdm2	0.489	R6160	G1	225.01	Y		10	127484507	I532T	T	C	missense		Het	probably damaging	0.998			10/10/2017
50	489793		Rcn1	0.000	R6160	G1	225.01	Y		2	105392017	D208G	T	C	missense		Het	probably damaging	1.000	0.629	phenotype	10/10/2017
51	489825		Recql5	0.351	R6160	G1	225.01	Y		11	115932787		A	G	critical splice donor site	2 bp	Het	probably null			phenotype	10/10/2017
52	489836		Rfc4	0.958	R6160	G1	225.01	Y		16	23114683	I242N	A	T	missense		Het	probably damaging	1.000		phenotype	10/10/2017
53	489785		Rims1	0.659	R6160	G1	225.01	Y		1	22432984	Y650C	T	C	missense		Het	probably damaging	0.975		phenotype	10/10/2017
54	489815		Shc2	0.000	R6160	G1	225.01	Y		10	79627019		C	T	critical splice donor site	1 bp	Het	probably null			phenotype	10/10/2017
55	489845		Slc14a2	0.000	R6160	G1	225.01	Y		18	78158975		A	T	critical splice donor site	2 bp	Het	probably null			phenotype	10/10/2017
56	501890		Slc6a6	0.000	R6160	G1	225.01	Y		6	91740014		A	T	splice site	3 bp	Het	probably null		0.976	phenotype	12/04/2017
57	489838		Synj2	0.159	R6160	G1	225.01	Y		17	6008061	H275N	C	A	missense		Het	possibly damaging	0.924	0.079	phenotype	10/10/2017
58	489839		T	0.948	R6160	G1	225.01	Y		17	8441786	T410S	A	T	missense		Het	probably benign	0.002	0.085	phenotype	10/10/2017
59	489808		Tarsl2	0.111	R6160	G1	225.01	Y		7	65682779	I543V	A	G	missense		Het	probably benign	0.325	0.087		10/10/2017
60	489786		Tbc1d8	0.000	R6160	G1	225.01	Y		1	39372403	K1117N	T	A	missense		Het	probably damaging	0.981			10/10/2017
61	489803		Tm7sf3	0.209	R6160	G1	225.01	Y		6	146606289	L425*	A	T	nonsense		Het	probably null				10/10/2017
62	489831		Trav14-3	0.382	R6160	G1	225.01	Y		14	53763521	Y63C	A	G	missense		Het	probably damaging	1.000			10/10/2017
63	489794		Tyro3	0.000	R6160	G1	225.01	Y		2	119803270	D133A	A	C	missense		Het	probably damaging	0.984	0.160	phenotype	10/10/2017
64	489805		Vmn1r119		R6160	G1	225.01	N		7	21011815	H214P	T	G	missense		Het	possibly damaging	0.470			10/10/2017
65	489843		Vmn2r120	0.105	R6160	G1	225.01	Y		17	57509418	P646S	G	A	missense		Het	probably benign	0.031			10/10/2017
66	489844		Zbtb7c	0.180	R6160	G1	225.01	N		18	76145833	Y454F	A	T	missense		Het	probably benign	0.050		phenotype	10/10/2017
67	489832		Zmym2	0.651	R6160	G1	225.01	Y		14	56950309	L1144P	T	C	missense		Het	probably damaging	1.000		phenotype	10/10/2017
[records 1 to 67 of 67]