Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01871:Rhov'

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178700

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rhov

Ensembl Gene

ENSMUSG00000034226

Gene Name

ras homolog family member V

Synonyms

Arhv, A030005A06Rik

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.253) question?

Stock #

IGL01871

Quality Score

Status

Chromosome

Chromosomal Location

119269201-119271272 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 119270738 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 71 (Q71K)

Ref Sequence

ENSEMBL: ENSMUSP00000041411 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037360]

Predicted Effect

probably benign
Transcript: ENSMUST00000037360
AA Change: Q71K

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000041411
Gene: ENSMUSG00000034226
AA Change: Q71K

Domain	Start	End	E-Value	Type
low complexity region	2	30	N/A	INTRINSIC
RHO	34	208	3.12e-89	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	T	13: 81,472,394		probably null	Het
Aqp7	G	A	4: 41,045,321	R20*	probably null	Het
Asxl2	G	T	12: 3,502,112	V1285L	probably benign	Het
Bdp1	A	T	13: 100,066,053	S688T	probably benign	Het
Cc2d2a	A	T	5: 43,688,969	I357F	probably damaging	Het
Clasp1	A	T	1: 118,570,889	I884F	probably damaging	Het
Cpne4	T	G	9: 104,925,757	M200R	possibly damaging	Het
Cyp2d10	T	A	15: 82,403,885	D180V	probably damaging	Het
Dicer1	A	T	12: 104,704,180	V1042D	probably damaging	Het
Dlc1	G	A	8: 36,850,180	T447I	probably damaging	Het
Efl1	T	C	7: 82,763,319	M972T	possibly damaging	Het
Erbin	A	G	13: 103,834,766	S781P	probably damaging	Het
Fam46b	A	G	4: 133,486,309	I164V	possibly damaging	Het
Galnt4	G	A	10: 99,109,241	G276D	probably damaging	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gmppa	A	G	1: 75,437,017	I41V	probably damaging	Het
Golga1	C	T	2: 39,050,198		probably benign	Het
H2-Ob	G	T	17: 34,242,545	W86L	probably damaging	Het
Hnrnpr	G	A	4: 136,339,574	R482H	unknown	Het
L2hgdh	T	C	12: 69,722,095	E81G	probably damaging	Het
Mre11a	T	C	9: 14,811,897	V389A	possibly damaging	Het
Mxra8	A	G	4: 155,842,801	T372A	probably benign	Het
Ncapg	T	A	5: 45,688,581	S593R	probably benign	Het
Ndufaf1	C	T	2: 119,658,287	W250*	probably null	Het
Neb	T	C	2: 52,153,069	E6783G	probably damaging	Het
Nmt2	T	C	2: 3,312,674	Y175H	probably damaging	Het
Olfml2b	T	C	1: 170,662,355		probably benign	Het
Pitpnm3	T	A	11: 72,056,138	M812L	probably damaging	Het
Pou2f3	A	G	9: 43,134,473		probably benign	Het
Prkdc	A	G	16: 15,783,087	T2871A	probably benign	Het
Rapgef4	A	G	2: 72,198,360	T392A	possibly damaging	Het
Slc22a15	T	C	3: 101,860,794		probably benign	Het
Spaca1	T	A	4: 34,040,894	N22Y	probably damaging	Het
Stmnd1	A	G	13: 46,289,713	E107G	probably damaging	Het
Timm22	T	C	11: 76,407,437	V78A	probably damaging	Het
Usp47	T	C	7: 112,077,786		probably benign	Het
Utp4	A	C	8: 106,912,317	K419T	probably benign	Het
Zfp410	T	C	12: 84,325,791		probably null	Het

Other mutations in Rhov

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0732:Rhov	UTSW	2	119271014	missense	probably damaging	1.00
R1646:Rhov	UTSW	2	119271020	missense	probably damaging	1.00
R4997:Rhov	UTSW	2	119270468	missense	probably damaging	1.00
R5124:Rhov	UTSW	2	119271087	missense	unknown
R5993:Rhov	UTSW	2	119270052	missense	probably damaging	1.00
R6168:Rhov	UTSW	2	119270972	missense	probably damaging	1.00
Z1177:Rhov	UTSW	2	119270415	nonsense	probably null

Posted On

2014-05-07