Mutagenetix > Incidental Mutations

Incidental Mutation 'R8126:Vmn2r-ps117'

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631784

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r-ps117

Ensembl Gene

ENSMUSG00000093531

Gene Name

vomeronasal 2, receptor, pseudogene 117

Synonyms

EG665303

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R8126 (G1)

Quality Score

202.009

Status

Validated

Chromosome

Chromosomal Location

18810835-18838900 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 18822552 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 74 (Y74F)

Ref Sequence

ENSEMBL: ENSMUSP00000156026 (fasta)

Predicted Effect

probably benign
Transcript: ENSMUST00000176899
AA Change: Y74F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.0%
20x: 97.3%

Validation Efficiency

95% (42/44)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	T	13: 81,440,225	V4414E	possibly damaging	Het
Aplp1	T	A	7: 30,441,739	D299V	probably damaging	Het
Atad2	T	C	15: 58,105,591	I841M	probably benign	Het
BC067074	T	A	13: 113,368,163	I1942N		Het
Bdp1	T	C	13: 100,056,282	E1348G	probably damaging	Het
Cacna1a	A	G	8: 84,633,252	T1948A	probably benign	Het
Cdh12	T	C	15: 21,558,307	Y431H	probably benign	Het
Cfap74	C	A	4: 155,427,374	D446E		Het
Clpsl2	G	A	17: 28,550,728	G55R	probably damaging	Het
Col4a4	T	C	1: 82,453,286	T1632A	unknown	Het
Csnk2a2	G	A	8: 95,455,947	P296L		Het
Cstl1	A	G	2: 148,754,671	E98G	probably benign	Het
Ddx49	A	T	8: 70,295,596	I303N	probably damaging	Het
Ddx60	C	T	8: 61,983,911	A965V	probably benign	Het
Evl	C	T	12: 108,681,524	R295*	probably null	Het
Gm13083	T	A	4: 143,617,065	C312S	possibly damaging	Het
Gm14295	A	G	2: 176,810,865	D716G	probably benign	Het
Gsap	T	A	5: 21,270,012	H556Q	probably benign	Het
Hsp90b1	T	C	10: 86,694,382	I538V	probably damaging	Het
Ighv1-49	C	T	12: 115,055,610		probably benign	Het
Lrrk1	T	C	7: 66,292,315	N725S	probably damaging	Het
Mfsd4b2	A	G	10: 39,921,988	S124P	probably benign	Het
Ncoa1	A	T	12: 4,290,951	L827Q	probably damaging	Het
Ncor2	T	C	5: 125,106,204	N59D	unknown	Het
Nfkbid	T	A	7: 30,424,374	S120T	probably benign	Het
Nktr	T	C	9: 121,746,448	Y341H	probably damaging	Het
Npat	T	C	9: 53,552,334	V139A	probably benign	Het
Olfr290	T	A	7: 84,915,906	N42K	probably damaging	Het
Plxnb2	T	C	15: 89,163,303	D721G	probably benign	Het
Ppl	C	T	16: 5,088,861	R1190H	probably damaging	Het
Ppp3ca	T	A	3: 136,903,191	D348E	probably damaging	Het
Rnf146	T	C	10: 29,347,376	I171M	probably damaging	Het
Snrpa	G	T	7: 27,192,948	F62L	possibly damaging	Het
Spata3	C	T	1: 86,024,353	R110C	unknown	Het
Tbc1d2b	T	C	9: 90,222,316	H591R	probably benign	Het
Tnfsf8	T	G	4: 63,834,186	D214A	possibly damaging	Het
Trdmt1	C	T	2: 13,520,005	R213H	probably benign	Het
Uspl1	C	T	5: 149,214,620	L877F	probably damaging	Het
Vmn1r22	C	A	6: 57,900,684	V103F	possibly damaging	Het
Vmn2r102	T	C	17: 19,660,450	S18P	probably benign	Het
Wdr90	A	G	17: 25,848,977	F1429S	possibly damaging	Het
Zdhhc20	C	A	14: 57,846,945	V238F	probably damaging	Het

Other mutations in Vmn2r-ps117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R6903:Vmn2r-ps117	UTSW	17	18838290	missense	possibly damaging	0.94
R6912:Vmn2r-ps117	UTSW	17	18827202	missense	probably damaging	1.00
R6934:Vmn2r-ps117	UTSW	17	18824705	nonsense	probably null
R6953:Vmn2r-ps117	UTSW	17	18824833	missense	probably benign
R6974:Vmn2r-ps117	UTSW	17	18838233	missense	probably benign	0.15
R7373:Vmn2r-ps117	UTSW	17	18824686	missense	probably benign
R7630:Vmn2r-ps117	UTSW	17	18824647	missense	probably benign	0.01
R7776:Vmn2r-ps117	UTSW	17	18823672	missense	probably damaging	0.96
R8060:Vmn2r-ps117	UTSW	17	18837862	missense	possibly damaging	0.85
Z1177:Vmn2r-ps117	UTSW	17	18838076	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GTAAAGGAGCTTGCTTAAACCTAAC -3'
(R):5'- GAGTGCAGCAGTGAAATTTCTC -3'

Sequencing Primer
(F):5'- TCTGTTCATGGGAAGGCA -3'
(R):5'- ATGATTTCCGTCACCAAGAGCTG -3'

Posted On

2020-06-30