Incidental Mutation 'IGL02268:1500015O10Rik'
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ID286976
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol 1500015O10Rik
Ensembl Gene ENSMUSG00000026051
Gene NameRIKEN cDNA 1500015O10 gene
SynonymsEcrg4
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02268
Quality Score
Status
Chromosome1
Chromosomal Location43730602-43742578 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 43730951 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 23 (C23S)
Ref Sequence ENSEMBL: ENSMUSP00000027217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027217]
Predicted Effect probably damaging
Transcript: ENSMUST00000027217
AA Change: C23S

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000027217
Gene: ENSMUSG00000026051
AA Change: C23S

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Pfam:Augurin 32 148 2.9e-56 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: No notable pheontype was detected in high throughput screens of homozygous mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik C T 10: 28,986,246 C16Y probably benign Het
5330417C22Rik C A 3: 108,467,797 A585S probably benign Het
Abca13 C T 11: 9,290,626 L830F probably benign Het
Apcdd1 T C 18: 62,950,188 V363A probably damaging Het
Cachd1 A G 4: 100,952,097 I260V possibly damaging Het
Cass4 T A 2: 172,427,042 M350K possibly damaging Het
Ccdc129 A T 6: 55,884,688 probably benign Het
Ccnjl A G 11: 43,579,788 T128A probably benign Het
Cd6 C T 19: 10,796,388 G361D probably benign Het
Cdh22 T C 2: 165,123,719 probably benign Het
Ces2h T A 8: 105,019,940 F475Y probably benign Het
Col15a1 A T 4: 47,245,380 T44S probably damaging Het
Cplx3 C T 9: 57,602,458 E86K possibly damaging Het
Crbn A G 6: 106,795,043 V100A possibly damaging Het
D430041D05Rik C A 2: 104,241,155 V1267L possibly damaging Het
F930017D23Rik A G 10: 43,604,409 noncoding transcript Het
Fam214b T A 4: 43,036,468 R88* probably null Het
Fastkd3 A G 13: 68,583,677 D39G probably damaging Het
Gm17689 T C 9: 36,581,870 Y52C possibly damaging Het
Golgb1 T A 16: 36,913,128 S912R probably benign Het
H2-T24 T C 17: 36,017,372 Y73C probably damaging Het
Ifna9 A T 4: 88,592,354 L11* probably null Het
Igsf10 A T 3: 59,331,152 L536* probably null Het
Kcnma1 A T 14: 23,543,076 I215K probably damaging Het
Kdm4c A C 4: 74,373,716 I857L possibly damaging Het
Kptn A T 7: 16,123,861 H229L probably benign Het
Krt32 A T 11: 100,088,141 M29K probably benign Het
Lama2 A G 10: 27,001,116 probably benign Het
Lpcat2b A C 5: 107,434,116 D437A probably damaging Het
Lrrc8c T C 5: 105,607,898 L513P probably damaging Het
Mon1a T C 9: 107,901,798 V407A possibly damaging Het
Myo5c C T 9: 75,246,237 P135L probably damaging Het
Myof C T 19: 37,954,429 V218M possibly damaging Het
Myof T A 19: 37,974,863 I429F possibly damaging Het
Nbas A G 12: 13,405,397 D1204G possibly damaging Het
Nckap1 G A 2: 80,528,618 P560S probably benign Het
Notch2 G A 3: 98,137,397 G1545D probably damaging Het
Ntrk1 G A 3: 87,781,531 H572Y probably damaging Het
Olfr314 T C 11: 58,786,725 F164L probably benign Het
Olfr873 T C 9: 20,300,292 S31P probably damaging Het
Pcdh15 A T 10: 74,342,672 D587V probably damaging Het
Pik3cb T C 9: 99,046,556 Y882C probably benign Het
Plch1 T A 3: 63,699,283 *1074C probably null Het
Plcxd1 T C 5: 110,100,274 probably benign Het
Ppp2r2d A G 7: 138,872,971 N27S probably null Het
Prkar2a A G 9: 108,746,953 M390V probably benign Het
Rab3gap1 A G 1: 127,868,958 T18A probably damaging Het
Ranbp2 T C 10: 58,493,653 probably benign Het
Rasl12 T C 9: 65,398,664 S34P probably damaging Het
Rpusd3 A T 6: 113,418,857 L65Q possibly damaging Het
Rtf2 A G 2: 172,468,719 K290R probably damaging Het
Rwdd4a T A 8: 47,550,696 L179* probably null Het
Scgb1b24 A G 7: 33,744,963 E87G possibly damaging Het
Sgo2a A G 1: 58,017,722 I1022V probably benign Het
Smg1 A C 7: 118,182,541 I1174M probably benign Het
Spata17 A T 1: 187,140,398 M72K probably damaging Het
Synpo2 G A 3: 123,116,983 P338S probably damaging Het
Tpi1 G A 6: 124,814,124 T50I probably benign Het
Trpm1 A G 7: 64,217,614 E354G probably damaging Het
Uba2 A G 7: 34,142,736 probably null Het
Wnk1 G A 6: 119,937,373 R1823* probably null Het
Zfp248 A C 6: 118,453,840 probably benign Het
Zfp51 A T 17: 21,463,419 K99* probably null Het
Other mutations in 1500015O10Rik
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0543:1500015O10Rik UTSW 1 43742289 missense possibly damaging 0.95
R2149:1500015O10Rik UTSW 1 43742336 missense probably damaging 1.00
R4621:1500015O10Rik UTSW 1 43737252 splice site probably null
R4622:1500015O10Rik UTSW 1 43742321 missense possibly damaging 0.79
R5940:1500015O10Rik UTSW 1 43737241 nonsense probably null
R6648:1500015O10Rik UTSW 1 43738691 missense probably damaging 1.00
R6776:1500015O10Rik UTSW 1 43742391 missense probably damaging 1.00
RF007:1500015O10Rik UTSW 1 43737192 critical splice acceptor site probably benign
RF045:1500015O10Rik UTSW 1 43737192 critical splice acceptor site probably benign
Posted On2015-04-16