Incidental Mutation 'R1160:Syt13'
Institutional Source Beutler Lab
Gene Symbol Syt13
Ensembl Gene ENSMUSG00000027220
Gene Namesynaptotagmin XIII
MMRRC Submission 039233-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.091) question?
Stock #R1160 (G1)
Quality Score225
Status Not validated
Chromosomal Location92915098-92956058 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to A at 92943042 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000028648 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028648]
Predicted Effect probably null
Transcript: ENSMUST00000028648
SMART Domains Protein: ENSMUSP00000028648
Gene: ENSMUSG00000027220

transmembrane domain 7 29 N/A INTRINSIC
low complexity region 108 120 N/A INTRINSIC
Pfam:C2 165 277 5e-8 PFAM
C2 303 419 7.86e-14 SMART
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.3%
  • 10x: 92.7%
  • 20x: 81.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810403A07Rik C A 3: 88,708,862 P452Q probably damaging Het
Agap1 G T 1: 89,843,154 K622N probably damaging Het
Ap3b2 A T 7: 81,466,169 probably null Het
Arl5b T C 2: 15,069,837 V43A probably benign Het
Astn1 T C 1: 158,600,365 V702A possibly damaging Het
Bach1 T C 16: 87,715,434 V15A probably benign Het
Cacna1c C T 6: 118,612,625 R1446H probably damaging Het
Ccar2 C T 14: 70,139,769 V774M probably benign Het
Dcaf5 T C 12: 80,340,215 D379G possibly damaging Het
Dcpp1 T A 17: 23,881,431 I45K possibly damaging Het
Ddx17 T A 15: 79,541,087 S128C probably damaging Het
Eml3 A G 19: 8,933,250 N192S probably benign Het
Epha3 T G 16: 63,773,068 D219A probably damaging Het
Fhod3 C T 18: 24,985,236 A210V probably damaging Het
Klhl5 A G 5: 65,141,340 N154S probably benign Het
Lrif1 A G 3: 106,732,717 N373D possibly damaging Het
Map3k20 A G 2: 72,441,520 N664S probably benign Het
Olfr625-ps1 A G 7: 103,682,861 N38D possibly damaging Het
Parp14 G A 16: 35,856,760 A946V probably benign Het
Pdia3 G A 2: 121,432,377 G275S probably damaging Het
Pglyrp4 T A 3: 90,728,831 probably null Het
Pole A G 5: 110,295,253 E349G possibly damaging Het
Ptprj A G 2: 90,444,524 Y1165H probably damaging Het
Rasd1 T A 11: 59,964,721 I29F possibly damaging Het
Scamp3 T C 3: 89,181,198 F237S probably damaging Het
Sccpdh T G 1: 179,684,210 D82E probably benign Het
Slc19a3 A C 1: 83,022,692 H201Q possibly damaging Het
Slc5a4a G A 10: 76,178,161 A401T possibly damaging Het
Snupn T G 9: 56,957,105 C29W probably benign Het
Sorbs2 A G 8: 45,770,576 Y222C probably damaging Het
Sox17 A T 1: 4,491,852 V310E probably damaging Het
Srgap1 T A 10: 121,855,477 Y284F probably benign Het
Srpk1 C A 17: 28,599,774 V363F probably benign Het
Taf2 A G 15: 55,071,397 V45A probably benign Het
Tal1 A T 4: 115,068,616 D294V probably damaging Het
Tbl2 A G 5: 135,159,392 T347A probably benign Het
Tet3 A G 6: 83,404,452 S110P probably benign Het
Tmem132a A G 19: 10,858,574 V864A probably damaging Het
Trak1 T C 9: 121,392,007 I80T probably benign Het
Trappc6b G A 12: 59,050,278 T86I probably damaging Het
Usf3 T A 16: 44,218,547 I1130N probably damaging Het
Xirp2 T C 2: 67,509,887 V824A possibly damaging Het
Zfp810 T C 9: 22,278,532 Y360C possibly damaging Het
Zmiz1 T A 14: 25,654,512 V685E probably damaging Het
Zp2 A T 7: 120,136,045 D368E probably damaging Het
Other mutations in Syt13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02236:Syt13 APN 2 92940865 missense probably damaging 0.96
IGL02332:Syt13 APN 2 92940804 missense probably benign 0.02
IGL03015:Syt13 APN 2 92951380 missense possibly damaging 0.94
R0345:Syt13 UTSW 2 92946067 missense possibly damaging 0.66
R0367:Syt13 UTSW 2 92915251 missense probably benign 0.01
R1635:Syt13 UTSW 2 92953415 missense probably damaging 1.00
R1639:Syt13 UTSW 2 92945971 missense probably benign 0.04
R1844:Syt13 UTSW 2 92940820 missense probably damaging 1.00
R1869:Syt13 UTSW 2 92946103 missense possibly damaging 0.90
R2032:Syt13 UTSW 2 92953401 missense probably damaging 1.00
R2306:Syt13 UTSW 2 92940967 missense probably benign 0.04
R2375:Syt13 UTSW 2 92946151 missense probably benign 0.02
R4958:Syt13 UTSW 2 92953449 missense probably damaging 1.00
R5341:Syt13 UTSW 2 92953552 missense probably benign 0.00
R7605:Syt13 UTSW 2 92943133 missense probably benign 0.27
X0024:Syt13 UTSW 2 92943075 missense probably benign 0.00
Predicted Primers
Posted On2014-01-15