Incidental Mutation 'R1162:Or5ac15'
ID 100519
Institutional Source Beutler Lab
Gene Symbol Or5ac15
Ensembl Gene ENSMUSG00000063020
Gene Name olfactory receptor family 5 subfamily AC member 15
Synonyms MOR182-13, MOR182-7P, GA_x54KRFPKG5P-55348161-55347241, Olfr194
MMRRC Submission 039235-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R1162 (G1)
Quality Score 175
Status Not validated
Chromosome 16
Chromosomal Location 58939511-58940431 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58939735 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 233 (R233G)
Ref Sequence ENSEMBL: ENSMUSP00000149379 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072608] [ENSMUST00000213228] [ENSMUST00000216519]
AlphaFold L7N1Y8
Predicted Effect probably benign
Transcript: ENSMUST00000072608
AA Change: R233G

PolyPhen 2 Score 0.284 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000072407
Gene: ENSMUSG00000063020
AA Change: R233G

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 1.7e-47 PFAM
Pfam:7tm_1 40 289 1.9e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213228
AA Change: R233G

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000216519
AA Change: R233G

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.9%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430015G10Rik T C 4: 156,206,875 (GRCm39) probably null Het
Adamts12 T A 15: 11,277,544 (GRCm39) probably null Het
Ccn3 T A 15: 54,611,178 (GRCm39) C104* probably null Het
Cops4 T C 5: 100,678,023 (GRCm39) probably benign Het
Cul7 T A 17: 46,974,116 (GRCm39) L1467H probably damaging Het
Dgkh A G 14: 78,861,891 (GRCm39) C125R probably damaging Het
Dgkz A T 2: 91,774,789 (GRCm39) I65N probably damaging Het
Dock10 T A 1: 80,546,559 (GRCm39) H743L possibly damaging Het
Dscaml1 T C 9: 45,663,647 (GRCm39) probably benign Het
Flt4 C T 11: 49,527,166 (GRCm39) probably benign Het
Gbe1 A T 16: 70,178,738 (GRCm39) probably benign Het
Gm7275 A G 16: 47,894,395 (GRCm39) noncoding transcript Het
Gpatch1 A G 7: 35,002,905 (GRCm39) probably benign Het
Gpr137c A G 14: 45,481,615 (GRCm39) I144V possibly damaging Het
Igsf9b T C 9: 27,238,185 (GRCm39) S563P probably benign Het
Insl5 C T 4: 102,875,438 (GRCm39) R104Q probably benign Het
Kcnj2 T A 11: 110,963,793 (GRCm39) V395D probably benign Het
Ksr2 A G 5: 117,693,020 (GRCm39) probably benign Het
Lrrc4 C A 6: 28,831,083 (GRCm39) L177F probably damaging Het
Mapkbp1 A G 2: 119,855,799 (GRCm39) E1506G possibly damaging Het
Morc3 A C 16: 93,649,996 (GRCm39) Y259S probably damaging Het
Mrpl43 T G 19: 44,994,797 (GRCm39) S13R possibly damaging Het
Myh4 A G 11: 67,149,439 (GRCm39) N1724D probably damaging Het
Nab1 A G 1: 52,529,186 (GRCm39) M237T probably damaging Het
Nav2 A G 7: 49,185,788 (GRCm39) probably benign Het
Nfix G A 8: 85,453,155 (GRCm39) R300C probably damaging Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or2h15 A T 17: 38,441,984 (GRCm39) V33D possibly damaging Het
Or5p80 A G 7: 108,230,120 (GRCm39) N307S probably benign Het
Phf2 A T 13: 48,973,117 (GRCm39) probably benign Het
Ppef2 A C 5: 92,400,980 (GRCm39) F13L probably benign Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Sap130 C T 18: 31,781,226 (GRCm39) P130S probably damaging Het
Scn11a A G 9: 119,634,710 (GRCm39) probably benign Het
Sec31b C A 19: 44,506,087 (GRCm39) E940* probably null Het
Sgce A G 6: 4,691,419 (GRCm39) probably benign Het
Sh3glb2 A T 2: 30,240,600 (GRCm39) I155N probably damaging Het
Sirt2 A T 7: 28,485,247 (GRCm39) D218V probably damaging Het
Slc16a10 T C 10: 39,952,549 (GRCm39) H315R probably benign Het
Sox5 A G 6: 143,906,538 (GRCm39) Y306H probably damaging Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Tab2 A G 10: 7,800,483 (GRCm39) V23A probably damaging Het
Trak1 G T 9: 121,282,407 (GRCm39) V429F possibly damaging Het
Trat1 T C 16: 48,560,572 (GRCm39) S102G possibly damaging Het
Trub1 G A 19: 57,461,191 (GRCm39) V156I probably benign Het
Tspan32 T A 7: 142,560,735 (GRCm39) M61K probably damaging Het
Unc13a T A 8: 72,100,561 (GRCm39) T1076S probably benign Het
Vangl2 A G 1: 171,832,414 (GRCm39) Y481H probably damaging Het
Vmn2r105 C T 17: 20,447,973 (GRCm39) E284K probably benign Het
Vmn2r60 A T 7: 41,845,195 (GRCm39) I853F probably benign Het
Yrdc T C 4: 124,748,254 (GRCm39) probably benign Het
Zfp595 A T 13: 67,465,259 (GRCm39) C335S probably damaging Het
Zfp872 A G 9: 22,110,910 (GRCm39) S149G possibly damaging Het
Other mutations in Or5ac15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01807:Or5ac15 APN 16 58,939,936 (GRCm39) missense possibly damaging 0.94
IGL02098:Or5ac15 APN 16 58,940,433 (GRCm39) utr 5 prime probably benign
IGL02276:Or5ac15 APN 16 58,940,378 (GRCm39) missense probably benign 0.01
IGL03122:Or5ac15 APN 16 58,939,801 (GRCm39) missense probably benign 0.00
R0781:Or5ac15 UTSW 16 58,940,187 (GRCm39) missense probably damaging 0.97
R1526:Or5ac15 UTSW 16 58,940,293 (GRCm39) missense probably damaging 1.00
R1654:Or5ac15 UTSW 16 58,940,052 (GRCm39) missense possibly damaging 0.50
R4379:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R4380:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R5768:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5771:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5942:Or5ac15 UTSW 16 58,940,039 (GRCm39) nonsense probably null
R6131:Or5ac15 UTSW 16 58,940,256 (GRCm39) missense probably damaging 1.00
R6539:Or5ac15 UTSW 16 58,940,114 (GRCm39) missense probably damaging 0.99
R6621:Or5ac15 UTSW 16 58,940,287 (GRCm39) missense probably benign 0.19
R7642:Or5ac15 UTSW 16 58,940,011 (GRCm39) missense possibly damaging 0.94
R8308:Or5ac15 UTSW 16 58,939,899 (GRCm39) missense probably damaging 1.00
R8863:Or5ac15 UTSW 16 58,939,712 (GRCm39) nonsense probably null
RF009:Or5ac15 UTSW 16 58,940,274 (GRCm39) missense probably damaging 0.99
Z1177:Or5ac15 UTSW 16 58,939,735 (GRCm39) nonsense probably null
Predicted Primers
Posted On 2014-01-15