Incidental Mutation 'R1211:Gm10608'
| ID |
100693 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gm10608
|
| Ensembl Gene |
ENSMUSG00000074029 |
| Gene Name |
predicted gene 10608 |
| Synonyms |
EG546165 |
| MMRRC Submission |
039280-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.082)
|
| Stock # |
R1211 (G1)
|
| Quality Score |
121 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
118991798-118992473 bp(+) (GRCm39) |
| Type of Mutation |
frame shift |
| DNA Base Change (assembly) |
C to CNNNNNNNN
at 118989780 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091246
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000010795]
[ENSMUST00000093527]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000010795
|
| SMART Domains |
Protein: ENSMUSP00000010795
Gene: ENSMUSG00000010651
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Thiolase_N
|
38 |
291 |
6.7e-90 |
PFAM |
|
Pfam:Thiolase_C
|
298 |
421 |
3e-53 |
PFAM |
|
Pfam:ACP_syn_III_C
|
329 |
420 |
1.8e-7 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000093527
|
| SMART Domains |
Protein: ENSMUSP00000091246
Gene: ENSMUSG00000074029
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3915
|
11 |
80 |
3.1e-10 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000213924
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.2%
- 10x: 95.3%
- 20x: 89.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 15 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgra3 |
T |
C |
5: 50,164,218 (GRCm39) |
M254V |
possibly damaging |
Het |
| Arrdc3 |
A |
G |
13: 81,038,817 (GRCm39) |
T40A |
possibly damaging |
Het |
| Cntnap1 |
C |
A |
11: 101,075,536 (GRCm39) |
Q905K |
probably damaging |
Het |
| Dclk1 |
A |
G |
3: 55,288,244 (GRCm39) |
I256V |
probably benign |
Het |
| Dync1h1 |
G |
A |
12: 110,602,943 (GRCm39) |
E2195K |
probably benign |
Het |
| Erlec1 |
A |
G |
11: 30,898,298 (GRCm39) |
|
probably null |
Het |
| Gm10160 |
A |
T |
7: 81,505,497 (GRCm39) |
Y16N |
probably benign |
Het |
| H2-T13 |
A |
T |
17: 36,391,965 (GRCm39) |
V207D |
probably damaging |
Het |
| Kcna4 |
AGAGGAGGAGGAGGAGGAGG |
AGAGGAGGAGGAGGAGG |
2: 107,125,660 (GRCm39) |
|
probably benign |
Het |
| Mycbp2 |
A |
T |
14: 103,357,999 (GRCm39) |
D4488E |
probably benign |
Het |
| Ndufaf1 |
A |
G |
2: 119,486,156 (GRCm39) |
S319P |
probably damaging |
Het |
| Or5h25 |
A |
C |
16: 58,930,523 (GRCm39) |
V150G |
possibly damaging |
Het |
| Smad4 |
T |
C |
18: 73,782,982 (GRCm39) |
|
probably null |
Het |
| Spaca7 |
T |
C |
8: 12,623,139 (GRCm39) |
S12P |
probably damaging |
Het |
| Stx11 |
A |
G |
10: 12,817,155 (GRCm39) |
S190P |
probably damaging |
Het |
|
| Other mutations in Gm10608 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
3-1:Gm10608
|
UTSW |
9 |
118,990,156 (GRCm39) |
unclassified |
probably benign |
|
|
R1023:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R1053:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1148:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1148:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1167:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1172:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1601:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1743:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R1766:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R1939:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2016:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R2127:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R2217:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2270:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2372:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R2844:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2959:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R2968:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R3084:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R3607:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R3702:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R3779:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R3839:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R3900:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R3947:Gm10608
|
UTSW |
9 |
118,989,730 (GRCm39) |
small deletion |
probably benign |
|
|
R4015:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
frame shift |
probably null |
|
|
R4024:Gm10608
|
UTSW |
9 |
118,989,784 (GRCm39) |
small deletion |
probably benign |
|
|
R5346:Gm10608
|
UTSW |
9 |
118,989,792 (GRCm39) |
frame shift |
probably null |
|
|
R8225:Gm10608
|
UTSW |
9 |
118,989,776 (GRCm39) |
frame shift |
probably null |
|
|
X0065:Gm10608
|
UTSW |
9 |
118,989,931 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACCATAATGTGACAGGTGCCACAAC -3'
(R):5'- CACAGAAAAGATGCCATTGCCTGC -3'
Sequencing Primer
(F):5'- GTGCCACAACAGGGCAG -3'
(R):5'- TCAGATGGCAAAGCTTCCTG -3'
|
| Posted On |
2014-01-15 |
Incidental Mutation