Incidental Mutation 'R1190:Or4d10c'
ID 100761
Institutional Source Beutler Lab
Gene Symbol Or4d10c
Ensembl Gene ENSMUSG00000044994
Gene Name olfactory receptor family 4 subfamily D member 10C
Synonyms Olfr1426, MOR239-1, GA_x6K02T2RE5P-2447610-2446675
MMRRC Submission 039262-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R1190 (G1)
Quality Score 150
Status Not validated
Chromosome 19
Chromosomal Location 12064974-12069211 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 12066051 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 35 (T35K)
Ref Sequence ENSEMBL: ENSMUSP00000151988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112952] [ENSMUST00000208703] [ENSMUST00000217952] [ENSMUST00000219005] [ENSMUST00000219155] [ENSMUST00000219996] [ENSMUST00000220005]
AlphaFold Q8VG74
Predicted Effect possibly damaging
Transcript: ENSMUST00000112952
AA Change: T35K

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000108575
Gene: ENSMUSG00000044994
AA Change: T35K

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 2.1e-49 PFAM
Pfam:7tm_1 39 300 1.1e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208703
AA Change: T35K

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217952
AA Change: T35K

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000219005
AA Change: T35K

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000219155
AA Change: T35K

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000219996
AA Change: T35K

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000220005
AA Change: T35K

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Antxrl T C 14: 33,791,207 (GRCm39) F367L probably benign Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Dnah17 G A 11: 117,933,001 (GRCm39) R3586W probably damaging Het
Dpysl2 A G 14: 67,061,850 (GRCm39) V252A probably benign Het
Dus2 T C 8: 106,771,497 (GRCm39) S208P possibly damaging Het
Elk3 T C 10: 93,101,058 (GRCm39) N231S probably benign Het
Ephx1 A T 1: 180,821,494 (GRCm39) M280K probably benign Het
Fstl4 T C 11: 52,959,373 (GRCm39) M138T probably benign Het
Iqsec1 A T 6: 90,666,659 (GRCm39) Y593N probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lep G T 6: 29,071,173 (GRCm39) E166* probably null Het
Limch1 A G 5: 67,126,540 (GRCm39) D56G probably damaging Het
Pkn2 A T 3: 142,517,286 (GRCm39) probably null Het
Plxna4 A G 6: 32,228,071 (GRCm39) Y512H probably damaging Het
Tekt1 A T 11: 72,246,039 (GRCm39) I161N probably damaging Het
Tex14 T G 11: 87,385,934 (GRCm39) probably null Het
Trpc3 T C 3: 36,725,497 (GRCm39) N160D probably benign Het
Zfp369 T C 13: 65,440,107 (GRCm39) S264P probably damaging Het
Zfp747 G A 7: 126,973,726 (GRCm39) A148V probably damaging Het
Other mutations in Or4d10c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Or4d10c APN 19 12,065,357 (GRCm39) missense probably benign 0.28
IGL01549:Or4d10c APN 19 12,065,329 (GRCm39) missense probably benign 0.20
IGL02479:Or4d10c APN 19 12,065,269 (GRCm39) missense probably benign 0.01
IGL03065:Or4d10c APN 19 12,065,975 (GRCm39) missense possibly damaging 0.91
IGL03092:Or4d10c APN 19 12,065,230 (GRCm39) nonsense probably null
IGL03046:Or4d10c UTSW 19 12,065,391 (GRCm39) missense probably damaging 0.98
R0734:Or4d10c UTSW 19 12,065,483 (GRCm39) missense probably benign 0.12
R1990:Or4d10c UTSW 19 12,065,620 (GRCm39) missense probably damaging 0.98
R2331:Or4d10c UTSW 19 12,065,522 (GRCm39) missense probably benign 0.00
R3500:Or4d10c UTSW 19 12,065,421 (GRCm39) missense possibly damaging 0.58
R3768:Or4d10c UTSW 19 12,065,304 (GRCm39) missense probably damaging 1.00
R3825:Or4d10c UTSW 19 12,065,391 (GRCm39) missense probably damaging 0.98
R4589:Or4d10c UTSW 19 12,065,305 (GRCm39) missense possibly damaging 0.61
R5175:Or4d10c UTSW 19 12,065,926 (GRCm39) missense probably damaging 1.00
R6436:Or4d10c UTSW 19 12,065,299 (GRCm39) missense probably benign 0.24
R6729:Or4d10c UTSW 19 12,065,860 (GRCm39) missense probably benign 0.04
R6965:Or4d10c UTSW 19 12,066,120 (GRCm39) missense possibly damaging 0.95
R7099:Or4d10c UTSW 19 12,065,530 (GRCm39) missense possibly damaging 0.78
R7393:Or4d10c UTSW 19 12,065,992 (GRCm39) missense probably benign 0.13
R7582:Or4d10c UTSW 19 12,065,370 (GRCm39) missense probably benign 0.01
R8000:Or4d10c UTSW 19 12,065,358 (GRCm39) missense probably damaging 0.98
R8803:Or4d10c UTSW 19 12,065,469 (GRCm39) missense probably benign 0.07
R8833:Or4d10c UTSW 19 12,065,643 (GRCm39) missense possibly damaging 0.92
R8846:Or4d10c UTSW 19 12,065,433 (GRCm39) missense probably damaging 0.96
R8951:Or4d10c UTSW 19 12,066,056 (GRCm39) nonsense probably null
R9469:Or4d10c UTSW 19 12,065,434 (GRCm39) missense probably benign 0.20
RF011:Or4d10c UTSW 19 12,065,611 (GRCm39) missense probably benign 0.09
Z1177:Or4d10c UTSW 19 12,065,308 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGATGGTCACATAGTGCAAGGGC -3'
(R):5'- CACCACTTTTGAGCACTTTGGCAG -3'

Sequencing Primer
(F):5'- CATCTGAGTGAGACAGCCATTG -3'
(R):5'- CTTTGGCAGAGCAGAAGAACTC -3'
Posted On 2014-01-15