Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00828:Dcaf6'

10080

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dcaf6

Ensembl Gene

ENSMUSG00000026571

Gene Name

DDB1 and CUL4 associated factor 6

Synonyms

NRIP, Iqwd1, 1200006M05Rik, PC326

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00828

Quality Score

Status

Chromosome

Chromosomal Location

165157069-165288475 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 165165916 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000027856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027856]

AlphaFold

Q9DC22

Predicted Effect

probably benign
Transcript: ENSMUST00000027856

SMART Domains

Protein: ENSMUSP00000027856
Gene: ENSMUSG00000026571

Domain	Start	End	E-Value	Type
WD40	40	79	5.77e-5	SMART
WD40	82	124	1.2e-2	SMART
WD40	130	170	2.15e-1	SMART
WD40	184	220	3.33e-1	SMART
WD40	238	281	6.66e-1	SMART
low complexity region	364	374	N/A	INTRINSIC
low complexity region	499	510	N/A	INTRINSIC
low complexity region	669	676	N/A	INTRINSIC
IQ	691	713	1.25e1	SMART
WD40	722	763	3.84e0	SMART
WD40	766	805	1.22e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193353

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(2) : Gene trapped(2)

Other mutations in this stock

Total: 10 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb3	T	A	1: 25,527,200 (GRCm39)	I372F	possibly damaging	Het
Dph7	A	T	2: 24,861,655 (GRCm39)	Q356L	probably benign	Het
Gpr107	A	T	2: 31,067,795 (GRCm39)		probably null	Het
Kmt2a	T	C	9: 44,732,073 (GRCm39)		probably benign	Het
Pign	A	T	1: 105,481,845 (GRCm39)	Y816N	probably damaging	Het
Slc17a5	G	A	9: 78,485,833 (GRCm39)	A84V	probably benign	Het
Trim6	A	G	7: 103,879,950 (GRCm39)	T230A	probably benign	Het
Usp40	G	A	1: 87,906,028 (GRCm39)		probably benign	Het
Zfp980	A	T	4: 145,428,561 (GRCm39)	H430L	probably benign	Het
Zmpste24	G	A	4: 120,931,717 (GRCm39)	R303C	possibly damaging	Het

Other mutations in Dcaf6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01377:Dcaf6	APN	1	165,216,293 (GRCm39)	missense	probably benign	0.01
IGL02027:Dcaf6	APN	1	165,251,910 (GRCm39)	missense	probably damaging	1.00
IGL02390:Dcaf6	APN	1	165,250,490 (GRCm39)	missense	possibly damaging	0.50
IGL02754:Dcaf6	APN	1	165,165,915 (GRCm39)	critical splice acceptor site	probably null
IGL02900:Dcaf6	APN	1	165,227,344 (GRCm39)	missense	probably damaging	1.00
IGL03119:Dcaf6	APN	1	165,167,545 (GRCm39)	missense	probably damaging	1.00
IGL03211:Dcaf6	APN	1	165,250,502 (GRCm39)	missense	possibly damaging	0.55
R0588:Dcaf6	UTSW	1	165,247,792 (GRCm39)	missense	possibly damaging	0.89
R1494:Dcaf6	UTSW	1	165,160,942 (GRCm39)	missense	probably damaging	0.99
R1512:Dcaf6	UTSW	1	165,179,589 (GRCm39)	missense	probably benign	0.22
R1840:Dcaf6	UTSW	1	165,227,317 (GRCm39)	missense	probably damaging	0.96
R2191:Dcaf6	UTSW	1	165,250,433 (GRCm39)	missense	probably benign	0.07
R2297:Dcaf6	UTSW	1	165,227,431 (GRCm39)	missense	probably damaging	1.00
R3082:Dcaf6	UTSW	1	165,250,421 (GRCm39)	splice site	probably benign
R3861:Dcaf6	UTSW	1	165,256,838 (GRCm39)	missense	probably damaging	1.00
R3907:Dcaf6	UTSW	1	165,251,949 (GRCm39)	nonsense	probably null
R4521:Dcaf6	UTSW	1	165,218,059 (GRCm39)	missense	probably damaging	0.98
R4531:Dcaf6	UTSW	1	165,239,036 (GRCm39)	missense	probably damaging	1.00
R4906:Dcaf6	UTSW	1	165,239,032 (GRCm39)	critical splice donor site	probably null
R4916:Dcaf6	UTSW	1	165,247,774 (GRCm39)	missense	probably damaging	1.00
R4956:Dcaf6	UTSW	1	165,216,354 (GRCm39)	missense	probably benign	0.00
R5080:Dcaf6	UTSW	1	165,247,690 (GRCm39)	missense	probably damaging	1.00
R5091:Dcaf6	UTSW	1	165,157,572 (GRCm39)	missense	possibly damaging	0.76
R5277:Dcaf6	UTSW	1	165,251,915 (GRCm39)	missense	probably benign	0.09
R5512:Dcaf6	UTSW	1	165,227,404 (GRCm39)	missense	possibly damaging	0.84
R5914:Dcaf6	UTSW	1	165,178,724 (GRCm39)	missense	probably benign
R6004:Dcaf6	UTSW	1	165,216,254 (GRCm39)	missense	probably benign	0.00
R6239:Dcaf6	UTSW	1	165,178,839 (GRCm39)	missense	possibly damaging	0.47
R6736:Dcaf6	UTSW	1	165,227,354 (GRCm39)	missense	possibly damaging	0.77
R7051:Dcaf6	UTSW	1	165,251,886 (GRCm39)	missense	possibly damaging	0.82
R7110:Dcaf6	UTSW	1	165,179,537 (GRCm39)	missense	probably benign	0.22
R7583:Dcaf6	UTSW	1	165,160,879 (GRCm39)	missense	probably damaging	1.00
R7776:Dcaf6	UTSW	1	165,179,623 (GRCm39)	nonsense	probably null
R7790:Dcaf6	UTSW	1	165,227,284 (GRCm39)	missense	probably damaging	1.00
R8369:Dcaf6	UTSW	1	165,185,043 (GRCm39)	missense	probably damaging	1.00
R8411:Dcaf6	UTSW	1	165,216,244 (GRCm39)	missense	probably benign	0.03
R9061:Dcaf6	UTSW	1	165,164,332 (GRCm39)	missense	probably damaging	0.99
R9307:Dcaf6	UTSW	1	165,227,236 (GRCm39)	missense	possibly damaging	0.90
R9375:Dcaf6	UTSW	1	165,185,052 (GRCm39)	missense	probably damaging	1.00
R9626:Dcaf6	UTSW	1	165,227,264 (GRCm39)	nonsense	probably null

Posted On

2012-12-06