Incidental Mutation 'R1196:Or7e168'
ID 101125
Institutional Source Beutler Lab
Gene Symbol Or7e168
Ensembl Gene ENSMUSG00000095448
Gene Name olfactory receptor family 7 subfamily E member 168
Synonyms Olfr859, GA_x6K02T2PVTD-13548326-13549255, MOR146-3, MOR146-10_p
MMRRC Submission 039268-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # R1196 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 19719616-19720545 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19719928 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 105 (I105V)
Ref Sequence ENSEMBL: ENSMUSP00000151076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086480] [ENSMUST00000212540] [ENSMUST00000217280]
AlphaFold Q7TRF5
Predicted Effect probably benign
Transcript: ENSMUST00000086480
AA Change: I105V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000083669
Gene: ENSMUSG00000095448
AA Change: I105V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2e-7 PFAM
Pfam:7tm_1 41 290 3.9e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212540
AA Change: I105V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000217280
AA Change: I105V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.3%
  • 10x: 94.9%
  • 20x: 86.8%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb T C 5: 114,383,153 (GRCm39) I2112T probably benign Het
Agtpbp1 C A 13: 59,598,132 (GRCm39) probably benign Het
Ash1l T C 3: 88,890,623 (GRCm39) M834T probably damaging Het
Aspg A G 12: 112,082,958 (GRCm39) T213A possibly damaging Het
Chpf2 T C 5: 24,794,646 (GRCm39) V272A possibly damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Ddah2 G T 17: 35,280,503 (GRCm39) D215Y probably damaging Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Fbrsl1 T A 5: 110,522,385 (GRCm39) M150L probably benign Het
Hmces T A 6: 87,913,164 (GRCm39) D306E probably benign Het
Itga2 C T 13: 115,002,691 (GRCm39) probably null Het
Jmjd1c T C 10: 67,075,015 (GRCm39) probably benign Het
Krr1 T A 10: 111,811,562 (GRCm39) H85Q probably benign Het
Krt87 C T 15: 101,389,314 (GRCm39) R6Q probably benign Het
Krtap24-1 T C 16: 88,408,530 (GRCm39) M199V probably benign Het
Krtap5-2 A T 7: 141,728,620 (GRCm39) C353* probably null Het
Myo7a T G 7: 97,746,880 (GRCm39) I178L possibly damaging Het
Myof G A 19: 37,899,408 (GRCm39) T1043I probably damaging Het
Noc4l C T 5: 110,798,450 (GRCm39) E247K probably damaging Het
Notch4 T C 17: 34,787,837 (GRCm39) C437R probably damaging Het
Nrbp1 T A 5: 31,403,157 (GRCm39) I210N probably damaging Het
Or4p19 A T 2: 88,242,890 (GRCm39) N37K probably damaging Het
Pank4 T C 4: 155,062,630 (GRCm39) F584L probably damaging Het
Prl2c2 G C 13: 13,176,786 (GRCm39) T47R probably damaging Het
Ranbp2 T A 10: 58,312,875 (GRCm39) F1198L probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Tent5c T C 3: 100,380,316 (GRCm39) T147A possibly damaging Het
Ttc28 G A 5: 111,373,543 (GRCm39) S962N probably damaging Het
Unc13a A G 8: 72,107,630 (GRCm39) I554T probably damaging Het
Zfc3h1 A G 10: 115,247,866 (GRCm39) D1023G probably damaging Het
Zfp791 T A 8: 85,837,583 (GRCm39) K94* probably null Het
Other mutations in Or7e168
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Or7e168 APN 9 19,719,692 (GRCm39) missense probably benign 0.09
IGL00897:Or7e168 APN 9 19,719,917 (GRCm39) missense probably damaging 0.97
IGL01132:Or7e168 APN 9 19,719,950 (GRCm39) missense probably damaging 0.97
IGL01768:Or7e168 APN 9 19,720,456 (GRCm39) missense possibly damaging 0.57
IGL02302:Or7e168 APN 9 19,719,981 (GRCm39) missense probably damaging 0.97
IGL02377:Or7e168 APN 9 19,720,343 (GRCm39) missense probably damaging 0.99
IGL02972:Or7e168 APN 9 19,720,238 (GRCm39) missense probably damaging 0.97
R0139:Or7e168 UTSW 9 19,720,165 (GRCm39) missense probably damaging 0.99
R0367:Or7e168 UTSW 9 19,719,839 (GRCm39) missense probably damaging 0.99
R0521:Or7e168 UTSW 9 19,720,156 (GRCm39) missense probably benign 0.00
R3742:Or7e168 UTSW 9 19,720,195 (GRCm39) missense probably benign 0.44
R5567:Or7e168 UTSW 9 19,719,674 (GRCm39) missense probably damaging 0.99
R6499:Or7e168 UTSW 9 19,719,847 (GRCm39) missense probably benign
R6501:Or7e168 UTSW 9 19,720,271 (GRCm39) missense possibly damaging 0.95
R6560:Or7e168 UTSW 9 19,720,412 (GRCm39) missense probably benign
R7291:Or7e168 UTSW 9 19,719,944 (GRCm39) missense possibly damaging 0.71
R7623:Or7e168 UTSW 9 19,720,225 (GRCm39) missense possibly damaging 0.93
R7627:Or7e168 UTSW 9 19,719,947 (GRCm39) missense probably damaging 0.99
R8680:Or7e168 UTSW 9 19,720,105 (GRCm39) missense possibly damaging 0.84
R8716:Or7e168 UTSW 9 19,720,165 (GRCm39) missense probably damaging 0.99
R8841:Or7e168 UTSW 9 19,719,885 (GRCm39) missense probably benign 0.02
R9360:Or7e168 UTSW 9 19,720,529 (GRCm39) missense possibly damaging 0.82
Z1177:Or7e168 UTSW 9 19,719,830 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGGACTCTCAGAGGACCCTGAAC -3'
(R):5'- TATTCCTGAGGCAGGGAGGAAACC -3'

Sequencing Primer
(F):5'- GGAAATGTTCTCATCATCTTGGC -3'
(R):5'- TTGTGACACCATAAAGCAGTGC -3'
Posted On 2014-01-15