Incidental Mutation 'R1167:Itgal'
| ID |
101136 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Itgal
|
| Ensembl Gene |
ENSMUSG00000030830 |
| Gene Name |
integrin alpha L |
| Synonyms |
Ly-21, Ly-15, Cd11a, LFA-1 |
| MMRRC Submission |
039240-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.143)
|
| Stock # |
R1167 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
126895432-126934310 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 126900111 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Asparagine
at position 123
(S123N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131847
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106306]
[ENSMUST00000117762]
[ENSMUST00000120857]
[ENSMUST00000170971]
|
| AlphaFold |
P24063 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106306
AA Change: S123N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101913
Gene: ENSMUSG00000030830
AA Change: S123N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1043 |
1059 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1087 |
1109 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1110 |
1124 |
5.8e-7 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117762
AA Change: S123N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113946
Gene: ENSMUSG00000030830
AA Change: S123N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1109 |
1123 |
5.8e-7 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120857
AA Change: S123N
PolyPhen 2
Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000113396
Gene: ENSMUSG00000030830
AA Change: S123N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170971
AA Change: S123N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000131847
Gene: ENSMUSG00000030830
AA Change: S123N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Int_alpha
|
38 |
81 |
5.01e0 |
SMART |
|
VWA
|
151 |
327 |
2.68e-32 |
SMART |
|
Int_alpha
|
398 |
450 |
1.27e-6 |
SMART |
|
Int_alpha
|
454 |
509 |
9.6e-7 |
SMART |
|
Int_alpha
|
515 |
568 |
3.58e-15 |
SMART |
|
Int_alpha
|
575 |
624 |
1.28e1 |
SMART |
|
low complexity region
|
1042 |
1058 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1086 |
1108 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1109 |
1123 |
1.2e-6 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205695
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mutations of this gene lead to increased leukocyte cell number, alter T cell activation, leukocyte migration and adhesion, spleen and lymph node morphology, and may affect humoral immune responses, metastatic potential, and susceptibility to endotoxin shock. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
A |
T |
7: 40,643,003 (GRCm39) |
D315V |
probably damaging |
Het |
| Acr |
T |
C |
15: 89,458,177 (GRCm39) |
I286T |
probably damaging |
Het |
| Adnp |
A |
G |
2: 168,026,420 (GRCm39) |
S292P |
probably benign |
Het |
| Apol6 |
T |
A |
15: 76,931,308 (GRCm39) |
Y17* |
probably null |
Het |
| Arhgap22 |
A |
G |
14: 33,065,264 (GRCm39) |
|
probably null |
Het |
| Bfar |
A |
G |
16: 13,516,758 (GRCm39) |
K202E |
possibly damaging |
Het |
| Bmpr2 |
A |
T |
1: 59,898,463 (GRCm39) |
S470C |
probably damaging |
Het |
| Cep135 |
A |
G |
5: 76,772,484 (GRCm39) |
E623G |
probably damaging |
Het |
| Clcn3 |
A |
G |
8: 61,375,822 (GRCm39) |
|
probably null |
Het |
| Clptm1 |
A |
T |
7: 19,368,136 (GRCm39) |
M523K |
probably damaging |
Het |
| Cyp26b1 |
A |
G |
6: 84,561,312 (GRCm39) |
W117R |
probably damaging |
Het |
| Dnmt3c |
T |
G |
2: 153,553,701 (GRCm39) |
|
probably null |
Het |
| Dst |
A |
G |
1: 34,262,939 (GRCm39) |
E2212G |
probably damaging |
Het |
| Edrf1 |
A |
G |
7: 133,245,795 (GRCm39) |
T238A |
probably benign |
Het |
| Elmo1 |
T |
C |
13: 20,369,625 (GRCm39) |
V10A |
probably damaging |
Het |
| Ermp1 |
A |
G |
19: 29,606,079 (GRCm39) |
S225P |
possibly damaging |
Het |
| Fem1al |
C |
T |
11: 29,773,567 (GRCm39) |
R630H |
probably damaging |
Het |
| Fes |
A |
T |
7: 80,032,857 (GRCm39) |
L296Q |
probably damaging |
Het |
| Foxn1 |
A |
T |
11: 78,249,892 (GRCm39) |
N544K |
probably damaging |
Het |
| Gga1 |
C |
G |
15: 78,772,370 (GRCm39) |
N223K |
probably damaging |
Het |
| Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably null |
Het |
| Gm4884 |
A |
T |
7: 40,693,336 (GRCm39) |
Q435L |
possibly damaging |
Het |
| Gm8444 |
T |
C |
15: 81,727,581 (GRCm39) |
|
probably benign |
Het |
| Ift140 |
T |
G |
17: 25,254,719 (GRCm39) |
S131A |
probably benign |
Het |
| Ipo4 |
A |
G |
14: 55,872,477 (GRCm39) |
L88P |
probably damaging |
Het |
| Kcnn3 |
C |
T |
3: 89,472,259 (GRCm39) |
Q344* |
probably null |
Het |
| Lrrc8e |
A |
T |
8: 4,285,337 (GRCm39) |
M521L |
probably benign |
Het |
| Myocd |
G |
T |
11: 65,087,203 (GRCm39) |
D113E |
possibly damaging |
Het |
| Nek4 |
G |
A |
14: 30,696,302 (GRCm39) |
R499H |
possibly damaging |
Het |
| Notch3 |
T |
C |
17: 32,341,719 (GRCm39) |
D2011G |
possibly damaging |
Het |
| Ola1 |
A |
G |
2: 72,927,538 (GRCm39) |
V347A |
probably damaging |
Het |
| Or13p5 |
C |
A |
4: 118,591,829 (GRCm39) |
F34L |
possibly damaging |
Het |
| Or6c75 |
G |
A |
10: 129,337,019 (GRCm39) |
V89I |
probably benign |
Het |
| Or8u10 |
A |
G |
2: 85,915,635 (GRCm39) |
V162A |
probably benign |
Het |
| Oxct2b |
A |
G |
4: 123,011,378 (GRCm39) |
T433A |
probably damaging |
Het |
| P2ry14 |
T |
C |
3: 59,022,552 (GRCm39) |
R312G |
probably damaging |
Het |
| Pbrm1 |
A |
G |
14: 30,772,099 (GRCm39) |
N398D |
probably damaging |
Het |
| Pdc |
T |
C |
1: 150,208,996 (GRCm39) |
Y160H |
probably damaging |
Het |
| Pdlim2 |
C |
T |
14: 70,402,228 (GRCm39) |
R296H |
probably damaging |
Het |
| Pop4 |
A |
T |
7: 37,962,693 (GRCm39) |
D190E |
probably benign |
Het |
| Prb1c |
G |
A |
6: 132,338,553 (GRCm39) |
P222S |
unknown |
Het |
| R3hdm4 |
A |
G |
10: 79,747,907 (GRCm39) |
|
probably null |
Het |
| Rab1a |
C |
A |
11: 20,173,172 (GRCm39) |
T91K |
possibly damaging |
Het |
| Rad9a |
A |
G |
19: 4,247,501 (GRCm39) |
V215A |
possibly damaging |
Het |
| Rassf3 |
A |
G |
10: 121,252,159 (GRCm39) |
V84A |
probably damaging |
Het |
| Rftn2 |
G |
A |
1: 55,243,458 (GRCm39) |
T270M |
probably damaging |
Het |
| Rho |
A |
G |
6: 115,912,384 (GRCm39) |
T100A |
probably damaging |
Het |
| Rnft2 |
T |
C |
5: 118,366,947 (GRCm39) |
I264V |
possibly damaging |
Het |
| Robo3 |
A |
T |
9: 37,335,203 (GRCm39) |
Y567* |
probably null |
Het |
| Rpp14 |
T |
A |
14: 8,083,705 (GRCm38) |
|
probably null |
Het |
| Rtkn2 |
T |
C |
10: 67,833,450 (GRCm39) |
S98P |
probably damaging |
Het |
| Ryr2 |
A |
G |
13: 11,674,999 (GRCm39) |
V3376A |
possibly damaging |
Het |
| Sbf2 |
A |
T |
7: 109,963,756 (GRCm39) |
W1030R |
probably damaging |
Het |
| Setbp1 |
G |
A |
18: 78,900,451 (GRCm39) |
A1072V |
possibly damaging |
Het |
| Slc4a10 |
A |
G |
2: 62,058,918 (GRCm39) |
K142E |
probably damaging |
Het |
| Slc52a2 |
A |
G |
15: 76,423,791 (GRCm39) |
E40G |
probably benign |
Het |
| Slc8a2 |
A |
G |
7: 15,891,312 (GRCm39) |
N784S |
possibly damaging |
Het |
| Spats2l |
A |
T |
1: 57,982,270 (GRCm39) |
Q384L |
probably damaging |
Het |
| Steap4 |
A |
C |
5: 8,026,520 (GRCm39) |
K161T |
probably benign |
Het |
| Taf10 |
T |
C |
7: 105,392,438 (GRCm39) |
S188G |
probably benign |
Het |
| Tbc1d4 |
C |
T |
14: 101,845,455 (GRCm39) |
D148N |
probably damaging |
Het |
| Tenm2 |
T |
G |
11: 36,755,511 (GRCm39) |
K162N |
probably benign |
Het |
| Tmem147 |
A |
G |
7: 30,427,221 (GRCm39) |
V146A |
probably benign |
Het |
| Tnfsf8 |
A |
G |
4: 63,755,323 (GRCm39) |
S100P |
possibly damaging |
Het |
| Trim56 |
T |
C |
5: 137,141,374 (GRCm39) |
Y714C |
probably damaging |
Het |
| Ubxn8 |
A |
G |
8: 34,131,929 (GRCm39) |
S13P |
probably damaging |
Het |
| Usp49 |
A |
G |
17: 47,983,151 (GRCm39) |
D52G |
possibly damaging |
Het |
| Vegfc |
A |
C |
8: 54,639,078 (GRCm39) |
Y408S |
probably benign |
Het |
| Vmn2r77 |
A |
G |
7: 86,450,954 (GRCm39) |
N280S |
probably benign |
Het |
| Vmn2r8 |
T |
A |
5: 108,951,042 (GRCm39) |
L134F |
probably benign |
Het |
| Wdfy3 |
T |
A |
5: 102,023,797 (GRCm39) |
I2437F |
probably benign |
Het |
| Wwc2 |
A |
T |
8: 48,311,814 (GRCm39) |
L783* |
probably null |
Het |
| Zer1 |
C |
T |
2: 29,998,258 (GRCm39) |
R351H |
probably benign |
Het |
| Zfp715 |
A |
T |
7: 42,947,861 (GRCm39) |
F700I |
possibly damaging |
Het |
| Zfp995 |
G |
A |
17: 22,098,960 (GRCm39) |
H425Y |
probably damaging |
Het |
|
| Other mutations in Itgal |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00987:Itgal
|
APN |
7 |
126,901,183 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01300:Itgal
|
APN |
7 |
126,913,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01345:Itgal
|
APN |
7 |
126,900,128 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL01826:Itgal
|
APN |
7 |
126,901,318 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02202:Itgal
|
APN |
7 |
126,929,351 (GRCm39) |
nonsense |
probably null |
|
|
IGL02212:Itgal
|
APN |
7 |
126,900,152 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02513:Itgal
|
APN |
7 |
126,927,844 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02608:Itgal
|
APN |
7 |
126,909,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02946:Itgal
|
APN |
7 |
126,913,540 (GRCm39) |
missense |
probably damaging |
0.99 |
|
sunglow
|
UTSW |
7 |
126,927,919 (GRCm39) |
missense |
probably null |
0.89 |
|
R0069:Itgal
|
UTSW |
7 |
126,909,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0069:Itgal
|
UTSW |
7 |
126,909,503 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0107:Itgal
|
UTSW |
7 |
126,927,731 (GRCm39) |
splice site |
probably benign |
|
|
R0331:Itgal
|
UTSW |
7 |
126,905,853 (GRCm39) |
splice site |
probably null |
|
|
R0350:Itgal
|
UTSW |
7 |
126,921,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Itgal
|
UTSW |
7 |
126,909,923 (GRCm39) |
nonsense |
probably null |
|
|
R0537:Itgal
|
UTSW |
7 |
126,910,445 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0546:Itgal
|
UTSW |
7 |
126,909,486 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0594:Itgal
|
UTSW |
7 |
126,913,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1377:Itgal
|
UTSW |
7 |
126,921,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1575:Itgal
|
UTSW |
7 |
126,900,060 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1690:Itgal
|
UTSW |
7 |
126,901,289 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1693:Itgal
|
UTSW |
7 |
126,904,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Itgal
|
UTSW |
7 |
126,904,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1720:Itgal
|
UTSW |
7 |
126,906,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1774:Itgal
|
UTSW |
7 |
126,908,794 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1824:Itgal
|
UTSW |
7 |
126,913,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1878:Itgal
|
UTSW |
7 |
126,909,843 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1951:Itgal
|
UTSW |
7 |
126,929,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2265:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2267:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2269:Itgal
|
UTSW |
7 |
126,905,873 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2276:Itgal
|
UTSW |
7 |
126,927,919 (GRCm39) |
missense |
probably null |
0.89 |
|
R2570:Itgal
|
UTSW |
7 |
126,913,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3925:Itgal
|
UTSW |
7 |
126,923,709 (GRCm39) |
splice site |
probably benign |
|
|
R4225:Itgal
|
UTSW |
7 |
126,904,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4377:Itgal
|
UTSW |
7 |
126,927,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4466:Itgal
|
UTSW |
7 |
126,927,684 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4579:Itgal
|
UTSW |
7 |
126,904,466 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4656:Itgal
|
UTSW |
7 |
126,921,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Itgal
|
UTSW |
7 |
126,927,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5012:Itgal
|
UTSW |
7 |
126,898,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5328:Itgal
|
UTSW |
7 |
126,910,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5365:Itgal
|
UTSW |
7 |
126,904,522 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5579:Itgal
|
UTSW |
7 |
126,906,101 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5849:Itgal
|
UTSW |
7 |
126,916,492 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5955:Itgal
|
UTSW |
7 |
126,904,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6254:Itgal
|
UTSW |
7 |
126,924,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6269:Itgal
|
UTSW |
7 |
126,929,389 (GRCm39) |
missense |
probably null |
1.00 |
|
R6520:Itgal
|
UTSW |
7 |
126,929,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6541:Itgal
|
UTSW |
7 |
126,910,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7049:Itgal
|
UTSW |
7 |
126,895,573 (GRCm39) |
unclassified |
probably benign |
|
|
R7168:Itgal
|
UTSW |
7 |
126,929,385 (GRCm39) |
missense |
probably benign |
|
|
R7419:Itgal
|
UTSW |
7 |
126,906,047 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7424:Itgal
|
UTSW |
7 |
126,916,537 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Itgal
|
UTSW |
7 |
126,926,936 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7567:Itgal
|
UTSW |
7 |
126,898,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7696:Itgal
|
UTSW |
7 |
126,929,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Itgal
|
UTSW |
7 |
126,927,470 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7987:Itgal
|
UTSW |
7 |
126,927,470 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8118:Itgal
|
UTSW |
7 |
126,910,417 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8297:Itgal
|
UTSW |
7 |
126,929,638 (GRCm39) |
missense |
unknown |
|
|
R8418:Itgal
|
UTSW |
7 |
126,929,454 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8477:Itgal
|
UTSW |
7 |
126,900,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Itgal
|
UTSW |
7 |
126,928,607 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8789:Itgal
|
UTSW |
7 |
126,904,421 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8838:Itgal
|
UTSW |
7 |
126,910,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Itgal
|
UTSW |
7 |
126,929,541 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8923:Itgal
|
UTSW |
7 |
126,895,533 (GRCm39) |
unclassified |
probably benign |
|
|
R9070:Itgal
|
UTSW |
7 |
126,927,873 (GRCm39) |
missense |
probably null |
0.98 |
|
R9104:Itgal
|
UTSW |
7 |
126,910,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9173:Itgal
|
UTSW |
7 |
126,896,789 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9179:Itgal
|
UTSW |
7 |
126,905,883 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9407:Itgal
|
UTSW |
7 |
126,921,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9545:Itgal
|
UTSW |
7 |
126,929,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9681:Itgal
|
UTSW |
7 |
126,929,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2014-01-15 |
Incidental Mutation