Incidental Mutation 'IGL00727:Dennd5b'
ID 10122
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dennd5b
Ensembl Gene ENSMUSG00000030313
Gene Name DENN/MADD domain containing 5B
Synonyms 9330160C06Rik, D030011O10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # IGL00727
Quality Score
Status
Chromosome 6
Chromosomal Location 148988071-149101680 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) G to T at 149006716 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107182 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111557]
AlphaFold A2RSQ0
Predicted Effect probably benign
Transcript: ENSMUST00000111557
SMART Domains Protein: ENSMUSP00000107182
Gene: ENSMUSG00000030313

DomainStartEndE-ValueType
uDENN 18 120 9.96e-39 SMART
low complexity region 145 161 N/A INTRINSIC
DENN 187 375 2.97e-78 SMART
dDENN 498 574 5.92e-23 SMART
RUN 866 929 2.13e-22 SMART
Pfam:PLAT 938 1043 1.7e-12 PFAM
low complexity region 1070 1081 N/A INTRINSIC
RUN 1205 1265 8.42e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117470
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 11 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T A 13: 81,524,684 Y1470F probably damaging Het
Fmnl3 G A 15: 99,322,670 T577I probably damaging Het
Klra17 A G 6: 129,831,509 Y254H probably benign Het
Kprp A T 3: 92,824,427 S439T unknown Het
Lrrc40 T C 3: 158,063,871 probably null Het
Mb21d1 G A 9: 78,435,488 P344L probably damaging Het
Nlrp4c A G 7: 6,066,702 E534G possibly damaging Het
Nsd3 T C 8: 25,641,158 S180P probably damaging Het
Phc2 T G 4: 128,745,844 V640G probably damaging Het
Ppp1r12a G A 10: 108,230,473 R175Q probably damaging Het
Prkd1 C T 12: 50,364,661 R768H probably damaging Het
Other mutations in Dennd5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00518:Dennd5b APN 6 149027330 missense probably damaging 1.00
IGL00590:Dennd5b APN 6 149068308 missense probably benign 0.03
IGL00838:Dennd5b APN 6 149005363 splice site probably benign
IGL01115:Dennd5b APN 6 149009748 splice site probably benign
IGL01150:Dennd5b APN 6 149068085 missense probably benign 0.01
IGL01873:Dennd5b APN 6 149044529 missense probably benign
IGL01991:Dennd5b APN 6 149080824 missense probably damaging 1.00
IGL02226:Dennd5b APN 6 149033301 missense probably benign 0.00
IGL02820:Dennd5b APN 6 149019342 missense probably null 0.51
IGL03056:Dennd5b APN 6 149055072 missense probably damaging 1.00
IGL03085:Dennd5b APN 6 149027395 missense probably damaging 1.00
IGL03329:Dennd5b APN 6 148998260 missense possibly damaging 0.53
R0081:Dennd5b UTSW 6 148993759 missense probably benign 0.13
R0617:Dennd5b UTSW 6 149033262 splice site probably benign
R1241:Dennd5b UTSW 6 149068490 missense probably benign 0.06
R1252:Dennd5b UTSW 6 149044487 missense probably damaging 1.00
R1255:Dennd5b UTSW 6 149041650 missense possibly damaging 0.48
R1641:Dennd5b UTSW 6 149068205 missense probably damaging 1.00
R1674:Dennd5b UTSW 6 148998284 missense probably damaging 1.00
R1781:Dennd5b UTSW 6 149027398 missense probably damaging 1.00
R1861:Dennd5b UTSW 6 149068262 missense probably damaging 1.00
R1907:Dennd5b UTSW 6 149041576 missense probably benign 0.00
R2412:Dennd5b UTSW 6 149005238 missense possibly damaging 0.88
R3794:Dennd5b UTSW 6 149101217 missense possibly damaging 0.87
R3825:Dennd5b UTSW 6 149044836 missense probably benign
R4581:Dennd5b UTSW 6 149016984 splice site silent
R4654:Dennd5b UTSW 6 149006837 missense probably damaging 1.00
R4725:Dennd5b UTSW 6 149044779 missense probably damaging 0.97
R4981:Dennd5b UTSW 6 149009772 missense possibly damaging 0.88
R4994:Dennd5b UTSW 6 149041500 splice site probably null
R5400:Dennd5b UTSW 6 149000016 missense probably damaging 1.00
R5452:Dennd5b UTSW 6 149041513 splice site probably null
R5548:Dennd5b UTSW 6 149019349 splice site probably null
R5841:Dennd5b UTSW 6 149044755 missense probably benign 0.11
R5996:Dennd5b UTSW 6 149068095 missense probably benign 0.22
R6082:Dennd5b UTSW 6 149068695 missense probably damaging 0.99
R6556:Dennd5b UTSW 6 149014251 splice site probably null
R6812:Dennd5b UTSW 6 149081132 start gained probably benign
R6828:Dennd5b UTSW 6 148993746 missense probably damaging 0.99
R7104:Dennd5b UTSW 6 149044604 missense probably damaging 1.00
R7231:Dennd5b UTSW 6 149044604 missense probably damaging 1.00
R7325:Dennd5b UTSW 6 149020570 missense probably benign 0.00
R7399:Dennd5b UTSW 6 149036483 missense probably damaging 1.00
R7516:Dennd5b UTSW 6 149068380 missense probably benign 0.02
R7751:Dennd5b UTSW 6 149017106 missense probably benign 0.01
R7763:Dennd5b UTSW 6 149068658 missense probably damaging 1.00
R7770:Dennd5b UTSW 6 149041716 missense probably damaging 0.99
R7788:Dennd5b UTSW 6 149068566 missense probably benign 0.00
R7854:Dennd5b UTSW 6 149068466 missense probably benign 0.00
R7899:Dennd5b UTSW 6 149041661 missense probably damaging 1.00
R8226:Dennd5b UTSW 6 149014248 splice site probably null
R8328:Dennd5b UTSW 6 149020617 missense probably damaging 1.00
R8489:Dennd5b UTSW 6 149084891 missense probably benign 0.00
R8517:Dennd5b UTSW 6 149029121 missense probably damaging 1.00
R8556:Dennd5b UTSW 6 148993770 missense probably damaging 1.00
R8693:Dennd5b UTSW 6 149009774 nonsense probably null
R8946:Dennd5b UTSW 6 149041987 intron probably benign
R8966:Dennd5b UTSW 6 148999976 missense probably damaging 1.00
R9122:Dennd5b UTSW 6 149006742 missense
R9178:Dennd5b UTSW 6 149033346 nonsense probably null
R9208:Dennd5b UTSW 6 149101200 missense probably benign 0.09
R9465:Dennd5b UTSW 6 149006762 missense probably damaging 1.00
R9535:Dennd5b UTSW 6 148993867 missense probably benign 0.03
R9541:Dennd5b UTSW 6 148998374 missense probably benign 0.00
R9731:Dennd5b UTSW 6 149068640 missense probably damaging 1.00
R9760:Dennd5b UTSW 6 149068499 missense probably benign 0.14
R9783:Dennd5b UTSW 6 149009844 missense probably damaging 1.00
Posted On 2012-12-06