Incidental Mutation 'IGL00091:Zfp58'
ID1013
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp58
Ensembl Gene ENSMUSG00000071291
Gene Namezinc finger protein 58
SynonymsZfp817, Mfg-1, A530094I17Rik, Mfg1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.142) question?
Stock #IGL00091
Quality Score
Status
Chromosome13
Chromosomal Location67490167-67500555 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 67490995 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 459 (V459A)
Ref Sequence ENSEMBL: ENSMUSP00000132285 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076123] [ENSMUST00000091523] [ENSMUST00000163534] [ENSMUST00000167914] [ENSMUST00000171518]
Predicted Effect probably benign
Transcript: ENSMUST00000076123
AA Change: V459A

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000075487
Gene: ENSMUSG00000071291
AA Change: V459A

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
ZnF_C2H2 162 184 5.67e-5 SMART
ZnF_C2H2 190 212 3.21e-4 SMART
ZnF_C2H2 218 240 2.57e-3 SMART
ZnF_C2H2 246 268 2.91e-2 SMART
ZnF_C2H2 274 296 9.73e-4 SMART
ZnF_C2H2 302 324 6.23e-2 SMART
ZnF_C2H2 330 352 1.03e-2 SMART
ZnF_C2H2 358 380 1.45e-2 SMART
ZnF_C2H2 386 408 2.99e-4 SMART
ZnF_C2H2 410 432 4.87e-4 SMART
ZnF_C2H2 438 460 2.75e-3 SMART
ZnF_C2H2 466 488 1.58e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091523
SMART Domains Protein: ENSMUSP00000089108
Gene: ENSMUSG00000071291

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
ZnF_C2H2 162 184 5.67e-5 SMART
ZnF_C2H2 190 212 3.21e-4 SMART
ZnF_C2H2 218 240 2.57e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163534
SMART Domains Protein: ENSMUSP00000129177
Gene: ENSMUSG00000071291

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167914
SMART Domains Protein: ENSMUSP00000137830
Gene: ENSMUSG00000097565

DomainStartEndE-ValueType
KRAB 5 65 4.41e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171518
AA Change: V459A

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000132285
Gene: ENSMUSG00000071291
AA Change: V459A

DomainStartEndE-ValueType
KRAB 2 62 2.19e-29 SMART
ZnF_C2H2 106 128 4.01e-5 SMART
ZnF_C2H2 134 156 9.73e-4 SMART
ZnF_C2H2 162 184 5.67e-5 SMART
ZnF_C2H2 190 212 3.21e-4 SMART
ZnF_C2H2 218 240 2.57e-3 SMART
ZnF_C2H2 246 268 2.91e-2 SMART
ZnF_C2H2 274 296 9.73e-4 SMART
ZnF_C2H2 302 324 6.23e-2 SMART
ZnF_C2H2 330 352 1.03e-2 SMART
ZnF_C2H2 358 380 1.45e-2 SMART
ZnF_C2H2 386 408 2.99e-4 SMART
ZnF_C2H2 410 432 4.87e-4 SMART
ZnF_C2H2 438 460 2.75e-3 SMART
ZnF_C2H2 466 488 1.58e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas2 A T 7: 132,883,428 Y400F probably benign Het
Adamts8 C A 9: 30,953,500 T429K probably damaging Het
Adgrv1 C T 13: 81,578,101 D602N probably damaging Het
Ano7 A T 1: 93,402,166 H775L probably benign Het
Apoo-ps A T 13: 107,414,634 noncoding transcript Het
Arid2 T C 15: 96,372,302 V1432A probably benign Het
Atoh1 T C 6: 64,729,584 S88P possibly damaging Het
C130050O18Rik A G 5: 139,414,846 E218G probably damaging Het
Cacna2d1 T A 5: 16,212,944 F155L probably damaging Het
Car4 C T 11: 84,965,767 P294S probably damaging Het
Cyp1a2 G T 9: 57,682,069 S154* probably null Het
Cyp3a25 A T 5: 146,001,463 Y68* probably null Het
Dmbt1 C A 7: 131,079,540 probably benign Het
Dnajc22 T A 15: 99,101,178 F81L possibly damaging Het
Eml5 G A 12: 98,873,209 probably benign Het
Fpgs A T 2: 32,686,547 probably benign Het
Gab2 T C 7: 97,302,443 S537P possibly damaging Het
Gmds G A 13: 32,234,390 S37L probably damaging Het
Ipo13 T C 4: 117,903,405 E626G probably benign Het
Kcng1 T C 2: 168,268,764 H160R probably benign Het
Lama3 A G 18: 12,580,292 T1608A probably benign Het
Lama4 A C 10: 39,072,805 S855R probably damaging Het
Ltbp1 C T 17: 75,225,338 H454Y probably damaging Het
Map3k14 C A 11: 103,227,579 G594C probably damaging Het
Mcph1 A G 8: 18,632,620 N591S possibly damaging Het
Moxd1 G A 10: 24,279,864 V289I probably damaging Het
Mptx2 T G 1: 173,274,888 N78T probably damaging Het
Muc4 G A 16: 32,754,086 G1321R probably benign Het
Muc6 A C 7: 141,638,584 S2059A probably benign Het
Nup50 T A 15: 84,935,404 F293Y probably benign Het
Ogn A G 13: 49,621,038 Y219C probably damaging Het
Pdia3 T C 2: 121,414,178 L47P probably damaging Het
Piwil4 A T 9: 14,703,097 D786E probably damaging Het
Pspc1 A G 14: 56,771,711 L222P probably damaging Het
Ptchd3 T A 11: 121,831,146 Y282N probably damaging Het
Reln C A 5: 22,039,565 G805V possibly damaging Het
Serpini2 T C 3: 75,249,242 Y327C probably damaging Het
Spire2 A G 8: 123,354,059 D14G probably damaging Het
Stab2 A T 10: 86,869,206 probably null Het
Timeless T C 10: 128,241,708 L219P probably damaging Het
Tmem63a C T 1: 180,963,088 T437M probably damaging Het
Tslp A G 18: 32,815,395 probably benign Het
Ttbk2 C A 2: 120,748,833 G534* probably null Het
Uggt1 T C 1: 36,179,552 probably benign Het
Vmn2r118 T C 17: 55,592,708 E732G probably damaging Het
Zfhx2 G A 14: 55,066,565 P1321S possibly damaging Het
Zfp831 T C 2: 174,645,658 S709P possibly damaging Het
Other mutations in Zfp58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02618:Zfp58 APN 13 67491356 missense possibly damaging 0.92
IGL03188:Zfp58 APN 13 67491409 missense probably benign 0.03
R0535:Zfp58 UTSW 13 67492082 nonsense probably null
R1470:Zfp58 UTSW 13 67492025 missense possibly damaging 0.71
R1470:Zfp58 UTSW 13 67492025 missense possibly damaging 0.71
R1750:Zfp58 UTSW 13 67491479 nonsense probably null
R1862:Zfp58 UTSW 13 67491188 missense probably damaging 1.00
R2697:Zfp58 UTSW 13 67491005 missense probably damaging 1.00
R3031:Zfp58 UTSW 13 67492112 missense probably benign 0.06
R3033:Zfp58 UTSW 13 67491622 missense probably damaging 1.00
R4200:Zfp58 UTSW 13 67491321 missense probably benign 0.25
R5827:Zfp58 UTSW 13 67491293 missense probably damaging 0.99
R6723:Zfp58 UTSW 13 67494073 missense probably damaging 1.00
R7230:Zfp58 UTSW 13 67491963 nonsense probably null
R7890:Zfp58 UTSW 13 67491995 missense possibly damaging 0.95
Posted On2011-07-12