Incidental Mutation 'R1168:Kif21a'
| ID |
101388 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
039241-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1168 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
90933276-91049948 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 90993753 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 284
(T284I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000067205
AA Change: T284I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: T284I
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000088614
AA Change: T284I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: T284I
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100304
AA Change: T284I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: T284I
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109287
AA Change: T284I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: T284I
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109288
AA Change: T284I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: T284I
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.1%
- 10x: 95.2%
- 20x: 88.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
T |
C |
3: 138,067,900 (GRCm38) |
V950A |
probably benign |
Het |
| Adgrb3 |
A |
T |
1: 25,826,199 (GRCm38) |
S188T |
probably benign |
Het |
| Ahr |
A |
T |
12: 35,504,532 (GRCm38) |
N529K |
possibly damaging |
Het |
| Akr1c21 |
A |
G |
13: 4,583,837 (GRCm38) |
N302D |
probably benign |
Het |
| Aldh8a1 |
T |
A |
10: 21,384,631 (GRCm38) |
|
probably null |
Het |
| Alpk3 |
A |
T |
7: 81,103,357 (GRCm38) |
K1554M |
probably damaging |
Het |
| Arhgef5 |
T |
A |
6: 43,273,396 (GRCm38) |
H360Q |
probably benign |
Het |
| Cacna1a |
A |
G |
8: 84,579,501 (GRCm38) |
I1293V |
probably damaging |
Het |
| Cacna2d4 |
C |
T |
6: 119,307,286 (GRCm38) |
R745W |
probably damaging |
Het |
| Cd200r4 |
T |
A |
16: 44,832,944 (GRCm38) |
W72R |
probably damaging |
Het |
| Ces2e |
A |
T |
8: 104,927,014 (GRCm38) |
D28V |
possibly damaging |
Het |
| Cfap20dc |
T |
C |
14: 8,442,939 (GRCm38) |
N610S |
probably benign |
Het |
| Cfap45 |
T |
C |
1: 172,545,697 (GRCm38) |
Y534H |
probably damaging |
Het |
| Cfap54 |
A |
T |
10: 92,937,920 (GRCm38) |
C87S |
probably damaging |
Het |
| Chmp7 |
C |
T |
14: 69,719,450 (GRCm38) |
M336I |
probably benign |
Het |
| Chrna4 |
T |
A |
2: 181,034,138 (GRCm38) |
M67L |
possibly damaging |
Het |
| Cts7 |
T |
A |
13: 61,353,817 (GRCm38) |
N290Y |
probably damaging |
Het |
| Enpp6 |
A |
T |
8: 47,030,454 (GRCm38) |
M94L |
probably damaging |
Het |
| Fam83d |
C |
T |
2: 158,768,523 (GRCm38) |
A137V |
probably benign |
Het |
| Foxd2 |
C |
T |
4: 114,907,678 (GRCm38) |
A382T |
possibly damaging |
Het |
| Galnt11 |
T |
G |
5: 25,250,246 (GRCm38) |
S193R |
probably damaging |
Het |
| Gapvd1 |
A |
T |
2: 34,704,469 (GRCm38) |
D856E |
probably damaging |
Het |
| Gclm |
T |
A |
3: 122,262,688 (GRCm38) |
H86Q |
possibly damaging |
Het |
| Gipc2 |
T |
C |
3: 152,107,997 (GRCm38) |
T220A |
probably benign |
Het |
| Gm12185 |
G |
T |
11: 48,915,355 (GRCm38) |
N336K |
possibly damaging |
Het |
| Gm5431 |
A |
T |
11: 48,895,364 (GRCm38) |
S61R |
probably benign |
Het |
| Gorasp2 |
C |
T |
2: 70,688,400 (GRCm38) |
P260S |
probably damaging |
Het |
| H2-M10.6 |
A |
G |
17: 36,813,160 (GRCm38) |
Q172R |
probably benign |
Het |
| Ibsp |
A |
G |
5: 104,302,152 (GRCm38) |
I6V |
probably damaging |
Het |
| Iqsec1 |
T |
C |
6: 90,689,676 (GRCm38) |
Y593C |
probably damaging |
Het |
| Irag1 |
T |
C |
7: 110,895,931 (GRCm38) |
K429R |
probably damaging |
Het |
| Itln1 |
G |
T |
1: 171,531,551 (GRCm38) |
Y61* |
probably null |
Het |
| Kif3a |
G |
A |
11: 53,598,312 (GRCm38) |
G621R |
probably damaging |
Het |
| Klb |
A |
G |
5: 65,378,974 (GRCm38) |
Y549C |
probably damaging |
Het |
| Lman1l |
G |
A |
9: 57,608,312 (GRCm38) |
R427C |
probably benign |
Het |
| Lrrc37 |
T |
C |
11: 103,618,950 (GRCm38) |
|
probably benign |
Het |
| Map4 |
T |
C |
9: 110,034,964 (GRCm38) |
V419A |
probably benign |
Het |
| Mastl |
A |
T |
2: 23,133,132 (GRCm38) |
D526E |
probably benign |
Het |
| Mtif2 |
A |
G |
11: 29,536,914 (GRCm38) |
D308G |
probably benign |
Het |
| Ncald |
A |
G |
15: 37,397,334 (GRCm38) |
F34S |
probably damaging |
Het |
| Ndc1 |
A |
G |
4: 107,395,812 (GRCm38) |
T593A |
probably benign |
Het |
| Ndst3 |
C |
T |
3: 123,606,968 (GRCm38) |
V15I |
probably benign |
Het |
| Nup214 |
A |
G |
2: 32,025,301 (GRCm38) |
N1166D |
probably benign |
Het |
| Or1a1 |
A |
G |
11: 74,196,421 (GRCm38) |
H306R |
probably benign |
Het |
| Or2ad1 |
A |
G |
13: 21,142,617 (GRCm38) |
S147P |
probably benign |
Het |
| Or4a68 |
G |
A |
2: 89,439,869 (GRCm38) |
Q137* |
probably null |
Het |
| Or5m8 |
A |
T |
2: 85,992,684 (GRCm38) |
Y289F |
probably damaging |
Het |
| Pcdhb8 |
T |
C |
18: 37,356,727 (GRCm38) |
I486T |
probably benign |
Het |
| Pdzrn4 |
A |
T |
15: 92,770,271 (GRCm38) |
Y768F |
probably benign |
Het |
| Pgf |
A |
G |
12: 85,171,767 (GRCm38) |
S70P |
probably benign |
Het |
| Plcl2 |
G |
A |
17: 50,607,072 (GRCm38) |
A370T |
possibly damaging |
Het |
| Pnkp |
T |
A |
7: 44,862,537 (GRCm38) |
W115R |
probably benign |
Het |
| Ppp1r16a |
C |
T |
15: 76,693,669 (GRCm38) |
Q328* |
probably null |
Het |
| Prag1 |
A |
G |
8: 36,146,645 (GRCm38) |
E1117G |
probably damaging |
Het |
| Prr12 |
T |
A |
7: 45,029,047 (GRCm38) |
Q1919L |
unknown |
Het |
| Ret |
G |
T |
6: 118,173,558 (GRCm38) |
H666N |
possibly damaging |
Het |
| Rfwd3 |
C |
T |
8: 111,288,242 (GRCm38) |
R326Q |
probably damaging |
Het |
| Robo2 |
C |
T |
16: 73,948,296 (GRCm38) |
G864S |
probably damaging |
Het |
| Rpa2 |
T |
G |
4: 132,771,860 (GRCm38) |
I80S |
probably damaging |
Het |
| Ryk |
A |
T |
9: 102,898,475 (GRCm38) |
D428V |
probably damaging |
Het |
| Slc29a1 |
A |
T |
17: 45,590,278 (GRCm38) |
N30K |
probably damaging |
Het |
| Stbd1 |
A |
G |
5: 92,604,936 (GRCm38) |
N95S |
probably benign |
Het |
| Tbc1d22a |
A |
G |
15: 86,292,134 (GRCm38) |
E212G |
probably benign |
Het |
| Tex14 |
A |
G |
11: 87,536,742 (GRCm38) |
T7A |
probably benign |
Het |
| Tmc8 |
T |
C |
11: 117,792,563 (GRCm38) |
V648A |
possibly damaging |
Het |
| Tmem132b |
G |
T |
5: 125,787,019 (GRCm38) |
V730F |
probably damaging |
Het |
| Tmub2 |
G |
A |
11: 102,287,370 (GRCm38) |
G33D |
possibly damaging |
Het |
| Trak1 |
G |
A |
9: 121,440,679 (GRCm38) |
D124N |
probably damaging |
Het |
| Ttc28 |
A |
T |
5: 111,231,111 (GRCm38) |
Y1154F |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,909,369 (GRCm38) |
T3609A |
probably benign |
Het |
| Tulp2 |
A |
G |
7: 45,517,842 (GRCm38) |
T99A |
probably benign |
Het |
| Ugt2a2 |
A |
T |
5: 87,465,568 (GRCm38) |
|
probably null |
Het |
| Ush2a |
G |
A |
1: 188,678,411 (GRCm38) |
V2419I |
probably benign |
Het |
| Vill |
C |
A |
9: 119,070,321 (GRCm38) |
P343Q |
probably damaging |
Het |
| Vmn2r66 |
T |
A |
7: 85,006,854 (GRCm38) |
H318L |
possibly damaging |
Het |
| Wdr3 |
A |
C |
3: 100,142,219 (GRCm38) |
N800K |
probably benign |
Het |
| Wdr93 |
A |
G |
7: 79,749,174 (GRCm38) |
K19E |
probably damaging |
Het |
| Wrn |
A |
G |
8: 33,316,408 (GRCm38) |
S333P |
probably damaging |
Het |
| Zfp418 |
T |
C |
7: 7,182,501 (GRCm38) |
S488P |
possibly damaging |
Het |
| Zfp804a |
A |
G |
2: 82,256,697 (GRCm38) |
E290G |
probably benign |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,937,301 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,943,864 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,995,637 (GRCm38) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,959,745 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,956,430 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,991,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,965,535 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,985,286 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,985,395 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,997,963 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,956,376 (GRCm38) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,968,358 (GRCm38) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,970,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,970,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,976,521 (GRCm38) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,969,774 (GRCm38) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,968,054 (GRCm38) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,959,683 (GRCm38) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,997,541 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,940,581 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,935,650 (GRCm38) |
missense |
probably benign |
0.17 |
|
R1324:Kif21a
|
UTSW |
15 |
90,948,322 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,956,419 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,942,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,984,805 (GRCm38) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,994,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,994,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,959,743 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,949,047 (GRCm38) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,972,727 (GRCm38) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,971,766 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,970,848 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,970,848 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,970,848 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,994,371 (GRCm38) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,985,362 (GRCm38) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,985,362 (GRCm38) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,985,362 (GRCm38) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,971,196 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,998,005 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,994,391 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,934,464 (GRCm38) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,972,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,965,595 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,968,074 (GRCm38) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,937,294 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,985,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,970,833 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,971,142 (GRCm38) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,968,089 (GRCm38) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,968,223 (GRCm38) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,940,545 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,940,545 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,956,305 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,984,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,937,190 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,949,010 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,968,358 (GRCm38) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,956,376 (GRCm38) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,993,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,968,113 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,951,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,935,647 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,935,812 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,980,892 (GRCm38) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,966,407 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,940,446 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,935,730 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,980,837 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,948,903 (GRCm38) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,980,883 (GRCm38) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,967,229 (GRCm38) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,993,796 (GRCm38) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,943,861 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,980,919 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,956,314 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,968,442 (GRCm38) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,935,761 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,971,196 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,959,124 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,968,179 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,971,727 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,956,356 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,937,196 (GRCm38) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,969,827 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,959,748 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,969,827 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,969,778 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,956,473 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,995,512 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,985,325 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,971,127 (GRCm38) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
|
| Posted On |
2014-01-15 |
Incidental Mutation