Incidental Mutation 'R1181:Trim66'
ID 101580
Institutional Source Beutler Lab
Gene Symbol Trim66
Ensembl Gene ENSMUSG00000031026
Gene Name tripartite motif-containing 66
Synonyms Tif1d, D7H11orf29
MMRRC Submission 039253-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # R1181 (G1)
Quality Score 151
Status Validated
Chromosome 7
Chromosomal Location 109449006-109508134 bp(-) (GRCm38)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 109484577 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000102352 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033339] [ENSMUST00000106739] [ENSMUST00000106741]
AlphaFold Q924W6
Predicted Effect probably null
Transcript: ENSMUST00000033339
SMART Domains Protein: ENSMUSP00000033339
Gene: ENSMUSG00000031026

DomainStartEndE-ValueType
PHD 4 69 7.77e0 SMART
BBC 108 234 1.61e-39 SMART
low complexity region 318 333 N/A INTRINSIC
low complexity region 452 486 N/A INTRINSIC
low complexity region 517 530 N/A INTRINSIC
low complexity region 568 581 N/A INTRINSIC
PHD 998 1041 4.09e-10 SMART
BROMO 1069 1175 8.22e-27 SMART
low complexity region 1185 1199 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106739
SMART Domains Protein: ENSMUSP00000102350
Gene: ENSMUSG00000031026

DomainStartEndE-ValueType
PHD 4 69 7.77e0 SMART
BBC 108 234 1.61e-39 SMART
low complexity region 318 333 N/A INTRINSIC
low complexity region 452 486 N/A INTRINSIC
low complexity region 517 530 N/A INTRINSIC
low complexity region 568 581 N/A INTRINSIC
PHD 998 1041 4.09e-10 SMART
BROMO 1069 1175 8.22e-27 SMART
low complexity region 1185 1199 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106741
SMART Domains Protein: ENSMUSP00000102352
Gene: ENSMUSG00000031026

DomainStartEndE-ValueType
RING 28 78 2.38e-2 SMART
BBOX 102 140 1.48e0 SMART
PHD 106 171 7.77e0 SMART
RING 107 170 4.38e0 SMART
BBOX 162 203 4.21e-3 SMART
BBC 210 336 1.61e-39 SMART
low complexity region 420 435 N/A INTRINSIC
low complexity region 554 588 N/A INTRINSIC
low complexity region 619 632 N/A INTRINSIC
low complexity region 670 683 N/A INTRINSIC
PHD 1100 1143 4.09e-10 SMART
BROMO 1171 1277 8.22e-27 SMART
low complexity region 1287 1301 N/A INTRINSIC
Meta Mutation Damage Score 0.9492 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 97.9%
  • 10x: 93.9%
  • 20x: 84.2%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn3 T A 19: 4,872,610 (GRCm38) Q64L probably benign Het
Ankrd12 T C 17: 66,042,574 (GRCm38) N88S probably benign Het
Apcdd1 A T 18: 62,937,097 (GRCm38) Y145F probably damaging Het
Bnipl C A 3: 95,245,649 (GRCm38) probably null Het
Bod1 T C 11: 31,666,943 (GRCm38) probably benign Het
Cbarp G T 10: 80,135,494 (GRCm38) H166N probably damaging Het
Cdr2l T A 11: 115,394,179 (GRCm38) I447N probably damaging Het
Cped1 T G 6: 22,215,562 (GRCm38) I698M probably damaging Het
Ecm1 G A 3: 95,735,350 (GRCm38) H404Y possibly damaging Het
Ehbp1 C T 11: 22,062,831 (GRCm38) V902I probably benign Het
Eps8 T C 6: 137,522,854 (GRCm38) Q209R possibly damaging Het
Fastk C T 5: 24,441,731 (GRCm38) probably null Het
Gm6797 T A X: 8,641,765 (GRCm38) noncoding transcript Het
Gp1ba C T 11: 70,641,427 (GRCm38) P673L probably damaging Het
Gstm1 A G 3: 108,014,811 (GRCm38) F170S probably damaging Het
Hgf G C 5: 16,618,925 (GRCm38) G707R probably damaging Het
Klhl5 T C 5: 65,162,885 (GRCm38) M594T probably damaging Het
Kyat3 A C 3: 142,737,770 (GRCm38) probably null Het
Mettl14 C T 3: 123,374,002 (GRCm38) G236S probably damaging Het
Nob1 G A 8: 107,421,490 (GRCm38) P107S probably damaging Het
Nupl1 A T 14: 60,244,670 (GRCm38) probably benign Het
Olfr1155 G A 2: 87,943,146 (GRCm38) L161F probably benign Het
Olfr1463 C A 19: 13,234,831 (GRCm38) H194N probably benign Het
Olfr444 T A 6: 42,955,558 (GRCm38) L20Q probably benign Het
Olfr503 C A 7: 108,545,302 (GRCm38) T257N probably benign Het
Olfr676 T A 7: 105,035,814 (GRCm38) N205K probably damaging Het
Olfr808 A G 10: 129,768,164 (GRCm38) I223V probably benign Het
Pald1 A G 10: 61,347,587 (GRCm38) probably benign Het
Pds5a A T 5: 65,627,202 (GRCm38) probably null Het
Pirb A T 7: 3,717,638 (GRCm38) L287Q probably benign Het
Plekha2 A C 8: 25,059,202 (GRCm38) S189A probably benign Het
Prune2 T C 19: 17,123,105 (GRCm38) V1991A probably benign Het
Sec61g A C 11: 16,504,722 (GRCm38) probably benign Het
Serinc3 T C 2: 163,625,526 (GRCm38) K445R probably damaging Het
Shf G A 2: 122,368,682 (GRCm38) P51S probably damaging Het
Slfn8 T C 11: 83,016,745 (GRCm38) E324G probably benign Het
Spink13 A G 18: 62,608,170 (GRCm38) probably benign Het
Tas2r121 A T 6: 132,700,169 (GRCm38) I280N probably damaging Het
Tbc1d7 T C 13: 43,153,139 (GRCm38) I242M probably damaging Het
Tenm2 C T 11: 36,063,177 (GRCm38) G1236R possibly damaging Het
Tnni3k A T 3: 154,875,513 (GRCm38) H600Q probably damaging Het
Ttn A T 2: 76,969,703 (GRCm38) I387N probably damaging Het
Tulp3 A T 6: 128,325,952 (GRCm38) H301Q possibly damaging Het
Ubqln5 T A 7: 104,128,741 (GRCm38) Q292L probably damaging Het
Zfp454 T C 11: 50,873,586 (GRCm38) K229E probably damaging Het
Other mutations in Trim66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01539:Trim66 APN 7 109,455,066 (GRCm38) missense probably benign 0.02
IGL01758:Trim66 APN 7 109,486,045 (GRCm38) critical splice donor site probably null
IGL01982:Trim66 APN 7 109,458,763 (GRCm38) missense probably benign 0.00
IGL01983:Trim66 APN 7 109,458,251 (GRCm38) nonsense probably null
IGL02149:Trim66 APN 7 109,460,902 (GRCm38) missense possibly damaging 0.66
IGL02392:Trim66 APN 7 109,460,274 (GRCm38) missense probably benign 0.01
IGL02483:Trim66 APN 7 109,477,630 (GRCm38) splice site probably benign
IGL02832:Trim66 APN 7 109,460,497 (GRCm38) missense probably damaging 1.00
IGL02945:Trim66 APN 7 109,460,176 (GRCm38) nonsense probably null
IGL03085:Trim66 APN 7 109,458,745 (GRCm38) missense probably benign 0.17
PIT1430001:Trim66 UTSW 7 109,475,247 (GRCm38) missense probably damaging 0.99
R0326:Trim66 UTSW 7 109,460,172 (GRCm38) missense probably benign 0.00
R0358:Trim66 UTSW 7 109,460,176 (GRCm38) nonsense probably null
R0401:Trim66 UTSW 7 109,475,264 (GRCm38) missense probably damaging 0.98
R0470:Trim66 UTSW 7 109,457,542 (GRCm38) splice site probably benign
R0568:Trim66 UTSW 7 109,460,695 (GRCm38) missense probably benign 0.00
R0669:Trim66 UTSW 7 109,454,992 (GRCm38) intron probably benign
R0980:Trim66 UTSW 7 109,455,670 (GRCm38) missense probably damaging 1.00
R1015:Trim66 UTSW 7 109,455,233 (GRCm38) missense probably damaging 1.00
R1078:Trim66 UTSW 7 109,472,319 (GRCm38) missense probably damaging 1.00
R1099:Trim66 UTSW 7 109,475,454 (GRCm38) missense probably benign 0.34
R1497:Trim66 UTSW 7 109,484,619 (GRCm38) missense probably benign 0.00
R1583:Trim66 UTSW 7 109,455,080 (GRCm38) missense probably damaging 1.00
R1843:Trim66 UTSW 7 109,475,839 (GRCm38) missense probably damaging 0.99
R1998:Trim66 UTSW 7 109,484,577 (GRCm38) critical splice donor site probably null
R2016:Trim66 UTSW 7 109,472,232 (GRCm38) critical splice donor site probably null
R2143:Trim66 UTSW 7 109,475,113 (GRCm38) missense probably damaging 0.98
R2144:Trim66 UTSW 7 109,475,113 (GRCm38) missense probably damaging 0.98
R2145:Trim66 UTSW 7 109,475,113 (GRCm38) missense probably damaging 0.98
R3945:Trim66 UTSW 7 109,472,268 (GRCm38) missense possibly damaging 0.94
R4012:Trim66 UTSW 7 109,458,131 (GRCm38) missense probably damaging 0.98
R4464:Trim66 UTSW 7 109,477,690 (GRCm38) missense possibly damaging 0.51
R4473:Trim66 UTSW 7 109,481,995 (GRCm38) missense probably damaging 1.00
R4729:Trim66 UTSW 7 109,456,060 (GRCm38) critical splice donor site probably null
R4730:Trim66 UTSW 7 109,483,069 (GRCm38) missense probably damaging 1.00
R4775:Trim66 UTSW 7 109,457,589 (GRCm38) nonsense probably null
R4819:Trim66 UTSW 7 109,457,586 (GRCm38) missense probably damaging 1.00
R5269:Trim66 UTSW 7 109,457,590 (GRCm38) missense probably benign 0.00
R5557:Trim66 UTSW 7 109,483,737 (GRCm38) missense probably benign 0.06
R5832:Trim66 UTSW 7 109,455,202 (GRCm38) missense probably damaging 1.00
R6220:Trim66 UTSW 7 109,483,093 (GRCm38) missense probably damaging 0.97
R6243:Trim66 UTSW 7 109,460,274 (GRCm38) missense probably benign 0.01
R6374:Trim66 UTSW 7 109,486,062 (GRCm38) missense probably benign
R6450:Trim66 UTSW 7 109,460,738 (GRCm38) missense probably benign 0.09
R6543:Trim66 UTSW 7 109,475,879 (GRCm38) missense probably benign 0.01
R6788:Trim66 UTSW 7 109,477,754 (GRCm38) missense probably damaging 1.00
R6842:Trim66 UTSW 7 109,460,776 (GRCm38) missense probably benign 0.00
R7169:Trim66 UTSW 7 109,455,121 (GRCm38) missense probably benign 0.25
R7257:Trim66 UTSW 7 109,460,244 (GRCm38) missense probably damaging 1.00
R7328:Trim66 UTSW 7 109,457,751 (GRCm38) missense probably damaging 0.99
R7616:Trim66 UTSW 7 109,483,749 (GRCm38) missense probably damaging 0.99
R8423:Trim66 UTSW 7 109,475,392 (GRCm38) missense possibly damaging 0.77
R8855:Trim66 UTSW 7 109,481,981 (GRCm38) missense probably damaging 1.00
R9130:Trim66 UTSW 7 109,477,689 (GRCm38) missense possibly damaging 0.90
R9137:Trim66 UTSW 7 109,475,123 (GRCm38) missense probably damaging 0.99
R9640:Trim66 UTSW 7 109,475,618 (GRCm38) missense probably damaging 1.00
RF013:Trim66 UTSW 7 109,460,753 (GRCm38) missense probably damaging 0.99
RF024:Trim66 UTSW 7 109,460,740 (GRCm38) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- GGCCTAGCTTCTGTGATTCAAGACC -3'
(R):5'- TGCTGCATACAGATGCAAGCCC -3'

Sequencing Primer
(F):5'- TCTGTGATTCAAGACCACACTC -3'
(R):5'- GTCACAGGTCACCAATTTTGGAC -3'
Posted On 2014-01-15