Incidental Mutation 'R1181:Sec61g'
ID 101590
Institutional Source Beutler Lab
Gene Symbol Sec61g
Ensembl Gene ENSMUSG00000078974
Gene Name SEC61 translocon subunit gamma
Synonyms
MMRRC Submission 039253-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1181 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 16451638-16458484 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to C at 16454722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137362 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109641] [ENSMUST00000109642] [ENSMUST00000109643] [ENSMUST00000166950] [ENSMUST00000178855]
AlphaFold P60060
Predicted Effect probably benign
Transcript: ENSMUST00000109641
SMART Domains Protein: ENSMUSP00000105269
Gene: ENSMUSG00000078974

DomainStartEndE-ValueType
Pfam:SecE 10 66 3.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109642
SMART Domains Protein: ENSMUSP00000105270
Gene: ENSMUSG00000078974

DomainStartEndE-ValueType
Pfam:SecE 10 66 3.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109643
SMART Domains Protein: ENSMUSP00000105271
Gene: ENSMUSG00000078974

DomainStartEndE-ValueType
Pfam:SecE 10 66 3.1e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131439
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138695
Predicted Effect probably benign
Transcript: ENSMUST00000166950
SMART Domains Protein: ENSMUSP00000132348
Gene: ENSMUSG00000078974

DomainStartEndE-ValueType
Pfam:SecE 44 97 5.4e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178855
SMART Domains Protein: ENSMUSP00000137362
Gene: ENSMUSG00000078974

DomainStartEndE-ValueType
Pfam:SecE 10 66 3.1e-19 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 97.9%
  • 10x: 93.9%
  • 20x: 84.2%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn3 T A 19: 4,922,638 (GRCm39) Q64L probably benign Het
Ankrd12 T C 17: 66,349,569 (GRCm39) N88S probably benign Het
Apcdd1 A T 18: 63,070,168 (GRCm39) Y145F probably damaging Het
Bnipl C A 3: 95,152,960 (GRCm39) probably null Het
Bod1 T C 11: 31,616,943 (GRCm39) probably benign Het
Cbarp G T 10: 79,971,328 (GRCm39) H166N probably damaging Het
Cdr2l T A 11: 115,285,005 (GRCm39) I447N probably damaging Het
Cped1 T G 6: 22,215,561 (GRCm39) I698M probably damaging Het
Ecm1 G A 3: 95,642,662 (GRCm39) H404Y possibly damaging Het
Ehbp1 C T 11: 22,012,831 (GRCm39) V902I probably benign Het
Eps8 T C 6: 137,499,852 (GRCm39) Q209R possibly damaging Het
Fastk C T 5: 24,646,729 (GRCm39) probably null Het
Gm6797 T A X: 8,508,004 (GRCm39) noncoding transcript Het
Gp1ba C T 11: 70,532,253 (GRCm39) P673L probably damaging Het
Gstm1 A G 3: 107,922,127 (GRCm39) F170S probably damaging Het
Hgf G C 5: 16,823,923 (GRCm39) G707R probably damaging Het
Klhl5 T C 5: 65,320,228 (GRCm39) M594T probably damaging Het
Kyat3 A C 3: 142,443,531 (GRCm39) probably null Het
Mettl14 C T 3: 123,167,651 (GRCm39) G236S probably damaging Het
Nob1 G A 8: 108,148,122 (GRCm39) P107S probably damaging Het
Nup58 A T 14: 60,482,119 (GRCm39) probably benign Het
Or2a56 T A 6: 42,932,492 (GRCm39) L20Q probably benign Het
Or52e7 T A 7: 104,685,021 (GRCm39) N205K probably damaging Het
Or52n4b C A 7: 108,144,509 (GRCm39) T257N probably benign Het
Or5b109 C A 19: 13,212,195 (GRCm39) H194N probably benign Het
Or5d16 G A 2: 87,773,490 (GRCm39) L161F probably benign Het
Or6c65 A G 10: 129,604,033 (GRCm39) I223V probably benign Het
Pald1 A G 10: 61,183,366 (GRCm39) probably benign Het
Pds5a A T 5: 65,784,545 (GRCm39) probably null Het
Pirb A T 7: 3,720,637 (GRCm39) L287Q probably benign Het
Plekha2 A C 8: 25,549,218 (GRCm39) S189A probably benign Het
Prune2 T C 19: 17,100,469 (GRCm39) V1991A probably benign Het
Serinc3 T C 2: 163,467,446 (GRCm39) K445R probably damaging Het
Shf G A 2: 122,199,163 (GRCm39) P51S probably damaging Het
Slfn8 T C 11: 82,907,571 (GRCm39) E324G probably benign Het
Spink13 A G 18: 62,741,241 (GRCm39) probably benign Het
Tas2r121 A T 6: 132,677,132 (GRCm39) I280N probably damaging Het
Tbc1d7 T C 13: 43,306,615 (GRCm39) I242M probably damaging Het
Tenm2 C T 11: 35,954,004 (GRCm39) G1236R possibly damaging Het
Tnni3k A T 3: 154,581,150 (GRCm39) H600Q probably damaging Het
Trim66 C T 7: 109,083,784 (GRCm39) probably null Het
Ttn A T 2: 76,800,047 (GRCm39) I387N probably damaging Het
Tulp3 A T 6: 128,302,915 (GRCm39) H301Q possibly damaging Het
Ubqln5 T A 7: 103,777,948 (GRCm39) Q292L probably damaging Het
Zfp454 T C 11: 50,764,413 (GRCm39) K229E probably damaging Het
Other mutations in Sec61g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Sec61g APN 11 16,451,817 (GRCm39) splice site probably benign
R1178:Sec61g UTSW 11 16,454,722 (GRCm39) splice site probably benign
R1180:Sec61g UTSW 11 16,454,722 (GRCm39) splice site probably benign
R1858:Sec61g UTSW 11 16,456,371 (GRCm39) critical splice donor site probably null
R1859:Sec61g UTSW 11 16,456,371 (GRCm39) critical splice donor site probably null
R1994:Sec61g UTSW 11 16,456,444 (GRCm39) missense probably damaging 0.97
R2066:Sec61g UTSW 11 16,458,124 (GRCm39) missense probably benign 0.02
R4596:Sec61g UTSW 11 16,458,127 (GRCm39) missense probably benign 0.26
R9048:Sec61g UTSW 11 16,458,129 (GRCm39) missense probably benign 0.25
Predicted Primers PCR Primer
(F):5'- AAGCACGGGCTCTCTACACCTTAC -3'
(R):5'- GCGAACCACTACTTCGGTTGACTTC -3'

Sequencing Primer
(F):5'- CATGAGTCTGCTCTGTCACTGAG -3'
(R):5'- tttttctttttgtgtttttGTCACTG -3'
Posted On 2014-01-15