Incidental Mutation 'R1154:Gpr6'
ID101638
Institutional Source Beutler Lab
Gene Symbol Gpr6
Ensembl Gene ENSMUSG00000046922
Gene NameG protein-coupled receptor 6
Synonyms
MMRRC Submission 039227-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R1154 (G1)
Quality Score225
Status Not validated
Chromosome10
Chromosomal Location41069977-41072285 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 41070837 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Glycine at position 250 (C250G)
Ref Sequence ENSEMBL: ENSMUSP00000057323 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061796]
Predicted Effect probably damaging
Transcript: ENSMUST00000061796
AA Change: C250G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000057323
Gene: ENSMUSG00000046922
AA Change: C250G

DomainStartEndE-ValueType
low complexity region 13 30 N/A INTRINSIC
low complexity region 37 59 N/A INTRINSIC
Pfam:7tm_1 90 330 2.5e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213704
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 2 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik C T 17: 35,568,776 P337L probably damaging Het
Aif1 G A 17: 35,172,151 P44L probably benign Het
Other mutations in Gpr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Gpr6 APN 10 41070816 missense probably damaging 0.99
IGL01010:Gpr6 APN 10 41071151 missense probably benign
IGL01098:Gpr6 APN 10 41070743 missense probably damaging 1.00
IGL01323:Gpr6 APN 10 41071559 missense possibly damaging 0.96
R1153:Gpr6 UTSW 10 41070837 missense probably damaging 1.00
R1622:Gpr6 UTSW 10 41071292 missense probably damaging 1.00
R1628:Gpr6 UTSW 10 41071548 missense possibly damaging 0.96
R1638:Gpr6 UTSW 10 41070534 missense probably benign 0.02
R1935:Gpr6 UTSW 10 41071481 missense probably benign 0.02
R1936:Gpr6 UTSW 10 41071481 missense probably benign 0.02
R2108:Gpr6 UTSW 10 41070653 missense possibly damaging 0.79
R2129:Gpr6 UTSW 10 41071172 missense possibly damaging 0.50
R4024:Gpr6 UTSW 10 41071268 missense probably damaging 1.00
R4237:Gpr6 UTSW 10 41070608 missense probably damaging 1.00
R4418:Gpr6 UTSW 10 41070608 missense probably damaging 1.00
R4703:Gpr6 UTSW 10 41071041 missense probably damaging 1.00
R4814:Gpr6 UTSW 10 41071262 missense possibly damaging 0.94
R6821:Gpr6 UTSW 10 41071008 missense probably benign 0.04
R7190:Gpr6 UTSW 10 41070960 missense probably damaging 1.00
R7573:Gpr6 UTSW 10 41070872 missense probably damaging 0.99
R7574:Gpr6 UTSW 10 41070656 missense possibly damaging 0.47
R7611:Gpr6 UTSW 10 41070879 missense probably benign 0.02
R8011:Gpr6 UTSW 10 41070915 missense not run
Predicted Primers
Posted On2014-01-15