Incidental Mutation 'R1155:Or51a8'
ID 101659
Institutional Source Beutler Lab
Gene Symbol Or51a8
Ensembl Gene ENSMUSG00000073964
Gene Name olfactory receptor family 51 subfamily A member 8
Synonyms Olfr570, MOR8-3, GA_x6K02T2PBJ9-5611412-5612350
MMRRC Submission 039228-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R1155 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 102549549-102550593 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 102549819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 82 (M82L)
Ref Sequence ENSEMBL: ENSMUSP00000148181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098215] [ENSMUST00000209778] [ENSMUST00000214160] [ENSMUST00000215773]
AlphaFold Q8VH12
Predicted Effect probably benign
Transcript: ENSMUST00000098215
AA Change: M82L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000095817
Gene: ENSMUSG00000073964
AA Change: M82L

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 6.9e-113 PFAM
Pfam:7TM_GPCR_Srsx 36 174 7.5e-11 PFAM
Pfam:7tm_1 42 292 2.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209778
AA Change: M82L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000214160
Predicted Effect probably benign
Transcript: ENSMUST00000215773
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700093K21Rik T C 11: 23,467,270 (GRCm39) E121G possibly damaging Het
Abtb3 A T 10: 85,465,155 (GRCm39) H665L probably damaging Het
Adgrg1 G A 8: 95,733,468 (GRCm39) V307I possibly damaging Het
Cilp A G 9: 65,176,869 (GRCm39) T42A probably benign Het
Col6a3 T A 1: 90,722,047 (GRCm39) K1493M probably null Het
Col6a6 A G 9: 105,659,289 (GRCm39) V552A possibly damaging Het
Cradd T C 10: 95,158,586 (GRCm39) T54A probably benign Het
Elfn2 A G 15: 78,557,344 (GRCm39) I401T probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Hoxc6 A G 15: 102,919,279 (GRCm39) I172V probably damaging Het
Knl1 T C 2: 118,901,635 (GRCm39) L1112P possibly damaging Het
Lipo4 T A 19: 33,480,595 (GRCm39) I258F probably benign Het
Morf4l1 A G 9: 89,976,557 (GRCm39) V257A probably benign Het
Rnpepl1 T A 1: 92,844,609 (GRCm39) M367K probably damaging Het
Robo2 A G 16: 73,831,996 (GRCm39) L228P probably damaging Het
Samd9l T A 6: 3,376,939 (GRCm39) E107D probably benign Het
Shc1 A G 3: 89,332,126 (GRCm39) I194V probably benign Het
Slc25a46 A G 18: 31,716,668 (GRCm39) I278T probably benign Het
Tmem178 T A 17: 81,308,429 (GRCm39) C275S possibly damaging Het
Tpsg1 A T 17: 25,592,768 (GRCm39) Q40L possibly damaging Het
Trank1 A G 9: 111,196,038 (GRCm39) E1354G possibly damaging Het
Vit T C 17: 78,873,456 (GRCm39) I44T probably damaging Het
Vstm5 T C 9: 15,168,849 (GRCm39) S138P probably damaging Het
Other mutations in Or51a8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01656:Or51a8 APN 7 102,550,472 (GRCm39) missense possibly damaging 0.96
IGL02307:Or51a8 APN 7 102,550,086 (GRCm39) missense probably benign 0.00
IGL02705:Or51a8 APN 7 102,550,449 (GRCm39) missense probably damaging 1.00
IGL03028:Or51a8 APN 7 102,550,036 (GRCm39) missense possibly damaging 0.81
IGL03086:Or51a8 APN 7 102,549,613 (GRCm39) missense probably damaging 1.00
PIT4434001:Or51a8 UTSW 7 102,549,837 (GRCm39) missense probably benign 0.12
R6603:Or51a8 UTSW 7 102,549,621 (GRCm39) missense probably benign 0.01
R7116:Or51a8 UTSW 7 102,549,842 (GRCm39) missense probably benign 0.20
R7329:Or51a8 UTSW 7 102,550,039 (GRCm39) missense probably damaging 0.97
R7471:Or51a8 UTSW 7 102,549,760 (GRCm39) missense probably benign 0.10
R8020:Or51a8 UTSW 7 102,550,472 (GRCm39) missense possibly damaging 0.96
R9649:Or51a8 UTSW 7 102,549,652 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2014-01-15