Incidental Mutation 'R1155:Vstm5'
ID101663
Institutional Source Beutler Lab
Gene Symbol Vstm5
Ensembl Gene ENSMUSG00000031937
Gene NameV-set and transmembrane domain containing 5
Synonyms
MMRRC Submission 039228-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #R1155 (G1)
Quality Score225
Status Not validated
Chromosome9
Chromosomal Location15239045-15259416 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 15257553 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 138 (S138P)
Ref Sequence ENSEMBL: ENSMUSP00000034413 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034411] [ENSMUST00000034413] [ENSMUST00000213788]
Predicted Effect probably benign
Transcript: ENSMUST00000034411
SMART Domains Protein: ENSMUSP00000034411
Gene: ENSMUSG00000031935

DomainStartEndE-ValueType
low complexity region 51 82 N/A INTRINSIC
Pfam:Med17 123 452 8.5e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000034413
AA Change: S138P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000034413
Gene: ENSMUSG00000031937
AA Change: S138P

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
IG 39 138 2e-3 SMART
transmembrane domain 147 169 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213788
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700093K21Rik T C 11: 23,517,270 E121G possibly damaging Het
Adgrg1 G A 8: 95,006,840 V307I possibly damaging Het
Btbd11 A T 10: 85,629,291 H665L probably damaging Het
Cilp A G 9: 65,269,587 T42A probably benign Het
Col6a3 T A 1: 90,794,325 K1493M probably null Het
Col6a6 A G 9: 105,782,090 V552A possibly damaging Het
Cradd T C 10: 95,322,724 T54A probably benign Het
Elfn2 A G 15: 78,673,144 I401T probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,577,224 probably null Het
Hoxc6 A G 15: 103,010,847 I172V probably damaging Het
Knl1 T C 2: 119,071,154 L1112P possibly damaging Het
Lipo4 T A 19: 33,503,195 I258F probably benign Het
Morf4l1 A G 9: 90,094,504 V257A probably benign Het
Olfr570 A T 7: 102,900,612 M82L probably benign Het
Rnpepl1 T A 1: 92,916,887 M367K probably damaging Het
Robo2 A G 16: 74,035,108 L228P probably damaging Het
Samd9l T A 6: 3,376,939 E107D probably benign Het
Shc1 A G 3: 89,424,819 I194V probably benign Het
Slc25a46 A G 18: 31,583,615 I278T probably benign Het
Tmem178 T A 17: 81,001,000 C275S possibly damaging Het
Tpsg1 A T 17: 25,373,794 Q40L possibly damaging Het
Trank1 A G 9: 111,366,970 E1354G possibly damaging Het
Vit T C 17: 78,566,027 I44T probably damaging Het
Other mutations in Vstm5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01597:Vstm5 APN 9 15257379 missense probably damaging 1.00
IGL01781:Vstm5 APN 9 15257672 missense probably damaging 1.00
IGL02940:Vstm5 APN 9 15257666 missense probably damaging 1.00
R1721:Vstm5 UTSW 9 15257367 missense probably benign 0.13
R2368:Vstm5 UTSW 9 15257731 missense probably benign 0.00
R3160:Vstm5 UTSW 9 15257298 missense probably benign 0.02
R3161:Vstm5 UTSW 9 15257298 missense probably benign 0.02
R3162:Vstm5 UTSW 9 15257298 missense probably benign 0.02
R4612:Vstm5 UTSW 9 15257493 missense probably benign 0.22
R4692:Vstm5 UTSW 9 15257422 missense probably damaging 0.99
R4950:Vstm5 UTSW 9 15257794 splice site probably null
R5088:Vstm5 UTSW 9 15257305 missense possibly damaging 0.87
R6351:Vstm5 UTSW 9 15257533 missense probably damaging 1.00
R7063:Vstm5 UTSW 9 15239253 start gained probably benign
R7720:Vstm5 UTSW 9 15239356 missense probably benign 0.08
Predicted Primers
Posted On2014-01-15