Incidental Mutation 'R1156:Olfr114'
ID101746
Institutional Source Beutler Lab
Gene Symbol Olfr114
Ensembl Gene ENSMUSG00000062629
Gene Nameolfactory receptor 114
SynonymsMOR218-10, GA_x6K02T2PSCP-2049802-2048870
MMRRC Submission 039229-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #R1156 (G1)
Quality Score225
Status Not validated
Chromosome17
Chromosomal Location37589233-37592743 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 37589517 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 279 (T279S)
Ref Sequence ENSEMBL: ENSMUSP00000149735 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076914] [ENSMUST00000214871] [ENSMUST00000216249]
Predicted Effect possibly damaging
Transcript: ENSMUST00000076914
AA Change: T279S

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000076181
Gene: ENSMUSG00000062629
AA Change: T279S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2e-43 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.7e-6 PFAM
Pfam:7tm_1 41 290 3e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214871
AA Change: T279S

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216249
AA Change: T279S

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.2%
  • 10x: 94.8%
  • 20x: 86.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 T C 1: 38,204,910 T927A probably benign Het
Ankrd13b G T 11: 77,472,861 H425Q probably damaging Het
Ano7 C A 1: 93,401,852 probably null Het
Cachd1 T C 4: 100,988,619 L1000P probably damaging Het
Dennd4c A G 4: 86,807,466 D719G probably damaging Het
Ehbp1l1 G T 19: 5,708,336 probably benign Het
Eml3 A G 19: 8,934,130 T326A probably damaging Het
Exoc6 T A 19: 37,682,897 N778K probably benign Het
Fat1 G A 8: 45,039,890 R3883H possibly damaging Het
Kcnt2 T A 1: 140,428,855 V344D probably damaging Het
Khdrbs2 C A 1: 32,467,875 T200K probably benign Het
Mtap A T 4: 89,171,222 T148S probably benign Het
Nos3 T C 5: 24,377,619 V615A probably benign Het
Nudt9 G A 5: 104,050,730 W37* probably null Het
Obp2a A G 2: 25,701,592 K108R possibly damaging Het
Sec23a A T 12: 59,001,836 S167T probably benign Het
Strn A G 17: 78,656,931 I535T probably damaging Het
Ttn G A 2: 76,974,403 T206M probably damaging Het
Vwf T C 6: 125,637,488 C1111R probably damaging Het
Zfp831 C A 2: 174,646,917 H1128Q possibly damaging Het
Zufsp T C 10: 33,949,226 T87A probably benign Het
Other mutations in Olfr114
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01534:Olfr114 APN 17 37590072 missense possibly damaging 0.93
IGL01624:Olfr114 APN 17 37589925 missense probably benign 0.00
IGL02026:Olfr114 APN 17 37589407 utr 3 prime probably benign
IGL02608:Olfr114 APN 17 37590219 missense probably damaging 1.00
IGL02632:Olfr114 APN 17 37590341 missense probably benign 0.00
IGL02990:Olfr114 APN 17 37589668 missense probably benign 0.00
R0114:Olfr114 UTSW 17 37589415 makesense probably null
R1366:Olfr114 UTSW 17 37589764 missense probably benign 0.03
R3413:Olfr114 UTSW 17 37589696 missense probably benign 0.00
R3701:Olfr114 UTSW 17 37589826 nonsense probably null
R6122:Olfr114 UTSW 17 37589926 missense probably benign 0.12
R6639:Olfr114 UTSW 17 37589931 missense probably damaging 1.00
R7066:Olfr114 UTSW 17 37590143 missense probably damaging 1.00
R7316:Olfr114 UTSW 17 37590135 missense probably damaging 0.99
R8340:Olfr114 UTSW 17 37590143 missense probably damaging 1.00
R8483:Olfr114 UTSW 17 37589975
R8555:Olfr114 UTSW 17 37589649
Predicted Primers
Posted On2014-01-15