Mutagenetix > Incidental Mutation

Incidental Mutation 'R1157:Pate12'

101813

Institutional Source

Beutler Lab

Gene Symbol

Pate12

Ensembl Gene

ENSMUSG00000023093

Gene Name

prostate and testis expressed 12

Synonyms

Gm7257

MMRRC Submission

039230-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R1157 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

36343180-36346234 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 36344143 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 42 (C42Y)

Ref Sequence

ENSEMBL: ENSMUSP00000048154 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041537]

AlphaFold

D3YX25

Predicted Effect

probably benign
Transcript: ENSMUST00000041537
AA Change: C42Y

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000048154
Gene: ENSMUSG00000023093
AA Change: C42Y

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.7%
20x: 93.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl4	C	A	3: 95,590,971 (GRCm39)	S332I	possibly damaging	Het
Alpl	A	G	4: 137,481,331 (GRCm39)	V107A	probably damaging	Het
Baz1a	A	T	12: 54,976,349 (GRCm39)	F442L	probably damaging	Het
Cachd1	T	A	4: 100,832,037 (GRCm39)	M733K	possibly damaging	Het
Cacna1c	C	T	6: 118,589,586 (GRCm39)	R1446H	probably damaging	Het
Cenpf	A	T	1: 189,390,650 (GRCm39)	C1061S	probably benign	Het
Crispld1	G	A	1: 17,815,587 (GRCm39)	V90M	possibly damaging	Het
Ergic1	T	A	17: 26,833,369 (GRCm39)	L41Q	probably damaging	Het
Fhod3	C	T	18: 25,118,293 (GRCm39)	A210V	probably damaging	Het
Gas2l2	G	A	11: 83,314,154 (GRCm39)	P386L	probably benign	Het
Gm21726	T	C	13: 90,731,724 (GRCm39)		noncoding transcript	Het
Hlx	G	T	1: 184,464,184 (GRCm39)	A52D	probably damaging	Het
Hoxa13	CCG	CCGCG	6: 52,237,618 (GRCm39)		probably null	Het
Iqsec1	A	G	6: 90,646,366 (GRCm39)	V771A	possibly damaging	Het
Klhl29	T	C	12: 5,140,650 (GRCm39)	N664S	possibly damaging	Het
Krit1	T	C	5: 3,882,176 (GRCm39)	Y659H	probably damaging	Het
Lap3	T	A	5: 45,664,490 (GRCm39)	D373E	probably damaging	Het
Lrrc7	A	G	3: 157,865,892 (GRCm39)	I1283T	probably damaging	Het
Lrrk1	T	C	7: 65,912,031 (GRCm39)	Y1843C	probably benign	Het
Mapre1	T	A	2: 153,599,937 (GRCm39)	D120E	probably benign	Het
Mgp	A	T	6: 136,850,204 (GRCm39)	M44K	possibly damaging	Het
Mrps25	A	T	6: 92,160,947 (GRCm39)	M3K	probably damaging	Het
Myo3a	G	T	2: 22,434,456 (GRCm39)		probably null	Het
Nedd9	C	T	13: 41,467,979 (GRCm39)		probably null	Het
Or52e4	A	G	7: 104,706,091 (GRCm39)	I213V	probably benign	Het
Or6c8b	T	G	10: 128,882,027 (GRCm39)	T302P	probably benign	Het
Or7c19	G	T	8: 85,957,889 (GRCm39)	C255F	probably damaging	Het
Pdia3	G	A	2: 121,262,858 (GRCm39)	G275S	probably damaging	Het
Pigs	T	C	11: 78,219,820 (GRCm39)	V65A	possibly damaging	Het
Pip5k1a	G	A	3: 94,985,423 (GRCm39)	T60I	probably benign	Het
Rp9	A	T	9: 22,370,036 (GRCm39)	Y44N	probably damaging	Het
Tcea1	T	A	1: 4,959,670 (GRCm39)		probably null	Het
Trim33	C	T	3: 103,261,146 (GRCm39)	T1098I	probably damaging	Het
Vmn2r114	T	A	17: 23,529,314 (GRCm39)	I263F	possibly damaging	Het
Wdr12	A	T	1: 60,117,389 (GRCm39)	S402R	probably damaging	Het
Zfp619	A	G	7: 39,186,282 (GRCm39)	S771G	probably damaging	Het

Other mutations in Pate12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00329:Pate12	APN	9	36,344,198 (GRCm39)	splice site	probably benign
IGL01799:Pate12	APN	9	36,344,179 (GRCm39)	missense	possibly damaging	0.59
IGL03018:Pate12	APN	9	36,344,723 (GRCm39)	missense	possibly damaging	0.89
IGL03178:Pate12	APN	9	36,344,132 (GRCm39)	missense	probably benign
IGL03284:Pate12	APN	9	36,344,759 (GRCm39)	missense	probably damaging	1.00
R2032:Pate12	UTSW	9	36,344,195 (GRCm39)	critical splice donor site	probably null
R4879:Pate12	UTSW	9	36,344,089 (GRCm39)	missense	probably damaging	1.00
R4954:Pate12	UTSW	9	36,344,156 (GRCm39)	missense	probably benign	0.28
R5019:Pate12	UTSW	9	36,343,198 (GRCm39)	missense	probably benign	0.05

Predicted Primers

Posted On

2014-01-15