Mutagenetix > Incidental Mutation

Incidental Mutation 'R1158:Zfp964'

101890

Institutional Source

Beutler Lab

Gene Symbol

Zfp964

Ensembl Gene

ENSMUSG00000091764

Gene Name

zinc finger protein 964

Synonyms

Gm7187

MMRRC Submission

039231-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R1158 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

70107129-70119632 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 70116503 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 368 (C368S)

Ref Sequence

ENSEMBL: ENSMUSP00000145354 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169125] [ENSMUST00000204285]

AlphaFold

B2RR88

Predicted Effect

unknown
Transcript: ENSMUST00000169125
AA Change: C367S

SMART Domains

Protein: ENSMUSP00000129822
Gene: ENSMUSG00000091764
AA Change: C367S

Domain	Start	End	E-Value	Type
KRAB	3	56	5.24e-18	SMART
ZnF_C2H2	216	238	4.54e-4	SMART
ZnF_C2H2	244	266	3.58e-2	SMART
ZnF_C2H2	272	294	2.2e-2	SMART
ZnF_C2H2	300	322	5.5e-3	SMART
ZnF_C2H2	328	350	8.22e-2	SMART
ZnF_C2H2	356	378	2.05e-2	SMART
ZnF_C2H2	384	406	6.32e-3	SMART
ZnF_C2H2	412	434	5.42e-2	SMART
ZnF_C2H2	440	462	1.28e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204062

Predicted Effect

unknown
Transcript: ENSMUST00000204285
AA Change: C368S

SMART Domains

Protein: ENSMUSP00000145354
Gene: ENSMUSG00000091764
AA Change: C368S

Domain	Start	End	E-Value	Type
KRAB	4	57	5.24e-18	SMART
ZnF_C2H2	217	239	4.54e-4	SMART
ZnF_C2H2	245	267	3.58e-2	SMART
ZnF_C2H2	273	295	2.2e-2	SMART
ZnF_C2H2	301	323	5.5e-3	SMART
ZnF_C2H2	329	351	8.22e-2	SMART
ZnF_C2H2	357	379	2.05e-2	SMART
ZnF_C2H2	385	407	6.32e-3	SMART
ZnF_C2H2	413	435	5.42e-2	SMART
ZnF_C2H2	441	463	1.28e-3	SMART

Meta Mutation Damage Score

0.1100

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.3%
20x: 89.3%

Validation Efficiency

98% (43/44)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adpgk	T	C	9: 59,217,566 (GRCm39)	V193A	possibly damaging	Het
Ahnak	A	C	19: 8,991,290 (GRCm39)	E4191D	probably benign	Het
BC024139	T	A	15: 76,004,542 (GRCm39)		probably benign	Het
Bpifb9a	T	G	2: 154,104,184 (GRCm39)	I209S	probably benign	Het
Bst1	T	G	5: 43,997,834 (GRCm39)		probably null	Het
Cacna1c	C	T	6: 118,589,586 (GRCm39)	R1446H	probably damaging	Het
Carf	A	G	1: 60,186,998 (GRCm39)	K499E	probably benign	Het
Casq2	A	G	3: 102,024,199 (GRCm39)	E147G	probably damaging	Het
Cd8a	T	A	6: 71,350,712 (GRCm39)	V59D	probably damaging	Het
Chrm5	T	C	2: 112,310,214 (GRCm39)	T301A	probably benign	Het
Cog5	G	A	12: 31,920,056 (GRCm39)		probably benign	Het
Csmd3	T	C	15: 48,156,170 (GRCm39)		probably null	Het
Dop1a	T	C	9: 86,367,609 (GRCm39)	S31P	probably damaging	Het
Eif1ad9	A	T	12: 88,296,438 (GRCm39)	I139F	unknown	Het
Epb41	T	C	4: 131,727,502 (GRCm39)		probably benign	Het
Fhod3	C	T	18: 25,118,293 (GRCm39)	A210V	probably damaging	Het
Gdpgp1	T	C	7: 79,888,250 (GRCm39)	F94L	probably benign	Het
Hlx	G	T	1: 184,464,184 (GRCm39)	A52D	probably damaging	Het
Htr3b	T	C	9: 48,847,390 (GRCm39)	K375R	possibly damaging	Het
Inhbe	G	A	10: 127,187,186 (GRCm39)	R77W	probably damaging	Het
Itgb8	T	C	12: 119,166,231 (GRCm39)	E100G	probably damaging	Het
Jakmip1	T	C	5: 37,248,472 (GRCm39)	V44A	possibly damaging	Het
Lrp12	A	G	15: 39,741,827 (GRCm39)	V315A	probably damaging	Het
Lrp1b	T	A	2: 40,567,506 (GRCm39)	T305S	unknown	Het
Map3k2	A	G	18: 32,350,211 (GRCm39)	T354A	probably benign	Het
Mmp16	T	C	4: 17,987,726 (GRCm39)		probably null	Het
Mphosph10	T	C	7: 64,038,607 (GRCm39)		probably benign	Het
Or10a48	A	G	7: 108,424,385 (GRCm39)	S274P	probably damaging	Het
Or10ak7	A	T	4: 118,791,614 (GRCm39)	C144S	probably damaging	Het
Or4c52	T	A	2: 89,845,598 (GRCm39)	I108N	possibly damaging	Het
Or4k47	T	C	2: 111,452,086 (GRCm39)	E111G	probably damaging	Het
Or5p52	G	A	7: 107,502,130 (GRCm39)	V69I	possibly damaging	Het
Slc43a3	C	A	2: 84,768,140 (GRCm39)	F37L	probably benign	Het
Slf2	G	T	19: 44,919,855 (GRCm39)	A36S	probably damaging	Het
Sorcs1	T	C	19: 50,132,598 (GRCm39)		probably benign	Het
Thsd7b	A	C	1: 130,117,672 (GRCm39)		probably null	Het
Tnfrsf18	A	C	4: 156,112,739 (GRCm39)	I142L	probably benign	Het
Ttn	A	G	2: 76,632,855 (GRCm39)		probably benign	Het
Tufm	T	A	7: 126,088,614 (GRCm39)		probably null	Het
Vmn2r69	A	T	7: 85,059,058 (GRCm39)		probably benign	Het
Zfp385c	T	C	11: 100,520,709 (GRCm39)		probably benign	Het
Zswim8	G	A	14: 20,771,736 (GRCm39)		probably benign	Het

Other mutations in Zfp964

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00580:Zfp964	APN	8	70,112,043 (GRCm39)	splice site	probably null
R0506:Zfp964	UTSW	8	70,116,587 (GRCm39)	missense	unknown
R0740:Zfp964	UTSW	8	70,115,828 (GRCm39)	missense	probably damaging	0.98
R0786:Zfp964	UTSW	8	70,116,731 (GRCm39)	missense	possibly damaging	0.71
R1204:Zfp964	UTSW	8	70,116,668 (GRCm39)	missense	probably benign	0.08
R1413:Zfp964	UTSW	8	70,115,720 (GRCm39)	missense	unknown
R1562:Zfp964	UTSW	8	70,115,654 (GRCm39)	missense	probably benign
R1663:Zfp964	UTSW	8	70,116,733 (GRCm39)	splice site	probably null
R1693:Zfp964	UTSW	8	70,116,800 (GRCm39)	missense	possibly damaging	0.55
R2029:Zfp964	UTSW	8	70,116,567 (GRCm39)	missense	unknown
R2847:Zfp964	UTSW	8	70,116,504 (GRCm39)	missense	unknown
R2849:Zfp964	UTSW	8	70,116,504 (GRCm39)	missense	unknown
R4111:Zfp964	UTSW	8	70,116,754 (GRCm39)	missense	probably benign	0.18
R4792:Zfp964	UTSW	8	70,116,665 (GRCm39)	missense	probably benign	0.18
R4907:Zfp964	UTSW	8	70,115,972 (GRCm39)	missense	possibly damaging	0.86
R4938:Zfp964	UTSW	8	70,116,758 (GRCm39)	missense	possibly damaging	0.64
R5688:Zfp964	UTSW	8	70,116,766 (GRCm39)	missense	probably benign	0.03
R5905:Zfp964	UTSW	8	70,116,563 (GRCm39)	missense	unknown
R6009:Zfp964	UTSW	8	70,116,106 (GRCm39)	missense	possibly damaging	0.71
R6021:Zfp964	UTSW	8	70,115,742 (GRCm39)	missense	unknown
R6028:Zfp964	UTSW	8	70,116,563 (GRCm39)	missense	unknown
R6374:Zfp964	UTSW	8	70,111,994 (GRCm39)	missense	possibly damaging	0.93
R6583:Zfp964	UTSW	8	70,115,633 (GRCm39)	missense	probably damaging	0.98
R7730:Zfp964	UTSW	8	70,116,360 (GRCm39)	missense	possibly damaging	0.85
R8263:Zfp964	UTSW	8	70,116,345 (GRCm39)	missense	possibly damaging	0.92
R8309:Zfp964	UTSW	8	70,115,924 (GRCm39)	missense	possibly damaging	0.53
R8889:Zfp964	UTSW	8	70,116,405 (GRCm39)	missense	probably damaging	1.00
R8892:Zfp964	UTSW	8	70,116,405 (GRCm39)	missense	probably damaging	1.00
R9133:Zfp964	UTSW	8	70,115,783 (GRCm39)	missense	probably benign	0.00
R9185:Zfp964	UTSW	8	70,115,873 (GRCm39)	missense	possibly damaging	0.53

Predicted Primers

Posted On

2014-01-15