Mutagenetix > Incidental Mutation

Incidental Mutation 'R1159:Vmn2r66'

101965

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r66

Ensembl Gene

ENSMUSG00000094950

Gene Name

vomeronasal 2, receptor 66

Synonyms

F830104D24Rik

MMRRC Submission

039232-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R1159 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

84643853-84661228 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 84644613 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 599 (I599N)

Ref Sequence

ENSEMBL: ENSMUSP00000122645 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000124773]

AlphaFold

A0A3B2W842

Predicted Effect

probably benign
Transcript: ENSMUST00000124773
AA Change: I599N

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: I599N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	463	5e-31	PFAM
Pfam:NCD3G	507	559	6e-21	PFAM
Pfam:7tm_3	589	827	3.8e-52	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 96.1%
20x: 91.8%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	G	A	6: 23,115,137 (GRCm39)	H164Y	probably damaging	Het
Acss2	T	C	2: 155,393,138 (GRCm39)	I288T	probably benign	Het
Akap9	C	T	5: 4,010,865 (GRCm39)	R541C	probably damaging	Het
Ano5	T	C	7: 51,229,222 (GRCm39)		probably benign	Het
Anp32b	T	C	4: 46,471,478 (GRCm39)		probably benign	Het
Avil	T	C	10: 126,847,659 (GRCm39)	V528A	possibly damaging	Het
Cacna1c	C	T	6: 118,589,586 (GRCm39)	R1446H	probably damaging	Het
Cdk10	T	C	8: 123,955,062 (GRCm39)		probably benign	Het
Cfap65	A	T	1: 74,968,499 (GRCm39)	F111Y	probably damaging	Het
Cryge	A	G	1: 65,089,967 (GRCm39)	F72L	probably benign	Het
Ercc3	C	T	18: 32,397,611 (GRCm39)	T614I	possibly damaging	Het
Fgd5	T	C	6: 91,965,483 (GRCm39)	I572T	probably benign	Het
Fubp1	A	G	3: 151,921,229 (GRCm39)	D88G	possibly damaging	Het
Gcnt1	C	A	19: 17,307,168 (GRCm39)	V186F	possibly damaging	Het
Gldc	A	T	19: 30,138,162 (GRCm39)		probably benign	Het
Gxylt2	A	G	6: 100,781,602 (GRCm39)	M426V	possibly damaging	Het
Hps5	A	T	7: 46,421,978 (GRCm39)		probably null	Het
Igf2bp2	G	A	16: 21,880,603 (GRCm39)		probably benign	Het
Lamb2	T	C	9: 108,358,607 (GRCm39)	S215P	probably damaging	Het
Mfsd13b	T	C	7: 120,613,766 (GRCm39)	M421T	probably damaging	Het
Mtif2	C	A	11: 29,490,729 (GRCm39)	R478S	possibly damaging	Het
Nadk2	G	A	15: 9,106,925 (GRCm39)	R351H	possibly damaging	Het
Nt5dc1	T	C	10: 34,274,169 (GRCm39)	D167G	possibly damaging	Het
Nup98	T	A	7: 101,809,923 (GRCm39)	T536S	probably damaging	Het
Parp14	G	A	16: 35,677,130 (GRCm39)	A946V	probably benign	Het
Ppig	T	A	2: 69,580,568 (GRCm39)	S701T	unknown	Het
Pramel17	T	C	4: 101,695,224 (GRCm39)	E29G	possibly damaging	Het
Ptprc	A	G	1: 138,000,057 (GRCm39)	S830P	probably damaging	Het
Rev3l	T	A	10: 39,727,921 (GRCm39)	L2690*	probably null	Het
Rgs22	A	T	15: 36,040,839 (GRCm39)	S883T	probably damaging	Het
Rxfp4	A	G	3: 88,559,894 (GRCm39)	W186R	probably damaging	Het
Sacm1l	T	C	9: 123,395,476 (GRCm39)	S200P	probably benign	Het
Serpinb6d	T	A	13: 33,855,212 (GRCm39)	D295E	probably damaging	Het
Slc38a10	A	G	11: 119,996,301 (GRCm39)	V932A	probably benign	Het
Top2b	T	C	14: 16,430,329 (GRCm38)	S1568P	possibly damaging	Het
Tox	T	G	4: 6,697,600 (GRCm39)	N401T	probably benign	Het
Trim24	T	C	6: 37,933,412 (GRCm39)		probably null	Het
Unc79	T	G	12: 103,013,311 (GRCm39)		probably benign	Het
Zfa-ps	T	A	10: 52,419,654 (GRCm39)		noncoding transcript	Het

Other mutations in Vmn2r66

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00321:Vmn2r66	APN	7	84,656,299 (GRCm39)	missense	probably benign
IGL01562:Vmn2r66	APN	7	84,656,495 (GRCm39)	missense	probably benign	0.03
IGL01689:Vmn2r66	APN	7	84,657,033 (GRCm39)	missense	probably damaging	1.00
IGL02237:Vmn2r66	APN	7	84,643,908 (GRCm39)	missense	probably benign
IGL02415:Vmn2r66	APN	7	84,656,020 (GRCm39)	missense	probably damaging	0.97
IGL02439:Vmn2r66	APN	7	84,654,455 (GRCm39)	splice site	probably benign
IGL02545:Vmn2r66	APN	7	84,655,798 (GRCm39)	missense	possibly damaging	0.50
IGL02708:Vmn2r66	APN	7	84,655,796 (GRCm39)	missense	probably benign	0.00
IGL02794:Vmn2r66	APN	7	84,644,623 (GRCm39)	missense	probably benign	0.00
IGL02885:Vmn2r66	APN	7	84,644,723 (GRCm39)	missense	probably benign	0.00
IGL02975:Vmn2r66	APN	7	84,656,182 (GRCm39)	missense	probably damaging	0.98
IGL03027:Vmn2r66	APN	7	84,644,777 (GRCm39)	splice site	probably benign
IGL03081:Vmn2r66	APN	7	84,657,138 (GRCm39)	missense	probably benign
PIT4131001:Vmn2r66	UTSW	7	84,644,301 (GRCm39)	missense	probably damaging	1.00
R0098:Vmn2r66	UTSW	7	84,654,965 (GRCm39)	missense	probably damaging	1.00
R0504:Vmn2r66	UTSW	7	84,656,023 (GRCm39)	missense	probably damaging	0.99
R0557:Vmn2r66	UTSW	7	84,643,972 (GRCm39)	missense	probably damaging	1.00
R0617:Vmn2r66	UTSW	7	84,644,484 (GRCm39)	missense	probably benign	0.02
R0883:Vmn2r66	UTSW	7	84,657,070 (GRCm39)	missense	probably benign
R1168:Vmn2r66	UTSW	7	84,656,062 (GRCm39)	missense	possibly damaging	0.46
R1172:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1175:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1538:Vmn2r66	UTSW	7	84,644,166 (GRCm39)	missense	possibly damaging	0.84
R1658:Vmn2r66	UTSW	7	84,656,955 (GRCm39)	missense	probably benign	0.07
R1937:Vmn2r66	UTSW	7	84,644,344 (GRCm39)	missense	probably damaging	0.99
R1989:Vmn2r66	UTSW	7	84,661,201 (GRCm39)	missense	probably benign	0.01
R2698:Vmn2r66	UTSW	7	84,644,607 (GRCm39)	missense	probably damaging	1.00
R2890:Vmn2r66	UTSW	7	84,661,027 (GRCm39)	splice site	probably null
R3686:Vmn2r66	UTSW	7	84,644,397 (GRCm39)	missense	probably damaging	0.96
R4152:Vmn2r66	UTSW	7	84,654,800 (GRCm39)	missense	probably benign	0.08
R4500:Vmn2r66	UTSW	7	84,657,162 (GRCm39)	missense	probably damaging	1.00
R4618:Vmn2r66	UTSW	7	84,644,296 (GRCm39)	missense	possibly damaging	0.62
R4656:Vmn2r66	UTSW	7	84,661,204 (GRCm39)	missense	possibly damaging	0.87
R4668:Vmn2r66	UTSW	7	84,643,905 (GRCm39)	missense	probably damaging	1.00
R4942:Vmn2r66	UTSW	7	84,656,980 (GRCm39)	missense	probably damaging	1.00
R5163:Vmn2r66	UTSW	7	84,656,017 (GRCm39)	missense	probably benign	0.01
R5223:Vmn2r66	UTSW	7	84,657,093 (GRCm39)	missense	probably benign
R5377:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R5512:Vmn2r66	UTSW	7	84,657,149 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r66	UTSW	7	84,654,951 (GRCm39)	nonsense	probably null
R5749:Vmn2r66	UTSW	7	84,655,979 (GRCm39)	nonsense	probably null
R6131:Vmn2r66	UTSW	7	84,644,224 (GRCm39)	missense	probably damaging	1.00
R6183:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R6509:Vmn2r66	UTSW	7	84,656,054 (GRCm39)	missense	probably benign	0.12
R6930:Vmn2r66	UTSW	7	84,661,216 (GRCm39)	missense	possibly damaging	0.80
R6992:Vmn2r66	UTSW	7	84,654,436 (GRCm39)	missense	possibly damaging	0.90
R7015:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R7302:Vmn2r66	UTSW	7	84,654,423 (GRCm39)	missense	probably benign	0.00
R7516:Vmn2r66	UTSW	7	84,661,176 (GRCm39)	missense	possibly damaging	0.51
R7763:Vmn2r66	UTSW	7	84,654,909 (GRCm39)	missense	probably benign	0.01
R7814:Vmn2r66	UTSW	7	84,656,472 (GRCm39)	missense	probably benign	0.02
R8077:Vmn2r66	UTSW	7	84,656,093 (GRCm39)	missense	probably benign
R8307:Vmn2r66	UTSW	7	84,656,270 (GRCm39)	missense	probably benign
R8315:Vmn2r66	UTSW	7	84,643,932 (GRCm39)	missense	possibly damaging	0.90
R8490:Vmn2r66	UTSW	7	84,654,794 (GRCm39)	critical splice donor site	probably null
R8511:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R8781:Vmn2r66	UTSW	7	84,644,355 (GRCm39)	nonsense	probably null
R8812:Vmn2r66	UTSW	7	84,654,893 (GRCm39)	missense	probably damaging	0.99
R9203:Vmn2r66	UTSW	7	84,654,950 (GRCm39)	missense	probably benign	0.01
R9277:Vmn2r66	UTSW	7	84,661,164 (GRCm39)	missense	probably benign	0.00

Predicted Primers

Posted On

2014-01-15