Incidental Mutation 'R1159:Cdk10'
ID |
101971 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cdk10
|
Ensembl Gene |
ENSMUSG00000033862 |
Gene Name |
cyclin dependent kinase 10 |
Synonyms |
|
MMRRC Submission |
039232-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.150)
|
Stock # |
R1159 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
8 |
Chromosomal Location |
123951581-123958989 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
T to C
at 123955062 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000148435
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036880]
[ENSMUST00000098327]
[ENSMUST00000127664]
[ENSMUST00000166768]
[ENSMUST00000212361]
[ENSMUST00000212193]
[ENSMUST00000213005]
|
AlphaFold |
Q3UMM4 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000036880
|
SMART Domains |
Protein: ENSMUSP00000045527 Gene: ENSMUSG00000033862
Domain | Start | End | E-Value | Type |
S_TKc
|
39 |
323 |
1.52e-87 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000098327
|
SMART Domains |
Protein: ENSMUSP00000095932 Gene: ENSMUSG00000033594
Domain | Start | End | E-Value | Type |
low complexity region
|
74 |
91 |
N/A |
INTRINSIC |
low complexity region
|
209 |
214 |
N/A |
INTRINSIC |
low complexity region
|
294 |
308 |
N/A |
INTRINSIC |
low complexity region
|
309 |
318 |
N/A |
INTRINSIC |
low complexity region
|
340 |
347 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000127664
|
SMART Domains |
Protein: ENSMUSP00000118564 Gene: ENSMUSG00000092329
Domain | Start | End | E-Value | Type |
Pfam:Glycos_transf_2
|
104 |
287 |
7.4e-31 |
PFAM |
Pfam:Glyco_transf_7C
|
261 |
331 |
4.9e-8 |
PFAM |
RICIN
|
406 |
531 |
9.28e-27 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000166768
|
SMART Domains |
Protein: ENSMUSP00000130306 Gene: ENSMUSG00000033594
Domain | Start | End | E-Value | Type |
low complexity region
|
74 |
91 |
N/A |
INTRINSIC |
low complexity region
|
209 |
214 |
N/A |
INTRINSIC |
low complexity region
|
294 |
308 |
N/A |
INTRINSIC |
low complexity region
|
309 |
318 |
N/A |
INTRINSIC |
low complexity region
|
340 |
347 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211845
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211876
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212021
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000212361
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212497
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000212028
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000212193
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212749
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000213005
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212532
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212904
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212035
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212784
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.1%
- 20x: 91.8%
|
Validation Efficiency |
100% (42/42) |
MGI Phenotype |
FUNCTION: The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aass |
G |
A |
6: 23,115,137 (GRCm39) |
H164Y |
probably damaging |
Het |
Acss2 |
T |
C |
2: 155,393,138 (GRCm39) |
I288T |
probably benign |
Het |
Akap9 |
C |
T |
5: 4,010,865 (GRCm39) |
R541C |
probably damaging |
Het |
Ano5 |
T |
C |
7: 51,229,222 (GRCm39) |
|
probably benign |
Het |
Anp32b |
T |
C |
4: 46,471,478 (GRCm39) |
|
probably benign |
Het |
Avil |
T |
C |
10: 126,847,659 (GRCm39) |
V528A |
possibly damaging |
Het |
Cacna1c |
C |
T |
6: 118,589,586 (GRCm39) |
R1446H |
probably damaging |
Het |
Cfap65 |
A |
T |
1: 74,968,499 (GRCm39) |
F111Y |
probably damaging |
Het |
Cryge |
A |
G |
1: 65,089,967 (GRCm39) |
F72L |
probably benign |
Het |
Ercc3 |
C |
T |
18: 32,397,611 (GRCm39) |
T614I |
possibly damaging |
Het |
Fgd5 |
T |
C |
6: 91,965,483 (GRCm39) |
I572T |
probably benign |
Het |
Fubp1 |
A |
G |
3: 151,921,229 (GRCm39) |
D88G |
possibly damaging |
Het |
Gcnt1 |
C |
A |
19: 17,307,168 (GRCm39) |
V186F |
possibly damaging |
Het |
Gldc |
A |
T |
19: 30,138,162 (GRCm39) |
|
probably benign |
Het |
Gxylt2 |
A |
G |
6: 100,781,602 (GRCm39) |
M426V |
possibly damaging |
Het |
Hps5 |
A |
T |
7: 46,421,978 (GRCm39) |
|
probably null |
Het |
Igf2bp2 |
G |
A |
16: 21,880,603 (GRCm39) |
|
probably benign |
Het |
Lamb2 |
T |
C |
9: 108,358,607 (GRCm39) |
S215P |
probably damaging |
Het |
Mfsd13b |
T |
C |
7: 120,613,766 (GRCm39) |
M421T |
probably damaging |
Het |
Mtif2 |
C |
A |
11: 29,490,729 (GRCm39) |
R478S |
possibly damaging |
Het |
Nadk2 |
G |
A |
15: 9,106,925 (GRCm39) |
R351H |
possibly damaging |
Het |
Nt5dc1 |
T |
C |
10: 34,274,169 (GRCm39) |
D167G |
possibly damaging |
Het |
Nup98 |
T |
A |
7: 101,809,923 (GRCm39) |
T536S |
probably damaging |
Het |
Parp14 |
G |
A |
16: 35,677,130 (GRCm39) |
A946V |
probably benign |
Het |
Ppig |
T |
A |
2: 69,580,568 (GRCm39) |
S701T |
unknown |
Het |
Pramel17 |
T |
C |
4: 101,695,224 (GRCm39) |
E29G |
possibly damaging |
Het |
Ptprc |
A |
G |
1: 138,000,057 (GRCm39) |
S830P |
probably damaging |
Het |
Rev3l |
T |
A |
10: 39,727,921 (GRCm39) |
L2690* |
probably null |
Het |
Rgs22 |
A |
T |
15: 36,040,839 (GRCm39) |
S883T |
probably damaging |
Het |
Rxfp4 |
A |
G |
3: 88,559,894 (GRCm39) |
W186R |
probably damaging |
Het |
Sacm1l |
T |
C |
9: 123,395,476 (GRCm39) |
S200P |
probably benign |
Het |
Serpinb6d |
T |
A |
13: 33,855,212 (GRCm39) |
D295E |
probably damaging |
Het |
Slc38a10 |
A |
G |
11: 119,996,301 (GRCm39) |
V932A |
probably benign |
Het |
Top2b |
T |
C |
14: 16,430,329 (GRCm38) |
S1568P |
possibly damaging |
Het |
Tox |
T |
G |
4: 6,697,600 (GRCm39) |
N401T |
probably benign |
Het |
Trim24 |
T |
C |
6: 37,933,412 (GRCm39) |
|
probably null |
Het |
Unc79 |
T |
G |
12: 103,013,311 (GRCm39) |
|
probably benign |
Het |
Vmn2r66 |
A |
T |
7: 84,644,613 (GRCm39) |
I599N |
probably benign |
Het |
Zfa-ps |
T |
A |
10: 52,419,654 (GRCm39) |
|
noncoding transcript |
Het |
|
Other mutations in Cdk10 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00332:Cdk10
|
APN |
8 |
123,957,063 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL01613:Cdk10
|
APN |
8 |
123,955,126 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01682:Cdk10
|
APN |
8 |
123,954,397 (GRCm39) |
critical splice acceptor site |
probably null |
|
IGL02536:Cdk10
|
APN |
8 |
123,953,754 (GRCm39) |
missense |
possibly damaging |
0.64 |
R0612:Cdk10
|
UTSW |
8 |
123,957,419 (GRCm39) |
missense |
probably benign |
0.16 |
R2356:Cdk10
|
UTSW |
8 |
123,955,908 (GRCm39) |
missense |
probably damaging |
0.99 |
R4838:Cdk10
|
UTSW |
8 |
123,957,353 (GRCm39) |
missense |
probably damaging |
1.00 |
R5453:Cdk10
|
UTSW |
8 |
123,953,131 (GRCm39) |
missense |
probably benign |
0.42 |
R5517:Cdk10
|
UTSW |
8 |
123,957,326 (GRCm39) |
splice site |
probably null |
|
R5804:Cdk10
|
UTSW |
8 |
123,955,579 (GRCm39) |
splice site |
probably null |
|
R6930:Cdk10
|
UTSW |
8 |
123,957,347 (GRCm39) |
missense |
probably damaging |
1.00 |
R6971:Cdk10
|
UTSW |
8 |
123,954,413 (GRCm39) |
missense |
probably damaging |
1.00 |
R7910:Cdk10
|
UTSW |
8 |
123,953,105 (GRCm39) |
missense |
probably damaging |
1.00 |
R8356:Cdk10
|
UTSW |
8 |
123,955,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
|
Posted On |
2014-01-15 |