Mutagenetix > Incidental Mutation

Incidental Mutation 'R1141:Vmn2r53'

102105

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r53

Ensembl Gene

ENSMUSG00000096002

Gene Name

vomeronasal 2, receptor 53

Synonyms

EG637908

MMRRC Submission

039214-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R1141 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

12315397-12342583 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 12334673 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 329 (T329I)

Ref Sequence

ENSEMBL: ENSMUSP00000126979 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170412]

AlphaFold

A0A3B2W4A7

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000118665

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170412
AA Change: T329I

PolyPhen 2 Score 0.543 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: T329I

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	3.6e-58	PFAM
Pfam:NCD3G	442	495	2.2e-19	PFAM
Pfam:7tm_3	526	763	3.1e-53	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.0%
10x: 94.1%
20x: 84.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	G	A	6: 86,942,458 (GRCm39)		probably null	Het
Asap2	A	G	12: 21,235,111 (GRCm39)	N71S	probably damaging	Het
Brinp1	T	C	4: 68,711,215 (GRCm39)	H331R	probably benign	Het
Brinp2	C	A	1: 158,074,840 (GRCm39)	C427F	probably damaging	Het
Ccr6	A	G	17: 8,474,834 (GRCm39)	Y13C	probably damaging	Het
Celf4	T	C	18: 25,637,961 (GRCm39)	D187G	probably damaging	Het
Clcn6	T	G	4: 148,098,356 (GRCm39)	T556P	probably damaging	Het
Dst	A	T	1: 34,227,777 (GRCm39)	Q1968L	possibly damaging	Het
Elavl4	G	A	4: 110,108,565 (GRCm39)	Q53*	probably null	Het
Fbxw15	G	A	9: 109,387,314 (GRCm39)	S227F	probably damaging	Het
Gli2	T	C	1: 118,765,667 (GRCm39)	H828R	possibly damaging	Het
Gpr108	A	G	17: 57,544,219 (GRCm39)	V397A	probably damaging	Het
Lrba	T	C	3: 86,526,865 (GRCm39)	I2241T	probably damaging	Het
Map3k21	G	A	8: 126,668,471 (GRCm39)	V686M	probably benign	Het
Nfatc4	A	T	14: 56,070,088 (GRCm39)	E752V	probably damaging	Het
R3hdm1	G	A	1: 128,159,142 (GRCm39)	R939H	probably benign	Het
Rnf213	A	G	11: 119,326,809 (GRCm39)	T1599A	probably benign	Het
Sft2d1rt	G	A	11: 45,942,781 (GRCm39)	A114V	possibly damaging	Het
Slc3a1	T	C	17: 85,336,077 (GRCm39)	F73S	possibly damaging	Het
Sppl3	TGG	TG	5: 115,226,352 (GRCm39)		probably null	Het
Stx1b	T	C	7: 127,410,098 (GRCm39)		probably null	Het
Tnc	C	T	4: 63,932,231 (GRCm39)	V728M	probably damaging	Het
Trim24	C	T	6: 37,892,228 (GRCm39)	H254Y	probably damaging	Het
Ttbk2	A	G	2: 120,637,332 (GRCm39)	L42P	probably damaging	Het
Zfp174	T	A	16: 3,667,321 (GRCm39)	I170N	probably benign	Het
Zfp455	T	A	13: 67,346,655 (GRCm39)	L22Q	probably damaging	Het

Other mutations in Vmn2r53

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01090:Vmn2r53	APN	7	12,334,835 (GRCm39)	missense	possibly damaging	0.70
IGL01997:Vmn2r53	APN	7	12,316,373 (GRCm39)	missense	possibly damaging	0.54
IGL02442:Vmn2r53	APN	7	12,315,656 (GRCm39)	missense	probably damaging	1.00
IGL02449:Vmn2r53	APN	7	12,316,288 (GRCm39)	missense	probably damaging	1.00
IGL02589:Vmn2r53	APN	7	12,315,872 (GRCm39)	missense	possibly damaging	0.93
IGL02986:Vmn2r53	APN	7	12,315,393 (GRCm39)	unclassified	probably benign
IGL03064:Vmn2r53	APN	7	12,334,937 (GRCm39)	missense	possibly damaging	0.89
IGL03093:Vmn2r53	APN	7	12,334,791 (GRCm39)	missense	probably benign	0.03
IGL03244:Vmn2r53	APN	7	12,340,435 (GRCm39)	missense	probably damaging	1.00
IGL03252:Vmn2r53	APN	7	12,340,318 (GRCm39)	missense	probably damaging	1.00
IGL03264:Vmn2r53	APN	7	12,315,819 (GRCm39)	missense	possibly damaging	0.95
IGL03293:Vmn2r53	APN	7	12,332,349 (GRCm39)	missense	probably benign	0.34
R0109:Vmn2r53	UTSW	7	12,315,993 (GRCm39)	missense	probably damaging	1.00
R0453:Vmn2r53	UTSW	7	12,316,338 (GRCm39)	missense	probably damaging	1.00
R0735:Vmn2r53	UTSW	7	12,315,707 (GRCm39)	missense	probably benign
R0881:Vmn2r53	UTSW	7	12,334,859 (GRCm39)	missense	probably benign	0.01
R0894:Vmn2r53	UTSW	7	12,335,141 (GRCm39)	missense	probably benign	0.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0974:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0990:Vmn2r53	UTSW	7	12,315,429 (GRCm39)	missense	probably benign
R1102:Vmn2r53	UTSW	7	12,332,410 (GRCm39)	missense	possibly damaging	0.94
R1263:Vmn2r53	UTSW	7	12,315,533 (GRCm39)	missense	probably benign	0.41
R1343:Vmn2r53	UTSW	7	12,318,701 (GRCm39)	missense	probably benign	0.08
R1750:Vmn2r53	UTSW	7	12,315,632 (GRCm39)	missense	probably damaging	1.00
R1836:Vmn2r53	UTSW	7	12,334,812 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r53	UTSW	7	12,332,438 (GRCm39)	missense	possibly damaging	0.76
R2202:Vmn2r53	UTSW	7	12,335,366 (GRCm39)	missense	probably damaging	1.00
R3707:Vmn2r53	UTSW	7	12,315,981 (GRCm39)	missense	possibly damaging	0.95
R4372:Vmn2r53	UTSW	7	12,315,656 (GRCm39)	missense	probably damaging	0.98
R4615:Vmn2r53	UTSW	7	12,316,229 (GRCm39)	missense	probably damaging	1.00
R4655:Vmn2r53	UTSW	7	12,315,932 (GRCm39)	missense	possibly damaging	0.83
R4663:Vmn2r53	UTSW	7	12,334,901 (GRCm39)	missense	probably benign	0.21
R4708:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4710:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4774:Vmn2r53	UTSW	7	12,334,692 (GRCm39)	nonsense	probably null
R4859:Vmn2r53	UTSW	7	12,335,330 (GRCm39)	missense	probably damaging	1.00
R5061:Vmn2r53	UTSW	7	12,315,741 (GRCm39)	missense	probably benign	0.01
R5561:Vmn2r53	UTSW	7	12,335,347 (GRCm39)	missense	probably damaging	1.00
R5729:Vmn2r53	UTSW	7	12,334,733 (GRCm39)	missense	probably damaging	1.00
R6004:Vmn2r53	UTSW	7	12,316,328 (GRCm39)	missense	probably benign	0.12
R6083:Vmn2r53	UTSW	7	12,315,808 (GRCm39)	missense	probably benign
R6312:Vmn2r53	UTSW	7	12,332,566 (GRCm39)	critical splice acceptor site	probably null
R6700:Vmn2r53	UTSW	7	12,315,633 (GRCm39)	missense	probably damaging	0.96
R6783:Vmn2r53	UTSW	7	12,335,360 (GRCm39)	missense	probably damaging	1.00
R6852:Vmn2r53	UTSW	7	12,340,441 (GRCm39)	missense	probably damaging	0.99
R6889:Vmn2r53	UTSW	7	12,335,069 (GRCm39)	missense	probably benign	0.10
R6940:Vmn2r53	UTSW	7	12,316,343 (GRCm39)	missense	probably benign	0.19
R7100:Vmn2r53	UTSW	7	12,315,513 (GRCm39)	nonsense	probably null
R7174:Vmn2r53	UTSW	7	12,315,628 (GRCm39)	missense	probably benign	0.01
R7213:Vmn2r53	UTSW	7	12,334,983 (GRCm39)	missense	probably benign	0.17
R7276:Vmn2r53	UTSW	7	12,340,359 (GRCm39)	missense	probably damaging	0.99
R7515:Vmn2r53	UTSW	7	12,315,846 (GRCm39)	missense	probably benign	0.05
R7678:Vmn2r53	UTSW	7	12,332,425 (GRCm39)	missense	probably benign	0.04
R7714:Vmn2r53	UTSW	7	12,340,418 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r53	UTSW	7	12,316,026 (GRCm39)	missense	probably damaging	1.00
R8208:Vmn2r53	UTSW	7	12,335,322 (GRCm39)	missense	probably damaging	1.00
R8211:Vmn2r53	UTSW	7	12,315,843 (GRCm39)	missense	probably benign	0.01
R8478:Vmn2r53	UTSW	7	12,340,281 (GRCm39)	missense	probably benign	0.01
R8853:Vmn2r53	UTSW	7	12,315,737 (GRCm39)	missense	probably damaging	1.00
R8924:Vmn2r53	UTSW	7	12,334,752 (GRCm39)	missense	probably benign	0.17
R8963:Vmn2r53	UTSW	7	12,315,926 (GRCm39)	missense	probably damaging	1.00
R9042:Vmn2r53	UTSW	7	12,315,435 (GRCm39)	missense	probably benign
R9076:Vmn2r53	UTSW	7	12,340,231 (GRCm39)	missense	probably damaging	1.00
R9407:Vmn2r53	UTSW	7	12,335,124 (GRCm39)	missense	probably damaging	0.99
R9690:Vmn2r53	UTSW	7	12,315,912 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r53	UTSW	7	12,335,231 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

Posted On

2014-01-15