Incidental Mutation 'R1141:Zfp455'
| ID |
102121 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp455
|
| Ensembl Gene |
ENSMUSG00000051037 |
| Gene Name |
zinc finger protein 455 |
| Synonyms |
Rslcan-10, 3732412P20Rik |
| MMRRC Submission |
039214-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.356)
|
| Stock # |
R1141 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
67342570-67357362 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 67346655 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 22
(L22Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112546
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117110]
[ENSMUST00000120861]
|
| AlphaFold |
Q7M6X9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117110
|
| SMART Domains |
Protein: ENSMUSP00000113356
Gene: ENSMUSG00000051037
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
44 |
66 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
72 |
94 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
100 |
122 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
128 |
150 |
6.23e-2 |
SMART |
|
ZnF_C2H2
|
184 |
206 |
1.01e-1 |
SMART |
|
ZnF_C2H2
|
212 |
234 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
240 |
262 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
268 |
290 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
296 |
318 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
324 |
346 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
352 |
374 |
7.9e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120861
AA Change: L22Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112546
Gene: ENSMUSG00000051037
AA Change: L22Q
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
1.92e-34 |
SMART |
|
ZnF_C2H2
|
109 |
131 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
137 |
159 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
165 |
187 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
193 |
215 |
6.23e-2 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
1.01e-1 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
7.9e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.0%
- 10x: 94.1%
- 20x: 84.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aak1 |
G |
A |
6: 86,942,458 (GRCm39) |
|
probably null |
Het |
| Asap2 |
A |
G |
12: 21,235,111 (GRCm39) |
N71S |
probably damaging |
Het |
| Brinp1 |
T |
C |
4: 68,711,215 (GRCm39) |
H331R |
probably benign |
Het |
| Brinp2 |
C |
A |
1: 158,074,840 (GRCm39) |
C427F |
probably damaging |
Het |
| Ccr6 |
A |
G |
17: 8,474,834 (GRCm39) |
Y13C |
probably damaging |
Het |
| Celf4 |
T |
C |
18: 25,637,961 (GRCm39) |
D187G |
probably damaging |
Het |
| Clcn6 |
T |
G |
4: 148,098,356 (GRCm39) |
T556P |
probably damaging |
Het |
| Dst |
A |
T |
1: 34,227,777 (GRCm39) |
Q1968L |
possibly damaging |
Het |
| Elavl4 |
G |
A |
4: 110,108,565 (GRCm39) |
Q53* |
probably null |
Het |
| Fbxw15 |
G |
A |
9: 109,387,314 (GRCm39) |
S227F |
probably damaging |
Het |
| Gli2 |
T |
C |
1: 118,765,667 (GRCm39) |
H828R |
possibly damaging |
Het |
| Gpr108 |
A |
G |
17: 57,544,219 (GRCm39) |
V397A |
probably damaging |
Het |
| Lrba |
T |
C |
3: 86,526,865 (GRCm39) |
I2241T |
probably damaging |
Het |
| Map3k21 |
G |
A |
8: 126,668,471 (GRCm39) |
V686M |
probably benign |
Het |
| Nfatc4 |
A |
T |
14: 56,070,088 (GRCm39) |
E752V |
probably damaging |
Het |
| R3hdm1 |
G |
A |
1: 128,159,142 (GRCm39) |
R939H |
probably benign |
Het |
| Rnf213 |
A |
G |
11: 119,326,809 (GRCm39) |
T1599A |
probably benign |
Het |
| Sft2d1rt |
G |
A |
11: 45,942,781 (GRCm39) |
A114V |
possibly damaging |
Het |
| Slc3a1 |
T |
C |
17: 85,336,077 (GRCm39) |
F73S |
possibly damaging |
Het |
| Sppl3 |
TGG |
TG |
5: 115,226,352 (GRCm39) |
|
probably null |
Het |
| Stx1b |
T |
C |
7: 127,410,098 (GRCm39) |
|
probably null |
Het |
| Tnc |
C |
T |
4: 63,932,231 (GRCm39) |
V728M |
probably damaging |
Het |
| Trim24 |
C |
T |
6: 37,892,228 (GRCm39) |
H254Y |
probably damaging |
Het |
| Ttbk2 |
A |
G |
2: 120,637,332 (GRCm39) |
L42P |
probably damaging |
Het |
| Vmn2r53 |
G |
A |
7: 12,334,673 (GRCm39) |
T329I |
possibly damaging |
Het |
| Zfp174 |
T |
A |
16: 3,667,321 (GRCm39) |
I170N |
probably benign |
Het |
|
| Other mutations in Zfp455 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00743:Zfp455
|
APN |
13 |
67,355,962 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL03111:Zfp455
|
APN |
13 |
67,356,063 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03210:Zfp455
|
APN |
13 |
67,355,113 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03371:Zfp455
|
APN |
13 |
67,355,066 (GRCm39) |
nonsense |
probably null |
|
|
PIT4504001:Zfp455
|
UTSW |
13 |
67,346,685 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0245:Zfp455
|
UTSW |
13 |
67,355,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0277:Zfp455
|
UTSW |
13 |
67,346,728 (GRCm39) |
splice site |
probably null |
|
|
R1266:Zfp455
|
UTSW |
13 |
67,355,028 (GRCm39) |
nonsense |
probably null |
|
|
R1657:Zfp455
|
UTSW |
13 |
67,346,703 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1749:Zfp455
|
UTSW |
13 |
67,355,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1757:Zfp455
|
UTSW |
13 |
67,355,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Zfp455
|
UTSW |
13 |
67,355,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1867:Zfp455
|
UTSW |
13 |
67,355,509 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4411:Zfp455
|
UTSW |
13 |
67,355,389 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6060:Zfp455
|
UTSW |
13 |
67,355,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6544:Zfp455
|
UTSW |
13 |
67,355,121 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7132:Zfp455
|
UTSW |
13 |
67,347,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7524:Zfp455
|
UTSW |
13 |
67,355,688 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7966:Zfp455
|
UTSW |
13 |
67,347,302 (GRCm39) |
missense |
probably benign |
|
|
R8848:Zfp455
|
UTSW |
13 |
67,356,089 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8994:Zfp455
|
UTSW |
13 |
67,355,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zfp455
|
UTSW |
13 |
67,355,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2014-01-15 |
Incidental Mutation