Mutagenetix > Incidental Mutation

Incidental Mutation 'R1186:Olfr901'

102137

Institutional Source

Beutler Lab

Gene Symbol

Olfr901

Ensembl Gene

ENSMUSG00000052058

Gene Name

olfactory receptor 901

Synonyms

GA_x6K02T2PVTD-32123032-32123967, MOR162-8

MMRRC Submission

039258-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R1186 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

38429455-38432682 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 38431101 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 273 (V273A)

Ref Sequence

ENSEMBL: ENSMUSP00000150506 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063716] [ENSMUST00000216502] [ENSMUST00000216644]

AlphaFold

Q7TRD1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000063716
AA Change: V273A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000066714
Gene: ENSMUSG00000052058
AA Change: V273A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	308	4.2e-47	PFAM
Pfam:7tm_1	42	290	3.2e-23	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216502
AA Change: V273A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216644
AA Change: V273A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.5%
3x: 98.5%
10x: 95.7%
20x: 90.1%

Validation Efficiency

97% (69/71)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700020N01Rik	G	A	10: 21,621,652	R64Q	probably benign	Het
4932438A13Rik	T	C	3: 36,996,312		probably benign	Het
9530068E07Rik	G	A	11: 52,403,078	V49I	probably benign	Het
A2m	T	C	6: 121,661,534	S902P	probably benign	Het
Aatf	A	T	11: 84,470,549		probably benign	Het
Adamtsl1	A	G	4: 86,388,509	T1395A	probably benign	Het
Alpk2	T	C	18: 65,294,341		probably null	Het
Ank3	G	T	10: 69,867,460	A308S	probably damaging	Het
Arap1	A	G	7: 101,404,269		probably benign	Het
C4b	T	C	17: 34,736,309	D769G	possibly damaging	Het
Cep350	A	G	1: 155,875,376	S2017P	probably damaging	Het
Cfap54	T	A	10: 92,875,994	I2704F	unknown	Het
Crip2	G	A	12: 113,144,959		probably benign	Het
Cyp4f14	T	C	17: 32,916,786	I34V	probably benign	Het
Dcstamp	A	G	15: 39,754,629		probably null	Het
Ddx5	T	C	11: 106,783,979		probably null	Het
Dnah2	A	T	11: 69,515,700	L572Q	probably damaging	Het
Espl1	G	A	15: 102,304,039	A527T	probably benign	Het
Fam83d	A	G	2: 158,785,174	D261G	probably damaging	Het
Fbxo34	T	C	14: 47,530,586	F468L	probably damaging	Het
Gabarapl1	A	T	6: 129,533,405		probably benign	Het
Galnt17	G	T	5: 131,111,742	T179K	probably damaging	Het
Gm6768	A	C	12: 119,261,471		noncoding transcript	Het
Gm6899	C	T	11: 26,593,685		probably benign	Het
Helz2	T	A	2: 181,231,128	R2433W	probably damaging	Het
Hivep3	T	C	4: 119,814,723		probably benign	Het
Hsh2d	G	A	8: 72,200,460	D229N	probably benign	Het
Ica1	A	G	6: 8,672,326	L225P	probably damaging	Het
Inpp5f	T	C	7: 128,694,583	I195T	probably benign	Het
Isyna1	C	A	8: 70,595,201	N115K	probably benign	Het
Ly6g6e	T	C	17: 35,078,008	F75S	probably benign	Het
Ly96	A	G	1: 16,700,894	D101G	possibly damaging	Het
Mapk9	A	G	11: 49,878,269	T243A	probably damaging	Het
Mcc	A	G	18: 44,759,403	V48A	probably benign	Het
Mcpt2	C	T	14: 56,043,945		probably benign	Het
Med24	T	C	11: 98,717,757		probably benign	Het
Mtbp	G	A	15: 55,564,671	G162S	probably null	Het
Mtfr2	G	A	10: 20,352,852	C48Y	probably benign	Het
Naip2	C	T	13: 100,161,981	A516T	possibly damaging	Het
Naip2	AGGG	AGG	13: 100,162,037		probably null	Het
Nup107	A	C	10: 117,777,146	Y292*	probably null	Het
Nwd2	C	T	5: 63,650,024		probably benign	Het
Nxpe4	A	C	9: 48,393,392	N260H	probably benign	Het
Ofcc1	C	T	13: 40,208,829	G206R	probably benign	Het
Olfr1084	A	T	2: 86,639,463	L82M	probably damaging	Het
Olfr5	T	C	7: 6,480,542	I205V	probably benign	Het
Olfr911-ps1	T	C	9: 38,524,157	S142P	probably damaging	Het
P2rx7	T	C	5: 122,670,451	Y299H	probably damaging	Het
Per3	T	A	4: 151,026,138	E401V	probably damaging	Het
Rbm34	C	A	8: 126,965,447	E182*	probably null	Het
Sdk2	C	T	11: 113,838,646		silent	Het
Senp2	T	C	16: 22,011,504	S38P	probably damaging	Het
Slc36a2	A	T	11: 55,164,231		probably null	Het
Spred1	A	T	2: 117,177,697	R361S	possibly damaging	Het
Spry2	A	G	14: 105,892,907	C282R	probably damaging	Het
Srp54b	T	C	12: 55,255,528		probably benign	Het
Taar8c	G	C	10: 24,101,565	Y116*	probably null	Het
Tchh	C	G	3: 93,448,046	R1598G	unknown	Het
Tex15	A	G	8: 33,571,633	M364V	probably benign	Het
Ttbk1	T	C	17: 46,467,131	R662G	probably damaging	Het
Ttc5	G	A	14: 50,767,226	Q374*	probably null	Het
Usp46	C	T	5: 74,002,122	A312T	probably benign	Het
Vmn1r176	A	T	7: 23,835,626	L34Q	probably damaging	Het
Vmn1r178	A	T	7: 23,893,892	R122*	probably null	Het
Vmn2r6	T	A	3: 64,565,067	M78L	probably benign	Het
Zfp407	A	T	18: 84,209,448	I2012N	probably benign	Het
Zfp980	G	A	4: 145,702,083	G461S	probably benign	Het
Zfyve26	G	A	12: 79,263,949	L161F	probably damaging	Het

Other mutations in Olfr901

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01095:Olfr901	APN	9	38430515	missense	probably benign	0.20
IGL01875:Olfr901	APN	9	38430298	missense	probably damaging	1.00
R0010:Olfr901	UTSW	9	38430920	missense	possibly damaging	0.70
R1259:Olfr901	UTSW	9	38430873	missense	probably damaging	0.99
R1273:Olfr901	UTSW	9	38430684	missense	probably benign	0.05
R1475:Olfr901	UTSW	9	38430864	missense	probably benign	0.30
R1530:Olfr901	UTSW	9	38430324	missense	probably damaging	0.97
R1591:Olfr901	UTSW	9	38430411	missense	probably damaging	1.00
R1750:Olfr901	UTSW	9	38430690	missense	probably damaging	1.00
R1756:Olfr901	UTSW	9	38430995	missense	probably benign
R2080:Olfr901	UTSW	9	38431082	missense	probably benign	0.01
R3081:Olfr901	UTSW	9	38431056	missense	possibly damaging	0.82
R4174:Olfr901	UTSW	9	38431020	missense	probably damaging	0.97
R4299:Olfr901	UTSW	9	38430812	missense	probably damaging	1.00
R4898:Olfr901	UTSW	9	38430815	missense	probably benign	0.01
R5068:Olfr901	UTSW	9	38430464	missense	probably damaging	1.00
R5695:Olfr901	UTSW	9	38431176	missense	probably benign	0.01
R5973:Olfr901	UTSW	9	38430331	missense	probably damaging	0.99
R6929:Olfr901	UTSW	9	38431148	missense	probably benign	0.22
R8265:Olfr901	UTSW	9	38431173	missense	probably damaging	0.99
R8321:Olfr901	UTSW	9	38430554	missense	probably damaging	0.97
R9425:Olfr901	UTSW	9	38430990	missense	possibly damaging	0.60

Predicted Primers

PCR Primer
(F):5'- TCCTGCACAAACACCTCTGTCAATG -3'
(R):5'- TTCCAAGAGTCAGGTGGCTGAGAC -3'

Sequencing Primer
(F):5'- ACACCTCTGTCAATGAGCTGG -3'
(R):5'- CACAGTGGCTTAATCTGTGAACG -3'

Posted On

2014-01-15