Mutagenetix > Incidental Mutation

Incidental Mutation 'R1142:F830045P16Rik'

102143

Institutional Source

Beutler Lab

Gene Symbol

F830045P16Rik

Ensembl Gene

ENSMUSG00000043727

Gene Name

RIKEN cDNA F830045P16 gene

Synonyms

Sirpb3

MMRRC Submission

039215-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R1142 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

129300279-129378522 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 129302252 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 447 (K447*)

Ref Sequence

ENSEMBL: ENSMUSP00000058047 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050309]

AlphaFold

Q8BJ95

Predicted Effect

probably null
Transcript: ENSMUST00000050309
AA Change: K447*

SMART Domains

Protein: ENSMUSP00000058047
Gene: ENSMUSG00000043727
AA Change: K447*

Domain	Start	End	E-Value	Type
IG_like	51	123	7.95e-2	SMART
IGc1	156	227	5.66e-4	SMART
Pfam:C2-set_2	264	331	1.6e-6	PFAM
IGc1	359	432	2.28e-7	SMART
transmembrane domain	460	482	N/A	INTRINSIC

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh18a1	A	G	19: 40,539,657 (GRCm39)	S773P	probably damaging	Het
Alx3	T	C	3: 107,507,980 (GRCm39)	F163S	possibly damaging	Het
Apobr	A	G	7: 126,186,654 (GRCm39)	M722V	probably benign	Het
Col6a5	A	G	9: 105,811,516 (GRCm39)	S668P	unknown	Het
Cxadr	A	G	16: 78,131,727 (GRCm39)	T238A	probably benign	Het
Dph6	A	G	2: 114,478,260 (GRCm39)	I27T	probably damaging	Het
Ephx3	G	A	17: 32,404,248 (GRCm39)	H324Y	probably benign	Het
Gjb3	G	A	4: 127,220,224 (GRCm39)	R103W	probably damaging	Het
Hsp90ab1	C	A	17: 45,879,900 (GRCm39)	E539*	probably null	Het
Jmjd1c	T	C	10: 67,061,124 (GRCm39)	L1159P	probably damaging	Het
Lamc3	T	C	2: 31,830,733 (GRCm39)	I1490T	probably damaging	Het
Met	T	A	6: 17,527,182 (GRCm39)	C544*	probably null	Het
Pdlim3	C	A	8: 46,371,998 (GRCm39)	R348S	probably damaging	Het
Phkg1	A	G	5: 129,902,073 (GRCm39)	F101L	possibly damaging	Het
Polq	A	G	16: 36,833,579 (GRCm39)	M91V	probably damaging	Het
Slc38a9	T	C	13: 112,850,744 (GRCm39)	I376T	probably damaging	Het
Tnc	C	T	4: 63,932,231 (GRCm39)	V728M	probably damaging	Het
Vmn1r85	T	C	7: 12,818,481 (GRCm39)	N221S	probably benign	Het
Vmn2r91	T	A	17: 18,356,705 (GRCm39)	W791R	probably damaging	Het
Zc3h13	T	C	14: 75,553,424 (GRCm39)	Y284H	probably benign	Het

Other mutations in F830045P16Rik

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00339:F830045P16Rik	APN	2	129,302,449 (GRCm39)	missense	probably damaging	0.97
IGL01149:F830045P16Rik	APN	2	129,302,232 (GRCm39)	critical splice donor site	probably null
IGL01556:F830045P16Rik	APN	2	129,305,640 (GRCm39)	missense	probably benign	0.01
IGL01690:F830045P16Rik	APN	2	129,314,614 (GRCm39)	missense	probably damaging	1.00
IGL02169:F830045P16Rik	APN	2	129,305,492 (GRCm39)	missense	probably damaging	1.00
IGL03194:F830045P16Rik	APN	2	129,302,240 (GRCm39)	missense	possibly damaging	0.91
IGL03231:F830045P16Rik	APN	2	129,302,393 (GRCm39)	missense	probably damaging	1.00
R0062:F830045P16Rik	UTSW	2	129,305,624 (GRCm39)	missense	possibly damaging	0.94
R0062:F830045P16Rik	UTSW	2	129,305,624 (GRCm39)	missense	possibly damaging	0.94
R0234:F830045P16Rik	UTSW	2	129,305,384 (GRCm39)	missense	possibly damaging	0.85
R0234:F830045P16Rik	UTSW	2	129,305,384 (GRCm39)	missense	possibly damaging	0.85
R0333:F830045P16Rik	UTSW	2	129,314,777 (GRCm39)	missense	probably damaging	0.96
R0479:F830045P16Rik	UTSW	2	129,314,608 (GRCm39)	missense	possibly damaging	0.86
R0550:F830045P16Rik	UTSW	2	129,305,429 (GRCm39)	missense	probably damaging	1.00
R0827:F830045P16Rik	UTSW	2	129,314,696 (GRCm39)	missense	probably benign	0.01
R1087:F830045P16Rik	UTSW	2	129,314,639 (GRCm39)	missense	possibly damaging	0.55
R1642:F830045P16Rik	UTSW	2	129,305,634 (GRCm39)	missense	probably benign	0.00
R2022:F830045P16Rik	UTSW	2	129,314,585 (GRCm39)	missense	probably damaging	1.00
R2044:F830045P16Rik	UTSW	2	129,301,317 (GRCm39)	missense	possibly damaging	0.68
R4008:F830045P16Rik	UTSW	2	129,305,467 (GRCm39)	missense	probably damaging	1.00
R4009:F830045P16Rik	UTSW	2	129,305,467 (GRCm39)	missense	probably damaging	1.00
R4011:F830045P16Rik	UTSW	2	129,305,467 (GRCm39)	missense	probably damaging	1.00
R4212:F830045P16Rik	UTSW	2	129,302,273 (GRCm39)	missense	probably benign	0.00
R4579:F830045P16Rik	UTSW	2	129,305,423 (GRCm39)	missense	probably damaging	0.97
R4838:F830045P16Rik	UTSW	2	129,302,470 (GRCm39)	missense	possibly damaging	0.95
R5190:F830045P16Rik	UTSW	2	129,314,635 (GRCm39)	missense	probably benign	0.01
R5217:F830045P16Rik	UTSW	2	129,305,493 (GRCm39)	missense	probably damaging	1.00
R5297:F830045P16Rik	UTSW	2	129,302,473 (GRCm39)	missense	probably benign	0.10
R5352:F830045P16Rik	UTSW	2	129,314,821 (GRCm39)	missense	probably damaging	0.98
R6063:F830045P16Rik	UTSW	2	129,316,310 (GRCm39)	missense	probably damaging	1.00
R6072:F830045P16Rik	UTSW	2	129,314,614 (GRCm39)	missense	probably damaging	1.00
R6173:F830045P16Rik	UTSW	2	129,305,588 (GRCm39)	missense	probably damaging	1.00
R6383:F830045P16Rik	UTSW	2	129,378,358 (GRCm39)	missense	probably benign	0.04
R6386:F830045P16Rik	UTSW	2	129,314,738 (GRCm39)	missense	probably damaging	1.00
R6425:F830045P16Rik	UTSW	2	129,302,500 (GRCm39)	missense	probably damaging	1.00
R6699:F830045P16Rik	UTSW	2	129,302,341 (GRCm39)	missense	probably damaging	0.98
R6869:F830045P16Rik	UTSW	2	129,316,481 (GRCm39)	missense	probably damaging	0.99
R7751:F830045P16Rik	UTSW	2	129,302,367 (GRCm39)	missense	probably damaging	1.00
R8012:F830045P16Rik	UTSW	2	129,316,352 (GRCm39)	missense	possibly damaging	0.92
R8097:F830045P16Rik	UTSW	2	129,305,505 (GRCm39)	missense	possibly damaging	0.55
R8982:F830045P16Rik	UTSW	2	129,314,812 (GRCm39)	missense	probably damaging	0.98
R9143:F830045P16Rik	UTSW	2	129,316,502 (GRCm39)	missense	probably benign	0.00
R9179:F830045P16Rik	UTSW	2	129,314,708 (GRCm39)	missense	probably benign
R9280:F830045P16Rik	UTSW	2	129,314,774 (GRCm39)	missense	probably damaging	1.00
Z1176:F830045P16Rik	UTSW	2	129,378,450 (GRCm39)	start gained	probably benign

Predicted Primers

Posted On

2014-01-15