Incidental Mutation 'R1142:Vmn1r85'
ID102159
Institutional Source Beutler Lab
Gene Symbol Vmn1r85
Ensembl Gene ENSMUSG00000070817
Gene Namevomeronasal 1 receptor 85
SynonymsV1rj3
MMRRC Submission 039215-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #R1142 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location13084289-13087197 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 13084554 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 221 (N221S)
Ref Sequence ENSEMBL: ENSMUSP00000148178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094829] [ENSMUST00000209822]
Predicted Effect probably benign
Transcript: ENSMUST00000094829
AA Change: N221S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000092424
Gene: ENSMUSG00000070817
AA Change: N221S

DomainStartEndE-ValueType
Pfam:TAS2R 1 296 8.4e-18 PFAM
Pfam:V1R 24 298 2.5e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209822
AA Change: N221S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh18a1 A G 19: 40,551,213 S773P probably damaging Het
Alx3 T C 3: 107,600,664 F163S possibly damaging Het
Apobr A G 7: 126,587,482 M722V probably benign Het
Col6a5 A G 9: 105,934,317 S668P unknown Het
Cxadr A G 16: 78,334,839 T238A probably benign Het
Dph6 A G 2: 114,647,779 I27T probably damaging Het
Ephx3 G A 17: 32,185,274 H324Y probably benign Het
F830045P16Rik T A 2: 129,460,332 K447* probably null Het
Gjb3 G A 4: 127,326,431 R103W probably damaging Het
Hsp90ab1 C A 17: 45,568,974 E539* probably null Het
Jmjd1c T C 10: 67,225,345 L1159P probably damaging Het
Lamc3 T C 2: 31,940,721 I1490T probably damaging Het
Met T A 6: 17,527,183 C544* probably null Het
Pdlim3 C A 8: 45,918,961 R348S probably damaging Het
Phkg1 A G 5: 129,873,232 F101L possibly damaging Het
Polq A G 16: 37,013,217 M91V probably damaging Het
Slc38a9 T C 13: 112,714,210 I376T probably damaging Het
Tnc C T 4: 64,013,994 V728M probably damaging Het
Vmn2r91 T A 17: 18,136,443 W791R probably damaging Het
Zc3h13 T C 14: 75,315,984 Y284H probably benign Het
Other mutations in Vmn1r85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Vmn1r85 APN 7 13084534 nonsense probably null
IGL01520:Vmn1r85 APN 7 13085154 missense probably damaging 1.00
IGL01803:Vmn1r85 APN 7 13084569 missense probably damaging 0.98
IGL02285:Vmn1r85 APN 7 13084784 missense probably damaging 1.00
IGL02852:Vmn1r85 APN 7 13085083 missense possibly damaging 0.70
IGL03012:Vmn1r85 APN 7 13084765 missense probably benign 0.01
R0391:Vmn1r85 UTSW 7 13084588 missense probably benign 0.01
R0655:Vmn1r85 UTSW 7 13084723 missense probably damaging 1.00
R1452:Vmn1r85 UTSW 7 13084881 missense probably damaging 1.00
R1942:Vmn1r85 UTSW 7 13084741 missense possibly damaging 0.83
R3760:Vmn1r85 UTSW 7 13085005 missense probably damaging 0.96
R4783:Vmn1r85 UTSW 7 13084861 missense probably damaging 1.00
R4785:Vmn1r85 UTSW 7 13084861 missense probably damaging 1.00
R5373:Vmn1r85 UTSW 7 13084328 nonsense probably null
R6021:Vmn1r85 UTSW 7 13084689 missense probably benign 0.00
R6035:Vmn1r85 UTSW 7 13084927 missense probably damaging 1.00
R6035:Vmn1r85 UTSW 7 13084927 missense probably damaging 1.00
R6834:Vmn1r85 UTSW 7 13084644 missense probably damaging 1.00
R7340:Vmn1r85 UTSW 7 13085146 missense probably damaging 1.00
R7346:Vmn1r85 UTSW 7 13085037 missense probably damaging 0.99
R7836:Vmn1r85 UTSW 7 13084771 missense probably benign 0.06
R7896:Vmn1r85 UTSW 7 13084521 missense probably benign 0.22
R7919:Vmn1r85 UTSW 7 13084771 missense probably benign 0.06
R7979:Vmn1r85 UTSW 7 13084521 missense probably benign 0.22
Predicted Primers
Posted On2014-01-15