Incidental Mutation 'R1143:Apob'
ID | 102213 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Apob
|
Ensembl Gene |
ENSMUSG00000020609 |
Gene Name | apolipoprotein B |
Synonyms | apob-100, apob-48 |
MMRRC Submission |
039216-MU
|
Accession Numbers | |
Is this an essential gene? |
Probably essential (E-score: 0.917)
|
Stock # | R1143 (G1)
|
Quality Score | 225 |
Status |
Not validated
|
Chromosome | 12 |
Chromosomal Location | 7977648-8016835 bp(+) (GRCm38) |
Type of Mutation | missense |
DNA Base Change (assembly) |
A to C
at 8012354 bp
|
Zygosity | Heterozygous |
Amino Acid Change |
Aspartic acid to Alanine
at position 3612
(D3612A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000036044
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037520]
[ENSMUST00000037811]
[ENSMUST00000171239]
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000037520
AA Change: D3579A
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
SMART Domains |
Protein: ENSMUSP00000035761 Gene: ENSMUSG00000020609 AA Change: D3579A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
LPD_N
|
33 |
585 |
6.03e-94 |
SMART |
DUF1943
|
619 |
932 |
7.88e-97 |
SMART |
Pfam:DUF1081
|
945 |
1059 |
9.4e-32 |
PFAM |
low complexity region
|
1100 |
1109 |
N/A |
INTRINSIC |
Blast:LPD_N
|
1249 |
1311 |
9e-22 |
BLAST |
low complexity region
|
1632 |
1644 |
N/A |
INTRINSIC |
internal_repeat_1
|
1882 |
2038 |
6.61e-9 |
PROSPERO |
SCOP:d1gw5a_
|
2105 |
2577 |
9e-5 |
SMART |
internal_repeat_1
|
2973 |
3150 |
6.61e-9 |
PROSPERO |
low complexity region
|
3561 |
3580 |
N/A |
INTRINSIC |
low complexity region
|
3928 |
3936 |
N/A |
INTRINSIC |
Pfam:ApoB100_C
|
4401 |
4456 |
5.6e-34 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000037811
AA Change: D3612A
PolyPhen 2
Score 0.265 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000036044 Gene: ENSMUSG00000020609 AA Change: D3612A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
LPD_N
|
46 |
598 |
6.03e-94 |
SMART |
DUF1943
|
632 |
945 |
7.88e-97 |
SMART |
Pfam:DUF1081
|
960 |
1070 |
6.3e-39 |
PFAM |
low complexity region
|
1113 |
1122 |
N/A |
INTRINSIC |
Blast:LPD_N
|
1282 |
1344 |
1e-21 |
BLAST |
low complexity region
|
1665 |
1677 |
N/A |
INTRINSIC |
internal_repeat_1
|
1915 |
2071 |
6.6e-9 |
PROSPERO |
SCOP:d1gw5a_
|
2138 |
2610 |
9e-5 |
SMART |
internal_repeat_1
|
3006 |
3183 |
6.6e-9 |
PROSPERO |
low complexity region
|
3594 |
3613 |
N/A |
INTRINSIC |
low complexity region
|
3961 |
3969 |
N/A |
INTRINSIC |
Pfam:ApoB100_C
|
4434 |
4490 |
1.6e-32 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000171239
|
SMART Domains |
Protein: ENSMUSP00000129496 Gene: ENSMUSG00000020609
Domain | Start | End | E-Value | Type |
low complexity region
|
348 |
356 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.3%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008] PHENOTYPE: Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable. [provided by MGI curators]
|
Allele List at MGI | |
Other mutations in this stock |
Total: 13 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Bcr |
G |
A |
10: 75,061,365 |
E114K |
probably benign |
Het |
Car13 |
A |
G |
3: 14,656,268 |
I164V |
probably benign |
Het |
Dner |
C |
T |
1: 84,445,464 |
A473T |
probably damaging |
Het |
Fbxw15 |
G |
A |
9: 109,558,246 |
S227F |
probably damaging |
Het |
Gm7247 |
T |
C |
14: 51,523,418 |
V148A |
probably benign |
Het |
Htr1a |
T |
C |
13: 105,445,068 |
V272A |
probably benign |
Het |
Lmnb2 |
CGCTGCTGCTGCTGCTGCT |
CGCTGCTGCTGCTGCT |
10: 80,904,315 |
|
probably benign |
Het |
Myh15 |
A |
G |
16: 49,065,086 |
H108R |
probably benign |
Het |
Skint2 |
T |
A |
4: 112,625,936 |
N179K |
probably benign |
Het |
Smarcad1 |
G |
A |
6: 65,096,694 |
R645H |
probably benign |
Het |
Tbc1d5 |
G |
A |
17: 50,742,059 |
Q690* |
probably null |
Het |
Vmn1r28 |
T |
C |
6: 58,265,742 |
V190A |
probably benign |
Het |
Zfhx3 |
T |
A |
8: 108,794,411 |
C722S |
probably damaging |
Het |
|
Other mutations in Apob |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00402:Apob
|
APN |
12 |
7993065 |
splice site |
probably benign |
|
IGL00421:Apob
|
APN |
12 |
8010197 |
missense |
probably damaging |
0.99 |
IGL00658:Apob
|
APN |
12 |
8009471 |
missense |
probably benign |
0.08 |
IGL00768:Apob
|
APN |
12 |
8002107 |
missense |
probably damaging |
1.00 |
IGL00833:Apob
|
APN |
12 |
8010101 |
missense |
probably benign |
0.14 |
IGL00926:Apob
|
APN |
12 |
8015421 |
missense |
probably benign |
0.01 |
IGL01065:Apob
|
APN |
12 |
8003299 |
missense |
probably damaging |
0.99 |
IGL01313:Apob
|
APN |
12 |
8000898 |
missense |
probably damaging |
1.00 |
IGL01419:Apob
|
APN |
12 |
8002251 |
missense |
probably damaging |
0.99 |
IGL01461:Apob
|
APN |
12 |
8001884 |
missense |
probably benign |
0.13 |
IGL02002:Apob
|
APN |
12 |
7994822 |
missense |
probably benign |
0.03 |
IGL02031:Apob
|
APN |
12 |
8015222 |
missense |
probably benign |
|
IGL02102:Apob
|
APN |
12 |
7989407 |
missense |
possibly damaging |
0.94 |
IGL02115:Apob
|
APN |
12 |
7992923 |
missense |
probably benign |
0.06 |
IGL02513:Apob
|
APN |
12 |
7992979 |
missense |
probably benign |
0.01 |
IGL02967:Apob
|
APN |
12 |
8015366 |
nonsense |
probably null |
|
IGL03005:Apob
|
APN |
12 |
7993059 |
splice site |
probably benign |
|
IGL03011:Apob
|
APN |
12 |
7997883 |
missense |
probably damaging |
1.00 |
IGL03116:Apob
|
APN |
12 |
8016350 |
missense |
probably damaging |
0.98 |
IGL03215:Apob
|
APN |
12 |
8013818 |
missense |
possibly damaging |
0.92 |
IGL03227:Apob
|
APN |
12 |
8016089 |
missense |
probably benign |
0.04 |
Aesthete
|
UTSW |
12 |
8010080 |
nonsense |
probably null |
|
Essence
|
UTSW |
12 |
8007769 |
nonsense |
probably null |
|
Ethos
|
UTSW |
12 |
7990394 |
missense |
probably null |
1.00 |
IGL02835:Apob
|
UTSW |
12 |
8015097 |
missense |
possibly damaging |
0.86 |
IGL02837:Apob
|
UTSW |
12 |
8005102 |
missense |
probably damaging |
1.00 |
R0071:Apob
|
UTSW |
12 |
8002111 |
missense |
probably damaging |
0.98 |
R0071:Apob
|
UTSW |
12 |
8002111 |
missense |
probably damaging |
0.98 |
R0116:Apob
|
UTSW |
12 |
7989113 |
unclassified |
probably benign |
|
R0180:Apob
|
UTSW |
12 |
8008285 |
nonsense |
probably null |
|
R0288:Apob
|
UTSW |
12 |
7990779 |
nonsense |
probably null |
|
R0295:Apob
|
UTSW |
12 |
8002181 |
nonsense |
probably null |
|
R0305:Apob
|
UTSW |
12 |
8012210 |
missense |
probably damaging |
1.00 |
R0312:Apob
|
UTSW |
12 |
8009034 |
missense |
probably benign |
|
R0324:Apob
|
UTSW |
12 |
8010521 |
missense |
probably benign |
0.41 |
R0326:Apob
|
UTSW |
12 |
7990307 |
missense |
probably damaging |
1.00 |
R0363:Apob
|
UTSW |
12 |
8010136 |
missense |
probably damaging |
1.00 |
R0390:Apob
|
UTSW |
12 |
7988678 |
missense |
probably damaging |
0.99 |
R0462:Apob
|
UTSW |
12 |
8000896 |
missense |
probably damaging |
1.00 |
R0471:Apob
|
UTSW |
12 |
7990406 |
missense |
probably damaging |
1.00 |
R0532:Apob
|
UTSW |
12 |
8016188 |
missense |
possibly damaging |
0.48 |
R0548:Apob
|
UTSW |
12 |
8006282 |
missense |
probably damaging |
1.00 |
R0560:Apob
|
UTSW |
12 |
8005101 |
missense |
probably damaging |
1.00 |
R0595:Apob
|
UTSW |
12 |
8008369 |
missense |
probably benign |
0.01 |
R0600:Apob
|
UTSW |
12 |
8006440 |
missense |
probably damaging |
1.00 |
R0626:Apob
|
UTSW |
12 |
8016193 |
missense |
probably benign |
0.45 |
R0685:Apob
|
UTSW |
12 |
8010742 |
missense |
probably benign |
|
R0765:Apob
|
UTSW |
12 |
8016518 |
missense |
probably benign |
|
R0790:Apob
|
UTSW |
12 |
8010245 |
missense |
probably damaging |
1.00 |
R0918:Apob
|
UTSW |
12 |
7983941 |
missense |
probably benign |
0.10 |
R0962:Apob
|
UTSW |
12 |
7989191 |
missense |
probably damaging |
0.98 |
R1055:Apob
|
UTSW |
12 |
7994963 |
missense |
probably damaging |
1.00 |
R1077:Apob
|
UTSW |
12 |
8006017 |
missense |
probably benign |
|
R1163:Apob
|
UTSW |
12 |
8011654 |
missense |
probably damaging |
1.00 |
R1266:Apob
|
UTSW |
12 |
8006093 |
missense |
probably benign |
0.37 |
R1434:Apob
|
UTSW |
12 |
8009715 |
missense |
probably damaging |
1.00 |
R1442:Apob
|
UTSW |
12 |
7986165 |
missense |
probably benign |
0.31 |
R1445:Apob
|
UTSW |
12 |
8016084 |
missense |
possibly damaging |
0.48 |
R1459:Apob
|
UTSW |
12 |
8006047 |
missense |
probably benign |
|
R1459:Apob
|
UTSW |
12 |
8011937 |
missense |
possibly damaging |
0.92 |
R1465:Apob
|
UTSW |
12 |
8011421 |
missense |
possibly damaging |
0.91 |
R1465:Apob
|
UTSW |
12 |
8011421 |
missense |
possibly damaging |
0.91 |
R1508:Apob
|
UTSW |
12 |
8011481 |
missense |
possibly damaging |
0.92 |
R1518:Apob
|
UTSW |
12 |
7989207 |
missense |
probably benign |
0.01 |
R1531:Apob
|
UTSW |
12 |
7997880 |
missense |
possibly damaging |
0.65 |
R1547:Apob
|
UTSW |
12 |
8003368 |
missense |
probably benign |
0.08 |
R1574:Apob
|
UTSW |
12 |
7990839 |
missense |
possibly damaging |
0.51 |
R1574:Apob
|
UTSW |
12 |
7990839 |
missense |
possibly damaging |
0.51 |
R1682:Apob
|
UTSW |
12 |
8012365 |
missense |
probably benign |
0.00 |
R1709:Apob
|
UTSW |
12 |
8009306 |
missense |
probably damaging |
0.98 |
R1718:Apob
|
UTSW |
12 |
8016087 |
missense |
probably benign |
0.02 |
R1752:Apob
|
UTSW |
12 |
7988766 |
missense |
probably benign |
0.01 |
R1781:Apob
|
UTSW |
12 |
8009603 |
missense |
possibly damaging |
0.96 |
R1818:Apob
|
UTSW |
12 |
8006834 |
missense |
probably damaging |
0.98 |
R1818:Apob
|
UTSW |
12 |
8013064 |
missense |
possibly damaging |
0.93 |
R1842:Apob
|
UTSW |
12 |
8011559 |
missense |
probably damaging |
1.00 |
R1843:Apob
|
UTSW |
12 |
8007602 |
missense |
possibly damaging |
0.65 |
R1853:Apob
|
UTSW |
12 |
8010928 |
nonsense |
probably null |
|
R1990:Apob
|
UTSW |
12 |
8001039 |
missense |
probably damaging |
1.00 |
R2016:Apob
|
UTSW |
12 |
8007751 |
missense |
possibly damaging |
0.48 |
R2017:Apob
|
UTSW |
12 |
8007751 |
missense |
possibly damaging |
0.48 |
R2023:Apob
|
UTSW |
12 |
8011090 |
missense |
probably benign |
0.01 |
R2037:Apob
|
UTSW |
12 |
8007488 |
missense |
probably benign |
0.37 |
R2054:Apob
|
UTSW |
12 |
8013134 |
missense |
probably damaging |
1.00 |
R2057:Apob
|
UTSW |
12 |
8002164 |
nonsense |
probably null |
|
R2085:Apob
|
UTSW |
12 |
8012240 |
missense |
probably damaging |
1.00 |
R2159:Apob
|
UTSW |
12 |
8010081 |
missense |
probably benign |
0.12 |
R2209:Apob
|
UTSW |
12 |
8007752 |
missense |
probably benign |
0.28 |
R2249:Apob
|
UTSW |
12 |
8007499 |
missense |
probably damaging |
1.00 |
R2254:Apob
|
UTSW |
12 |
8011256 |
missense |
possibly damaging |
0.92 |
R2265:Apob
|
UTSW |
12 |
8015475 |
missense |
possibly damaging |
0.74 |
R2266:Apob
|
UTSW |
12 |
8015475 |
missense |
possibly damaging |
0.74 |
R2267:Apob
|
UTSW |
12 |
8015475 |
missense |
possibly damaging |
0.74 |
R2268:Apob
|
UTSW |
12 |
8015475 |
missense |
possibly damaging |
0.74 |
R2296:Apob
|
UTSW |
12 |
7994879 |
missense |
probably damaging |
0.97 |
R2897:Apob
|
UTSW |
12 |
8010356 |
missense |
probably damaging |
1.00 |
R3431:Apob
|
UTSW |
12 |
8010778 |
missense |
probably damaging |
1.00 |
R3723:Apob
|
UTSW |
12 |
8006327 |
missense |
probably damaging |
1.00 |
R3723:Apob
|
UTSW |
12 |
8011763 |
missense |
possibly damaging |
0.46 |
R3899:Apob
|
UTSW |
12 |
8015849 |
missense |
possibly damaging |
0.87 |
R4020:Apob
|
UTSW |
12 |
7994914 |
nonsense |
probably null |
|
R4050:Apob
|
UTSW |
12 |
8015390 |
missense |
probably benign |
0.02 |
R4351:Apob
|
UTSW |
12 |
7993054 |
missense |
probably benign |
0.03 |
R4365:Apob
|
UTSW |
12 |
8016083 |
missense |
possibly damaging |
0.95 |
R4366:Apob
|
UTSW |
12 |
8016083 |
missense |
possibly damaging |
0.95 |
R4456:Apob
|
UTSW |
12 |
8015445 |
missense |
probably damaging |
1.00 |
R4458:Apob
|
UTSW |
12 |
8015445 |
missense |
probably damaging |
1.00 |
R4600:Apob
|
UTSW |
12 |
8008568 |
missense |
probably damaging |
1.00 |
R4611:Apob
|
UTSW |
12 |
8011331 |
missense |
probably damaging |
1.00 |
R4646:Apob
|
UTSW |
12 |
8012759 |
missense |
probably benign |
0.21 |
R4678:Apob
|
UTSW |
12 |
7995585 |
missense |
probably damaging |
1.00 |
R4685:Apob
|
UTSW |
12 |
8006456 |
missense |
probably benign |
0.00 |
R4707:Apob
|
UTSW |
12 |
8006205 |
missense |
probably damaging |
0.96 |
R4726:Apob
|
UTSW |
12 |
7990267 |
missense |
probably damaging |
0.98 |
R4792:Apob
|
UTSW |
12 |
8008051 |
missense |
probably benign |
0.26 |
R4822:Apob
|
UTSW |
12 |
8015741 |
missense |
probably benign |
0.04 |
R4834:Apob
|
UTSW |
12 |
8014101 |
missense |
possibly damaging |
0.49 |
R4835:Apob
|
UTSW |
12 |
8015391 |
missense |
possibly damaging |
0.56 |
R4887:Apob
|
UTSW |
12 |
8013099 |
missense |
probably damaging |
1.00 |
R4910:Apob
|
UTSW |
12 |
8007848 |
missense |
probably damaging |
1.00 |
R5072:Apob
|
UTSW |
12 |
8008714 |
missense |
probably benign |
0.00 |
R5073:Apob
|
UTSW |
12 |
8005219 |
critical splice donor site |
probably null |
|
R5074:Apob
|
UTSW |
12 |
8005219 |
critical splice donor site |
probably null |
|
R5101:Apob
|
UTSW |
12 |
8011934 |
missense |
probably benign |
0.09 |
R5123:Apob
|
UTSW |
12 |
8007630 |
splice site |
probably null |
|
R5133:Apob
|
UTSW |
12 |
8008898 |
missense |
probably damaging |
0.99 |
R5135:Apob
|
UTSW |
12 |
8010086 |
missense |
probably damaging |
1.00 |
R5137:Apob
|
UTSW |
12 |
8011384 |
missense |
possibly damaging |
0.63 |
R5160:Apob
|
UTSW |
12 |
8012126 |
missense |
possibly damaging |
0.90 |
R5173:Apob
|
UTSW |
12 |
8008238 |
missense |
probably benign |
0.00 |
R5202:Apob
|
UTSW |
12 |
8013737 |
missense |
probably damaging |
0.98 |
R5229:Apob
|
UTSW |
12 |
7977806 |
missense |
probably benign |
|
R5292:Apob
|
UTSW |
12 |
8005912 |
missense |
probably benign |
0.01 |
R5378:Apob
|
UTSW |
12 |
8011865 |
missense |
probably damaging |
0.99 |
R5494:Apob
|
UTSW |
12 |
8011762 |
missense |
probably damaging |
0.99 |
R5517:Apob
|
UTSW |
12 |
7990906 |
missense |
probably damaging |
1.00 |
R5576:Apob
|
UTSW |
12 |
7998662 |
missense |
probably damaging |
1.00 |
R5582:Apob
|
UTSW |
12 |
8010788 |
missense |
probably damaging |
1.00 |
R5629:Apob
|
UTSW |
12 |
8007847 |
missense |
probably damaging |
1.00 |
R5678:Apob
|
UTSW |
12 |
7991494 |
missense |
possibly damaging |
0.92 |
R5732:Apob
|
UTSW |
12 |
8010353 |
missense |
probably benign |
0.15 |
R5734:Apob
|
UTSW |
12 |
7988781 |
missense |
probably damaging |
1.00 |
R5742:Apob
|
UTSW |
12 |
8007191 |
missense |
probably damaging |
1.00 |
R5751:Apob
|
UTSW |
12 |
8012619 |
nonsense |
probably null |
|
R5776:Apob
|
UTSW |
12 |
8006149 |
missense |
possibly damaging |
0.57 |
R5778:Apob
|
UTSW |
12 |
8015074 |
missense |
probably benign |
0.45 |
R5783:Apob
|
UTSW |
12 |
8001022 |
missense |
probably damaging |
1.00 |
R5786:Apob
|
UTSW |
12 |
8015304 |
missense |
possibly damaging |
0.48 |
R5837:Apob
|
UTSW |
12 |
8003277 |
missense |
probably benign |
0.04 |
R5857:Apob
|
UTSW |
12 |
8015397 |
missense |
probably benign |
0.00 |
R6029:Apob
|
UTSW |
12 |
8016243 |
missense |
probably damaging |
0.99 |
R6032:Apob
|
UTSW |
12 |
7995513 |
missense |
probably benign |
0.02 |
R6032:Apob
|
UTSW |
12 |
7995513 |
missense |
probably benign |
0.02 |
R6086:Apob
|
UTSW |
12 |
8015164 |
missense |
probably benign |
|
R6110:Apob
|
UTSW |
12 |
8011883 |
missense |
probably damaging |
1.00 |
R6131:Apob
|
UTSW |
12 |
8015874 |
missense |
probably benign |
0.17 |
R6157:Apob
|
UTSW |
12 |
8006077 |
missense |
probably benign |
|
R6179:Apob
|
UTSW |
12 |
8005060 |
nonsense |
probably null |
|
R6247:Apob
|
UTSW |
12 |
8001801 |
missense |
probably damaging |
1.00 |
R6279:Apob
|
UTSW |
12 |
8007769 |
nonsense |
probably null |
|
R6300:Apob
|
UTSW |
12 |
8007769 |
nonsense |
probably null |
|
R6320:Apob
|
UTSW |
12 |
7989194 |
missense |
probably benign |
0.27 |
R6339:Apob
|
UTSW |
12 |
8016188 |
missense |
probably damaging |
0.99 |
R6353:Apob
|
UTSW |
12 |
8009421 |
missense |
probably damaging |
1.00 |
R6395:Apob
|
UTSW |
12 |
8008507 |
missense |
probably benign |
0.45 |
R6441:Apob
|
UTSW |
12 |
7987796 |
missense |
probably damaging |
1.00 |
R6492:Apob
|
UTSW |
12 |
8008261 |
missense |
probably damaging |
0.99 |
R6495:Apob
|
UTSW |
12 |
7990394 |
missense |
probably null |
1.00 |
R6502:Apob
|
UTSW |
12 |
8001814 |
missense |
probably damaging |
0.99 |
R6520:Apob
|
UTSW |
12 |
7983124 |
missense |
probably damaging |
1.00 |
R6644:Apob
|
UTSW |
12 |
8009077 |
missense |
probably damaging |
0.97 |
R6704:Apob
|
UTSW |
12 |
8010379 |
missense |
probably damaging |
0.98 |
R6750:Apob
|
UTSW |
12 |
7997853 |
missense |
probably damaging |
1.00 |
R6759:Apob
|
UTSW |
12 |
8011049 |
missense |
probably benign |
0.06 |
R6812:Apob
|
UTSW |
12 |
7983062 |
missense |
probably damaging |
0.98 |
R6865:Apob
|
UTSW |
12 |
8008847 |
missense |
probably benign |
0.05 |
R6873:Apob
|
UTSW |
12 |
8015995 |
missense |
probably benign |
0.00 |
R7013:Apob
|
UTSW |
12 |
8010080 |
nonsense |
probably null |
|
R7067:Apob
|
UTSW |
12 |
8009423 |
missense |
probably damaging |
1.00 |
R7084:Apob
|
UTSW |
12 |
8009591 |
missense |
probably benign |
|
R7113:Apob
|
UTSW |
12 |
7995539 |
missense |
probably damaging |
1.00 |
R7175:Apob
|
UTSW |
12 |
8007034 |
missense |
probably benign |
0.33 |
R7196:Apob
|
UTSW |
12 |
7983893 |
missense |
possibly damaging |
0.90 |
R7199:Apob
|
UTSW |
12 |
8005072 |
missense |
probably damaging |
1.00 |
R7205:Apob
|
UTSW |
12 |
8005087 |
missense |
probably damaging |
0.98 |
R7251:Apob
|
UTSW |
12 |
8007037 |
missense |
probably damaging |
0.98 |
R7474:Apob
|
UTSW |
12 |
8009185 |
missense |
probably benign |
0.29 |
R7484:Apob
|
UTSW |
12 |
8006884 |
nonsense |
probably null |
|
R7538:Apob
|
UTSW |
12 |
8002219 |
missense |
probably damaging |
0.98 |
R7636:Apob
|
UTSW |
12 |
8009516 |
missense |
possibly damaging |
0.86 |
R7646:Apob
|
UTSW |
12 |
8009189 |
missense |
probably damaging |
0.99 |
R7787:Apob
|
UTSW |
12 |
7990780 |
missense |
probably damaging |
0.97 |
R7793:Apob
|
UTSW |
12 |
8008124 |
missense |
probably damaging |
0.99 |
R7836:Apob
|
UTSW |
12 |
8001885 |
missense |
possibly damaging |
0.72 |
R7895:Apob
|
UTSW |
12 |
8011933 |
missense |
probably benign |
0.00 |
R8005:Apob
|
UTSW |
12 |
8009744 |
missense |
probably benign |
0.01 |
R8013:Apob
|
UTSW |
12 |
8010798 |
missense |
possibly damaging |
0.94 |
R8014:Apob
|
UTSW |
12 |
8010798 |
missense |
possibly damaging |
0.94 |
R8111:Apob
|
UTSW |
12 |
8008801 |
missense |
probably benign |
0.16 |
R8117:Apob
|
UTSW |
12 |
8006435 |
missense |
probably damaging |
0.99 |
R8226:Apob
|
UTSW |
12 |
8009056 |
missense |
probably benign |
0.00 |
R8244:Apob
|
UTSW |
12 |
8010548 |
missense |
probably damaging |
0.96 |
R8280:Apob
|
UTSW |
12 |
8010851 |
missense |
possibly damaging |
0.46 |
R8310:Apob
|
UTSW |
12 |
8009033 |
missense |
probably benign |
0.00 |
R8327:Apob
|
UTSW |
12 |
8001015 |
missense |
possibly damaging |
0.72 |
R8329:Apob
|
UTSW |
12 |
8011135 |
missense |
probably damaging |
0.98 |
R8331:Apob
|
UTSW |
12 |
8001882 |
missense |
probably benign |
0.28 |
R8351:Apob
|
UTSW |
12 |
8006356 |
missense |
probably benign |
0.29 |
R8412:Apob
|
UTSW |
12 |
8008069 |
missense |
probably benign |
0.33 |
R8425:Apob
|
UTSW |
12 |
7988842 |
missense |
possibly damaging |
0.70 |
R8493:Apob
|
UTSW |
12 |
8009009 |
missense |
possibly damaging |
0.87 |
R8529:Apob
|
UTSW |
12 |
8007353 |
missense |
probably damaging |
1.00 |
R8554:Apob
|
UTSW |
12 |
7987830 |
missense |
probably damaging |
0.98 |
X0027:Apob
|
UTSW |
12 |
8007975 |
missense |
probably benign |
|
Z1088:Apob
|
UTSW |
12 |
8005074 |
missense |
possibly damaging |
0.91 |
Z1088:Apob
|
UTSW |
12 |
8005945 |
nonsense |
probably null |
|
Z1088:Apob
|
UTSW |
12 |
8012936 |
missense |
possibly damaging |
0.95 |
Z1176:Apob
|
UTSW |
12 |
7998011 |
missense |
probably damaging |
1.00 |
Z1176:Apob
|
UTSW |
12 |
8004978 |
missense |
probably benign |
0.00 |
Z1177:Apob
|
UTSW |
12 |
7988765 |
missense |
probably benign |
0.43 |
Z1177:Apob
|
UTSW |
12 |
8015249 |
frame shift |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TCAGGAAGTGTTGCCAATGAAGCC -3'
(R):5'- ATCTATCAGCCAGTTCTTGCACGG -3'
Sequencing Primer
(F):5'- ATTTTGCTGGAGAAGCCACC -3'
(R):5'- TGAAGCTTGAAGATACTGTCGC -3'
|
Posted On | 2014-01-15 |