Incidental Mutation 'R1147:Olfr434'
Institutional Source Beutler Lab
Gene Symbol Olfr434
Ensembl Gene ENSMUSG00000059411
Gene Nameolfactory receptor 434
SynonymsGA_x6K02T2P3E9-4341246-4340281, MOR261-10
MMRRC Submission 039220-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.159) question?
Stock #R1147 (G1)
Quality Score225
Status Not validated
Chromosomal Location43213021-43218113 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 43217212 bp
Amino Acid Change Threonine to Serine at position 100 (T100S)
Ref Sequence ENSEMBL: ENSMUSP00000149678 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076752] [ENSMUST00000216562]
Predicted Effect probably damaging
Transcript: ENSMUST00000076752
AA Change: T100S

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076039
Gene: ENSMUSG00000059411
AA Change: T100S

Pfam:7tm_4 30 307 7.7e-62 PFAM
Pfam:7tm_1 40 289 2.1e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204448
AA Change: T100S
SMART Domains Protein: ENSMUSP00000145171
Gene: ENSMUSG00000059411
AA Change: T100S

Pfam:7tm_4 30 156 1.2e-26 PFAM
Pfam:7TM_GPCR_Srsx 34 156 3.5e-6 PFAM
Pfam:7tm_1 40 156 7.5e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215485
Predicted Effect probably damaging
Transcript: ENSMUST00000216562
AA Change: T100S

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Meta Mutation Damage Score 0.2442 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 97.7%
  • 10x: 89.5%
  • 20x: 66.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530032D15Rik C G 1: 85,099,505 K113N probably benign Het
Adam20 T C 8: 40,795,618 I255T possibly damaging Het
Aknad1 T A 3: 108,752,541 N290K possibly damaging Het
Als2cr12 A T 1: 58,669,463 Y215N probably damaging Het
Ano8 C A 8: 71,482,017 V447F probably damaging Het
Arsi G A 18: 60,916,651 G202E probably benign Het
Ash1l A T 3: 88,984,887 M1358L possibly damaging Het
Ccdc110 A G 8: 45,944,084 K837E possibly damaging Het
Cd19 T A 7: 126,411,045 D384V possibly damaging Het
Ces1f C T 8: 93,258,281 V473I possibly damaging Het
Chd6 C T 2: 160,990,271 E994K probably damaging Het
Col5a2 G T 1: 45,376,771 N1405K probably damaging Het
Dnah7b A G 1: 46,340,266 D3720G probably damaging Het
Dsel T C 1: 111,862,209 T199A possibly damaging Het
Fabp3 C T 4: 130,312,387 T57I probably benign Het
Hrg G T 16: 22,961,004 C344F probably damaging Het
Htt T C 5: 34,851,252 Y1462H probably damaging Het
Kcnh2 T A 5: 24,324,387 I784F probably damaging Het
Kifc3 T C 8: 95,137,918 T55A probably damaging Het
Kirrel C T 3: 87,089,151 M380I probably null Het
Olfr692 G A 7: 105,369,277 R308Q probably benign Het
Oog3 A G 4: 144,158,412 F318S possibly damaging Het
Pde5a C T 3: 122,794,313 T376M probably damaging Het
Pkhd1l1 A G 15: 44,537,441 I2204V probably null Het
Ppp1r13l A G 7: 19,375,847 D731G probably damaging Het
Ptk6 C T 2: 181,195,797 G443D probably benign Het
Ptpro T A 6: 137,443,594 V1007D probably damaging Het
Ptprs T C 17: 56,423,504 D749G probably damaging Het
Ralgapa1 A T 12: 55,702,480 D1212E probably damaging Het
Rsad1 T C 11: 94,544,140 Y290C probably damaging Het
Sfi1 CCTCTC CCTCTCTC 11: 3,177,419 probably benign Het
Slc6a11 T A 6: 114,244,870 I507N possibly damaging Het
Sybu A T 15: 44,746,255 F78I probably damaging Het
Tox A T 4: 6,823,055 N87K possibly damaging Het
Trrap G A 5: 144,804,766 G1308R probably damaging Het
Trub2 A G 2: 29,787,632 probably benign Het
Vmn2r114 A T 17: 23,311,063 H123Q probably benign Het
Vmn2r15 T A 5: 109,293,206 Y262F probably damaging Het
Vmn2r33 C T 7: 7,554,145 E519K probably benign Het
Zfp106 A T 2: 120,520,536 C1545S probably damaging Het
Other mutations in Olfr434
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00339:Olfr434 APN 6 43217848 missense probably benign 0.00
R0347:Olfr434 UTSW 6 43217362 missense probably benign
R1099:Olfr434 UTSW 6 43217624 missense probably damaging 1.00
R1147:Olfr434 UTSW 6 43217212 missense probably damaging 0.99
R1353:Olfr434 UTSW 6 43217690 missense probably benign 0.41
R1570:Olfr434 UTSW 6 43217351 missense probably benign
R1720:Olfr434 UTSW 6 43217560 missense probably damaging 1.00
R2098:Olfr434 UTSW 6 43217503 missense probably benign 0.02
R4707:Olfr434 UTSW 6 43216949 missense probably benign 0.27
R4942:Olfr434 UTSW 6 43216994 missense probably damaging 1.00
R5008:Olfr434 UTSW 6 43217057 missense probably damaging 0.98
R5084:Olfr434 UTSW 6 43217660 missense probably damaging 1.00
R6472:Olfr434 UTSW 6 43217359 missense probably benign
R7592:Olfr434 UTSW 6 43217245 missense probably damaging 1.00
R7756:Olfr434 UTSW 6 43217016 nonsense probably null
R7784:Olfr434 UTSW 6 43217388 missense possibly damaging 0.82
R8056:Olfr434 UTSW 6 43217044 missense probably damaging 0.99
Predicted Primers
Posted On2014-01-15