Incidental Mutation 'R0085:Or11g25'
ID 102578
Institutional Source Beutler Lab
Gene Symbol Or11g25
Ensembl Gene ENSMUSG00000095765
Gene Name olfactory receptor family 11 subfamily G member 25
Synonyms MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786
MMRRC Submission 038372-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R0085 (G1)
Quality Score 131
Status Validated
Chromosome 14
Chromosomal Location 50710514-50723852 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50723791 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 292 (M292K)
Ref Sequence ENSEMBL: ENSMUSP00000151020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]
AlphaFold L7N1Y5
Predicted Effect probably benign
Transcript: ENSMUST00000071932
AA Change: M292K

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: M292K

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.2e-55 PFAM
Pfam:7tm_1 45 294 2.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205518
AA Change: M292K

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000213903
AA Change: M292K

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
Meta Mutation Damage Score 0.4041 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.4%
Validation Efficiency 95% (71/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad12 A G 5: 121,742,357 (GRCm39) I417T possibly damaging Het
Adcy9 T C 16: 4,106,088 (GRCm39) T1009A probably benign Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
Baat T C 4: 49,490,425 (GRCm39) probably benign Het
Bpi T A 2: 158,115,072 (GRCm39) L311* probably null Het
Brd2 A C 17: 34,332,233 (GRCm39) F294L probably damaging Het
Carmil1 T A 13: 24,209,850 (GRCm39) E804D probably benign Het
Cd209g A T 8: 4,184,785 (GRCm39) probably benign Het
Cfi A G 3: 129,668,635 (GRCm39) I554V probably benign Het
Clvs2 G C 10: 33,498,542 (GRCm39) S129R possibly damaging Het
Dst T C 1: 34,268,268 (GRCm39) S2897P probably damaging Het
Efcab7 T C 4: 99,761,877 (GRCm39) probably benign Het
Fbxo2 T C 4: 148,249,367 (GRCm39) probably null Het
Fgfr2 C A 7: 129,797,993 (GRCm39) R400L probably damaging Het
Hsd17b14 T C 7: 45,205,834 (GRCm39) probably benign Het
Il23r T C 6: 67,463,206 (GRCm39) N96D probably damaging Het
Ints13 T A 6: 146,476,285 (GRCm39) probably benign Het
Khdc4 T A 3: 88,619,046 (GRCm39) S583R probably damaging Het
Lig1 A G 7: 13,041,495 (GRCm39) I776V possibly damaging Het
Madd T C 2: 90,993,083 (GRCm39) I997V probably benign Het
Mgat4b C T 11: 50,121,826 (GRCm39) H116Y possibly damaging Het
Myh11 C A 16: 14,041,883 (GRCm39) Q720H probably damaging Het
Myo5b A C 18: 74,834,751 (GRCm39) D937A probably benign Het
Nox3 T C 17: 3,685,556 (GRCm39) N584S probably benign Het
Ogfr A G 2: 180,232,830 (GRCm39) probably null Het
Or13p3 T C 4: 118,567,078 (GRCm39) V158A probably benign Het
Or8b1b T C 9: 38,375,958 (GRCm39) I207T probably benign Het
Osbpl6 G T 2: 76,423,758 (GRCm39) V728F probably benign Het
Picalm T A 7: 89,831,525 (GRCm39) S453T probably benign Het
Piezo1 A G 8: 123,228,354 (GRCm39) L310P probably damaging Het
Pitrm1 C T 13: 6,599,604 (GRCm39) probably benign Het
Pkd1 T C 17: 24,805,197 (GRCm39) F3250L probably damaging Het
Plekha4 C T 7: 45,193,373 (GRCm39) R376* probably null Het
Pnma8b A T 7: 16,679,474 (GRCm39) S153C unknown Het
Rp1l1 C T 14: 64,259,744 (GRCm39) R129W probably damaging Het
Ryr3 A G 2: 112,690,108 (GRCm39) V1147A probably damaging Het
Sema3d G A 5: 12,620,953 (GRCm39) V520I probably benign Het
Sgsm1 A G 5: 113,427,136 (GRCm39) probably benign Het
Slc13a2 A G 11: 78,297,694 (GRCm39) V58A probably damaging Het
Slc1a4 A G 11: 20,254,510 (GRCm39) probably benign Het
Slc4a10 G A 2: 62,074,690 (GRCm39) probably benign Het
Tab1 G T 15: 80,040,094 (GRCm39) A305S probably benign Het
Tmem30a T A 9: 79,678,576 (GRCm39) T327S probably benign Het
Tpr A C 1: 150,293,164 (GRCm39) E863A possibly damaging Het
Upk3bl A G 5: 136,088,969 (GRCm39) N161D probably benign Het
Ush1c T A 7: 45,874,979 (GRCm39) I131F probably benign Het
Wdfy4 C A 14: 32,800,200 (GRCm39) R1975S possibly damaging Het
Zbtb18 C T 1: 177,275,501 (GRCm39) A287V probably benign Het
Zfp712 T C 13: 67,189,256 (GRCm39) T424A probably benign Het
Zfp791 G T 8: 85,838,862 (GRCm39) Y56* probably null Het
Other mutations in Or11g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Or11g25 APN 14 50,723,230 (GRCm39) missense probably damaging 0.98
IGL01796:Or11g25 APN 14 50,722,998 (GRCm39) missense probably benign 0.28
IGL01916:Or11g25 APN 14 50,722,950 (GRCm39) missense probably benign 0.01
IGL02686:Or11g25 APN 14 50,723,426 (GRCm39) missense probably benign 0.01
IGL02874:Or11g25 APN 14 50,723,686 (GRCm39) missense possibly damaging 0.57
IGL02898:Or11g25 APN 14 50,723,643 (GRCm39) missense probably damaging 1.00
PIT4515001:Or11g25 UTSW 14 50,723,536 (GRCm39) missense probably benign 0.03
R1777:Or11g25 UTSW 14 50,723,757 (GRCm39) missense probably benign 0.08
R1850:Or11g25 UTSW 14 50,723,055 (GRCm39) missense probably benign
R2270:Or11g25 UTSW 14 50,723,494 (GRCm39) missense probably damaging 1.00
R2338:Or11g25 UTSW 14 50,723,097 (GRCm39) missense possibly damaging 0.47
R2971:Or11g25 UTSW 14 50,723,065 (GRCm39) missense probably damaging 0.99
R4594:Or11g25 UTSW 14 50,723,619 (GRCm39) missense probably benign 0.00
R5383:Or11g25 UTSW 14 50,723,509 (GRCm39) nonsense probably null
R5708:Or11g25 UTSW 14 50,723,452 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R7116:Or11g25 UTSW 14 50,723,025 (GRCm39) missense probably benign 0.00
R7702:Or11g25 UTSW 14 50,723,751 (GRCm39) missense possibly damaging 0.79
R8169:Or11g25 UTSW 14 50,723,692 (GRCm39) missense probably benign 0.13
R9040:Or11g25 UTSW 14 50,722,995 (GRCm39) missense probably benign 0.00
R9139:Or11g25 UTSW 14 50,723,707 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CCTTGCCTGTTCCAGAGTCCCAT -3'
(R):5'- GCTGCAACCACTAACTGTATAACTTCTCC -3'

Sequencing Primer
(F):5'- CTGTTCCAGAGTCCCATTGATAGAG -3'
(R):5'- GAGTACAGTATTTGACTTCCCATAAC -3'
Posted On 2014-01-15