Incidental Mutation 'IGL01645:Unc119b'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Unc119b
Ensembl Gene ENSMUSG00000046562
Gene Nameunc-119 lipid binding chaperone B
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01645
Quality Score
Chromosomal Location115122550-115134975 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 115127312 bp
Amino Acid Change Valine to Isoleucine at position 154 (V154I)
Ref Sequence ENSEMBL: ENSMUSP00000055475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060798]
Predicted Effect probably benign
Transcript: ENSMUST00000060798
AA Change: V154I

PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000055475
Gene: ENSMUSG00000046562
AA Change: V154I

low complexity region 18 35 N/A INTRINSIC
Pfam:GMP_PDE_delta 88 247 3.8e-76 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137140
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153403
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3632451O06Rik T C 14: 49,773,554 E232G probably damaging Het
Abcc8 C T 7: 46,115,053 C1156Y possibly damaging Het
Armc4 T C 18: 7,268,491 S343G probably benign Het
Atp8b1 G A 18: 64,546,113 H766Y probably benign Het
BC030867 T C 11: 102,255,186 L96P probably damaging Het
Cacna2d1 C A 5: 16,012,391 probably null Het
Card11 T A 5: 140,878,023 T987S probably benign Het
Dmxl2 A T 9: 54,378,733 Y2723N possibly damaging Het
Dnah11 T A 12: 118,186,998 I342F possibly damaging Het
Dnajc10 A G 2: 80,340,527 H454R possibly damaging Het
Dpy19l3 T C 7: 35,695,338 T592A probably benign Het
Eea1 T A 10: 95,989,589 S49T probably damaging Het
Esd T A 14: 74,749,719 N294K probably benign Het
Fmo3 A G 1: 162,964,006 V234A possibly damaging Het
Folh1 A G 7: 86,742,227 F420L probably damaging Het
Gabra1 T C 11: 42,135,562 N301S probably damaging Het
Gm5422 A T 10: 31,250,073 noncoding transcript Het
Gorab A T 1: 163,386,431 L310Q possibly damaging Het
Gsdme A G 6: 50,251,336 Y51H probably damaging Het
Itpr1 T C 6: 108,473,599 I1964T possibly damaging Het
Lmbr1 A G 5: 29,235,055 L410P probably damaging Het
Lrrc37a T C 11: 103,504,264 R112G probably benign Het
Mrgpra6 T C 7: 47,185,933 T247A probably benign Het
Mroh4 A G 15: 74,611,358 probably benign Het
Mycbpap T C 11: 94,503,467 probably null Het
Myoz2 T A 3: 123,034,232 K12N probably damaging Het
Olfr412 T C 11: 74,365,533 I288T possibly damaging Het
P3h1 T G 4: 119,236,783 F212V probably damaging Het
Pcnx2 T C 8: 125,887,917 D265G probably damaging Het
Pkd1l3 C T 8: 109,635,302 T992I possibly damaging Het
Prss58 T C 6: 40,897,310 D144G probably damaging Het
Pth2 T A 7: 45,181,340 L29Q possibly damaging Het
Rab1b A C 19: 5,104,934 probably benign Het
Rasa2 A T 9: 96,582,781 C190* probably null Het
Scn9a T C 2: 66,487,642 K1501E possibly damaging Het
Selenoi A G 5: 30,257,823 probably benign Het
Slc11a2 T C 15: 100,389,118 N558S probably benign Het
Sox10 T C 15: 79,156,339 I173V probably benign Het
Sra1 A C 18: 36,671,473 F476C probably damaging Het
St5 T A 7: 109,527,634 K540* probably null Het
Tmem119 T A 5: 113,795,348 K131* probably null Het
Trim12c T A 7: 104,345,054 K198* probably null Het
Ttn A G 2: 76,851,560 probably benign Het
Usp47 T A 7: 112,054,862 S108R probably damaging Het
Vmn1r15 T A 6: 57,258,562 C138* probably null Het
Vmn1r191 T C 13: 22,179,444 I47V probably benign Het
Wnt3 C T 11: 103,812,378 A229V probably benign Het
Other mutations in Unc119b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02207:Unc119b APN 5 115134754 missense probably benign
R1695:Unc119b UTSW 5 115134826 nonsense probably null
R2306:Unc119b UTSW 5 115125475 nonsense probably null
R3871:Unc119b UTSW 5 115130508 missense probably damaging 1.00
R4970:Unc119b UTSW 5 115125494 missense probably damaging 0.97
R5112:Unc119b UTSW 5 115125494 missense probably damaging 0.97
R5933:Unc119b UTSW 5 115127449 intron probably benign
R5977:Unc119b UTSW 5 115130553 missense probably benign 0.10
R7423:Unc119b UTSW 5 115134684 missense probably damaging 1.00
Posted On2014-01-21