Incidental Mutation 'IGL00769:Dock11'
ID10268
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dock11
Ensembl Gene ENSMUSG00000031093
Gene Namededicator of cytokinesis 11
SynonymsZizimin2, 5033414A21Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.312) question?
Stock #IGL00769
Quality Score
Status
ChromosomeX
Chromosomal Location35888832-36076562 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 36004062 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 796 (N796S)
Ref Sequence ENSEMBL: ENSMUSP00000110921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115266]
Predicted Effect probably benign
Transcript: ENSMUST00000033419
AA Change: N980S

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093
AA Change: N980S

DomainStartEndE-ValueType
Pfam:DUF3398 52 145 4.2e-39 PFAM
PH 166 274 1.4e-17 SMART
Blast:PH 329 440 4e-58 BLAST
Pfam:DOCK-C2 636 827 2.4e-53 PFAM
low complexity region 1254 1270 N/A INTRINSIC
Pfam:DHR-2 1510 2029 7.3e-210 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000115266
AA Change: N796S

PolyPhen 2 Score 0.735 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093
AA Change: N796S

DomainStartEndE-ValueType
PH 1 90 6.82e-7 SMART
Blast:PH 145 256 5e-58 BLAST
Pfam:DOCK-C2 451 644 1.3e-60 PFAM
low complexity region 1083 1099 N/A INTRINSIC
low complexity region 1521 1529 N/A INTRINSIC
Pfam:Ded_cyto 1681 1858 1.2e-68 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001P01Rik A G 11: 97,771,581 F155S probably damaging Het
9930111J21Rik1 A G 11: 48,948,212 V516A possibly damaging Het
A730017C20Rik T C 18: 59,072,277 S88P probably damaging Het
Ambp G A 4: 63,144,165 T279I probably damaging Het
Ankrd28 A G 14: 31,743,365 V285A possibly damaging Het
Arfgef3 A G 10: 18,660,604 S220P probably benign Het
Atp9b G T 18: 80,912,853 H129N probably benign Het
Cdh10 C A 15: 18,985,099 P283Q possibly damaging Het
Cep295 A G 9: 15,326,144 S1941P probably damaging Het
Dmbt1 T A 7: 131,082,500 S575R probably damaging Het
Enam A T 5: 88,501,484 Y284F possibly damaging Het
F8 A T X: 75,334,180 probably benign Het
Fbxo42 C T 4: 141,180,449 T140M probably damaging Het
Galnt13 G A 2: 54,880,104 E303K probably benign Het
Mrgprb4 T A 7: 48,198,901 D93V probably benign Het
Msl3 T A X: 168,668,748 E215V probably damaging Het
Pglyrp3 A T 3: 92,014,622 probably benign Het
Prdx1 G A 4: 116,692,965 D115N probably benign Het
Psd3 A T 8: 67,908,679 probably benign Het
Rundc1 A G 11: 101,434,274 D602G probably damaging Het
Slc4a1ap T G 5: 31,553,777 Y742D probably damaging Het
Ugt1a6a C T 1: 88,139,050 P193S probably damaging Het
Vmn2r96 G A 17: 18,583,819 V252M probably benign Het
Wdr53 G A 16: 32,256,497 W173* probably null Het
Other mutations in Dock11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Dock11 APN X 35994434 missense probably benign 0.15
IGL00650:Dock11 APN X 36006593 splice site probably benign
IGL00963:Dock11 APN X 36032382 missense possibly damaging 0.63
IGL01389:Dock11 APN X 35993048 missense probably benign 0.43
IGL01410:Dock11 APN X 36037643 missense probably damaging 1.00
IGL01519:Dock11 APN X 35963353 missense probably benign
IGL02023:Dock11 APN X 35968769 missense probably benign 0.09
IGL02253:Dock11 APN X 36041128 missense probably damaging 1.00
IGL02416:Dock11 APN X 36020086 missense probably damaging 0.97
IGL02583:Dock11 APN X 36006717 missense possibly damaging 0.48
IGL03014:Dock11 APN X 36047046 splice site probably benign
IGL03037:Dock11 APN X 36047046 splice site probably benign
IGL03065:Dock11 APN X 36047046 splice site probably benign
IGL03277:Dock11 APN X 36013950 missense probably benign 0.32
R0816:Dock11 UTSW X 36020035 missense probably damaging 1.00
R0819:Dock11 UTSW X 36020035 missense probably damaging 1.00
R0820:Dock11 UTSW X 36020035 missense probably damaging 1.00
R1430:Dock11 UTSW X 36069912 missense probably benign 0.00
R1512:Dock11 UTSW X 36020035 missense probably damaging 1.00
Z1088:Dock11 UTSW X 36002533 missense probably benign 0.01
Z1176:Dock11 UTSW X 35984848 missense possibly damaging 0.69
Posted On2012-12-06