Incidental Mutation 'IGL01647:Wnt8b'
ID 102715
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wnt8b
Ensembl Gene ENSMUSG00000036961
Gene Name wingless-type MMTV integration site family, member 8B
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01647
Quality Score
Status
Chromosome 19
Chromosomal Location 44481912-44502712 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 44499704 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 151 (D151V)
Ref Sequence ENSEMBL: ENSMUSP00000042867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041163]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000041163
AA Change: D151V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000042867
Gene: ENSMUSG00000036961
AA Change: D151V

DomainStartEndE-ValueType
WNT1 38 351 1.02e-185 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik T A 2: 35,266,097 (GRCm39) D191V probably damaging Het
Adcy6 T C 15: 98,498,156 (GRCm39) D382G probably damaging Het
Arhgef33 A T 17: 80,672,695 (GRCm39) probably benign Het
Armc10 A G 5: 21,851,091 (GRCm39) probably benign Het
Bcas1 T A 2: 170,191,172 (GRCm39) Q586L probably damaging Het
Bltp3b T C 10: 89,609,982 (GRCm39) probably null Het
Ccdc88a A C 11: 29,454,321 (GRCm39) probably benign Het
Cep250 T A 2: 155,825,296 (GRCm39) C1057S probably benign Het
Ctsm A T 13: 61,688,087 (GRCm39) M14K probably benign Het
Dpy19l1 C T 9: 24,396,365 (GRCm39) R117Q probably damaging Het
Frem1 A G 4: 82,868,593 (GRCm39) Y1463H possibly damaging Het
Garin3 G T 11: 46,296,224 (GRCm39) E199* probably null Het
Gck A T 11: 5,854,472 (GRCm39) M251K probably damaging Het
Gzf1 C T 2: 148,525,570 (GRCm39) P14S probably damaging Het
Iws1 A T 18: 32,230,275 (GRCm39) K748* probably null Het
Kif15 T A 9: 122,792,536 (GRCm39) probably benign Het
Ly6g6f A G 17: 35,299,817 (GRCm39) probably benign Het
Mrps30 C T 13: 118,517,146 (GRCm39) G358R probably damaging Het
Nfrkb T A 9: 31,307,801 (GRCm39) probably benign Het
Or5m3b C T 2: 85,872,441 (GRCm39) P261S probably damaging Het
Pakap A T 4: 57,688,477 (GRCm39) I107F possibly damaging Het
Pcnt T A 10: 76,205,835 (GRCm39) K2506* probably null Het
Pgc G T 17: 48,043,329 (GRCm39) G226W probably damaging Het
Pip5k1a C T 3: 94,981,383 (GRCm39) V82M probably damaging Het
Plk3 A G 4: 116,987,554 (GRCm39) V466A probably damaging Het
Prss44 C A 9: 110,643,745 (GRCm39) Q130K probably damaging Het
Rbck1 T C 2: 152,165,152 (GRCm39) Y66C probably damaging Het
Rbm6 T C 9: 107,730,081 (GRCm39) E189G probably benign Het
Rtn4r G T 16: 17,969,190 (GRCm39) R206L probably damaging Het
Ryr2 C T 13: 11,600,366 (GRCm39) G4613E probably damaging Het
Sema5a T G 15: 32,417,587 (GRCm39) L19R possibly damaging Het
Slc30a5 T C 13: 100,957,653 (GRCm39) T139A possibly damaging Het
Slco2a1 T G 9: 102,947,495 (GRCm39) S265A possibly damaging Het
Smad4 A G 18: 73,773,544 (GRCm39) probably benign Het
St13 C T 15: 81,255,708 (GRCm39) R240Q probably damaging Het
Tcea3 A C 4: 136,002,087 (GRCm39) probably benign Het
Vmn1r177 T C 7: 23,565,600 (GRCm39) Y92C probably damaging Het
Zfp426 T A 9: 20,389,453 (GRCm39) M1L possibly damaging Het
Other mutations in Wnt8b
AlleleSourceChrCoordTypePredicted EffectPPH Score
Manorborne UTSW 19 44,500,396 (GRCm39) missense probably damaging 1.00
Prospero UTSW 19 44,500,280 (GRCm39) missense probably damaging 1.00
R0601:Wnt8b UTSW 19 44,482,106 (GRCm39) missense probably benign 0.01
R0948:Wnt8b UTSW 19 44,498,968 (GRCm39) missense possibly damaging 0.69
R1315:Wnt8b UTSW 19 44,500,462 (GRCm39) missense probably damaging 1.00
R1672:Wnt8b UTSW 19 44,499,715 (GRCm39) missense probably damaging 1.00
R1864:Wnt8b UTSW 19 44,482,029 (GRCm39) missense probably benign 0.08
R5728:Wnt8b UTSW 19 44,499,757 (GRCm39) missense possibly damaging 0.69
R6180:Wnt8b UTSW 19 44,500,082 (GRCm39) missense probably benign 0.01
R6997:Wnt8b UTSW 19 44,500,280 (GRCm39) missense probably damaging 1.00
R7187:Wnt8b UTSW 19 44,500,121 (GRCm39) missense probably benign 0.04
R7216:Wnt8b UTSW 19 44,500,511 (GRCm39) missense probably benign
R7469:Wnt8b UTSW 19 44,500,001 (GRCm39) missense possibly damaging 0.83
R7673:Wnt8b UTSW 19 44,500,127 (GRCm39) missense possibly damaging 0.73
R8003:Wnt8b UTSW 19 44,500,396 (GRCm39) missense probably damaging 1.00
R8055:Wnt8b UTSW 19 44,481,952 (GRCm39) start gained probably benign
Posted On 2014-01-21