Incidental Mutation 'IGL01649:Psg17'
ID102756
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Psg17
Ensembl Gene ENSMUSG00000004540
Gene Namepregnancy specific glycoprotein 17
SynonymsmmCGM5, Cea-2, Cea2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01649
Quality Score
Status
Chromosome7
Chromosomal Location18813937-18821607 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 18816802 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 376 (V376A)
Ref Sequence ENSEMBL: ENSMUSP00000004655 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004655]
Predicted Effect possibly damaging
Transcript: ENSMUST00000004655
AA Change: V376A

PolyPhen 2 Score 0.599 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000004655
Gene: ENSMUSG00000004540
AA Change: V376A

DomainStartEndE-ValueType
low complexity region 19 34 N/A INTRINSIC
IG 40 141 1.84e-2 SMART
IG 160 261 3.63e0 SMART
IG 280 381 2.03e-4 SMART
IGc2 397 461 2.35e-9 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930430A15Rik A T 2: 111,214,576 probably benign Het
4931429L15Rik A G 9: 46,305,818 S220P probably benign Het
Adam18 T C 8: 24,614,896 N634S possibly damaging Het
Arhgef18 T A 8: 3,441,211 probably benign Het
Birc6 A G 17: 74,604,546 S1518G probably benign Het
Cltc A G 11: 86,726,400 V341A probably benign Het
Dlg5 A G 14: 24,138,691 V1721A probably damaging Het
Dnah10 A T 5: 124,732,489 I274F probably damaging Het
Dock1 T A 7: 134,777,410 L622Q probably damaging Het
Dysf A G 6: 84,199,839 D1960G probably damaging Het
Fat3 T C 9: 16,376,719 T503A possibly damaging Het
Glb1 A G 9: 114,423,948 Y73C probably damaging Het
Gm9396 G T 3: 130,068,619 noncoding transcript Het
Gml2 G T 15: 74,824,221 E155* probably null Het
Ikzf4 G A 10: 128,635,820 R323C probably damaging Het
Kiz A G 2: 146,889,309 T240A probably benign Het
Lzts3 T C 2: 130,635,431 K480E probably damaging Het
Mcm7 T C 5: 138,169,436 H105R probably damaging Het
Mpdz A G 4: 81,303,633 L1464P probably damaging Het
Mrgpra9 A C 7: 47,235,152 L256V probably benign Het
Mrpl40 T C 16: 18,872,579 Q127R probably benign Het
Myom2 G T 8: 15,113,755 R1003L probably benign Het
Nav2 A G 7: 49,575,729 T1806A probably damaging Het
Olfr248 T C 1: 174,391,408 L113P probably damaging Het
Pibf1 A T 14: 99,187,763 Y562F possibly damaging Het
Ppm1n A T 7: 19,278,197 probably benign Het
Sept8 T A 11: 53,535,028 F143I possibly damaging Het
Sestd1 A G 2: 77,199,045 Y330H probably damaging Het
Sntg1 C T 1: 8,681,969 probably benign Het
Stpg2 C A 3: 139,419,862 P472Q probably damaging Het
Thbs1 A G 2: 118,114,982 K314R probably benign Het
Vav3 T C 3: 109,562,762 Y508H probably benign Het
Other mutations in Psg17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Psg17 APN 7 18820166 missense probably damaging 1.00
IGL02171:Psg17 APN 7 18818787 missense probably damaging 0.98
PIT4151001:Psg17 UTSW 7 18814605 missense probably benign 0.26
R1178:Psg17 UTSW 7 18814455 missense probably benign 0.13
R1767:Psg17 UTSW 7 18816802 missense possibly damaging 0.60
R1991:Psg17 UTSW 7 18814652 missense probably benign 0.02
R4428:Psg17 UTSW 7 18816792 missense probably benign 0.31
R5285:Psg17 UTSW 7 18820201 missense probably benign 0.01
R5507:Psg17 UTSW 7 18819926 missense probably benign 0.04
R5516:Psg17 UTSW 7 18814533 missense probably benign 0.30
R5837:Psg17 UTSW 7 18820215 missense possibly damaging 0.58
R6481:Psg17 UTSW 7 18814450 missense probably damaging 1.00
R6817:Psg17 UTSW 7 18814640 missense probably damaging 1.00
R7124:Psg17 UTSW 7 18814496 missense probably damaging 1.00
R7124:Psg17 UTSW 7 18814497 missense probably damaging 1.00
R7243:Psg17 UTSW 7 18818715 missense probably damaging 1.00
R7268:Psg17 UTSW 7 18814661 missense possibly damaging 0.64
R7384:Psg17 UTSW 7 18818660 missense possibly damaging 0.67
R7544:Psg17 UTSW 7 18819972 missense probably benign 0.25
R7555:Psg17 UTSW 7 18817094 missense probably benign 0.03
R7634:Psg17 UTSW 7 18814491 missense probably damaging 1.00
Z1088:Psg17 UTSW 7 18816910 missense probably benign 0.03
Posted On2014-01-21