Incidental Mutation 'IGL01650:Or6c69'
ID 102792
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6c69
Ensembl Gene ENSMUSG00000063715
Gene Name olfactory receptor family 6 subfamily C member 69
Synonyms MOR113-1, Olfr816, GA_x6K02T2PULF-11590830-11589892
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # IGL01650
Quality Score
Chromosome 10
Chromosomal Location 129747207-129748145 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129747550 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 199 (V199A)
Ref Sequence ENSEMBL: ENSMUSP00000149515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071605] [ENSMUST00000213438]
AlphaFold Q8VFU2
Predicted Effect probably benign
Transcript: ENSMUST00000071605
AA Change: V199A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071534
Gene: ENSMUSG00000063715
AA Change: V199A

Pfam:7tm_4 29 306 6.9e-50 PFAM
Pfam:7tm_1 39 288 1.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213438
AA Change: V199A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213618
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl1 A G 7: 76,070,067 (GRCm39) D281G probably damaging Het
Arhgap28 T C 17: 68,180,127 (GRCm39) E236G probably damaging Het
Bltp1 G A 3: 37,046,822 (GRCm39) probably benign Het
Btbd3 A T 2: 138,126,025 (GRCm39) D334V probably damaging Het
Cabp4 T C 19: 4,189,323 (GRCm39) E78G probably benign Het
Clcn4 T C 7: 7,287,280 (GRCm39) probably benign Het
Col14a1 A G 15: 55,270,089 (GRCm39) Y600C unknown Het
Cpne4 A G 9: 104,778,710 (GRCm39) D167G probably damaging Het
Eif3a T A 19: 60,762,434 (GRCm39) I450F probably damaging Het
Enpp2 T A 15: 54,783,329 (GRCm39) Y10F probably benign Het
Fam227a A T 15: 79,518,274 (GRCm39) H339Q possibly damaging Het
Far2 C A 6: 148,074,985 (GRCm39) T406K possibly damaging Het
Fmo1 A G 1: 162,661,153 (GRCm39) S377P probably benign Het
Fsip2 G A 2: 82,821,430 (GRCm39) S5721N probably benign Het
Gatb T C 3: 85,520,791 (GRCm39) I300T possibly damaging Het
Gpam T C 19: 55,070,132 (GRCm39) N375D probably benign Het
Gsdma G T 11: 98,564,513 (GRCm39) D331Y probably damaging Het
Kif13b T C 14: 65,002,594 (GRCm39) V1073A probably benign Het
Mfsd4b1 T A 10: 39,879,115 (GRCm39) M261L probably benign Het
Nav1 A T 1: 135,382,498 (GRCm39) D1321E probably damaging Het
Or4f59 A G 2: 111,872,720 (GRCm39) I219T possibly damaging Het
Or52j3 A G 7: 102,836,286 (GRCm39) I159M probably benign Het
Or6c76b T A 10: 129,692,936 (GRCm39) L183Q probably damaging Het
Or8g32 G T 9: 39,305,252 (GRCm39) S55I probably damaging Het
Ppp1r10 G T 17: 36,242,053 (GRCm39) R857L unknown Het
Prune2 T A 19: 17,145,656 (GRCm39) I2752N possibly damaging Het
Pxdn T C 12: 30,052,400 (GRCm39) I859T probably benign Het
Ros1 T C 10: 52,031,075 (GRCm39) D510G probably damaging Het
Sema3g C A 14: 30,943,744 (GRCm39) P208H probably benign Het
Smcr8 T C 11: 60,669,010 (GRCm39) F53L probably damaging Het
Tnfsf13b A T 8: 10,081,411 (GRCm39) I219F probably damaging Het
Vmn1r62 T C 7: 5,679,024 (GRCm39) V235A probably damaging Het
Vmn2r44 C A 7: 8,383,103 (GRCm39) probably null Het
Zkscan7 A G 9: 122,723,892 (GRCm39) D287G probably benign Het
Other mutations in Or6c69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Or6c69 APN 10 129,748,114 (GRCm39) missense possibly damaging 0.89
IGL01766:Or6c69 APN 10 129,747,649 (GRCm39) missense probably damaging 1.00
IGL02738:Or6c69 APN 10 129,747,200 (GRCm39) utr 3 prime probably benign
IGL02824:Or6c69 APN 10 129,747,565 (GRCm39) missense probably damaging 1.00
R0401:Or6c69 UTSW 10 129,747,785 (GRCm39) missense probably benign 0.18
R0688:Or6c69 UTSW 10 129,747,752 (GRCm39) missense probably damaging 0.99
R1589:Or6c69 UTSW 10 129,747,550 (GRCm39) missense probably benign 0.00
R1744:Or6c69 UTSW 10 129,747,262 (GRCm39) missense probably damaging 1.00
R2049:Or6c69 UTSW 10 129,748,036 (GRCm39) missense probably benign 0.30
R3763:Or6c69 UTSW 10 129,747,314 (GRCm39) missense probably damaging 1.00
R3952:Or6c69 UTSW 10 129,747,505 (GRCm39) missense probably benign 0.00
R3971:Or6c69 UTSW 10 129,747,742 (GRCm39) missense probably benign 0.01
R4557:Or6c69 UTSW 10 129,747,398 (GRCm39) missense probably damaging 1.00
R5538:Or6c69 UTSW 10 129,747,871 (GRCm39) missense probably benign 0.13
R6127:Or6c69 UTSW 10 129,747,284 (GRCm39) missense probably damaging 1.00
R6227:Or6c69 UTSW 10 129,747,536 (GRCm39) missense probably damaging 1.00
R6394:Or6c69 UTSW 10 129,747,789 (GRCm39) missense probably damaging 1.00
R6707:Or6c69 UTSW 10 129,747,608 (GRCm39) missense probably benign 0.02
R7257:Or6c69 UTSW 10 129,748,156 (GRCm39) start gained probably benign
R7258:Or6c69 UTSW 10 129,748,156 (GRCm39) start gained probably benign
R7260:Or6c69 UTSW 10 129,748,156 (GRCm39) start gained probably benign
R7409:Or6c69 UTSW 10 129,748,120 (GRCm39) missense possibly damaging 0.74
R7539:Or6c69 UTSW 10 129,747,932 (GRCm39) missense probably damaging 1.00
R7782:Or6c69 UTSW 10 129,747,392 (GRCm39) missense probably damaging 1.00
R7984:Or6c69 UTSW 10 129,747,941 (GRCm39) missense probably benign 0.00
R8879:Or6c69 UTSW 10 129,747,731 (GRCm39) missense probably damaging 1.00
R9533:Or6c69 UTSW 10 129,747,404 (GRCm39) missense probably benign 0.20
R9717:Or6c69 UTSW 10 129,748,048 (GRCm39) missense probably damaging 1.00
X0019:Or6c69 UTSW 10 129,747,964 (GRCm39) missense probably damaging 1.00
Z1191:Or6c69 UTSW 10 129,747,826 (GRCm39) missense possibly damaging 0.94
Posted On 2014-01-21