Incidental Mutation 'IGL01650:Olfr951'
ID 102794
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr951
Ensembl Gene ENSMUSG00000094269
Gene Name olfactory receptor 951
Synonyms MOR171-49, MOR171-33P, GA_x6K02T2PVTD-33090395-33091330
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL01650
Quality Score
Status
Chromosome 9
Chromosomal Location 39387410-39395633 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 39393956 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Isoleucine at position 55 (S55I)
Ref Sequence ENSEMBL: ENSMUSP00000077615 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078531] [ENSMUST00000216107]
AlphaFold Q9EQ94
Predicted Effect probably damaging
Transcript: ENSMUST00000078531
AA Change: S55I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000077615
Gene: ENSMUSG00000094269
AA Change: S55I

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.5e-52 PFAM
Pfam:7tm_1 44 293 5e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216107
AA Change: S52I

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik G A 3: 36,992,673 probably benign Het
Agbl1 A G 7: 76,420,319 D281G probably damaging Het
Arhgap28 T C 17: 67,873,132 E236G probably damaging Het
Btbd3 A T 2: 138,284,105 D334V probably damaging Het
Cabp4 T C 19: 4,139,324 E78G probably benign Het
Clcn4 T C 7: 7,284,281 probably benign Het
Col14a1 A G 15: 55,406,693 Y600C unknown Het
Cpne4 A G 9: 104,901,511 D167G probably damaging Het
Eif3a T A 19: 60,773,996 I450F probably damaging Het
Enpp2 T A 15: 54,919,933 Y10F probably benign Het
Fam227a A T 15: 79,634,073 H339Q possibly damaging Het
Far2 C A 6: 148,173,487 T406K possibly damaging Het
Fmo1 A G 1: 162,833,584 S377P probably benign Het
Fsip2 G A 2: 82,991,086 S5721N probably benign Het
Gatb T C 3: 85,613,484 I300T possibly damaging Het
Gpam T C 19: 55,081,700 N375D probably benign Het
Gsdma G T 11: 98,673,687 D331Y probably damaging Het
Kif13b T C 14: 64,765,145 V1073A probably benign Het
Mfsd4b1 T A 10: 40,003,119 M261L probably benign Het
Nav1 A T 1: 135,454,760 D1321E probably damaging Het
Olfr1312 A G 2: 112,042,375 I219T possibly damaging Het
Olfr592 A G 7: 103,187,079 I159M probably benign Het
Olfr813 T A 10: 129,857,067 L183Q probably damaging Het
Olfr816 A G 10: 129,911,681 V199A probably benign Het
Ppp1r10 G T 17: 35,931,161 R857L unknown Het
Prune2 T A 19: 17,168,292 I2752N possibly damaging Het
Pxdn T C 12: 30,002,401 I859T probably benign Het
Ros1 T C 10: 52,154,979 D510G probably damaging Het
Sema3g C A 14: 31,221,787 P208H probably benign Het
Smcr8 T C 11: 60,778,184 F53L probably damaging Het
Tnfsf13b A T 8: 10,031,411 I219F probably damaging Het
Vmn1r62 T C 7: 5,676,025 V235A probably damaging Het
Vmn2r44 C A 7: 8,380,104 probably null Het
Zkscan7 A G 9: 122,894,827 D287G probably benign Het
Other mutations in Olfr951
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01527:Olfr951 APN 9 39393818 missense probably benign 0.01
IGL02134:Olfr951 APN 9 39394534 missense probably damaging 0.99
IGL03113:Olfr951 APN 9 39394685 missense probably damaging 1.00
R0127:Olfr951 UTSW 9 39393942 missense probably benign 0.16
R1730:Olfr951 UTSW 9 39394222 missense probably benign 0.01
R1783:Olfr951 UTSW 9 39394222 missense probably benign 0.01
R1924:Olfr951 UTSW 9 39393867 missense possibly damaging 0.93
R3785:Olfr951 UTSW 9 39394382 missense probably benign 0.07
R3787:Olfr951 UTSW 9 39394382 missense probably benign 0.07
R4607:Olfr951 UTSW 9 39394735 makesense probably null
R4803:Olfr951 UTSW 9 39394636 missense probably benign 0.26
R5314:Olfr951 UTSW 9 39394489 missense probably damaging 1.00
R5338:Olfr951 UTSW 9 39394075 missense probably damaging 1.00
R5360:Olfr951 UTSW 9 39394402 missense probably benign 0.00
R5468:Olfr951 UTSW 9 39393961 missense probably benign 0.33
R6590:Olfr951 UTSW 9 39394549 missense probably benign 0.00
R6690:Olfr951 UTSW 9 39394549 missense probably benign 0.00
R6925:Olfr951 UTSW 9 39393860 missense probably benign 0.32
R6925:Olfr951 UTSW 9 39393861 missense probably benign 0.01
R6982:Olfr951 UTSW 9 39394322 missense probably damaging 1.00
R7662:Olfr951 UTSW 9 39394093 missense probably benign 0.01
R8074:Olfr951 UTSW 9 39393946 missense probably damaging 1.00
R8389:Olfr951 UTSW 9 39394616 missense probably damaging 1.00
R9444:Olfr951 UTSW 9 39394069 missense probably benign 0.19
R9642:Olfr951 UTSW 9 39394561 missense probably damaging 1.00
Posted On 2014-01-21