Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01650:Zkscan7'

102817

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zkscan7

Ensembl Gene

ENSMUSG00000063488

Gene Name

zinc finger with KRAB and SCAN domains 7

Synonyms

Zfp167

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01650

Quality Score

Status

Chromosome

Chromosomal Location

122885685-122898618 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 122894827 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 287 (D287G)

Ref Sequence

ENSEMBL: ENSMUSP00000071695 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063980] [ENSMUST00000215872]

AlphaFold

E9PVW1

Predicted Effect

probably benign
Transcript: ENSMUST00000063980
AA Change: D287G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071695
Gene: ENSMUSG00000063488
AA Change: D287G

Domain	Start	End	E-Value	Type
SCAN	45	156	1.18e-65	SMART
ZnF_C2H2	350	372	5.59e-4	SMART
ZnF_C2H2	378	400	3.69e-4	SMART
ZnF_C2H2	434	456	8.4e1	SMART
ZnF_C2H2	487	509	4.24e-4	SMART
ZnF_C2H2	515	537	8.34e-3	SMART
ZnF_C2H2	543	565	7.37e-4	SMART
ZnF_C2H2	571	593	1.92e-2	SMART
ZnF_C2H2	599	621	1.13e-4	SMART
ZnF_C2H2	627	649	2.24e-3	SMART
ZnF_C2H2	655	677	4.17e-3	SMART
ZnF_C2H2	683	705	1.04e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180486

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180877

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214426

Predicted Effect

probably benign
Transcript: ENSMUST00000215872

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216429

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216924

Meta Mutation Damage Score

0.0746

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	G	A	3: 36,992,673		probably benign	Het
Agbl1	A	G	7: 76,420,319	D281G	probably damaging	Het
Arhgap28	T	C	17: 67,873,132	E236G	probably damaging	Het
Btbd3	A	T	2: 138,284,105	D334V	probably damaging	Het
Cabp4	T	C	19: 4,139,324	E78G	probably benign	Het
Clcn4	T	C	7: 7,284,281		probably benign	Het
Col14a1	A	G	15: 55,406,693	Y600C	unknown	Het
Cpne4	A	G	9: 104,901,511	D167G	probably damaging	Het
Eif3a	T	A	19: 60,773,996	I450F	probably damaging	Het
Enpp2	T	A	15: 54,919,933	Y10F	probably benign	Het
Fam227a	A	T	15: 79,634,073	H339Q	possibly damaging	Het
Far2	C	A	6: 148,173,487	T406K	possibly damaging	Het
Fmo1	A	G	1: 162,833,584	S377P	probably benign	Het
Fsip2	G	A	2: 82,991,086	S5721N	probably benign	Het
Gatb	T	C	3: 85,613,484	I300T	possibly damaging	Het
Gpam	T	C	19: 55,081,700	N375D	probably benign	Het
Gsdma	G	T	11: 98,673,687	D331Y	probably damaging	Het
Kif13b	T	C	14: 64,765,145	V1073A	probably benign	Het
Mfsd4b1	T	A	10: 40,003,119	M261L	probably benign	Het
Nav1	A	T	1: 135,454,760	D1321E	probably damaging	Het
Olfr1312	A	G	2: 112,042,375	I219T	possibly damaging	Het
Olfr592	A	G	7: 103,187,079	I159M	probably benign	Het
Olfr813	T	A	10: 129,857,067	L183Q	probably damaging	Het
Olfr816	A	G	10: 129,911,681	V199A	probably benign	Het
Olfr951	G	T	9: 39,393,956	S55I	probably damaging	Het
Ppp1r10	G	T	17: 35,931,161	R857L	unknown	Het
Prune2	T	A	19: 17,168,292	I2752N	possibly damaging	Het
Pxdn	T	C	12: 30,002,401	I859T	probably benign	Het
Ros1	T	C	10: 52,154,979	D510G	probably damaging	Het
Sema3g	C	A	14: 31,221,787	P208H	probably benign	Het
Smcr8	T	C	11: 60,778,184	F53L	probably damaging	Het
Tnfsf13b	A	T	8: 10,031,411	I219F	probably damaging	Het
Vmn1r62	T	C	7: 5,676,025	V235A	probably damaging	Het
Vmn2r44	C	A	7: 8,380,104		probably null	Het

Other mutations in Zkscan7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00594:Zkscan7	APN	9	122895594	missense	possibly damaging	0.95
IGL01905:Zkscan7	APN	9	122890761	missense	possibly damaging	0.93
IGL02466:Zkscan7	APN	9	122888885	missense	probably damaging	0.98
R0310:Zkscan7	UTSW	9	122888893	nonsense	probably null
R0355:Zkscan7	UTSW	9	122888807	missense	probably damaging	1.00
R0477:Zkscan7	UTSW	9	122890809	splice site	probably null
R1276:Zkscan7	UTSW	9	122890723	missense	probably damaging	0.98
R1426:Zkscan7	UTSW	9	122895163	missense	probably benign
R2055:Zkscan7	UTSW	9	122888937	missense	probably damaging	1.00
R2195:Zkscan7	UTSW	9	122895621	missense	possibly damaging	0.73
R2354:Zkscan7	UTSW	9	122894827	missense	probably benign
R4878:Zkscan7	UTSW	9	122890800	nonsense	probably null
R5106:Zkscan7	UTSW	9	122896133	unclassified	probably benign
R6266:Zkscan7	UTSW	9	122895234	nonsense	probably null
R6299:Zkscan7	UTSW	9	122888717	missense	probably damaging	1.00
R6513:Zkscan7	UTSW	9	122896105	missense	probably benign	0.00
R6881:Zkscan7	UTSW	9	122888701	missense	possibly damaging	0.96
R7640:Zkscan7	UTSW	9	122896056	missense	possibly damaging	0.71
R7920:Zkscan7	UTSW	9	122895909	missense	probably benign	0.19

Posted On

2014-01-21