Incidental Mutation 'IGL01651:Zfp474'
ID102826
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp474
Ensembl Gene ENSMUSG00000046886
Gene Namezinc finger protein 474
Synonyms4933409D10Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL01651
Quality Score
Status
Chromosome18
Chromosomal Location52615915-52639830 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 52638583 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 103 (S103P)
Ref Sequence ENSEMBL: ENSMUSP00000147873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072666] [ENSMUST00000209270]
Predicted Effect probably damaging
Transcript: ENSMUST00000072666
AA Change: S103P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072453
Gene: ENSMUSG00000046886
AA Change: S103P

DomainStartEndE-ValueType
Pfam:zf-C2HC_2 90 114 1.8e-10 PFAM
Pfam:zf-C2HC_2 161 185 3.3e-13 PFAM
Pfam:zf-C2HC_2 217 241 1.2e-10 PFAM
low complexity region 250 267 N/A INTRINSIC
Pfam:zf-C2HC_2 280 304 1.1e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209270
AA Change: S103P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16b T C 2: 181,494,738 probably benign Het
Alms1 T A 6: 85,656,476 V2980E probably benign Het
Anxa7 A G 14: 20,456,501 L457P probably damaging Het
Asic2 T C 11: 80,894,030 D310G probably damaging Het
Btbd9 T C 17: 30,220,417 S599G unknown Het
Col25a1 G A 3: 130,566,485 M487I probably benign Het
Ddx42 T A 11: 106,248,029 F885I probably benign Het
Foxi3 T C 6: 70,956,991 V154A probably damaging Het
Golga3 A C 5: 110,192,905 probably null Het
Igdcc4 T C 9: 65,124,112 V491A possibly damaging Het
Kcnh7 T A 2: 62,734,284 D877V possibly damaging Het
Kcnu1 A G 8: 25,861,095 D162G probably damaging Het
Morc2a T C 11: 3,658,727 probably null Het
Ndufv2 T C 17: 66,089,471 N47S possibly damaging Het
Npepl1 T A 2: 174,114,388 probably benign Het
Olfr424 A T 1: 174,137,341 D199V probably damaging Het
Otud7b C T 3: 96,153,490 Q441* probably null Het
Pard3b A C 1: 62,479,804 probably benign Het
Pfkfb3 T C 2: 11,489,684 E143G probably damaging Het
Pphln1 C A 15: 93,488,983 Q321K probably damaging Het
Rnf121 A G 7: 102,042,655 S2P probably damaging Het
Slc25a42 G A 8: 70,186,600 R276C possibly damaging Het
Smgc T C 15: 91,859,788 probably benign Het
Tdrd5 C T 1: 156,301,827 M104I probably benign Het
Vmn2r26 T A 6: 124,050,673 N457K probably benign Het
Zfp53 A G 17: 21,508,086 N127S probably benign Het
Other mutations in Zfp474
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Zfp474 APN 18 52638493 missense possibly damaging 0.52
IGL01750:Zfp474 APN 18 52639277 missense possibly damaging 0.59
IGL02013:Zfp474 APN 18 52638899 missense possibly damaging 0.86
PIT4469001:Zfp474 UTSW 18 52638719 missense possibly damaging 0.77
PIT4618001:Zfp474 UTSW 18 52638404 missense probably damaging 0.97
R0615:Zfp474 UTSW 18 52638349 missense probably benign 0.02
R1178:Zfp474 UTSW 18 52638742 nonsense probably null
R1180:Zfp474 UTSW 18 52638742 nonsense probably null
R1610:Zfp474 UTSW 18 52638365 missense probably benign
R1819:Zfp474 UTSW 18 52638800 missense probably damaging 1.00
R4854:Zfp474 UTSW 18 52638431 missense possibly damaging 0.59
R6270:Zfp474 UTSW 18 52638364 missense probably benign
R7574:Zfp474 UTSW 18 52639189 missense probably benign 0.00
R8194:Zfp474 UTSW 18 52639157 missense probably damaging 1.00
Posted On2014-01-21