Incidental Mutation 'IGL01651:Zfp474'
ID 102826
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp474
Ensembl Gene ENSMUSG00000046886
Gene Name zinc finger protein 474
Synonyms 4933409D10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL01651
Quality Score
Status
Chromosome 18
Chromosomal Location 52748987-52772902 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52771655 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 103 (S103P)
Ref Sequence ENSEMBL: ENSMUSP00000147873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072666] [ENSMUST00000209270]
AlphaFold Q6V5K9
Predicted Effect probably damaging
Transcript: ENSMUST00000072666
AA Change: S103P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072453
Gene: ENSMUSG00000046886
AA Change: S103P

DomainStartEndE-ValueType
Pfam:zf-C2HC_2 90 114 1.8e-10 PFAM
Pfam:zf-C2HC_2 161 185 3.3e-13 PFAM
Pfam:zf-C2HC_2 217 241 1.2e-10 PFAM
low complexity region 250 267 N/A INTRINSIC
Pfam:zf-C2HC_2 280 304 1.1e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209270
AA Change: S103P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16b T C 2: 181,136,531 (GRCm39) probably benign Het
Alms1 T A 6: 85,633,458 (GRCm39) V2980E probably benign Het
Anxa7 A G 14: 20,506,569 (GRCm39) L457P probably damaging Het
Asic2 T C 11: 80,784,856 (GRCm39) D310G probably damaging Het
Btbd9 T C 17: 30,439,391 (GRCm39) S599G unknown Het
Col25a1 G A 3: 130,360,134 (GRCm39) M487I probably benign Het
Ddx42 T A 11: 106,138,855 (GRCm39) F885I probably benign Het
Foxi3 T C 6: 70,933,975 (GRCm39) V154A probably damaging Het
Golga3 A C 5: 110,340,771 (GRCm39) probably null Het
Igdcc4 T C 9: 65,031,394 (GRCm39) V491A possibly damaging Het
Kcnh7 T A 2: 62,564,628 (GRCm39) D877V possibly damaging Het
Kcnu1 A G 8: 26,351,123 (GRCm39) D162G probably damaging Het
Morc2a T C 11: 3,608,727 (GRCm39) probably null Het
Ndufv2 T C 17: 66,396,466 (GRCm39) N47S possibly damaging Het
Npepl1 T A 2: 173,956,181 (GRCm39) probably benign Het
Or6k4 A T 1: 173,964,907 (GRCm39) D199V probably damaging Het
Otud7b C T 3: 96,060,807 (GRCm39) Q441* probably null Het
Pard3b A C 1: 62,518,963 (GRCm39) probably benign Het
Pfkfb3 T C 2: 11,494,495 (GRCm39) E143G probably damaging Het
Pphln1 C A 15: 93,386,864 (GRCm39) Q321K probably damaging Het
Rnf121 A G 7: 101,691,862 (GRCm39) S2P probably damaging Het
Slc25a42 G A 8: 70,639,250 (GRCm39) R276C possibly damaging Het
Smgc T C 15: 91,743,986 (GRCm39) probably benign Het
Tdrd5 C T 1: 156,129,397 (GRCm39) M104I probably benign Het
Vmn2r26 T A 6: 124,027,632 (GRCm39) N457K probably benign Het
Zfp53 A G 17: 21,728,348 (GRCm39) N127S probably benign Het
Other mutations in Zfp474
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Zfp474 APN 18 52,771,565 (GRCm39) missense possibly damaging 0.52
IGL01750:Zfp474 APN 18 52,772,349 (GRCm39) missense possibly damaging 0.59
IGL02013:Zfp474 APN 18 52,771,971 (GRCm39) missense possibly damaging 0.86
PIT4469001:Zfp474 UTSW 18 52,771,791 (GRCm39) missense possibly damaging 0.77
PIT4618001:Zfp474 UTSW 18 52,771,476 (GRCm39) missense probably damaging 0.97
R0615:Zfp474 UTSW 18 52,771,421 (GRCm39) missense probably benign 0.02
R1178:Zfp474 UTSW 18 52,771,814 (GRCm39) nonsense probably null
R1180:Zfp474 UTSW 18 52,771,814 (GRCm39) nonsense probably null
R1610:Zfp474 UTSW 18 52,771,437 (GRCm39) missense probably benign
R1819:Zfp474 UTSW 18 52,771,872 (GRCm39) missense probably damaging 1.00
R4854:Zfp474 UTSW 18 52,771,503 (GRCm39) missense possibly damaging 0.59
R6270:Zfp474 UTSW 18 52,771,436 (GRCm39) missense probably benign
R7574:Zfp474 UTSW 18 52,772,261 (GRCm39) missense probably benign 0.00
R8194:Zfp474 UTSW 18 52,772,229 (GRCm39) missense probably damaging 1.00
R8799:Zfp474 UTSW 18 52,772,166 (GRCm39) missense probably benign 0.00
R9407:Zfp474 UTSW 18 52,771,502 (GRCm39) missense probably benign 0.37
R9652:Zfp474 UTSW 18 52,772,015 (GRCm39) missense probably damaging 1.00
Posted On 2014-01-21