Incidental Mutation 'IGL01652:Vmn1r80'
| ID |
102853 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r80
|
| Ensembl Gene |
ENSMUSG00000115744 |
| Gene Name |
vomeronasal 1 receptor 80 |
| Synonyms |
V1rg3 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
IGL01652
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
11926892-11927818 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 11927063 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 58
(I58V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153967
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075053]
[ENSMUST00000227205]
[ENSMUST00000227471]
[ENSMUST00000227755]
[ENSMUST00000228028]
[ENSMUST00000228578]
|
| AlphaFold |
L7N1Z3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075053
AA Change: I58V
PolyPhen 2
Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000074564
Gene: ENSMUSG00000115744
AA Change: I58V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
301 |
5.4e-11 |
PFAM |
|
Pfam:7tm_1
|
23 |
290 |
5.3e-7 |
PFAM |
|
Pfam:V1R
|
31 |
298 |
3e-31 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227205
AA Change: I58V
PolyPhen 2
Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227240
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227471
AA Change: I58V
PolyPhen 2
Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227755
AA Change: I58V
PolyPhen 2
Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228028
AA Change: I58V
PolyPhen 2
Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228047
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228578
AA Change: I58V
PolyPhen 2
Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228563
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alk |
A |
T |
17: 72,910,526 (GRCm39) |
V60E |
probably damaging |
Het |
| Ank2 |
T |
C |
3: 126,726,690 (GRCm39) |
K868R |
probably benign |
Het |
| Ankrd13a |
A |
T |
5: 114,929,397 (GRCm39) |
D158V |
probably damaging |
Het |
| Arhgap12 |
G |
T |
18: 6,061,853 (GRCm39) |
N380K |
possibly damaging |
Het |
| Cpn1 |
A |
T |
19: 43,974,533 (GRCm39) |
F65L |
possibly damaging |
Het |
| Dlec1 |
T |
A |
9: 118,972,975 (GRCm39) |
H1496Q |
probably benign |
Het |
| Dock1 |
C |
T |
7: 134,379,226 (GRCm39) |
|
probably benign |
Het |
| Dok1 |
T |
C |
6: 83,009,543 (GRCm39) |
N143D |
probably damaging |
Het |
| Fcmr |
C |
T |
1: 130,806,244 (GRCm39) |
P363L |
probably benign |
Het |
| Galk2 |
A |
G |
2: 125,738,685 (GRCm39) |
T171A |
probably benign |
Het |
| Hrh3 |
G |
T |
2: 179,742,896 (GRCm39) |
P244Q |
possibly damaging |
Het |
| Icam1 |
T |
C |
9: 20,930,472 (GRCm39) |
Y109H |
probably damaging |
Het |
| Nup93 |
T |
C |
8: 95,023,187 (GRCm39) |
V132A |
possibly damaging |
Het |
| Or4c113 |
A |
T |
2: 88,884,913 (GRCm39) |
Y286N |
probably damaging |
Het |
| Pla2g4f |
T |
C |
2: 120,132,716 (GRCm39) |
I707V |
possibly damaging |
Het |
| Rpgrip1 |
G |
A |
14: 52,382,949 (GRCm39) |
|
probably benign |
Het |
| Sbf2 |
A |
T |
7: 110,046,327 (GRCm39) |
V290E |
probably damaging |
Het |
| Stard3 |
T |
G |
11: 98,269,559 (GRCm39) |
|
probably benign |
Het |
| Sufu |
T |
C |
19: 46,464,059 (GRCm39) |
Y424H |
probably damaging |
Het |
| Trim35 |
T |
G |
14: 66,546,250 (GRCm39) |
V339G |
probably damaging |
Het |
|
| Other mutations in Vmn1r80 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01610:Vmn1r80
|
APN |
7 |
11,927,307 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02102:Vmn1r80
|
APN |
7 |
11,927,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02165:Vmn1r80
|
APN |
7 |
11,927,379 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02328:Vmn1r80
|
APN |
7 |
11,927,405 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02336:Vmn1r80
|
APN |
7 |
11,927,181 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL02606:Vmn1r80
|
APN |
7 |
11,926,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0310:Vmn1r80
|
UTSW |
7 |
11,927,775 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0399:Vmn1r80
|
UTSW |
7 |
11,927,244 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1983:Vmn1r80
|
UTSW |
7 |
11,927,588 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2079:Vmn1r80
|
UTSW |
7 |
11,927,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4278:Vmn1r80
|
UTSW |
7 |
11,927,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4501:Vmn1r80
|
UTSW |
7 |
11,927,318 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5894:Vmn1r80
|
UTSW |
7 |
11,927,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5991:Vmn1r80
|
UTSW |
7 |
11,927,423 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6552:Vmn1r80
|
UTSW |
7 |
11,927,684 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7560:Vmn1r80
|
UTSW |
7 |
11,927,750 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7659:Vmn1r80
|
UTSW |
7 |
11,926,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8313:Vmn1r80
|
UTSW |
7 |
11,926,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9171:Vmn1r80
|
UTSW |
7 |
11,927,124 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1189:Vmn1r80
|
UTSW |
7 |
11,927,360 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2014-01-21 |
Incidental Mutation