Incidental Mutation 'IGL01653:Scgb2b19'
ID 102873
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scgb2b19
Ensembl Gene ENSMUSG00000096467
Gene Name secretoglobin, family 2B, member 19
Synonyms Gm5894, Abpbg19
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.033) question?
Stock # IGL01653
Quality Score
Status
Chromosome 7
Chromosomal Location 33278370-33280338 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 33279728 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 43 (Y43F)
Ref Sequence ENSEMBL: ENSMUSP00000136155 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179688]
AlphaFold J3QM75
Predicted Effect probably damaging
Transcript: ENSMUST00000179688
AA Change: Y43F

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000136155
Gene: ENSMUSG00000096467
AA Change: Y43F

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Pfam:Feld-I_B 24 90 2.4e-31 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933421I07Rik T C 7: 42,446,974 D119G probably damaging Het
5430403G16Rik A C 5: 109,677,316 Y89* probably null Het
Apol7c A G 15: 77,526,300 C149R probably damaging Het
Arfgef1 G A 1: 10,159,908 R1235* probably null Het
Bpifb4 A G 2: 153,944,783 D285G probably damaging Het
Cep192 T A 18: 67,852,972 H1682Q possibly damaging Het
Cerk G T 15: 86,149,351 Y290* probably null Het
Cyld A T 8: 88,741,370 I544F probably damaging Het
Dcp1a T C 14: 30,505,571 S134P possibly damaging Het
Epha6 A C 16: 59,839,303 N817K probably benign Het
Ephb4 A G 5: 137,365,741 probably benign Het
Fcgr3 A T 1: 171,059,280 L25Q probably damaging Het
Heatr3 A G 8: 88,144,617 I83V probably benign Het
Hormad1 T A 3: 95,578,297 N265K possibly damaging Het
Kpna1 A G 16: 36,020,192 T201A probably benign Het
Krt6b T A 15: 101,679,114 T182S probably damaging Het
Macc1 A G 12: 119,450,353 K755E probably damaging Het
Med12l C T 3: 59,261,893 T1568M probably damaging Het
Muc4 G T 16: 32,761,348 probably null Het
Myt1l T C 12: 29,910,771 S1028P unknown Het
Nhlrc2 C T 19: 56,570,850 R256C probably benign Het
Olfr1230 T A 2: 89,297,127 T48S probably benign Het
Olfr1441 G A 19: 12,422,372 R21H probably benign Het
Pfkfb4 G A 9: 108,999,134 R79H probably damaging Het
Piezo2 T C 18: 63,182,833 probably benign Het
Pramel5 C T 4: 144,273,859 R49H probably benign Het
Ralgapb T A 2: 158,462,159 S613T possibly damaging Het
Ryr1 T C 7: 29,078,597 E2158G probably damaging Het
Slc17a6 A G 7: 51,668,022 T468A possibly damaging Het
Slc36a1 A G 11: 55,228,321 D374G possibly damaging Het
Wdtc1 T C 4: 133,295,232 D601G probably damaging Het
Other mutations in Scgb2b19
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4515001:Scgb2b19 UTSW 7 33279611 critical splice donor site probably null
R0580:Scgb2b19 UTSW 7 33278570 missense probably benign 0.15
R1437:Scgb2b19 UTSW 7 33278555 missense probably benign 0.08
R1445:Scgb2b19 UTSW 7 33279612 critical splice donor site probably null
R5332:Scgb2b19 UTSW 7 33278581 missense probably benign 0.07
R6424:Scgb2b19 UTSW 7 33278597 missense possibly damaging 0.91
R7102:Scgb2b19 UTSW 7 33280286 missense probably null
R7576:Scgb2b19 UTSW 7 33279786 missense possibly damaging 0.92
Posted On 2014-01-21