Incidental Mutation 'IGL01653:Dcp1a'
ID 102893
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcp1a
Ensembl Gene ENSMUSG00000021962
Gene Name decapping mRNA 1A
Synonyms 1110066A22Rik, Mitc1, 4930568L04Rik, SMIF, D14Ertd817e
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.293) question?
Stock # IGL01653
Quality Score
Status
Chromosome 14
Chromosomal Location 30479535-30527063 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30505571 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 134 (S134P)
Ref Sequence ENSEMBL: ENSMUSP00000153074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022535] [ENSMUST00000225196] [ENSMUST00000225286]
AlphaFold Q91YD3
Predicted Effect probably benign
Transcript: ENSMUST00000022535
AA Change: S153P

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000022535
Gene: ENSMUSG00000021962
AA Change: S153P

DomainStartEndE-ValueType
Pfam:DCP1 28 144 1.8e-44 PFAM
low complexity region 327 343 N/A INTRINSIC
low complexity region 457 472 N/A INTRINSIC
Pfam:mRNA_decap_C 559 601 6.3e-22 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000223658
AA Change: S134P
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224453
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224692
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224810
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225124
Predicted Effect probably benign
Transcript: ENSMUST00000225196
AA Change: S153P

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225243
Predicted Effect possibly damaging
Transcript: ENSMUST00000225286
AA Change: S134P

PolyPhen 2 Score 0.521 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225521
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225806
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225923
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933421I07Rik T C 7: 42,446,974 D119G probably damaging Het
5430403G16Rik A C 5: 109,677,316 Y89* probably null Het
Apol7c A G 15: 77,526,300 C149R probably damaging Het
Arfgef1 G A 1: 10,159,908 R1235* probably null Het
Bpifb4 A G 2: 153,944,783 D285G probably damaging Het
Cep192 T A 18: 67,852,972 H1682Q possibly damaging Het
Cerk G T 15: 86,149,351 Y290* probably null Het
Cyld A T 8: 88,741,370 I544F probably damaging Het
Epha6 A C 16: 59,839,303 N817K probably benign Het
Ephb4 A G 5: 137,365,741 probably benign Het
Fcgr3 A T 1: 171,059,280 L25Q probably damaging Het
Heatr3 A G 8: 88,144,617 I83V probably benign Het
Hormad1 T A 3: 95,578,297 N265K possibly damaging Het
Kpna1 A G 16: 36,020,192 T201A probably benign Het
Krt6b T A 15: 101,679,114 T182S probably damaging Het
Macc1 A G 12: 119,450,353 K755E probably damaging Het
Med12l C T 3: 59,261,893 T1568M probably damaging Het
Muc4 G T 16: 32,761,348 probably null Het
Myt1l T C 12: 29,910,771 S1028P unknown Het
Nhlrc2 C T 19: 56,570,850 R256C probably benign Het
Olfr1230 T A 2: 89,297,127 T48S probably benign Het
Olfr1441 G A 19: 12,422,372 R21H probably benign Het
Pfkfb4 G A 9: 108,999,134 R79H probably damaging Het
Piezo2 T C 18: 63,182,833 probably benign Het
Pramel5 C T 4: 144,273,859 R49H probably benign Het
Ralgapb T A 2: 158,462,159 S613T possibly damaging Het
Ryr1 T C 7: 29,078,597 E2158G probably damaging Het
Scgb2b19 T A 7: 33,279,728 Y43F probably damaging Het
Slc17a6 A G 7: 51,668,022 T468A possibly damaging Het
Slc36a1 A G 11: 55,228,321 D374G possibly damaging Het
Wdtc1 T C 4: 133,295,232 D601G probably damaging Het
Other mutations in Dcp1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02698:Dcp1a APN 14 30505542 splice site probably benign
IGL02799:Dcp1a UTSW 14 30519679 critical splice donor site probably null
R0240:Dcp1a UTSW 14 30484594 splice site probably benign
R0387:Dcp1a UTSW 14 30519679 critical splice donor site probably null
R0646:Dcp1a UTSW 14 30502885 missense probably damaging 1.00
R1781:Dcp1a UTSW 14 30513075 missense probably benign 0.37
R1843:Dcp1a UTSW 14 30518983 missense probably damaging 0.99
R2111:Dcp1a UTSW 14 30519370 missense probably benign 0.00
R3176:Dcp1a UTSW 14 30505542 splice site probably benign
R4948:Dcp1a UTSW 14 30479767 missense probably damaging 1.00
R5541:Dcp1a UTSW 14 30502839 missense probably damaging 1.00
R6178:Dcp1a UTSW 14 30523304 makesense probably null
R7767:Dcp1a UTSW 14 30479818 critical splice donor site probably null
R7818:Dcp1a UTSW 14 30479721 missense probably damaging 0.99
R8248:Dcp1a UTSW 14 30479598 intron probably benign
R8248:Dcp1a UTSW 14 30522926 missense possibly damaging 0.87
R8250:Dcp1a UTSW 14 30522926 missense possibly damaging 0.87
R8271:Dcp1a UTSW 14 30522926 missense possibly damaging 0.87
R8297:Dcp1a UTSW 14 30522926 missense possibly damaging 0.87
R8302:Dcp1a UTSW 14 30522926 missense possibly damaging 0.87
R8326:Dcp1a UTSW 14 30519570 nonsense probably null
R8333:Dcp1a UTSW 14 30522926 missense possibly damaging 0.87
R8818:Dcp1a UTSW 14 30518942 missense possibly damaging 0.64
Posted On 2014-01-21