Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01654:Apol10b'

102915

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Apol10b

Ensembl Gene

ENSMUSG00000050014

Gene Name

apolipoprotein L 10B

Synonyms

9130218O11Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01654

Quality Score

Status

Chromosome

Chromosomal Location

77468019-77480325 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 77472996 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 19 (D19E)

Ref Sequence

ENSEMBL: ENSMUSP00000086890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089465]

AlphaFold

G3X9K7

Predicted Effect

probably benign
Transcript: ENSMUST00000089465
AA Change: D19E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000086890
Gene: ENSMUSG00000050014
AA Change: D19E

Domain	Start	End	E-Value	Type
Pfam:ApoL	28	328	2.8e-88	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700034J05Rik	T	A	6: 146,854,838 (GRCm39)	E68V	probably damaging	Het
Abcb1a	T	C	5: 8,765,065 (GRCm39)		probably null	Het
Abcg2	T	A	6: 58,660,306 (GRCm39)		probably null	Het
Adgrf5	T	C	17: 43,762,061 (GRCm39)	I1252T	possibly damaging	Het
Bbs9	T	A	9: 22,402,238 (GRCm39)		probably null	Het
Bod1l	T	C	5: 41,975,519 (GRCm39)	T1932A	probably damaging	Het
C2cd5	A	G	6: 143,027,133 (GRCm39)	V124A	probably benign	Het
Cd151	T	A	7: 141,050,275 (GRCm39)	I170N	probably benign	Het
Ckap5	C	T	2: 91,407,954 (GRCm39)	H827Y	probably benign	Het
Clk3	C	T	9: 57,659,046 (GRCm39)	V572M	probably damaging	Het
Ddrgk1	T	C	2: 130,496,629 (GRCm39)	D245G	probably damaging	Het
Enpp5	A	G	17: 44,392,066 (GRCm39)	D165G	possibly damaging	Het
Epha6	A	C	16: 59,659,666 (GRCm39)	N817K	probably benign	Het
Fbxw14	T	C	9: 109,115,648 (GRCm39)		probably benign	Het
Fes	C	T	7: 80,036,558 (GRCm39)		probably null	Het
Gemin4	A	T	11: 76,104,224 (GRCm39)	L179H	probably damaging	Het
Gm3327	A	G	14: 44,362,317 (GRCm39)	E72G	unknown	Het
Gm4847	C	T	1: 166,465,917 (GRCm39)	R224Q	probably damaging	Het
Lonp2	T	C	8: 87,440,714 (GRCm39)	V357A	probably damaging	Het
Mc2r	A	G	18: 68,541,143 (GRCm39)	I50T	probably benign	Het
Mmp19	C	T	10: 128,634,389 (GRCm39)	A310V	probably damaging	Het
Naip6	C	T	13: 100,435,853 (GRCm39)	R890Q	probably benign	Het
Npdc1	T	C	2: 25,297,649 (GRCm39)	S101P	possibly damaging	Het
Phldb1	T	C	9: 44,629,654 (GRCm39)		probably null	Het
Pkd2l1	T	C	19: 44,142,662 (GRCm39)	N460S	probably damaging	Het
Pnpo	A	G	11: 96,834,555 (GRCm39)		probably null	Het
Prkcq	A	T	2: 11,288,654 (GRCm39)	T536S	probably damaging	Het
Rft1	T	A	14: 30,398,837 (GRCm39)	V269E	probably damaging	Het
Skint4	A	T	4: 111,977,254 (GRCm39)	I215F	probably damaging	Het
Slc12a5	G	A	2: 164,815,675 (GRCm39)	D41N	possibly damaging	Het
Srp68	T	C	11: 116,138,638 (GRCm39)		probably benign	Het
Wdr17	T	C	8: 55,115,914 (GRCm39)	T623A	probably damaging	Het
Zfand2a	A	G	5: 139,467,823 (GRCm39)		probably benign	Het
Zfp644	T	C	5: 106,783,796 (GRCm39)	Y917C	probably damaging	Het
Zmym6	C	T	4: 127,017,519 (GRCm39)	S1008L	probably damaging	Het

Other mutations in Apol10b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01295:Apol10b	APN	15	77,469,796 (GRCm39)	missense	probably damaging	1.00
IGL01905:Apol10b	APN	15	77,469,559 (GRCm39)	missense	possibly damaging	0.92
IGL01969:Apol10b	APN	15	77,472,885 (GRCm39)	splice site	probably null
IGL02305:Apol10b	APN	15	77,469,630 (GRCm39)	missense	possibly damaging	0.55
R0361:Apol10b	UTSW	15	77,469,586 (GRCm39)	missense	possibly damaging	0.82
R0395:Apol10b	UTSW	15	77,469,840 (GRCm39)	missense	probably damaging	1.00
R0437:Apol10b	UTSW	15	77,469,608 (GRCm39)	missense	probably benign	0.00
R0502:Apol10b	UTSW	15	77,476,349 (GRCm39)	splice site	probably benign
R0688:Apol10b	UTSW	15	77,469,419 (GRCm39)	missense	probably damaging	0.99
R1663:Apol10b	UTSW	15	77,472,914 (GRCm39)	missense	probably damaging	1.00
R1763:Apol10b	UTSW	15	77,469,215 (GRCm39)	missense	probably benign	0.14
R4884:Apol10b	UTSW	15	77,473,006 (GRCm39)	missense	possibly damaging	0.93
R6177:Apol10b	UTSW	15	77,469,987 (GRCm39)	missense	possibly damaging	0.50
R7062:Apol10b	UTSW	15	77,469,473 (GRCm39)	missense	probably benign	0.00
R7480:Apol10b	UTSW	15	77,472,988 (GRCm39)	missense	probably benign	0.02
R8511:Apol10b	UTSW	15	77,469,211 (GRCm39)	missense	probably benign	0.43
R8511:Apol10b	UTSW	15	77,469,210 (GRCm39)	missense	probably benign	0.03
R8703:Apol10b	UTSW	15	77,472,897 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-01-21