Incidental Mutation 'IGL01656:Nlrp4d'
ID102999
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nlrp4d
Ensembl Gene ENSMUSG00000034122
Gene NameNLR family, pyrin domain containing 4D
SynonymsNalp4d, Nalp-beta
Accession Numbers

Genbank: XM_001481310; Ensembl: ENSMUST00000184509

 

Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01656
Quality Score
Status
Chromosome7
Chromosomal Location10358862-10388935 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 10364147 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 853 (Y853C)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182420
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184509
AA Change: Y853C
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123L14Rik A G 6: 96,165,694 V123A possibly damaging Het
4732456N10Rik T A 15: 101,555,443 Q392L probably damaging Het
Acrbp A C 6: 125,053,712 E232A possibly damaging Het
Anapc11 T A 11: 120,599,347 F30I possibly damaging Het
Ap5z1 A G 5: 142,470,314 D318G probably benign Het
Cfap43 T C 19: 47,751,900 E1278G possibly damaging Het
Cylc1 A G X: 111,123,716 T589A probably benign Het
Dcaf15 T C 8: 84,097,988 I527V probably benign Het
Ddhd2 C T 8: 25,727,712 V713I probably benign Het
Edc4 T C 8: 105,886,377 V283A possibly damaging Het
Elf5 A G 2: 103,442,861 probably benign Het
Flnb C T 14: 7,902,010 probably benign Het
Flnc C T 6: 29,443,508 probably benign Het
Fstl4 T C 11: 53,000,374 L113P probably damaging Het
Gemin4 C T 11: 76,213,810 V42M probably damaging Het
Gm10076 A G 14: 105,681,920 noncoding transcript Het
Grina A G 15: 76,248,301 Y116C probably damaging Het
Hectd4 T A 5: 121,322,700 L914H probably damaging Het
Il17re T C 6: 113,462,973 probably benign Het
Ivl G A 3: 92,571,655 Q368* probably null Het
Kbtbd8 A G 6: 95,118,676 H73R probably benign Het
Magea3 A T X: 154,949,141 M122K probably damaging Het
Mapk8ip3 T C 17: 24,918,029 D237G probably damaging Het
Nln T C 13: 104,061,741 probably null Het
Nol11 T C 11: 107,189,172 D29G probably benign Het
Nr3c2 C T 8: 77,187,537 L791F probably damaging Het
Olfm3 T C 3: 115,122,633 Y385H probably damaging Het
Olfr126 C T 17: 37,851,138 P182L possibly damaging Het
Olfr1475 G A 19: 13,480,090 A36V probably benign Het
Olfr570 A G 7: 102,901,265 I299M possibly damaging Het
Pklr G T 3: 89,144,995 G505C probably damaging Het
Plxna2 A G 1: 194,790,161 E1071G possibly damaging Het
Prkcq G T 2: 11,226,955 A30S probably damaging Het
Rilpl1 A G 5: 124,503,649 F104L probably damaging Het
Rsph6a C T 7: 19,054,845 T34I probably benign Het
Sec23ip C T 7: 128,750,245 P12L probably damaging Het
Slc25a21 A C 12: 56,738,495 V199G probably damaging Het
Smc1b T C 15: 85,114,776 E483G probably damaging Het
Sucnr1 T C 3: 60,086,411 M120T possibly damaging Het
Tas2r116 T C 6: 132,855,433 probably benign Het
Tbrg4 T A 11: 6,618,522 Q419L possibly damaging Het
Tc2n A G 12: 101,649,089 probably benign Het
Tgfbr2 A C 9: 116,109,669 S388R probably damaging Het
Vmn2r1 A G 3: 64,081,853 E71G probably damaging Het
Xpc A T 6: 91,505,467 I176K probably damaging Het
Xylt1 G T 7: 117,548,993 R264L probably damaging Het
Other mutations in Nlrp4d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00981:Nlrp4d APN 7 10382094 exon noncoding transcript
IGL01076:Nlrp4d APN 7 10372083 missense unknown 0.00
IGL01889:Nlrp4d APN 7 10378334 missense unknown 0.00
IGL02110:Nlrp4d APN 7 10382564 exon noncoding transcript
IGL02271:Nlrp4d APN 7 10388698 exon noncoding transcript
IGL02637:Nlrp4d APN 7 10382555 exon noncoding transcript
snoop UTSW 7 10374891 missense probably benign 0.02
1mM(1):Nlrp4d UTSW 7 10381713 missense probably benign 0.09
F5493:Nlrp4d UTSW 7 10381084 missense possibly damaging 0.84
IGL03048:Nlrp4d UTSW 7 10358954 unclassified noncoding transcript
R0116:Nlrp4d UTSW 7 10374891 missense probably benign 0.02
R0125:Nlrp4d UTSW 7 10382389 missense probably damaging 1.00
R0390:Nlrp4d UTSW 7 10388778 missense probably benign 0.04
R0452:Nlrp4d UTSW 7 10378292 missense probably benign 0.01
R0595:Nlrp4d UTSW 7 10381045 missense probably benign 0.00
R0729:Nlrp4d UTSW 7 10377685 critical splice donor site probably benign
R0733:Nlrp4d UTSW 7 10382522 missense probably benign 0.02
R1147:Nlrp4d UTSW 7 10388717 missense probably benign 0.00
R1217:Nlrp4d UTSW 7 10364267 missense probably benign 0.36
R1378:Nlrp4d UTSW 7 10364184 missense probably benign 0.23
R1414:Nlrp4d UTSW 7 10382601 missense probably benign 0.22
R1583:Nlrp4d UTSW 7 10382237 missense probably damaging 0.99
R1585:Nlrp4d UTSW 7 10382510 missense probably benign 0.02
R1882:Nlrp4d UTSW 7 10382677 critical splice acceptor site noncoding transcript
R2422:Nlrp4d UTSW 7 10362945 missense probably benign 0.29
R2907:Nlrp4d UTSW 7 10378427 missense probably benign 0.00
R2964:Nlrp4d UTSW 7 10378329 nonsense probably null
R2974:Nlrp4d UTSW 7 10378440 critical splice acceptor site probably benign
R3401:Nlrp4d UTSW 7 10362854 missense probably damaging 1.00
R3402:Nlrp4d UTSW 7 10362854 missense probably damaging 1.00
R4240:Nlrp4d UTSW 7 10381316 missense noncoding transcript
R4682:Nlrp4d UTSW 7 10374952 missense noncoding transcript
R4766:Nlrp4d UTSW 7 10362779 critical splice donor site unknown
R4864:Nlrp4d UTSW 7 10381161 missense noncoding transcript
R4910:Nlrp4d UTSW 7 10378409 exon noncoding transcript
R5307:Nlrp4d UTSW 7 10362782 nonsense probably null
R5596:Nlrp4d UTSW 7 10382024 missense noncoding transcript
R5857:Nlrp4d UTSW 7 10382377 missense noncoding transcript
Posted On2014-01-21