Incidental Mutation 'IGL01656:Olfm3'
ID 103013
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfm3
Ensembl Gene ENSMUSG00000027965
Gene Name olfactomedin 3
Synonyms B230206G02Rik, optimedin
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # IGL01656
Quality Score
Status
Chromosome 3
Chromosomal Location 114697727-114919371 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 114916282 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 385 (Y385H)
Ref Sequence ENSEMBL: ENSMUSP00000080448 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051309] [ENSMUST00000081752] [ENSMUST00000149158]
AlphaFold P63056
Predicted Effect probably damaging
Transcript: ENSMUST00000051309
AA Change: Y405H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000060985
Gene: ENSMUSG00000027965
AA Change: Y405H

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Noelin-1 46 145 3.9e-52 PFAM
Blast:OLF 162 207 3e-8 BLAST
OLF 220 470 4.33e-114 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000081752
AA Change: Y385H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080448
Gene: ENSMUSG00000027965
AA Change: Y385H

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Noelin-1 25 125 7.6e-54 PFAM
Blast:OLF 142 187 3e-8 BLAST
OLF 200 450 4.33e-114 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149158
SMART Domains Protein: ENSMUSP00000121097
Gene: ENSMUSG00000027965

DomainStartEndE-ValueType
Pfam:Noelin-1 12 112 2.5e-51 PFAM
Blast:OLF 129 174 1e-8 BLAST
Blast:OLF 187 210 1e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acrbp A C 6: 125,030,675 (GRCm39) E232A possibly damaging Het
Anapc11 T A 11: 120,490,173 (GRCm39) F30I possibly damaging Het
Ap5z1 A G 5: 142,456,069 (GRCm39) D318G probably benign Het
Cfap43 T C 19: 47,740,339 (GRCm39) E1278G possibly damaging Het
Cylc1 A G X: 110,167,485 (GRCm39) T589A probably benign Het
Dcaf15 T C 8: 84,824,617 (GRCm39) I527V probably benign Het
Ddhd2 C T 8: 26,217,739 (GRCm39) V713I probably benign Het
Edc4 T C 8: 106,613,009 (GRCm39) V283A possibly damaging Het
Elf5 A G 2: 103,273,206 (GRCm39) probably benign Het
Flnb C T 14: 7,902,010 (GRCm38) probably benign Het
Flnc C T 6: 29,443,507 (GRCm39) probably benign Het
Fstl4 T C 11: 52,891,201 (GRCm39) L113P probably damaging Het
Gemin4 C T 11: 76,104,636 (GRCm39) V42M probably damaging Het
Gm10076 A G 14: 105,919,354 (GRCm39) noncoding transcript Het
Grina A G 15: 76,132,501 (GRCm39) Y116C probably damaging Het
Hectd4 T A 5: 121,460,763 (GRCm39) L914H probably damaging Het
Il17re T C 6: 113,439,934 (GRCm39) probably benign Het
Ivl G A 3: 92,478,962 (GRCm39) Q368* probably null Het
Kbtbd8 A G 6: 95,095,657 (GRCm39) H73R probably benign Het
Krt90 T A 15: 101,463,878 (GRCm39) Q392L probably damaging Het
Magea3 A T X: 153,732,137 (GRCm39) M122K probably damaging Het
Mapk8ip3 T C 17: 25,137,003 (GRCm39) D237G probably damaging Het
Nln T C 13: 104,198,249 (GRCm39) probably null Het
Nlrp4d T C 7: 10,098,074 (GRCm39) Y853C noncoding transcript Het
Nol11 T C 11: 107,079,998 (GRCm39) D29G probably benign Het
Nr3c2 C T 8: 77,914,166 (GRCm39) L791F probably damaging Het
Nup50l A G 6: 96,142,675 (GRCm39) V123A possibly damaging Het
Or14j5 C T 17: 38,162,029 (GRCm39) P182L possibly damaging Het
Or51a8 A G 7: 102,550,472 (GRCm39) I299M possibly damaging Het
Or5b119 G A 19: 13,457,454 (GRCm39) A36V probably benign Het
Pklr G T 3: 89,052,302 (GRCm39) G505C probably damaging Het
Plxna2 A G 1: 194,472,469 (GRCm39) E1071G possibly damaging Het
Prkcq G T 2: 11,231,766 (GRCm39) A30S probably damaging Het
Rilpl1 A G 5: 124,641,712 (GRCm39) F104L probably damaging Het
Rsph6a C T 7: 18,788,770 (GRCm39) T34I probably benign Het
Sec23ip C T 7: 128,351,969 (GRCm39) P12L probably damaging Het
Slc25a21 A C 12: 56,785,280 (GRCm39) V199G probably damaging Het
Smc1b T C 15: 84,998,977 (GRCm39) E483G probably damaging Het
Sucnr1 T C 3: 59,993,832 (GRCm39) M120T possibly damaging Het
Tas2r116 T C 6: 132,832,396 (GRCm39) probably benign Het
Tbrg4 T A 11: 6,568,522 (GRCm39) Q419L possibly damaging Het
Tc2n A G 12: 101,615,348 (GRCm39) probably benign Het
Tgfbr2 A C 9: 115,938,737 (GRCm39) S388R probably damaging Het
Vmn2r1 A G 3: 63,989,274 (GRCm39) E71G probably damaging Het
Xpc A T 6: 91,482,449 (GRCm39) I176K probably damaging Het
Xylt1 G T 7: 117,148,228 (GRCm39) R264L probably damaging Het
Other mutations in Olfm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01686:Olfm3 APN 3 114,916,497 (GRCm39) missense probably benign 0.00
IGL01732:Olfm3 APN 3 114,890,649 (GRCm39) missense possibly damaging 0.82
IGL02539:Olfm3 APN 3 114,895,579 (GRCm39) missense possibly damaging 0.93
IGL02580:Olfm3 APN 3 114,916,157 (GRCm39) missense probably damaging 1.00
IGL02999:Olfm3 APN 3 114,916,397 (GRCm39) missense probably damaging 1.00
IGL03142:Olfm3 APN 3 114,890,679 (GRCm39) missense probably damaging 0.97
IGL03239:Olfm3 APN 3 114,916,243 (GRCm39) missense probably damaging 0.99
R0361:Olfm3 UTSW 3 114,914,622 (GRCm39) missense probably damaging 1.00
R0373:Olfm3 UTSW 3 114,916,454 (GRCm39) missense probably damaging 0.99
R0505:Olfm3 UTSW 3 114,916,330 (GRCm39) missense possibly damaging 0.46
R0689:Olfm3 UTSW 3 114,916,194 (GRCm39) missense probably benign 0.28
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0974:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R1253:Olfm3 UTSW 3 114,916,418 (GRCm39) missense probably damaging 0.98
R1293:Olfm3 UTSW 3 114,895,579 (GRCm39) missense possibly damaging 0.93
R1952:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably null 1.00
R2255:Olfm3 UTSW 3 114,915,842 (GRCm39) splice site probably null
R2334:Olfm3 UTSW 3 114,895,608 (GRCm39) nonsense probably null
R2510:Olfm3 UTSW 3 114,915,959 (GRCm39) missense probably damaging 1.00
R4222:Olfm3 UTSW 3 114,883,820 (GRCm39) nonsense probably null
R4716:Olfm3 UTSW 3 114,874,755 (GRCm39) missense probably benign 0.00
R4912:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably damaging 1.00
R5084:Olfm3 UTSW 3 114,698,202 (GRCm39) critical splice donor site probably null
R5649:Olfm3 UTSW 3 114,890,573 (GRCm39) missense probably damaging 0.99
R5681:Olfm3 UTSW 3 114,915,924 (GRCm39) missense probably benign 0.28
R5861:Olfm3 UTSW 3 114,916,052 (GRCm39) missense probably damaging 1.00
R5924:Olfm3 UTSW 3 114,916,187 (GRCm39) missense probably benign 0.44
R5929:Olfm3 UTSW 3 114,895,529 (GRCm39) missense probably damaging 0.97
R5958:Olfm3 UTSW 3 114,915,955 (GRCm39) missense probably damaging 0.99
R6166:Olfm3 UTSW 3 114,916,074 (GRCm39) missense probably damaging 1.00
R6299:Olfm3 UTSW 3 114,914,632 (GRCm39) missense probably damaging 1.00
R6804:Olfm3 UTSW 3 114,916,328 (GRCm39) missense probably benign 0.10
R7032:Olfm3 UTSW 3 114,883,805 (GRCm39) missense probably damaging 1.00
R7565:Olfm3 UTSW 3 114,916,393 (GRCm39) missense probably damaging 0.98
R7600:Olfm3 UTSW 3 114,890,589 (GRCm39) missense possibly damaging 0.65
R7976:Olfm3 UTSW 3 114,874,794 (GRCm39) missense probably benign 0.00
R8070:Olfm3 UTSW 3 114,895,604 (GRCm39) missense probably damaging 0.96
R8334:Olfm3 UTSW 3 114,916,206 (GRCm39) missense probably damaging 0.96
R8527:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8542:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8835:Olfm3 UTSW 3 114,916,061 (GRCm39) missense probably damaging 1.00
R9063:Olfm3 UTSW 3 114,914,582 (GRCm39) missense probably benign 0.36
R9594:Olfm3 UTSW 3 114,883,785 (GRCm39) missense probably damaging 1.00
R9690:Olfm3 UTSW 3 114,890,594 (GRCm39) nonsense probably null
R9690:Olfm3 UTSW 3 114,890,593 (GRCm39) missense probably benign 0.39
R9719:Olfm3 UTSW 3 114,916,091 (GRCm39) nonsense probably null
Z1088:Olfm3 UTSW 3 114,698,317 (GRCm39) start gained probably benign
Z1177:Olfm3 UTSW 3 114,874,750 (GRCm39) missense probably benign 0.01
Posted On 2014-01-21