Incidental Mutation 'IGL01656:Anapc11'
ID 103028
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Anapc11
Ensembl Gene ENSMUSG00000025135
Gene Name anaphase promoting complex subunit 11
Synonyms 1110011I19Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.871) question?
Stock # IGL01656
Quality Score
Status
Chromosome 11
Chromosomal Location 120489247-120499024 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 120490173 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 30 (F30I)
Ref Sequence ENSEMBL: ENSMUSP00000097714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026125] [ENSMUST00000026128] [ENSMUST00000093140]
AlphaFold Q9CPX9
Predicted Effect probably benign
Transcript: ENSMUST00000026125
SMART Domains Protein: ENSMUSP00000026125
Gene: ENSMUSG00000025134

DomainStartEndE-ValueType
low complexity region 16 53 N/A INTRINSIC
low complexity region 56 75 N/A INTRINSIC
low complexity region 94 105 N/A INTRINSIC
RRM 106 178 7.64e-20 SMART
FoP_duplication 187 255 1.33e-12 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000026128
AA Change: F30I

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000026128
Gene: ENSMUSG00000025135
AA Change: F30I

DomainStartEndE-ValueType
RING 23 76 4.48e-1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000093140
AA Change: F30I

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097714
Gene: ENSMUSG00000025135
AA Change: F30I

DomainStartEndE-ValueType
RING 23 76 4.48e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129263
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148114
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155325
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156685
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acrbp A C 6: 125,030,675 (GRCm39) E232A possibly damaging Het
Ap5z1 A G 5: 142,456,069 (GRCm39) D318G probably benign Het
Cfap43 T C 19: 47,740,339 (GRCm39) E1278G possibly damaging Het
Cylc1 A G X: 110,167,485 (GRCm39) T589A probably benign Het
Dcaf15 T C 8: 84,824,617 (GRCm39) I527V probably benign Het
Ddhd2 C T 8: 26,217,739 (GRCm39) V713I probably benign Het
Edc4 T C 8: 106,613,009 (GRCm39) V283A possibly damaging Het
Elf5 A G 2: 103,273,206 (GRCm39) probably benign Het
Flnb C T 14: 7,902,010 (GRCm38) probably benign Het
Flnc C T 6: 29,443,507 (GRCm39) probably benign Het
Fstl4 T C 11: 52,891,201 (GRCm39) L113P probably damaging Het
Gemin4 C T 11: 76,104,636 (GRCm39) V42M probably damaging Het
Gm10076 A G 14: 105,919,354 (GRCm39) noncoding transcript Het
Grina A G 15: 76,132,501 (GRCm39) Y116C probably damaging Het
Hectd4 T A 5: 121,460,763 (GRCm39) L914H probably damaging Het
Il17re T C 6: 113,439,934 (GRCm39) probably benign Het
Ivl G A 3: 92,478,962 (GRCm39) Q368* probably null Het
Kbtbd8 A G 6: 95,095,657 (GRCm39) H73R probably benign Het
Krt90 T A 15: 101,463,878 (GRCm39) Q392L probably damaging Het
Magea3 A T X: 153,732,137 (GRCm39) M122K probably damaging Het
Mapk8ip3 T C 17: 25,137,003 (GRCm39) D237G probably damaging Het
Nln T C 13: 104,198,249 (GRCm39) probably null Het
Nlrp4d T C 7: 10,098,074 (GRCm39) Y853C noncoding transcript Het
Nol11 T C 11: 107,079,998 (GRCm39) D29G probably benign Het
Nr3c2 C T 8: 77,914,166 (GRCm39) L791F probably damaging Het
Nup50l A G 6: 96,142,675 (GRCm39) V123A possibly damaging Het
Olfm3 T C 3: 114,916,282 (GRCm39) Y385H probably damaging Het
Or14j5 C T 17: 38,162,029 (GRCm39) P182L possibly damaging Het
Or51a8 A G 7: 102,550,472 (GRCm39) I299M possibly damaging Het
Or5b119 G A 19: 13,457,454 (GRCm39) A36V probably benign Het
Pklr G T 3: 89,052,302 (GRCm39) G505C probably damaging Het
Plxna2 A G 1: 194,472,469 (GRCm39) E1071G possibly damaging Het
Prkcq G T 2: 11,231,766 (GRCm39) A30S probably damaging Het
Rilpl1 A G 5: 124,641,712 (GRCm39) F104L probably damaging Het
Rsph6a C T 7: 18,788,770 (GRCm39) T34I probably benign Het
Sec23ip C T 7: 128,351,969 (GRCm39) P12L probably damaging Het
Slc25a21 A C 12: 56,785,280 (GRCm39) V199G probably damaging Het
Smc1b T C 15: 84,998,977 (GRCm39) E483G probably damaging Het
Sucnr1 T C 3: 59,993,832 (GRCm39) M120T possibly damaging Het
Tas2r116 T C 6: 132,832,396 (GRCm39) probably benign Het
Tbrg4 T A 11: 6,568,522 (GRCm39) Q419L possibly damaging Het
Tc2n A G 12: 101,615,348 (GRCm39) probably benign Het
Tgfbr2 A C 9: 115,938,737 (GRCm39) S388R probably damaging Het
Vmn2r1 A G 3: 63,989,274 (GRCm39) E71G probably damaging Het
Xpc A T 6: 91,482,449 (GRCm39) I176K probably damaging Het
Xylt1 G T 7: 117,148,228 (GRCm39) R264L probably damaging Het
Other mutations in Anapc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02689:Anapc11 APN 11 120,490,168 (GRCm39) missense probably benign 0.06
IGL02738:Anapc11 APN 11 120,490,102 (GRCm39) missense probably benign 0.07
R0373:Anapc11 UTSW 11 120,496,203 (GRCm39) missense probably benign
R0575:Anapc11 UTSW 11 120,490,192 (GRCm39) missense probably benign 0.00
R8167:Anapc11 UTSW 11 120,490,112 (GRCm39) missense probably benign 0.04
R9480:Anapc11 UTSW 11 120,496,176 (GRCm39) missense probably damaging 1.00
R9487:Anapc11 UTSW 11 120,496,250 (GRCm39) makesense probably null
Posted On 2014-01-21