Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01656:Nln'

103032

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nln

Ensembl Gene

ENSMUSG00000021710

Gene Name

neurolysin (metallopeptidase M3 family)

Synonyms

4930472G13Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

IGL01656

Quality Score

Status

Chromosome

Chromosomal Location

104159565-104246122 bp(-) (GRCm39)

Type of Mutation

splice site (4 bp from exon)

DNA Base Change (assembly)

T to C at 104198249 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109315] [ENSMUST00000224945]

AlphaFold

Q91YP2

Predicted Effect

probably null
Transcript: ENSMUST00000109315

SMART Domains

Protein: ENSMUSP00000104938
Gene: ENSMUSG00000021710

Domain	Start	End	E-Value	Type
Pfam:Peptidase_M3	251	701	1.8e-158	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000224945

Predicted Effect

probably null
Transcript: ENSMUST00000225324

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit increased glucose tolerance, insulin sensitivity, and gluconeogensis. Mice also show decreased body weight and run less in a low intensity regime to exhaustion. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acrbp	A	C	6: 125,030,675 (GRCm39)	E232A	possibly damaging	Het
Anapc11	T	A	11: 120,490,173 (GRCm39)	F30I	possibly damaging	Het
Ap5z1	A	G	5: 142,456,069 (GRCm39)	D318G	probably benign	Het
Cfap43	T	C	19: 47,740,339 (GRCm39)	E1278G	possibly damaging	Het
Cylc1	A	G	X: 110,167,485 (GRCm39)	T589A	probably benign	Het
Dcaf15	T	C	8: 84,824,617 (GRCm39)	I527V	probably benign	Het
Ddhd2	C	T	8: 26,217,739 (GRCm39)	V713I	probably benign	Het
Edc4	T	C	8: 106,613,009 (GRCm39)	V283A	possibly damaging	Het
Elf5	A	G	2: 103,273,206 (GRCm39)		probably benign	Het
Flnb	C	T	14: 7,902,010 (GRCm38)		probably benign	Het
Flnc	C	T	6: 29,443,507 (GRCm39)		probably benign	Het
Fstl4	T	C	11: 52,891,201 (GRCm39)	L113P	probably damaging	Het
Gemin4	C	T	11: 76,104,636 (GRCm39)	V42M	probably damaging	Het
Gm10076	A	G	14: 105,919,354 (GRCm39)		noncoding transcript	Het
Grina	A	G	15: 76,132,501 (GRCm39)	Y116C	probably damaging	Het
Hectd4	T	A	5: 121,460,763 (GRCm39)	L914H	probably damaging	Het
Il17re	T	C	6: 113,439,934 (GRCm39)		probably benign	Het
Ivl	G	A	3: 92,478,962 (GRCm39)	Q368*	probably null	Het
Kbtbd8	A	G	6: 95,095,657 (GRCm39)	H73R	probably benign	Het
Krt90	T	A	15: 101,463,878 (GRCm39)	Q392L	probably damaging	Het
Magea3	A	T	X: 153,732,137 (GRCm39)	M122K	probably damaging	Het
Mapk8ip3	T	C	17: 25,137,003 (GRCm39)	D237G	probably damaging	Het
Nlrp4d	T	C	7: 10,098,074 (GRCm39)	Y853C	noncoding transcript	Het
Nol11	T	C	11: 107,079,998 (GRCm39)	D29G	probably benign	Het
Nr3c2	C	T	8: 77,914,166 (GRCm39)	L791F	probably damaging	Het
Nup50l	A	G	6: 96,142,675 (GRCm39)	V123A	possibly damaging	Het
Olfm3	T	C	3: 114,916,282 (GRCm39)	Y385H	probably damaging	Het
Or14j5	C	T	17: 38,162,029 (GRCm39)	P182L	possibly damaging	Het
Or51a8	A	G	7: 102,550,472 (GRCm39)	I299M	possibly damaging	Het
Or5b119	G	A	19: 13,457,454 (GRCm39)	A36V	probably benign	Het
Pklr	G	T	3: 89,052,302 (GRCm39)	G505C	probably damaging	Het
Plxna2	A	G	1: 194,472,469 (GRCm39)	E1071G	possibly damaging	Het
Prkcq	G	T	2: 11,231,766 (GRCm39)	A30S	probably damaging	Het
Rilpl1	A	G	5: 124,641,712 (GRCm39)	F104L	probably damaging	Het
Rsph6a	C	T	7: 18,788,770 (GRCm39)	T34I	probably benign	Het
Sec23ip	C	T	7: 128,351,969 (GRCm39)	P12L	probably damaging	Het
Slc25a21	A	C	12: 56,785,280 (GRCm39)	V199G	probably damaging	Het
Smc1b	T	C	15: 84,998,977 (GRCm39)	E483G	probably damaging	Het
Sucnr1	T	C	3: 59,993,832 (GRCm39)	M120T	possibly damaging	Het
Tas2r116	T	C	6: 132,832,396 (GRCm39)		probably benign	Het
Tbrg4	T	A	11: 6,568,522 (GRCm39)	Q419L	possibly damaging	Het
Tc2n	A	G	12: 101,615,348 (GRCm39)		probably benign	Het
Tgfbr2	A	C	9: 115,938,737 (GRCm39)	S388R	probably damaging	Het
Vmn2r1	A	G	3: 63,989,274 (GRCm39)	E71G	probably damaging	Het
Xpc	A	T	6: 91,482,449 (GRCm39)	I176K	probably damaging	Het
Xylt1	G	T	7: 117,148,228 (GRCm39)	R264L	probably damaging	Het

Other mutations in Nln

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00466:Nln	APN	13	104,172,153 (GRCm39)	missense	probably damaging	1.00
R0025:Nln	UTSW	13	104,173,399 (GRCm39)	missense	probably damaging	0.98
R0294:Nln	UTSW	13	104,189,087 (GRCm39)	missense	probably damaging	1.00
R1396:Nln	UTSW	13	104,198,261 (GRCm39)	missense	probably benign	0.01
R1657:Nln	UTSW	13	104,173,455 (GRCm39)	missense	possibly damaging	0.94
R2087:Nln	UTSW	13	104,173,877 (GRCm39)	missense	probably damaging	0.96
R2847:Nln	UTSW	13	104,161,533 (GRCm39)	missense	probably damaging	1.00
R3034:Nln	UTSW	13	104,173,947 (GRCm39)	missense	possibly damaging	0.91
R5576:Nln	UTSW	13	104,195,338 (GRCm39)	missense	probably damaging	1.00
R5585:Nln	UTSW	13	104,161,569 (GRCm39)	missense	possibly damaging	0.73
R5882:Nln	UTSW	13	104,196,006 (GRCm39)	missense	probably benign	0.08
R6763:Nln	UTSW	13	104,172,163 (GRCm39)	missense	probably damaging	1.00
R7209:Nln	UTSW	13	104,209,406 (GRCm39)	nonsense	probably null
R7347:Nln	UTSW	13	104,187,355 (GRCm39)	missense	probably damaging	0.96
R7417:Nln	UTSW	13	104,173,478 (GRCm39)	missense	probably damaging	1.00
R7467:Nln	UTSW	13	104,161,530 (GRCm39)	missense	possibly damaging	0.75
R7491:Nln	UTSW	13	104,205,831 (GRCm39)	missense	probably damaging	1.00
R7553:Nln	UTSW	13	104,186,924 (GRCm39)	frame shift	probably null
R7842:Nln	UTSW	13	104,189,137 (GRCm39)	missense	probably benign
R8842:Nln	UTSW	13	104,209,486 (GRCm39)	missense	probably benign	0.24
R9295:Nln	UTSW	13	104,186,924 (GRCm39)	frame shift	probably null
R9512:Nln	UTSW	13	104,198,274 (GRCm39)	missense	possibly damaging	0.89
R9544:Nln	UTSW	13	104,198,356 (GRCm39)	missense	probably benign	0.31
R9606:Nln	UTSW	13	104,186,924 (GRCm39)	frame shift	probably null
X0020:Nln	UTSW	13	104,198,318 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-01-21